What Could Go Right?

Episoder

• Why AI and Drones Won’t Bring the Apocalypse | with Sarah Kreps 03.06.2026 46min

  What does a future where autonomous weapons and artificial intelligence collide on the battlefield look like? Sarah Kreps, a Cornell University professor and former US Air Force officer, joins host Zachary Karabell to navigate the rapidly evolving landscape of drones and military AI. The conversation looks beyond the doomsday prognostications surrounding lethal tech. Kreps shares insights from her time in the military around 9/11, reflecting on how constantly gaming out worst-case scenarios surprisingly led her to a more optimistic view of the future. Together, Karabell and Kreps explore the recent tensions between AI companies like Anthropic and the Pentagon. They also examine whether historical conventions for nuclear or biological weapons can offer a blueprint for governing AI and ubiquitous drone swarms. While acknowledging the genuine uncertainties of our technological leap, Kreps explains why false certainty about the apocalypse is dangerous and why she believes society can harness this disruption without breaking. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/
• What the Headlines Aren’t Telling You About Ebola, Plus India's Solar Revolution and a Chicago Medical Miracle 01.06.2026 15min

  A rare strain of Ebola is making headlines — but before you spiral, there's more to the story than what meets the eye. The Democratic Republic of Congo has successfully contained 15 previous outbreaks, and scientists are working around the clock on experimental treatments. We know one thing for certain: this is not the 2014–2016 outbreak.  Plus: India is on its way to becoming the first major country in history to industrialize using solar energy; Hungary's new prime minister has proposed a constitutional amendment that would effectively bar his authoritarian predecessor Viktor Orbán from ever returning to power; and a 28-year-old woman from Chicago's South Side underwent a successful quadruple organ transplant — only the sixth of its kind in the United States. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Follow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• The Surprising Ritual Renaissance | with Bruce Feiler 27.05.2026 49min

  What happens when the traditional ways we gather and mourn start to disappear? Bestselling author Bruce Feiler joins host Zachary Karabell to discuss his latest book, A Time to Gather, and explore the modern celebration recession. Instead of yielding to isolation, Feiler reveals a surprising grassroots renaissance of human connection happening right now.Feiler shares deeply personal stories, from navigating his father's funeral to establishing a meaningful family ritual following the recent loss of his sister-in-law. Karabell and Feiler also discuss the dual nature of social media, highlighting how it acts as an amplification tool that helps democratize new traditions, like hospital honor walks for organ donors and even Taylor Swift-themed divorce parties.While acknowledging the very real threats of loneliness and the isolating effects of our digital lives, Feiler explains why he remains optimistic about our collective future. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/
• American Dads Are Stepping Up, Hope for Pancreatic Cancer Patients, and Oklahoma Bans Child Marriage 25.05.2026 13min

  The pandemic triggered something unexpected:  American fathers started working less and spending significantly more time on childcare and housework — and new research suggests it wasn't remote work or job loss driving the shift, but a genuine realignment of gender norms. Plus: some scientists are calling this the biggest advancement in cancer treatment in 15 years – a drug called daraxonrasib which is nearing FDA approval and substantially extends the lives of pancreatic cancer patients; Brazil has officially begun demarcating over a million acres of protected land for an uncontacted Indigenous tribe in the Amazon; and Oklahoma became the 17th U.S. state to ban child marriage, ruffling some feathers.  What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Follow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• Real Progress: Why We Ignore How Good We Have It | with Nick Gillespie 20.05.2026 52min

  Why does historic abundance breed widespread cultural anger? Nick Gillespie, editor-at-large of Reason Magazine and host of the Reason podcast, joins host Zachary Karabell to unpack the great conundrum of the 21st century: why humans have more security and financial means than ever before, yet feel increasingly dissatisfied. In a world deeply divided along absolute binary lines, Gillespie explains how a philosophy of libertarianism provides a refreshing, pre-partisan alternative to standard political gridlock. Moving past abstract data, Gillespie shares his own personal history as the son of a high school dropout from a working-class white ghetto in Hell's Kitchen. He contrasts his own path of white-knuckling student debt payments with the unique anxieties facing modern generations. And they ask the question, what does the world look like post Trump season two? What Could Go Right? is produced by The Progress Network and Kaleidoscope.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgSubscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/Watch the podcast on YouTube: / theprogressnetworkFollow us on X, Instagram, Facebook, TikTok: @progressntwrkSubscribe to Zachary’s Substack: www.edgyoptimist.substack.com/
• Looted Artifacts Returned, Rape Kit Backlogs Slashed, and a Fatal Disease That's Now Treatable 18.05.2026 14min

  France just passed a landmark law allowing the return of cultural artifacts taken from nations during the colonial era — a long-overdue step nearly a decade in the making.  Plus: all 50 U.S. states have now enacted rape kit reform, cutting the national backlog in half; violent crime in major American cities is falling faster than you might expect; and a new drug is doing something doctors have never been able to say about ALS — it's making some patients actually improve. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Follow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• The Case for Not Knowing | with Simone Stolzoff 13.05.2026 53min

  What happens when our biological need for certainty clashes with an increasingly unpredictable world? Simone Stolzoff, author of How to Not Know, joins host Zachary Karabell to discuss why our modern intolerance for uncertainty is fueling a global anxiety crisis. Rather than seeing the unknown as a threat, Stolzoff argues that uncertainty is the fundamental birthplace of scientific breakthroughs, original art, and human progress. Stolzoff and Karabell explore how to navigate everything from the climate crisis and the AI revolution to high-stakes parenting and career choices through the framework that the false certainty we cling to might actually be detrimental to our success. While acknowledging the hard truths of today's world, Stolzoff explains why "action absorbs anxiety" and makes the case for diversifying our identities so we remain adaptable in the face of an unwritten future.  What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/
• Gene Therapy Is Giving Blind People Their Sight Back + The UK Bans Smoking Forever and Solar Power From Space 11.05.2026 11min

  Gene therapy has been quietly pulling off miracles, and this week, it got its Oscars moment. Emma Varvaloucas, Executive Director of The Progress Network, breaks down how a husband-and-wife scientific team's decades-long quest has restored sight to over 100 blind Americans, and how a brand-new drug called Otarmeni just became the first-ever FDA-approved gene therapy for genetic deafness. The science is extraordinary. The price tags, less so.Plus: The United Kingdom passes a genuinely radical generational ban on smoking; the US Senate unanimously bans members and staffers from betting on prediction markets, after some were caught betting on their own races; and Meta inks a deal to beam solar power down from space.What Could Go Right? is produced by The Progress Network and Kaleidoscope.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgSubscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/Watch the podcast on YouTube: / theprogressnetworkFollow us on X, Instagram, Facebook, TikTok: @progressntwrkFollow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• Why $6 Gas Isn't the End of the World | with Jason Bordoff 06.05.2026 36min

  What happens when the global energy supply faces its greatest disruption since the 1970s? Jason Bordoff, a leading energy expert and former advisor in the Obama White House, joins host Zachary Karabell to navigate a world where the Strait of Hormuz is closed and gasoline prices are soaring.   The conversation moves past the immediate panic at the pump to look at the future of how we power our lives. Bordoff shares personal stories of his father’s Brooklyn gas station in the 1970s, contrasting that era with today's physical reality of the shale revolution. The discussion focuses heavily on the innovation frontier. Bordoff and Karabell explore whether new technologies like advanced geothermal, modular nuclear power, and even fusion can finally deliver on the promise of universal energy abundance.   While acknowledging the hard truths of climate change and the energy needs of emerging markets, Bordoff explains why he is betting on policy and technology over pessimism. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/
• Chernobyl’s Unintended Nature Reserve + The End of the Coal Era and a New Frontier in IVF 04.05.2026 13min

  For the first time in over a century, renewables have knocked coal out of the top spot for global electricity generation — and solar is the reason why. Emma Varvaloucas, Executive Director of The Progress Network, breaks down what this energy milestone actually means, and why geopolitics is unexpectedly accelerating the clean energy transition. Plus: forty years after the worst nuclear disaster in history, wildlife is flourishing inside the Chernobyl exclusion zone; a Utah startup claims it has grown functional human sperm in a lab — a potential breakthrough for male infertility; and NASA is branching into the human organ delivery industry.  What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Follow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• Can We Achieve "Super Abundance" Without AI Doom? | with Sebastian Mallaby 29.04.2026 42min

  What happens when the person building the world's most powerful technology is just as worried about it as we are? Sebastian Mallaby, the Pulitzer Prize-nominated author of The Infinity Machine, joins host Zachary Karabell to pull back the curtain on Demis Hassabis, the founder of DeepMind who is currently leading the global charge into artificial intelligence. From the "Ender’s Game" mission that drives Hassabis to the chilling logic of why machines might accidentally develop a "survival instinct," this episode explores the mindset of the people shaping our future. Mallaby and Karabell discuss the "infinity" of data required to make these systems work and why the massive hunger for compute power is reshaping the global economy in real-time . Drawing a haunting parallel to Alan Greenspan and the 2008 financial crisis, Mallaby asks a difficult question: Can "the man who knew" the risks actually prevent the catastrophe he sees coming?. Together, they navigate the tension between pure scientific discovery and cutthroat Silicon Valley competition, the potential for a "Nuclear Non-Proliferation" style agreement with China, and the hidden dangers of the "open vs. closed" model debate.What Could Go Right? is produced by The Progress Network and Kaleidoscope.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgSubscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/Watch the podcast on YouTube: / theprogressnetworkFollow us on X, Instagram, Facebook, TikTok: @progressntwrkSubscribe to Zachary’s Substack: www.edgyoptimist.substack.com/Follow him LinkedIn: www.linkedin.com/in/zacharykarabell
• Trump’s Surprising Move on Psychedelics + A Record Year for Humpback Whales 27.04.2026 11min

  Trump just signed an executive order to fast-track psychedelic medical research. Emma Varvaloucas, the Executive Director of The Progress Network, breaks down how a 50-year political taboo went mainstream. Plus: San Diego achieves water independence and starts brewing beer from recycled sewage, a humpback whale stampede breaks a sighting record off South Africa, and gene-edited bananas that don't turn brown are finally here.What Could Go Right? is produced by The Progress Network and Kaleidoscope.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgSubscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/Watch the podcast on YouTube: / theprogressnetworkFollow us on X, Instagram, Facebook, TikTok: @progressntwrkFollow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• Is the World Order Actually Disintegrating? | with Ian Bremmer 22.04.2026 40min

  What happens when the rules of the global game are being rewritten in real-time? Ian Bremmer, the founder of Eurasia Group and GZERO Media, joins host Zachary Karabell to discuss how to navigate a world defined by a "long geopolitical recession" and the erosion of the post-1945 order. From the escalating conflicts in the Middle East and the surprising vulnerabilities of the economic models in the Gulf to the "asymmetric war fighting" that allows drones to bring the global economy to its knees, this episode reckons with a world that seems to be disintegrating rather than coming together. Bremmer and Karabell explore why we aren’t getting a better picture of what’s happening on the ground in places like Iran and Yemen, and whether the "noise" of modern social media is a tool for freedom or a new mechanism for state control. As political revolutionaries rise and established media organizations downsize, Bremmer and Karabell ask: is our current information environment worse than it was 30 years ago, or can individuals still "sniff out" the truth? And: Is this the peak of global chaos, or just a cyclical trough before a new rebound? What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/ Follow him LinkedIn: www.linkedin.com/in/zacharykarabell Follow Zachary on X @zacharykarabell
• How Hungary Ousted an Authoritarian + Ocean Progress, Falling Rents, and Thailand’s New DM Laws 20.04.2026 10min

  Hungary just voted out its authoritarian prime minister of 16 years, and did it with an 80% voter turnout powered by Gen Z. Emma Varvaloucas, the Executive Director of The Progress Network, breaks down how they pulled it off and what it means for democracies under pressure elsewhere.  Plus: over 10% of the world's oceans are now protected, US rents are finally dropping, and Thailand just criminalized online sexual harassment, including in your DMs. What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrkFollow Emma on Instagram: https://www.instagram.com/heyemmavarv/
• Do we need a NEW America? | with Anne-Marie Slaughter 15.04.2026 54min

  What do we do when our systems stop working? Anne-Marie Slaughter, the CEO of New America, former Director of Policy Planning at the U.S. State Department under Secretary Hillary Clinton, and one of the most influential voices in American foreign policy joins Zachary Karabell to reckon with a country in the middle of a massive realignment. From democratic reform and the collapse of the two-party system to America's fraying role on the world stage, this conversation refuses easy answers. In this wide-ranging discussion, they explore the shifting geopolitical landscape, including the heightened risks associated with the war in Iran, and how the escalating competition with China challenges us to look inward and ask what we truly stand for. Then they revisit the question Anne Marie has been trying to answer for much of her career, whether or not modern women really can have it all.  So, what does it mean to still believe in liberal democracy when the system isn't delivering? Is this a moment of unraveling, or the messy beginning of a rebirth? What Could Go Right? is produced by The Progress Network and Kaleidoscope. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Subscribe to our (FREE) Substack newsletter: https://theprogressnetwork.org/newsletter/ Watch the podcast on YouTube: / theprogressnetwork Follow us on X, Instagram, Facebook, TikTok: @progressntwrk Subscribe to Zachary’s Substack: www.edgyoptimist.substack.com/ Follow him LinkedIn: www.linkedin.com/in/zacharykarabell Follow Zachary on X @zacharykarabell
• Turning Down the Headline Noise 08.10.2025 54min

  Let’s close out Season 7! Zachary and Emma look back on seven months of thought-provoking positive conversations, from global politics to the depths of sci-fi, exploring how to stay hopeful in a world hooked on negative news. They dive into protecting your mental health by controlling your news intake while also celebrating how social media platforms empower 8 billion voices to be heard!What Could Go Right? is produced by The Progress Network and The Podglomerate.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgWatch the podcast on YouTube: ⁠⁠⁠https://www.youtube.com/theprogressnetwork⁠⁠⁠And follow us on X, Instagram, Facebook, TikTok: @progressntwrk
• The Progress Report: China’s Climate Change Commitment 03.10.2025 20min

  Get ready for a Progress Report season finale packed with good news as Emma shares some life-changing breakthroughs! The Gates Foundation is funding a game-changing GBS vaccine, while a cutting-edge AI stroke diagnosis system in England is significantly improving recovery rates. Plus, China steps up with a bold pledge to slash greenhouse gas emissions while NASA’s James Webb Telescope just uncovered an astonishing 6,000 new planets.
• Whatever Happened to Civics? with Nick Capodice 01.10.2025 55min

  It’s time for a lesson in civics! Zachary and Emma are joined by Nick Capodice, co-host of the Civics 101 podcast where he gets into the basics of how the U.S. government works and also helps teachers design lesson plans to pair with the show. Nick highlights how our collective grasp on how things work in Washington is slipping, the decrease of civics education funding since the 1950s, and the recent rise of deep divisions in American politics. He focuses on the importance of civic participation and voting and how to reclaim your voice beyond the ballot box.What Could Go Right? is produced by The Progress Network and The Podglomerate.For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.orgWatch the podcast on YouTube: ⁠⁠⁠https://www.youtube.com/theprogressnetwork⁠⁠⁠And follow us on X, Instagram, Facebook, TikTok: @progressntwrk
• The Progress Report: This Bacteria Beats Dengue Fever 26.09.2025 20min

  Emma brings you a solo edition of the Progress Report, highlighting several positive global advancements. Brazil goes bold with a two-part strategy against dengue fever, involving both a homegrown vaccine and specially bred mosquitoes that carry an anti-dengue bacteria. Africa is leading a major expansion of school meal programs for children. And around the world we have two stories of security, with the High Seas Treaty recently ratified to protect international waters along with a reported rise in people’s sense of safety.
• Turning Science Fiction Into Reality with Ed Finn 24.09.2025 55min

  Can today’s science fiction become tomorrow’s guidebook for change? Zachary and Emma sit down with Ed Finn, the visionary behind the Center for Science and the Imagination at ASU and academic director of Future Tense. Ed explores the intersection between sci-fi and real world science, the complexities of new technologies like AI and gene editing, and why our imaginations can be the launchpad for tomorrow’s innovations and building the future we dream about. What Could Go Right? is produced by The Progress Network and The Podglomerate. For transcripts, to join the newsletter, and for more information, visit: theprogressnetwork.org Watch the podcast on YouTube: ⁠⁠⁠https://www.youtube.com/theprogressnetwork⁠⁠⁠ And follow us on X, Instagram, Facebook, TikTok: @progressntwrk