MeSsy with Christina Applegate & Jamie Lynn Sigler

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  Look for the Signs with Kate Doerge 30.07.2026 58Min.

  On this episode of Living With It, Jamie sits down with Kate Doerge to discuss finding hope after profound loss, recognizing signs from loved ones, and the five actions that can transform the way we move through grief.
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  Hope Can Exist Alongside Fear with Myriam Sandler 28.07.2026 1Std. 7Min.

  This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned.
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  It's Okay Not to Be Okay with Amy Kurtz 23.07.2026 55Min.

  On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better.
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  All Eyes on Me 21.07.2026 48Min.

  This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. CBDistillery - Visit https://CBDistillery.com and use my code MESSY for 25% off. That’s C B Distillery dot com, code MESSY C B Distillery dot com. ZocDoc  -Head to https://Zocdoc.com/MESSY to get started and check that appointment off your to-do list! Radiance -For 20% off and FREE SHIPPING. Go to https://BRICKHOUSENUTRITION.com and use code - MESSY Lola Blankets  -Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.
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  Tamsen Fadal 14.07.2026 56Min.

  This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY. Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at ⁠https://rythm.health/messy⁠   Stop guessing, start testing. Rythm DOT HEALTH slash messy    Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad
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  You Do Not Have to Become Someone Else to Heal 07.07.2026 51Min.

  This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Zbiotics - Go to  https://zbiotics.com/MESSY and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy 
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  Erin Moriarty 30.06.2026 1Std. 2Min.

  This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerability may be the greatest form of strength. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY  #mudwtrpodHoneylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod
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  Mia Calabrese 23.06.2026 50Min.

  This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. ZocDoc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today.  MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY  #mudwtrpodOneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod
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  Choose Yourself 16.06.2026 49Min.

  This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY. Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. Veracity- For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.   K18- Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at k18hair.com
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  Our Favorite Bravo Men 09.06.2026 1Std. 3Min.

  This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy  NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started  https://learn.nocd.com/messy
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  Aida Turturro 02.06.2026 55Min.

  This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY. Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY  #Ridgepod
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  What the F*ck Is Normal Anyway? 26.05.2026 48Min.

  This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy! #mudwtrpod OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy   Stop guessing, start testing. Rythm DOT HEALTH slash messy  NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.  
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  Lena Hall 19.05.2026 1Std. 10Min.

  This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY  #Ridgepod Q30 - For a FREE sleeve with your order, head to  https://Q30.com/MESSY  and use code MESSY.  Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. k18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at https://k18hair.com Zoc Doc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today. 
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  Revisiting Our Convo with Martin Short 12.05.2026 1Std. 10Min.

  In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad NOCD - Go to https://NOCD.com to book a free 15-minute call.  OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod 
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  A Conversation with Jamie’s Therapist 05.05.2026 1Std. 27Min.

  This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.Honey - loveSave 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/messy and using code MESSY at checkout.
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  The Friendship Episode 28.04.2026 1Std. 1Min.

  This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Tumble - Machine Washable Rugs, Made Better. For a limited time only, our listeners get 10% off + free shipping at https://tumbleliving.com/MESSY #Tumble #ad MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/MESSY! #mudwtrpod One Skin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpodHoneylove - Save 20% Off Honeylove by going to https://honeylove.com/messy#honeylovepod
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  A Conversation with Jamie's Husband 21.04.2026 1Std. 3Min.

  This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression. Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to ⁠https://fatty15.com/messy⁠ and using code MESSY at checkout. Lola - Get 40% off your entire order at ⁠https://Lolablankets.com⁠ by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. Honeylove - Save 20% Off Honeylove by going to ⁠https://honeylove.com/messy⁠#honeylovepod Jones Road - Use code MESS at ⁠https://jonesroadbeauty.com⁠ to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a doctor you love today. 
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  A MeSsy Update! 31.03.2026

  We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes!
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  Olivia Munn 24.03.2026 1Std. 10Min.

  This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more.  Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Veracity - Head to https://VeracityHealth.co and use code MESSY for up to 60% off your order.  Jones Road - Use code MESSY at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase #JonesRoadBeauty #ad
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  Carl Radke 17.03.2026 1Std. 16Min.

  This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and  host of "More Life with Carl Radke.” They discuss his journey to sobriety, holding in shame, forgiveness, behind-the-scenes of the show, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to https://Wildgrain.com/MESSY to start your subscription today. Fatty15- Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/messy and using code MESSY at checkout. Jones Road - Use code MESSY at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty #ad Lola Blankets - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.