The Human Upgrade: Biohacking for Longevity & Performance

Επεισόδια

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  Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537 16.09.2026 55λ

  This episode is a wide-ranging conversation covering testosterone and hormone replacement therapy, peptides, biohacking, psychedelics and spirituality, parenting, and building a health/longevity business, with the hosts sharing personal experiences throughout.
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  The Peptide Secrets to a Youthful Face : 1536 15.09.2026 55λ

  Dave Asprey and Carolina Reis de Oliveira break down how senescent cells, menopause, hydration loss, and peptide science affect skin aging, and what the latest research suggests may help make skin function biologically younger.
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  What 36 Hours Without Sugar Does to Your Body : 1535 13.09.2026 12λ

  This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements.
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  New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534 11.09.2026 9λ

  This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat.
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  Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533 08.09.2026 1ώ 9λ

  Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.
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  If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532 06.09.2026 10λ

  Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.
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  Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531 04.09.2026 7λ

  This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.
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  Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530 03.09.2026 1ώ 58λ

  Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.
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  3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529 01.09.2026 35λ

  Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.
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  7 Brain Compounds I Take For Superhuman Focus : 1528 30.08.2026 9λ

  can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll also learn" section based on this episode's content: You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties Want me to add this to the script, or adjust the tone or number of bullets? give me a dash in front of each bullet You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties can you give me timestamps for this episode. similar to this previous example: Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Timestamps: 00:00 – Intro & The Brain Fog Problem 01:12 – Fixing Brain Energy 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 now i need a one sentence summary of this episode After overcoming his own brain fog, the creator breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance.
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  Change Your Morning, Change Your Life! Hal Elrod : 1527 28.08.2026 1ώ 13λ

  Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.
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  Learn THIS And You’ll Become Impossible To Trigger : 1526 27.08.2026 1ώ 1λ

  Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity.
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  Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525 25.08.2026 1ώ 1λ

  Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.
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  The Most Important Longevity Molecule I've Ever Found : 1524 23.08.2026 14λ

  Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.
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  The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523 21.08.2026 35λ

  Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.
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  The Wild New Theory of Cancer (It's GOOD For You?) : 1522 20.08.2026 1ώ 3λ

  Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.
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  Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521 18.08.2026 2ώ 46λ

  Dave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.
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  It's Weird, But It Turns On Your Anti-Aging Switch : 1520 16.08.2026 15λ

  Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back onTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Longevity Switch00:59 – Mitochondria: Power Plants02:14 – What Is Mitophagy04:05 – How Stress Blocks It05:36 – Exercise Extremes07:29 – NAD+ and Silent Damage08:59 – Reversing It: Fasting10:27 – REHIT and Cold Exposure12:02 – The Supplement StackConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519 14.08.2026 10λ

  Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.
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  Dave Solo Pod: The Original Smart Drug Masterclass : 1518 13.08.2026 41λ

  Dave Asprey breaks down piracetam and the racetam family, the original nootropics that launched the smart drug movement, covering how they work, who benefits, proper dosing, and the safety and regulatory landscape around them.