Biohacking Beauty: The Anti-Aging Skincare Podcast

Jaksot

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  271. Dr. Mamina Turegano: What Your Skin Reveals About Your Health, Aging & Hormones 16.09.2026 57min

  Most of us assume that if something serious was happening inside our body, we would know. We would feel sick. Something would hurt. A blood test would catch it. But some health problems can develop quietly for years, and sometimes the clue that finally gets your attention is sitting right where you can see it: on your skin.In this episode of Biohacking Beauty, we get into the skin changes that can point to something happening beyond the surface, from psoriasis and multiple skin tags to persistent rashes, hair loss, and subtle signs of skin cancer. We also talk about what makes a dermatologist look deeper, how long sun damage can build before it becomes visible, and when a skin concern deserves more than another product or treatment.Dr. Mamina Turegano is a triple board-certified dermatologist, internist, and dermatopathologist, giving her a unique perspective that connects what is happening on the skin with what may be happening throughout the body. Her background in internal medicine and dermatopathology allows her to look beyond the appearance of a skin change and consider the metabolic, autoimmune, inflammatory, and systemic conditions that may be connected to it.What’s Discussed:(01:25) Why you can feel perfectly healthy while something is already changing internally.(02:48) Why psoriasis can warrant looking at cardiovascular and metabolic health too.(04:49) What multiple skin tags may tell you about insulin resistance.(16:07) When an unexplained rash or chronic itching deserves a deeper workup.(19:18) The skin cancer signs people may overlook and when hair loss needs more attention.(23:14) How sugar, alcohol, stress, sleep, and circadian disruption can accelerate skin aging.(35:31) Why Dr. Mamina is comfortable with topical peptides but not injectable peptides yet.(45:24) Whether Google, AI skin scanners, and self-diagnosis are helping or hurting.(48:53) How long sun damage may be building before you finally see it.Listen to this episode of Biohacking Beauty to learn which skin changes are worth paying closer attention to, and why treating what you see is not always the end of the conversation.Resources mentioned:Want to find out more about Autophagy? Listen here: The Overlooked Side of Autophagy Causing Aging - Part 1The Overlooked Side of Autophagy Causing Aging - Part 2Find more from Young Goose:Website: younggoose.comUse code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use code PODCAST5 to get 5% OFF.Instagram: @young_goose_skincareFind more from Dr. Mamina Turegano:Website: DrMamina.com Instagram: @dr.maminaTikTok: @dr.maminaYouTube: @dr.mamina
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  270. Your Most-Asked Skincare Questions, Answered With Science 09.09.2026 33min

  Social media has made skincare information easier to access than ever. One video can convince you to increase your retinol. Another influencer can tell you an ingredient is “toxic.” Then someone else swears your skin has stopped responding because you have used the same product for too long.But think about what that can do to your skin when you follow every new rule without understanding what the product is actually doing. More stimulation is not always better. “Clean” does not automatically mean effective. A rosacea flare is not always something another soothing serum can fix. And moving to a stronger retinol just because your current one feels less intense may be the wrong move entirely.In this Biohacking Beauty Class, we are answering the skincare questions our community keeps asking and unpacking the advice that sounds simple online but becomes much more complicated once you understand how skin actually responds. We also get into collagen supplements and share a few of the new Young Goose products and technologies we have been working on behind the scenes.What’s Discussed:(02:25) Can your skin actually get used to skincare products?(07:44) Why “clean skincare” does not automatically mean better skincare.(16:20) What may be driving rosacea when nothing seems to help.(19:09) Why stronger retinol is not always the smarter next step.(25:29) Do collagen supplements actually help your skin?(30:10) The new cleanser and eye product coming to Young Goose.(34:28) The new skincare technology we are testing in ampule form.Listen to this episode of Biohacking Beauty before the next skincare tip on your feed convinces you to change something that may not need changing at all.And before you go, we have a little listener bonus.If you want to receive a product from us, leave us a review on Apple Podcasts. That is all you have to do.If we read your review out loud on the podcast, we will send you a product in the mail. So leave us a review, make it cute, make it honest, and you might hear it in an upcoming Biohacking Beauty Class episode.Find more from Young Goose:Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  269. Cynthia Thurlow: What Midlife Gut Changes Have To Do With Your Skin 02.09.2026 52min

  When your skin starts changing in midlife, it is easy to assume the products that used to work suddenly stopped working. And when changing the routine does not fix it, hormones usually get the blame.But there is another shift happening at the same time that rarely gets brought into the skin conversation: your gut. In this episode of Biohacking Beauty, we get into what starts changing in the gut through perimenopause and menopause, the surprising ways those changes can show up far beyond digestion, and why some of the health strategies women swear by before 40 may need to be reconsidered later.Cynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author of The Menopause Gut, and an international speaker with more than 25 years of experience in women’s health, metabolic health, perimenopause, menopause, and intermittent fasting.What’s Discussed:(04:01) The health crisis that changed the way Cynthia understood midlife health.(19:12) The gut-hormone connection most women do not know exists.(23:14) What changes when estrogen, immunity, and the gut start shifting together.(29:13) The early signs that progesterone may be changing.(35:49) What your gut may have to do with ovarian and mitochondrial aging.(41:46) The part of longevity Cynthia thinks we are seriously underestimating.(47:54) Why Cynthia changed her own approach to intermittent fasting after 40.Listen to this episode of Biohacking Beauty to learn what midlife gut changes may have to do with your skin, and why the answer may go much deeper than changing your skincare routine.Find more from Young Goose:Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Cynthia Thurlow:Twitter: @_CynthiaThurlowInstagram: @cynthia_thurlow_LinkedIn: cynthia-thurlowYouTube: cynthiathurlowWebsite: cynthiathurlow.com/The Midlife Pause supplements: themidlifepause.com
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  268. 10 Habits for Younger Skin That Have Nothing To Do With Skincare 26.08.2026 19min

  Everyone wants skin that looks brighter, firmer, smoother, and healthier for longer.But sometimes the thing holding your skin back is not the serum you forgot to buy. It is the blood sugar spike you keep missing, the protein you are not getting enough of, the sleep window you keep pushing, the strength training you keep delaying, or the daily stress your skin has to keep recovering from.In this Biohacking Beauty Class episode, we are talking about the habits we actually use to support skin health outside of skincare. We get into the choices that help your skin repair better, age slower, respond better to treatments, and build the kind of foundation no product can fully replace.What’s Discussed:(03:10) The dessert rule that helps reduce daily sugar exposure.(05:37) Why fiber matters beyond digestion.(06:26) What a glucose monitor can show you about foods that look “healthy.”(08:04) Why lifting weights can change how your skin looks over time.(10:13) What protein and micronutrients have to do with collagen support.(11:24) How morning sunlight, sleep, and circadian rhythm connect to skin repair.(16:16) Where red light therapy, antioxidants, and consistency fit into the bigger skin longevity picture.Listen to this episode of Biohacking Beauty to learn the habits we swear by when we want our skin to have more to work with than skincare alone.And before you go, we have a little listener bonus.If you want to receive a product on us, leave us a review on Apple Podcasts. That is all you have to do.If we read your review out loud on the podcast, we will send you a product in the mail. So leave us a review, make it cute, make it honest, and you might hear it in an upcoming Biohacking Beauty Class episode.Find more from Young Goose:Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  267. Dr. Amie Hornaman: The Thyroid Mistake That Keeps Women From Getting Answers 19.08.2026 55min

  Thyroid dysfunction is often treated like it is easy to rule out. You ask for labs, your doctor checks TSH, and if that one marker is not flagged, you are told your thyroid is fine.But what if that is the problem?In this episode of Biohacking Beauty, we sit down with Dr. Amie Hornaman to unpack what most thyroid conversations skip: the difference between being “normal” on paper and having enough active thyroid hormone available to your cells. She explains why TSH is not a thyroid hormone, why T4-only medication may not be enough for many people, and why women can keep struggling even after being told their thyroid is not the issue.Dr. Amie is known as The Thyroid Fixer, a functional medicine doctor, host of The Thyroid (and Hormone) Fixer podcast, founder of the Advanced Thyroid and Hormone Clinic, and author of The Thyroid Fix. After being misdiagnosed by six different doctors, she built her practice around helping patients get the answers conventional medicine often misses.What’s Discussed:(01:22) Why so many women feel like their body is rebelling against them.(04:32) Why the diagnosed hypothyroidism number may not reflect the real problem.(07:11) The difference between being undiagnosed, undertreated, and mistreated.(10:54) Why skin aging after 40 is not only an estrogen conversation.(14:22) How quickly thyroid and hormone changes can show up in the skin.(20:57) Why skin aging needs an inside-out and outside-in approach.(28:35) What markers belong on a full thyroid panel beyond TSH.(30:55) Why free T3, reverse T3, and thyroid antibodies matter.(38:48) What thyropause is and why it can overlap with perimenopause and menopause.(45:01) A one-morning plan to support thyroid, insulin, protein, sleep, and skin health.Listen to this episode of Biohacking Beauty to understand why your thyroid labs may not be telling the whole story, and why your skin, hair, metabolism, mood, and energy may be showing what one marker missed.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Amie Hornaman: Website: dramie.comInstagram: @dramiehornaman Podcast: dramie.com/podcast/
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  266. Q&A: Your Questions Answered on Exosome Skincare (Everything You Need To Know Before You Try) 12.08.2026 39min

  Exosomes have become one of the most talked-about ingredients in advanced skincare, but the conversation around them can get confusing fast. Some people hear “cellular messaging” and worry about DNA. Others see plant exosomes, stem cell claims, growth factors, or vampire facial comparisons and assume all exosome products are working the same way.The problem is that the word “exosome” does not tell you enough. Exosomes are messengers, and the message depends on the source. A plant-derived exosome, a mesenchymal-derived exosome, and a platelet-derived exosome are not carrying the same type of signal for the skin. So before you trust the trend, it helps to understand what kind of message your skin is actually receiving.In this Biohacking Beauty Q&A, we break down the biggest questions listeners have been asking about exosomes. We get into why exosomes do not change your DNA, what microRNA messaging means, why consistency matters, how plant exosomes compare to human-derived options, why platelet-derived exosomes may be especially relevant for skin repair, and what makes Vampire Exosomes® different from other exosome serums.What’s Discussed:03:05 Whether exosomes can change your DNA or transfer genetic material.07:08 How exosomes work through microRNA messaging instead of changing your genome.09:21 Why exosome messages do not stick around forever and need consistency.11:02 Where exosomes come from and why the source of the message matters.13:45 Why plant exosomes may offer some benefits, but may not be the strongest fit for skin repair.21:34 How mesenchymal-derived and platelet-derived exosomes differ in their relationship to skin repair.27:29 What makes Vampire Exosomes® different from other exosome serums, including dose, NAD support, barrier support, and batch verification.32:25 How Vampire Exosomes® compares to a vampire facial and why topical exosomes work differently.Listen to this episode of Biohacking Beauty to understand what exosomes actually are, what questions to ask before buying an exosome product, and why the source, dose, formula, and proof matter as much as the word “exosome” itself.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comYoung Goose Vampire Exosomes® https://www.younggoose.com/products/vampire-exosomesInstagram: @young_goose_skincare
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  265. Anastasia (Beauty Fascia) Part 2: The Hidden Cost of Fillers, Botox, and Skin Tightening Devices 05.08.2026 53min

  A lot of beauty treatments are sold around the result people want most: tighter skin, fewer lines, more volume, and a face that looks refreshed without going under the knife.And because these treatments have become so common, it can feel like the decision is simply about when to start, who to go to, or which device or injectable will give the most natural-looking result.But Anastasia looks at the face through a different lens. In Part 2 of this conversation, she challenges the idea that a visible result is the only thing worth paying attention to. She brings the conversation back to the tissue underneath the skin, the movement of the face, how the body responds, and what people may want to question before choosing treatments that promise to tighten, fill, freeze, or stimulate the face.What’s Discussed:35:15 Why tightening devices are often positioned as an alternative to plastic surgery.36:55 What people may want to consider before choosing treatments that rely on stimulation or controlled damage.41:51 Why the risks of beauty shortcuts are not always obvious at first.45:24 What to know about training, devices, and the person performing the treatment.51:15 What Anastasia wants people to think about before getting fillers.53:53 Why the body’s response to fillers deserves more attention.1:02:47 Why preventative Botox deserves a deeper conversation than wrinkle prevention.1:12:21 Where Anastasia lands on sun exposure, SPF, and skin protection.1:19:43 What she wants women to start questioning about beauty, aging, and the tissue underneath the skin.Before choosing the next treatment that promises to lift, tighten, smooth, or freeze time, this conversation asks you to slow down and look at what may be happening beneath the result.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Anastasia: Website: BeautyFascia.com/ Instagram: @anastasiabeautyfascia
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  264. Anastasia (Beauty Fascia) Part 1: Do Red Light Masks, Gua Sha, and Facial Devices Actually Work? 29.07.2026 37min

  Red light masks, facial sculpting devices, gua sha tools, and at-home lifting treatments are everywhere. And when a tool promises less puffiness, a sharper jawline, or younger-looking skin, it is easy to believe the right device could finally create the change you have been looking for.But a face is not a collection of surface-level problems. The way it looks and ages is also influenced by muscle tension, facial structure, breathing patterns, soft tissue, posture, and how fluid moves through the tissue. So when a beauty tool does not create the result you expected, the problem may be that the tool was never addressing what was actually driving the change.Anastasia, a board-certified Structural Integration Therapist and founder of Beauty Fascia, returns to explain what she looks at beyond skin appearance and what some of the biggest at-home beauty trends can realistically do. She shares why she prefers a red light panel over a mask, where facial devices may fall short, when gua sha can help, and why doing more is not always better for the skin.What’s Discussed: 03:13 What Anastasia looks at beyond wrinkles and skin appearance.04:35 How facial structure, muscle tension, breathing, and fluid flow influence the way the face looks.09:02 Why Anastasia prefers a red light panel over a mask.10:04 What to consider before spending money on a red light device.17:54 Why buying a beauty tool does not automatically create a self-care habit.23:56 What at-home facial devices can realistically change.28:48 When gua sha may help, why under-eye bags are not always a lymphatic problem, and how overdoing it can backfire.Before investing in another device or adding another technique to your routine, it helps to know what problem you are actually trying to solve and whether the tool was designed to address it.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Anastasia: Website: BeautyFascia.com/Instagram: @anastasiabeautyfascia
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  263. Q&A: The Skincare Trends Worth Questioning Before You Buy 22.07.2026 33min

  Skincare trends are moving fast, and it can be hard to tell what is actually worth your attention. One day everyone is talking about red light masks, then peptide lip balms, at-home microneedling, men’s skincare, acne protocols, or another product claiming to be the next thing your skin needs.The problem is that some of these tools can be useful, but the way they are marketed often leaves out the context that matters most. A red light device is not just about wavelength. Acne is not just about bacteria. Peptides in skincare are not automatically effective just because the word is on the label. And not every trend deserves to become the center of your routine.In this Q&A episode of Biohacking Beauty, we’re answering the skincare questions you sent in and breaking down what to look at before buying into the hype. We get into acne, red light therapy masks, at-home microneedling, men’s skincare, and the peptide skincare problem so you can think about these trends with more science and less noise.What’s Discussed:(03:14) Why acne is not just a bacteria problem.(07:24) What to know before buying a red light therapy mask.(13:36) The red light devices we actually use at home.(16:06) At-home microneedling, skin barrier risk, and where to draw the line.(21:02) Why men’s skincare is mostly marketing.(25:10) What performance skincare may actually mean.(29:41) Why peptide skincare claims are harder to verify than they seem.Listen to this episode of Biohacking Beauty to understand which skincare trends deserve a closer look, what questions to ask before buying, and where the science matters more than the marketing.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  262. Chris Duffin: The Peptide Mistake That Keeps Regenerative Protocols From Working 15.07.2026 1t 10min

  Peptides are being treated like the missing piece in recovery, skin longevity, fat loss, performance, and aging. The usual belief is that if you find the right compound, the right dose, or the right stack, the body will finally respond the way you want it to. But what if the protocol is not the first thing that needs to be fixed?In this episode of Biohacking Beauty, I sit down with Chris Duffin to unpack what most peptide conversations skip: the state of the body receiving the signal. They get into why cellular terrain matters, what happens when people chase regenerative tools before the foundation is ready, and how skin can reveal whether the body is actually prepared to adapt, repair, and age well.Chris Duffin is the Human Performance Expert, an internationally recognized authority in human performance science, and the first person in history to squat and deadlift over 1,000 pounds for multiple reps. His work sits at the intersection of strength, resilience, peptide science, executive performance, and regenerative health, which makes this conversation a rare look at what it actually takes to build a body that can respond to advanced tools instead of just relying on them.What’s Discussed:(02:15) Why peptides are powerful, but not the whole answer.(05:12) What cellular terrain has to do with regeneration.(09:18) Why looking healthy does not always mean the body is resilient.(15:07) How peptides fit into a bigger recovery and longevity strategy.(27:09) What peptide reactions may reveal about the body underneath.(50:06) Why skin rejuvenation depends on the body’s ability to respond.(01:06:05) How peptide hype is changing the longevity conversation.Listen to this episode of Biohacking Beauty to understand what needs to happen inside the body before peptides, procedures, or any regenerative tool can actually move the needle.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/ FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/ Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Chris Duffin: Instagram: @mad_scientist_duffinWebsite: enhancedexecutive.com/
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  261. Reacting To Allure’s LED Mask Advice: What To Know Before Spending Money On a LED Mask 08.07.2026 19min

  If you have been thinking about buying a LED mask, the hardest part is knowing what actually matters. The price range is all over the place, every brand seems to have some version of “FDA cleared” on the page, and a lot of the buying advice sounds scientific enough to trust. But none of that automatically tells you whether the device is strong enough to do anything meaningful for your skin.That is why we wanted to take a closer look at an Allure post called So You Wanna Buy a LED Mask. The guide brings up the same things people usually look at before buying one: price, number of bulbs, FDA clearance, clinical trials, and how often you have to use it. Some of those details can be useful, but they can also distract from the real questions: how much light does the device actually deliver, what wavelengths does it use, and is the coverage strong enough to create meaningful stimulation?That matters if you are about to spend a few hundred dollars on a device and you are using the wrong signals to decide. A high price, FDA clearance, or a small clinical study can make a mask sound more credible, but those details do not always answer the question you actually care about: Will this device give my skin enough stimulation to be worth using?What’s Discussed:(04:22) Why we are reacting to Allure’s LED mask buying guide.(05:12) Why the $100 to $1000 LED mask price range is not very helpful.(07:31) Why diode count matters, but output matters more.(08:33) Whether you actually need to use a LED mask every day.(10:55) What FDA clearance does and does not tell you.(13:35) Why a five-subject clinical trial is not strong proof.(15:45) The wavelengths that matter for red light therapy.Listen to this episode of Biohacking Beauty to understand what actually matters before buying a LED mask, and why the most scientific-sounding claims are not always the ones that tell you if a device will work.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/ FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/ Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  260. Dr. Jennifer Berman: Peptides, Hormones, and the Anti-Aging Protocol Most Women Start Too Late 01.07.2026 1t 5min

  We have been getting the same question in our DMs for months now. Peptides are everywhere. Everyone is talking about them. But what actually has evidence behind it, what is hype, and where do hormones fit into all of this? So we went and found someone who has been living this conversation for 35 years, not just talking about it.Dr. Jennifer Berman is a urologist, New York Times bestselling author, and one of the leading voices in female sexual and menopausal health. She pioneered the field at UCLA, runs the Berman Women's Wellness Center in Beverly Hills, and has been her own first patient through every transition she now treats. She is the kind of doctor who was doing things a decade before they became mainstream and has the clinical receipts to back all of it up.In this episode we get into why peptides are the missing piece of the menopause puzzle, what hormones are really doing to your skin from the inside out, and how treatments that were written off as fringe became the new gold standard for longevity.What's Discussed:(01:42) Why peptide production declines with age and what that actually means for how women look and feel in perimenopause.(04:04) The regulatory reality around peptides right now and why medical grade from a 503B pharmacy is the only route worth taking.(06:07) The specific peptides with the strongest evidence for skin, muscle, fat loss, recovery, and cognitive function.(13:12) Why your mid to late 30s is already perimenopausal by definition and why that changes when you start.(15:02) C-Link, C-Max, and PE22-28 for mood, neuroplasticity, and cognitive protection and why Dr. Berman stacks them together.(39:17) The exact point where topical skincare stops being enough and what hormone imbalance is doing to skin that no cream can fix.(53:08) Why cycling your peptides matters, what receptor attenuation actually is, and why the protocol on your feed is not a clinical protocol.By the end of this episode you will know which peptides have actual evidence behind them, where topical skincare stops working without hormonal support, and what an inside-out longevity protocol looks like from a doctor who has lived every transition she treats.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Jennifer Berman: Website: bermansexualhealth.com/Instagram: @jenbermanmd
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  259. Dr. Dan Pardi: How Creatine Supports Brain Function, Skin Health, and DNA Repair 24.06.2026 51min

  Creatine has been boxed in as a gym-bro supplement for decades, but the latest research shows it's doing far more than building muscle. It buffers brain energy under sleep deprivation, supporting bone density and mood stability through perimenopause, and freeing up methyl groups for detoxification and DNA repair.We dive deeper into this in the Biohacking Beauty Podcast with Dr. Dan Pardi. We also chat about why the bloating myth is backwards, how creatine and NAD work synergistically to support mitochondrial energy, and what topical creatine could mean for the future of skincare.Dr. Dan Pardi is a researcher whose first study in the 1990s focused on creatine, and he has spent three decades following the science as it expanded from sports performance into brain health, healthspan, and women's physiology. He is the Chief Health Officer at Qualia Life Sciences, where the team has earned recognition from the Nutrition Business Journal for science and innovation. His work focuses on translating peer-reviewed research into formulations that support cellular energy, methylation, and longevity.Let's dive in.Use code YOUNGGOOSE at https://www.qualialife.com/ for a special discount.What's Discussed:(4:32) Why creatine went from a niche Olympic edge to a billion-dollar category after the 1992 Games.(11:18) The sloping-surface analogy that explains why 5 grams saturates muscle but barely touches the brain.(15:47) How creatine buffers cognitive performance under sleep deprivation, with no decrement at baseline.(22:05) Why the bloating myth is backwards and what intracellular hydration actually feels like.(28:40) Topical creatine, the dermal layer, and why molecule size matters for skin delivery.(36:22) The decade of creatine in women: bone density, mood, and energy fluctuations through menopause.(42:15) Where the hair loss rumor really came from, and why creatine took the blame.(51:08) Why 40% to 70% of your body's methylation goes to making creatine, and what that means for NAD stacking.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Dan Pardi:Instagram: @drdanpardi Substack: @drdanpardi Find more from Qualia:Website: qualialife.com Instagram: @qualialife Qualia Creatine: qualialife.com/shop/qualia-creatine
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  258. SPF Is Not Enough: The Cellular Repair Protocol Your Skin Needs This Summer 17.06.2026 39min

  When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question worth asking: what is the sun doing to the cell before you ever see the damage in the mirror?In this episode of Biohacking Beauty, I want to take the sun conversation past burns, wrinkles, and dark spots. I’m walking through what UV exposure does to the systems your skin depends on to keep up with summer: cellular energy, NAD, mitochondrial function, and DNA repair. Because the skin does not only need protection from the sun. It also needs enough repair capacity to deal with the damage that gets through.Young Goose's Skin Under the Sun campaign is active from June 15 through June 28 at younggoose.comWhat’s Discussed:(01:50) The light-activated repair tool humans lost.(06:10) Why NAD matters for skin energy and repair.(10:15) How UV exposure increases oxidative stress and disrupts NAD supply.(16:44) What UV-induced DNA lesions are and why CPDs matter.(22:21) Why L.A.D.R. serum was built around light-activated repair-inspired science.(31:52) Why the sun is one of the biggest controllable inputs into biological skin aging.(35:43) The five protocol-level moves for supporting skin through summer.Listen to this episode of Biohacking Beauty to understand what UV is doing under the surface and how to build a smarter summer protocol around protection, energy, and repair.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  257. The Mitochondria Problem Behind Aging Skin + How to Recharge Your Skin and Look Younger 10.06.2026 34min

  Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.What's Discussed:(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.(04:10) Why skin is one of the most mitochondria-dense organs in your body.(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.(16:30) The second half of the decline almost no skincare addresses.(19:45) The master regulator that decides whether your cells can hire.(24:00) The two columns of mitochondrial biology and why most brands only work in one.(32:10) Why this is a ten-year strategy, not a two-week one.Resources Mentioned:Download the Cellular Energy Protocol: https://www.younggoose.com/pages/the-mitochondrial-skin-stackAge-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  Dr. Tyler Panzner: Hidden Trade-Offs of Longevity Supplements and the Advantage of Topical Delivery 03.06.2026 1t 9min

  Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.What's Discussed:03:15 Why supplements are the "Wild West" of holistic health.08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.29:45 Why your meditation practice may be failing because of a supplement.37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.46:08 The future of multi-omics testing and personalized protocols.Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Tyler Panzner:Website: drtylerpanzner.comInstagram: @drtylerpanznerFacebook: Dr. Tyler PanznerLinkedin: Tyler Panzner, Ph.D.YouTube: @drtylerpanznerFREE Guides: drtylerpanzner.com/free-guides1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourneyQuieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page
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  The Death of Anti-Aging Skincare & The Longevity Framework That Replaces It 29.05.2026 45min

  Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering at Dave Asprey's Beyond Conference and walk you through the 3-pillar framework that replaces traditional anti-aging skincare with longevity science in mind.Because the results you can feel today and results you can measure in ten years are not the same thing. And we think you deserve both.Let's dive in.What's Discussed:(2:29) The gap no one in longevity talks about.(3:06) Why your moisturizer is 38 years behind your supplements.(6:21) The 12 Hallmarks of Aging, decoded.(9:42) Pillar 1: The master pathway of skin aging.(12:18) Why NAD in a jar doesn't work (and what does).(14:22) The cellular housekeeping system that quietly shuts down with age.(15:17) The peptide that affects 32% of your skin's genome.(16:55) Pillar 2: The software updates your cells stop sending.(20:09) The PRP lineage that changed regenerative aesthetics.(22:54) Pillar 3: The pillar our community doesn't want to hear about.(29:09) The protocol, tiered by where you're starting.(37:55) How Young Goose fits into what you're already doing.(40:32) The two tests we're building to measure skin longevity.Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% off
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  The Overlooked Side of Autophagy Causing Aging - Part 2 27.05.2026 31min

  The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.What's Discussed:(01:06) Why skin needs autophagy more than almost any other organ(03:07) The cells on your face that may be older than your car(04:25) The 2013 paper that linked autophagy failure to dermatitis(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis(18:38) The 2019 Drexel rapamycin trial that proved this works in humans(23:22) The 2024 spermidine study that changes how we think about autophagy(29:51) Why your skin barrier collapses without this one moleculeResources Mentioned:Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  The Overlooked Side of Autophagy Causing Aging - Part 1 20.05.2026 26min

  What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.What's Discussed:(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out(3:14) What autophagy actually means, and why the science world ignored it for 30 years(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works(10:22) Why autophagy is not destruction, and what this means for your collagen supplements(16:44) The two master switches controlling whether your cells build or clean(20:10) The everyday habit silencing your body's most powerful anti-aging system(26:17) Why aging skin isn't broken, it has just never been told to cleanResources Mentioned:Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadiFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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  Chris Mirabile: Why One Ingredient Will Never Stop You From Aging (And What Actually Does) 13.05.2026 51min

  Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could.In this episode, we are joined for the second time around by Chris Mirabile, founder of NOVOS which is the first biotech company to target all 12 biological causes of aging. Chris collaborates with leading researchers at Harvard and MIT and has built his work around one premise: that real interventions require real testing on real humans, not just promising ingredients.Let's dive in.What's Discussed:(2:14) Why single ingredient marketing is a commercial story, not a scientific one.(9:56) The three hallmarks hitting skin hardest and how they feed each other.(12:02) How UV damage depletes 90% of NAD in the skin from a single exposure event.(22:14) Why stacking molecules requires human testing, not just ingredient research.(33:48) The NOVOS cardiovascular study and results that surprised the researchers.(48:12) Why spending more on your biology does not make your protocol safe.(1:02:18) What omics testing reveals that epigenetics alone cannot tell you.(1:09:45) Where skin longevity is heading in the next five years.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Chris Mirabile & Slow My Age:Instagram: @slowmyageYouTube: @slowmyageTikTok:@slowmyageX: @slowmyagePersonal Blog: slowmyage.comFind more from NOVOS:Website: NOVOSlabs.comInstagram: @NOVOSlabsFacebook: NOVOSYoutube: @NOVOSlabsTikTok: @NOVOSlabs_X: @NOVOSLabs