Making Sense with Sam Harris

Epizode

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  #486 — Luck All the Way Down 22.07.2026 21min

  Sam Harris speaks with Kathryn Paige Harden about behavioral genetics, moral luck, and the problem of blame. They discuss Harden's book Original Sin, the controversy over Charles Murray and Ezra Klein, why behavioral genetics remains taboo, the meaning of heritability, nature and nurture as feedback loops, why biological explanations can increase blame, psychopathy as a continuum, a hypothetical cure for evil, embryo selection and IVF, and other topics. Related Episode: #212 - A Conversation with Kathryn Paige Harden If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #485 — The New Science of Cancer 14.07.2026 1h 21min

  Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies, whether cancer is one disease or many, why prevention is so hard, inflammation and air pollution as carcinogens, the myth that cell phones cause cancer, liquid biopsies and Bayesian reasoning, immunotherapy and CAR T cells, drug pricing, the promise of AI in drug discovery, the state of American medical science, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #484 — Artificial Intimacy 08.07.2026 27min

  Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the importance of mattering to other people, digitally resurrecting the dead, whether AI can be conscious, the moral failings of artists, what science actually knows about parenting, the ethics of apology, why late converts from Trump provoke outrage, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  
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  #483 — The Knots We Tie Ourselves Into 01.07.2026 22min

  Sam Harris speaks with Alain de Botton about the psychology of unhappiness, the secular world's discomfort with ecstasy and ritual, psychedelics as a tool for self-discovery, Freud's legacy, AI as the ultimate mirror, the case against meritocracy, the cancel culture purity trap, the psychological meaning of death, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #482 — More From Sam: The Iran Deal, College in the AI Age, Mamdani's DSA, and More 25.06.2026 21min

  In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss topics from Making Sense Community, including one-world government, the value of a degree as AI reshapes careers, and factory farming ethics, along with Mamdani's DSA-aligned candidates, Trump's humiliating capitulation in the Iran deal, the Tulsi Gabbard guru story, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  
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  #481 — Sam Harris Receives the 2026 Richard Dawkins Award 17.06.2026 54min

  Richard Dawkins presents Sam Harris with the 2026 Richard Dawkins Award at a live Center for Inquiry event. After the tribute, the two friends discuss consciousness and epiphenomenalism, AI and the Turing test, the scientific basis of morality, the failures of democracy and Trump's corruption, the role of philosophy, changing deeply held beliefs, Sam's path to meditation, the legacy of Christopher Hitchens, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #480 — The Economics of Everything 12.06.2026 24min

  Sam Harris speaks with economist and Substack writer Noah Smith about the U.S. national debt, wealth inequality, and the economic consequences of AI. They discuss the mechanics of debt and inflation, the case for fiscal austerity, why the U.S. squandered low interest rates, modern monetary theory, how AI may restructure labor and ownership, the anti-billionaire politics of the American left, the degrowth movement and its failures, demographic decline and fertility trends, the role of smartphones in eroding democratic culture, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  
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  #479 — When Robots Take Over 04.06.2026 15min

  Sam Harris speaks with Vinod Khosla about AI, economic disruption, and political risk. They discuss the prospect of mass job displacement, a trillion-dollar policy framework to redistribute AI's gains, the failure of the California wealth tax, the corporate capitulation to Trump, Elon Musk's embrace of white nationalist rhetoric, US-China competition, semiconductor dependence, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #478 — The Psychedelic Mind 29.05.2026 30min

  Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential. They discuss the current state of the field, the FDA denial of MDMA-assisted therapy for PTSD, the critical role of set and setting, risks for vulnerable populations, the REBUS model of how psychedelics work on the brain, the default mode network and ego dissolution, microdosing, the neuroscience of consciousness, DMT entities, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  
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  #477 — More From Sam: Iran's Unraveling, The Gaza Information War, AI-Generated Music, and More 26.05.2026 21min

  Warning: This episode contains graphic descriptions of violence against civilians during the October 7 attacks (33:49 - 34:35). Listener discretion is advised. In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the Trump administration's bungled Iran campaign, the information war surrounding Gaza and October 7, Nicholas Kristof's disputed New York Times report on Israeli prisoner abuse, Sam's controversial take on AI-generated music, OpenAI solving a decades-old math problem, the ethics of concealing GLP-1 use, and other topics.  
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  #476 — The Bittersweet Age 20.05.2026 22min

  Sam Harris speaks with Susan Cain about writing, creativity, and what AI means for human culture. They discuss the future of books and reading, the tells AI inherits from good writers, why the advent of AI may spark a revival of the humanities, following your bliss, the ethics of curing sadness, the therapeutic potential of psychedelics, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #475 — The Hard Problem of Consciousness 12.05.2026 25min

  Sam Harris speaks with Michael Pollan about consciousness, the mind, and the self. They discuss Pollan's new book, the relationship between consciousness and intelligence, whether consciousness is a product of evolution, the role of psychedelics in consciousness research, AI and the question of machine consciousness, the illusion of the self, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #474 — More From Sam: Hasan Piker, Islamism, Making Sense Community, and More 07.05.2026 17min

  In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the launch of Making Sense Community, Sam's Ben Shapiro conversation, the New York Times's embrace of Hasan Piker, Zohran Mamdani's approach to Islamism, the misuse of the word "genocide," AI-driven job displacement, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #473 — Money, Power, and Moral Failure 29.04.2026 22min

  Sam Harris speaks with Lloyd Blankfein about finance, politics, and the state of American society. They discuss Blankfein's memoir, Goldman Sachs and its role as a market maker, the 2007-2008 financial crisis, the AI investment bubble, wealth inequality and the rise of trillionaires, the crisis of antisemitism on the left and right, Trump-era corruption and the post-truth political environment, the national debt, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #472 — Strange Days on the Right 24.04.2026 16min

  Sam Harris speaks with Ben Shapiro about their pre-election debate and the fractures on the right. They discuss Trump's second term surprises, familial corruption, tariff policy, the ideological world of Tucker Carlson, the spread of conspiracism on the right, antisemitism as the ur-conspiracy theory, JD Vance's political calculations, the future of Israel and the Palestinian question, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #471 — The End of History, Revisited 16.04.2026 18min

  Sam Harris speaks with Francis Fukuyama about liberal democracy, American politics, and global order. They discuss the misunderstood thesis of "The End of History," how conservatism has mutated into ethno-nationalism, the self-defeating extremes of both identity politics and neoliberalism, the damage of Trump's second term, the war in Iran, the future of Israel, antisemitism on the left and right, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.   
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  #470 — Democrats at a Crossroads 13.04.2026 21min

  Sam Harris speaks with Rahm Emanuel about American politics, the state of the Democratic Party, and the 2028 presidential race. They discuss Emanuel's possible presidential run, identity politics and the left's cultural cul-de-sac, the Mississippi reading miracle, antisemitism on the left and right, the Gaza war, Netanyahu's failures, U.S. policy toward China, wealth inequality, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #469 — Escaping an Anti-Human Future 10.04.2026 1h 49min

  Sam Harris speaks with Tristan Harris about the dangers of AI and the race to build it. They discuss the new documentary The AI Doc: Or How I Became an Apocaloptimist, the lessons of The Social Dilemma, the arms race dynamics between AI labs, the "intelligence curse" and its implications for human political power, the psychology of tech CEOs indifferent to extinction risk, the possibilities of US-China coordination on AI safety, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #468 — More From Sam: Gratitude, Bad Conversations, Conspiracy Addiction, Waffle House Teleportation, and More 07.04.2026 32min

  In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss how to cultivate gratitude and navigate anxiety in uncertain times, the role of mindfulness in coping with AI-driven job displacement, the slowing of religious decline in America, a FEMA official's claim that he teleported to a Waffle House, the irresponsibility of conspiracy-fueled podcasting, Sam on which conversations are worth having, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
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  #467 — EA, AI, and the End of Work 30.03.2026 29min

  Sam Harris speaks with William MacAskill about effective altruism, AI, and the future of humanity. They discuss the post-FTX recovery of the EA movement, global health and pandemic preparedness, the limits of quantifiable ethics, the intelligence explosion, risks of concentrated AI power, what a post-scarcity world might look like, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.