Peptides Explained

Episode

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  Cagrilintide vs GLP-1s: A Different Appetite Pathway? 27.07.2026 17mnt

  GLP-1 medications changed obesity treatment, but appetite regulation involves more than one hormonal signal. Cagrilintide is a long-acting analogue of amylin, a pancreatic peptide released alongside insulin that helps regulate satiety, gastric emptying, and post-meal glucagon signaling.In this episode of Peptides Explained, John Garrett breaks down what cagrilintide is, how it differs from GLP-1 receptor agonists, what standalone phase 2 data show, and what the phase 3 CagriSema trials tell us about combining cagrilintide with semaglutide.We also examine the REDEFINE 4 comparison with tirzepatide, common gastrointestinal adverse effects, unresolved questions about long-term outcomes and lean mass, and why online research products should not be treated as equivalent to the pharmaceutical trial material.Cagrilintide remains investigational and is not currently an FDA-approved treatment. This content is educational and is not medical advice.Peptides Explained is an affiliate partner with Offline Peptides. Research-use products are not approved medications and are not intended for human use.Visit: PeptidesExplained.info/OfflinePeptidesFor information on Compounded Peptides through Premier Pharmacy visit Peptide Solutions and submit a request for more informationVisit: Peptide-Solutions.info and submit a request for more informationSend a two- to three-minute N=1 video to john@peptidesexplained.info.
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  AOD-9604 Explained: Can a Growth Hormone Fragment Burn Fat? 22.07.2026 18mnt

  AOD-9604 is often marketed as the “fat-burning fragment” of human growth hormone. But what does it actually do, and did it work in human obesity trials?In this episode of Peptides Explained, John Garrett, RN, breaks down:• What AOD-9604 is and how it differs from full-length HGH• Lipolysis, lipogenesis, and beta-3 adrenergic signaling• Why animal studies looked promising• What the early human trials showed• Why the obesity-development program was discontinued• Whether AOD-9604 raises IGF-1• Regulatory status, risks, unknowns, and anti-doping concerns• A responsible framework for evaluating experimental fat-loss peptidesThe central takeaway: AOD-9604 has a plausible preclinical mechanism, but the available human evidence does not establish dependable, clinically meaningful fat loss.This episode is for informational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any therapy.This episode is brought to you by Offline Peptides. If you are interested in Research Peptides Learn more at PeptidesExplained.info/OfflinePeptides.For more information about Peptide Solutions, visit Peptide-Solutions.info.Send your 2–3 minute N=1 video to john@peptidesexplained.info.
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  SLU-PP-332 Explained: Exercise Mimetic or Experimental Hype? 20.07.2026 15mnt

  SLU-PP-332 is being promoted as an “exercise mimetic” that may increase fat oxidation, endurance, and energy expenditure. But it is not actually a peptide, it is not FDA-approved, and the most compelling evidence comes from cell and mouse research—not human clinical trials.In this episode, John Garrett, RN, explains estrogen-related receptors, mitochondrial energy metabolism, the published preclinical findings, the oral-bioavailability problem, potential risks, regulatory status, and the difference between mimicking selected exercise pathways and replacing physical exercise.This content is for education and discussion only and is not medical advice. SLU-PP-332 is an experimental research compound with no established human therapeutic use.Learn more: PeptidesExplained.infoPeptide Solutions: Peptide-Solutions.infoOffline Peptides: PeptidesExplained.info/OfflinePeptidesAffiliate disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.Send 2–3 minute N=1 videos to john@peptidesexplained.info.
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  Why Boomers Are Living Longer But Not Healthier: Where Peptides May Fit Into Healthy Aging 16.07.2026 15mnt

  Why are Americans living longer than ever before while spending more years battling chronic disease?In this episode of Peptides Explained, we explore one of the biggest questions in longevity medicine: the difference between lifespan and healthspan.You'll learn why muscle loss, metabolic dysfunction, chronic inflammation, mitochondrial decline, immune aging, and cognitive changes are major drivers of aging—and where peptide research may fit into each of these biological systems.We discuss several categories of peptides currently being investigated, including:• Growth Hormone Secretagogues (Tesamorelin, Ipamorelin, Sermorelin, CJC-1295)• GLP-1 and Metabolic Peptides (Semaglutide, Tirzepatide, Retatrutide)• Anti-Inflammatory Peptides (KPV, Thymosin Alpha-1, BPC-157)• Regenerative Peptides (BPC-157, TB-500, GHK-Cu)• Nootropic Peptides (Semax, Selank, Dihexa)• Mitochondrial Peptides (MOTS-c, SS-31, Epitalon)This episode discusses current science, emerging research, and where evidence is strong—and where it is still evolving.This podcast is for educational purposes only and is not medical advice.Sponsored by Peptide SolutionsLearn more:https://peptide-solutions.infoResearch Peptides (Affiliate):PeptidesExplained.info/OfflinePeptidesAffiliate Disclosure: Peptides Explained is an affiliate partner with Offline Peptides. #Peptides #HealthyAging #Longevity #GLP1 #Retatrutide #Semaglutide #BPC157 #MOTSc #Healthspan #PeptidesExplained
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  NAD+ and Cancer: What the Science Actually Says 12.07.2026 18mnt

  NAD+ is one of the most talked-about molecules in longevity and wellness. It is marketed for energy, mitochondrial support, cellular repair, brain fog, recovery, and anti-aging.But what happens when we bring cancer biology into the conversation?In this episode of Peptides Explained, we break down the relationship between NAD+ and cancer in clear, responsible language. NAD+ is essential for normal cellular function, DNA repair, mitochondrial energy production, redox balance, and immune signaling. But cancer cells may also rely on NAD+ metabolism to support growth, survival, DNA repair, oxidative stress control, and possible treatment resistance.This episode covers NAD+, NADH, NR, NMN, niacinamide, IV NAD+, NAMPT, PARP enzymes, DNA repair, cancer therapy, human evidence, preclinical evidence, and why active cancer or recent cancer changes the risk discussion.This is not a hype episode and not a fear episode. The real answer is context.NAD+ biology is real. The cancer concern is biologically plausible. The human evidence is incomplete.This podcast is for informational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy, supplement, peptide, injection, or infusion.Peptides Explained is powered by Peptide Solutions.Learn more: peptide-solutions.infoAffiliate disclosure: Peptides Explained is an affiliate partner with Offline Peptides . If you use my link, I may earn a commission at no additional cost to you.PeptidesExplained.info/OfflinePeptides#NAD #NADPlus #NMN #NR #CancerBiology #LongevityScience #Mitochondria #DNARepair #NAMPT #PARP #PeptidesExplained #PeptideScience
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  DSIP Explained: The Sleep Peptide That Science Still Can't Explain 08.07.2026 8mnt

  DescriptionCan a tiny peptide discovered nearly 50 years ago hold the key to better sleep?In this episode of Peptides Explained, we explore Delta Sleep-Inducing Peptide (DSIP)—one of the most mysterious compounds in peptide research. Unlike many peptides discussed today, DSIP has no confirmed receptor, conflicting clinical data, and decades of unanswered questions.In this episode you'll learn:✔️ What DSIP is✔️ How sleep is biologically regulated✔️ The fascinating history of DSIP's discovery in the 1970s✔️ Proposed mechanisms involving GABA, serotonin, dopamine, and the HPA axis✔️ Human and animal research findings✔️ Potential side effects and safety considerations✔️ Why DSIP is not FDA approved and why no major medical organization recommends it for insomnia or other sleep disordersThis podcast is intended for educational purposes only and is not medical advice.🌐 Peptide Solutionshttps://peptide-solutions.info🧬 Research Peptides (Affiliate Partner)PeptidesExplained.info/OfflinePeptidesIf you use my affiliate link, I may receive a commission at no additional cost to you.📧 N=1: Your Real-World ResultsHave you researched DSIP?Send a 2–3 minute video describing your experience to:john@peptidesexplained.infoYou may be featured in a future episode.#DSIP #SleepPeptide #Peptides #SleepScience #Insomnia #Longevity #PeptidesExplained #SleepResearch #Neuroscience #Biohacking
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  5-Amino-1MQ Explained: NNMT, NAD⁺, and Fat Cell Metabolism 06.07.2026 29mnt

  5-Amino-1MQ is often talked about in peptide circles, but it is not actually a peptide. It is a small-molecule NNMT inhibitor being studied for its potential role in nicotinamide metabolism, NAD⁺ biology, methylation, fat-cell function, insulin sensitivity, and liver metabolism.In this episode, John Garrett breaks down the proposed mechanism behind 5-Amino-1MQ, why people are discussing it for fat loss and body composition, and what the current research actually shows.The data is interesting, especially in preclinical studies involving adipocytes, diet-induced obese mice, glucose tolerance, insulin sensitivity, and fatty liver markers. But the human clinical evidence is still limited, and 5-Amino-1MQ is not FDA-approved for fat loss, obesity, metabolic disease, longevity, or body composition.This episode takes a balanced look at the science, the grey-market reality, and how to think about emerging metabolic compounds responsibly.This podcast is for informational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy.Peptides Explained is powered by Peptide Solutions.Peptides Explained is also an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you.Offline Peptides affiliate link:https://offlinepeptides.com/ref/JohnGarrett/Podcast website:https://peptidesexplained.infoPeptide Solutions:https://peptide-solutions.info
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  BPC-157 & TB-500 for Dogs: Healing, Recovery & the Science | Veterinary Series Ep. 1 03.07.2026 21mnt

  BPC-157 & TB-500 for Dogs: Healing, Recovery & the Current ScienceWelcome to Episode 1 of the Peptides Explained Veterinary Series.In this episode, we examine two of the most talked-about peptides in regenerative veterinary medicine—BPC-157 and TB-500.We'll discuss what researchers currently know about these experimental peptides, why they're generating interest among veterinarians and dog owners, how they may influence tendon, ligament, muscle, and connective tissue repair, and where the evidence remains limited.Whether you own an active family pet, a hunting dog, an agility competitor, or a working K9, this episode provides a balanced look at the science while separating evidence from online speculation.Educational only. BPC-157 and TB-500 are experimental compounds and are not FDA-approved veterinary medications.Learn more at https://peptide-solutions.infoPeptides Explained is an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/Have a real-world experience using peptides with your dog? Send a 2–3 minute horizontal video to john@peptidesexplained.info for a chance to be featured in our "N=1: Your Real-World Results" segment.
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  I Asked ChatGPT to Build the Ultimate Peptide Stack... Here's What It Chose 01.07.2026 13mnt

  I asked ChatGPT a simple question... and the answer surprised me.For Research Grade Peptides, check out Offline Peptides 🌐 ⁠OfflinePeptides.com/Ref/JohnGarrett⁠If ChatGPT were a 47-year-old peptide researcher who needed to lose 40 pounds, had a nagging knee injury, wanted to preserve muscle, improve energy, and had an unlimited budget, what peptide stack would it choose?Instead of recommending every popular peptide on the market, it built a surprisingly logical plan focused on solving the biggest problems first.In this episode of Peptides Explained, we break down the science and reasoning behind each selection:RetatrutideBPC-157TB-500TesamorelinMOTS-cGHK-CuWe also discuss why several well-known peptides didn't make the list, why ChatGPT preferred individual peptides over a Glow Stack, and how prioritizing your biggest health challenge may be more important than simply taking more compounds.This episode is an educational thought experiment—not medical advice—and is designed to spark discussion about peptide science, mechanisms, and evidence.Powered by Peptide SolutionsLooking for peptide education, research resources, or provider-guided peptide options?🌐 https://peptide-solutions.infoFor Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you choose to use my affiliate link, I may earn a commission at no additional cost to you.
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  Epitalon Explained: The Science of Telomeres, Aging & Longevity 29.06.2026 13mnt

  Can a peptide actually slow the aging process?In this episode of Peptides Explained, we take a deep dive into Epitalon—one of the most talked-about peptides in longevity medicine.You'll learn:What Epitalon is and where it came fromHow telomeres and telomerase workWhy the pineal gland may play a role in agingWhat the human and animal research actually showsWhy activating telomerase is both exciting and scientifically complexThe current FDA and regulatory status of EpitalonThe difference between promising mechanisms and proven clinical outcomesRather than relying on hype, we examine the available evidence and discuss what researchers know—and just as importantly, what they still don't know.New Segment – N=1: Your Real-World ResultsHave you used Epitalon or another peptide we've covered on the show?I'd love to feature your experience in a future episode.Record a 2–3 minute video sharing:• Which peptide you used• Why you decided to try it• Your results—positive, negative, or somewhere in between• Anything you learned along the wayEmail your video to:john@peptidesexplained.infoYour experience may be featured in an upcoming N=1: Your Real-World Results segment.This podcast is for educational purposes only and is not medical advice.
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  SS-31 Explained: The FDA-Approved Mitochondrial Peptide 24.06.2026 14mnt

  SS-31 (Elamipretide) may be one of the most fascinating peptides ever developed.Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy.In this episode of Peptides Explained, we break down:✅ What mitochondria actually do✅ The role of cardiolipin in cellular energy production✅ How SS-31 works biologically✅ Why SS-31 received FDA Accelerated Approval in 2025✅ What Barth Syndrome is✅ The latest human clinical data✅ How SS-31 compares with MOTS-c✅ Whether repairing mitochondria before metabolic optimization makes biological senseWe'll separate proven science from speculation and discuss what remains investigational.This podcast is for informational purposes only and is not medical advice.Support the ShowPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/For peptide education, provider resources, and information about compounded peptide options through licensed providers:https://peptide-solutions.info#PeptidesExplained #SS31 #Elamipretide #Forzinity #BarthSyndrome #Mitochondria #Longevity #MOTSc #Peptides
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  Peptide Math Explained: Dose, Volume, Concentration & Reconstitution 22.06.2026 12mnt

  Most peptide users understand what peptide they want to use, but many struggle with the math behind vial size, reconstitution, concentration, units, volume, and medication calculations.In this episode of Peptides Explained, we break down the fundamentals of peptide math in plain English. You'll learn the difference between total vial contents and dose, what reconstitution actually means, why concentration matters, how syringe units can create confusion, and the medication calculation formula used throughout healthcare.Whether you're interested in GLP-1 medications, growth hormone secretagogues, BPC-157, TB-500, Tesamorelin, or other peptides, these mathematical principles apply across the board.Topics Covered:• Vial Size vs. Dose• Reconstitution Explained• Concentration Made Simple• Units vs. Volume• The D ÷ H × V Medication Calculation Formula• Common Mistakes Peptide Users MakeThis podcast is for informational and educational purposes only and is not medical advice.Support the Show:Visit Peptide Solutions:https://peptide-solutions.infoPeptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/
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  Melanotan I, Melanotan II & PT-141 Explained: The Tanning Peptides That Changed Sexual Medicine 17.06.2026 10mnt

  What do tanning peptides have to do with sexual medicine?More than you might think.In this episode of Peptides Explained, we explore the fascinating science behind Melanotan I, Melanotan II, and PT-141 (Bremelanotide). What began as research into skin pigmentation and UV protection unexpectedly led to the development of an FDA-approved medication for hypoactive sexual desire disorder.You'll learn:• How the melanocortin system works• The role of alpha-MSH in pigmentation and physiology• The differences between Melanotan I and Melanotan II• Why Melanotan II became known for effects beyond tanning• How PT-141 was developed from Melanotan II research• The clinical data behind pigmentation and sexual function• Potential side effects and safety considerations• The current regulatory status of these compoundsWhether you're interested in peptide science, dermatology, sexual health, or drug development, this episode highlights one of the most unexpected stories in modern peptide research.This podcast is for informational purposes only and is not medical advice.Learn more at:📍 Peptide-Solutions.infoResearch Peptide Affiliate Partner:📍 https://offlinepeptides.com/ref/JohnGarrett/Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.#PeptidesExplained #Melanotan #Melanotan2 #Melanotan1 #PT141 #Bremelanotide #PeptideTherapy #Longevity #HealthPodcast #MedicalScience
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  Inside the Peptide Industry: Quality, Testing, Regulation & Grey Market Peptides 15.06.2026 35mnt

  The founder of Offline Peptides joins Peptides Explained for a candid discussion about grey market peptides, quality control, regulation, and the future of the peptide industry.What are grey market peptides, and why have they become one of the fastest-growing topics in health, wellness, longevity, and performance?In this episode of Peptides Explained, host John Garrett sits down with Matthew Pacheco, founder of Offline Peptides, for an in-depth conversation about the current peptide landscape, quality control, consumer education, and the realities of the peptide industry.Together, they discuss why peptides have exploded in popularity, what consumers should know about third-party testing and Certificates of Analysis (COAs), the challenges facing the industry, and how the regulatory environment may shape the future of peptide access.This is not a sales pitch. It's an honest discussion about one of the most talked-about areas in modern health and wellness.TOPICS COVERED• What "grey market peptides" actually means• Why peptides have become so popular• Quality control and third-party testing• Understanding COAs and lab testing• Common misconceptions about peptides• Regulatory and FDA considerations• Consumer safety and education• The future of peptide research• The role of transparency in the peptide industryGUESTMatthew PachecoFounder, Offline PeptidesPEPTIDE RESOURCESPeptides Explained Podcast Websitehttps://peptidesexplained.comPeptide Solutionshttps://peptide-solutions.infoPeptide Solutions was created to help connect listeners with peptide education and peptide access pathways through trusted partners.OPTION 1: RESEARCH PEPTIDESOffline Peptideshttps://offlinepeptides.com/ref/JohnGarrett/OPTION 2: LICENSED PROVIDER & COMPOUNDED PEPTIDESPremier PharmacyFor clinicians interested in prescribing peptides in their practice, or individuals interested in speaking with a licensed healthcare provider regarding peptide therapies, visit:https://peptide-solutions.infoAFFILIATE DISCLOSUREPeptides Explained is an affiliate partner with Offline Peptides. If you use the affiliate link above, I may earn a commission at no additional cost to you.ABOUT PEPTIDES EXPLAINEDPeptides Explained is a podcast dedicated to helping listeners understand peptide science, mechanisms, clinical research, and real-world applications through evidence-based discussions and expert interviews.DISCLAIMERThis podcast is for informational and educational purposes only and is not medical advice. Nothing discussed in this episode should be interpreted as medical, legal, or regulatory guidance. Always consult a qualified healthcare professional regarding your individual health needs.#PeptidesExplained #OfflinePeptides #PeptideSolutions #Peptides #GLP1 #Retatrutide #Tirzepatide #Semaglutide #Longevity #Healthcare #MedicalEducation #FunctionalMedicine #WeightLoss #PeptideResearch
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  KPV Explained: Gut Inflammation, Ulcerative Colitis, and the Science Behind the KLOW Blend 10.06.2026 18mnt

  In this episode of Peptides Explained, we take a deep dive into KPV, a three-amino-acid peptide derived from alpha-melanocyte stimulating hormone (alpha-MSH) that has generated growing interest for its potential anti-inflammatory effects.We explore the biology behind KPV, how it may influence inflammatory pathways such as NF-kB, and why researchers have studied it in models of ulcerative colitis, Crohn's disease, inflammatory bowel disease (IBD), and intestinal barrier dysfunction.You'll learn:• What KPV is and where it comes from• How KPV may reduce inflammatory signaling• The role of PepT1 transporters in the gut• What animal and laboratory studies have shown• The limitations of current human data• Why KPV has become popular in gut health discussionsWe also examine the growing interest in the KLOW Blend, a combination of:• KPV• BPC-157• TB-500• GHK-Cuand discuss the scientific rationale behind combining these peptides to target inflammation, tissue protection, cellular migration, and regeneration.As always, we separate biological mechanisms from marketing claims and review what the evidence actually shows.Peptide Solutions is owned and operated by host John Garrett and helps educate both patients and healthcare professionals about peptide science and peptide therapy pathways.Learn more at:Peptide-Solutions.infoPeptides Explained is an affiliate partner with OfflinePeptides.com.If you use the link below, I may earn a commission at no additional cost to you:https://offlinepeptides.com/ref/JohnGarrett/Healthcare providers interested in prescribing compounded peptides and individuals interested in telehealth consultation options can learn more through Peptide Solutions.Visit:Peptide-Solutions.infoDisclaimer: This podcast is for educational and informational purposes only and is not medical advice. KPV and the KLOW Blend are not FDA-approved therapies, and much of the research discussed comes from laboratory and animal studies. Always consult a licensed healthcare professional regarding medical decisions.Powered By Peptide SolutionsResearch Peptide Affiliate DisclosureCompounded Peptide Information
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  Selank vs Semax: The Russian Peptides for Anxiety, Focus, and Brain Health 08.06.2026 11mnt

  In this episode of Peptides Explained, we take a deep dive into two of the most talked-about Russian research peptides: Selank and Semax.We'll explore where these peptides came from, how they work in the brain, and why researchers have studied them for anxiety, stress resilience, cognitive performance, neuroprotection, and stroke recovery. You'll learn about key mechanisms involving GABA, dopamine, serotonin, BDNF, and neuroplasticity while separating scientific evidence from internet hype.We also review the available clinical data, discuss regulatory status in the United States, and explain what is known—and still unknown—about the safety and effectiveness of these compounds.Whether you're a clinician, researcher, peptide enthusiast, or simply curious about emerging neuroscience, this episode provides a balanced, evidence-based look at Selank and Semax.Topics Covered:• What are Selank and Semax?• Russian peptide research history• Anxiety and stress-response signaling• BDNF and neuroplasticity• Cognitive enhancement claims• Stroke recovery research• Safety considerations and limitations• Current regulatory statusSupport the PodcastPeptides Explained is powered by Peptide Solutions, owned and operated by John Garrett.For educational information about peptides and available options:Peptide Solutions: https://peptide-solutions.infoFor those interested in research-use peptides:https://offlinepeptides.com/ref/JohnGarrett/Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use the affiliate link above, I may earn a commission at no additional cost to you.This podcast is for informational and educational purposes only and does not constitute medical advice.
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  Can Peptides Help Menopause? The Truth About Libido, Weight Gain & Aging 03.06.2026 19mnt

  In this special episode of Peptides Explained, we're focusing on a topic that affects millions of women but often isn't discussed openly enough: menopause, hormonal signaling, libido, body composition, and the emerging role of peptides.Why does weight gain seem different during menopause? What causes the sudden changes in energy, sleep, skin, hair, and sexual desire? And where do peptides like Kisspeptin, PT-141 (Bremelanotide), Tesamorelin, GHK-Cu, BPC-157, and GLP-1 medications fit into the conversation?Join host John Garrett, RN, as he breaks down the science behind female hormone signaling in clear, understandable language. We'll explore the biology of menopause, the neurochemistry of desire, the "collagen cliff," metabolic changes, and the latest research on peptides being studied for women's health and aging.This episode covers:• Menopause and metabolic changes• GLP-1 medications and weight management• Kisspeptin and reproductive hormone signaling• PT-141 and female sexual desire• Tesamorelin and growth hormone pathways• GHK-Cu and collagen production• BPC-157 and recovery science• Oxytocin and emotional connection• What is evidence-based vs. what remains experimentalWhether you're navigating perimenopause, menopause, or simply interested in understanding how peptide science intersects with women's health, this episode delivers a balanced, evidence-based look at one of the most important conversations in modern medicine.Learn more:www.peptide-solutions.infoPodcast website:www.peptidesexplained.infoSupport the podcast and learn more about peptide research:offlinepeptides.com/ref/JohnGarrettAffiliate Disclosure: Peptides Explained is an affiliate partner with Offline Peptides. If you use my affiliate link, I may earn a commission at no additional cost to you.Follow Peptides Explained:• Instagram: @PeptidesExplained• Facebook: Peptides Explained• LinkedIn: Peptides Explained• Patreon: Peptides Explained• Skool: Peptides Explained CommunityIf you enjoy the show, please follow, subscribe, leave a review, and share this episode with someone who would benefit from understanding the science behind menopause, hormones, and peptide therapy.Peptides Explained is powered by Peptide Solutions, founded and operated by John Garrett, RN, providing education on peptide science and helping connect patients and clinicians with peptide-related resources.This podcast is for informational purposes only and is not medical advice.
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  GLP-1 Medications and the Brain | Mood, Anxiety, Motivation & Dopamine Explained 01.06.2026 15mnt

  GLP-1 medications may affect far more than appetite and weight loss.In this episode, we explore the growing evidence surrounding semaglutide, tirzepatide, and retatrutide and their potential effects on mood, anxiety, dopamine signaling, motivation, and compulsive behavior.We discuss both the research and the real-world patient reports clinicians are increasingly hearing in practice.
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  Do Growth Hormone Peptides Cause Cancer? | The Truth About IGF-1 25.05.2026 15mnt

  Do growth hormone secretagogues increase cancer risk?This episode breaks down the real science behind IGF-1, cancer biology, and compounds like MK-677, Ipamorelin, Sermorelin, CJC-1295, and Tesamorelin.We review:Human IGF-1 cancer studiesAcromegaly dataTumor signaling pathwaysObservational vs causal evidenceWhat current science actually supportsThis podcast is for informational purposes only and is not medical advice.Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.Support the show:OfflinePeptides Affiliate Link
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  BPC-157 and Cancer: What the Studies Actually Show 18.05.2026 30mnt

  Does BPC-157 cause cancer — or is that claim being oversimplified?In this episode of Peptides Explained, we take a study-review approach to one of the biggest concerns surrounding BPC-157: its potential angiogenic effects and whether that could theoretically contribute to cancer proliferation.Angiogenesis means new blood vessel formation. It is essential for normal wound healing and tissue repair, but it also plays a role in tumor biology. That overlap has led to concerns that BPC-157 could “feed” cancer growth.But what do the studies actually show?In this episode, we review key papers on BPC-157, including:• Hsieh et al., 2017 — VEGFR2 activation and angiogenesis• Radeljak, Seiwerth, and Sikiric, 2004 — melanoma cell-line data• Kang et al., 2018 — cancer cachexia context• Masnec et al., 2015 — corneal injury and neovascularizationWe break down the difference between physiologic repair signaling and pathologic tumor angiogenesis, and explain why the current evidence does not support the simple claim that BPC-157 causes cancer proliferation.That said, the lack of strong human oncology safety data means caution is still appropriate, especially for anyone with active cancer, prior cancer, unexplained symptoms, or elevated cancer risk.This episode is designed as a literature review for clinicians, physicians, and scientifically curious listeners who want a balanced, evidence-based explanation.Disclaimer: This content is for informational and educational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy.Affiliate disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you.https://offlinepeptides.com/ref/JohnGarrett/#BPC157 #PeptidesExplained #CancerRisk #Angiogenesis #PeptideScience #VEGF #TissueRepair #MedicalEducation #PhysicianReview #Peptides