The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
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Dave Asprey, the Father of Biohacking and creator of Bulletproof Coffee, hosts this masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to upgrade energy, focus, metabolism, and resilience. Guests include world-class scientists, doctors, and innovators discussing mitochondrial health, peptides, hormones, fasting, sleep, and neuroplasticity. The podcast aims to help listeners live longer, stronger, and smarter lives through data-backed human enhancement.
Episod
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Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545 27.09.2026 14minDave Asprey outlines six science-backed methods to melt visceral fat—ranging from high-protein eating and HIIT to cold exposure, weightlifting, quality sleep, and stress reduction—arguing that chronic stress is the root cause that must be addressed for lasting fat loss. -
Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544 25.09.2026 14minA roundup of five health stories — Novo Nordisk's interest in hair loss, nutritional deficiencies in kids on GLP-1s, stomach-brain synchronization and mental health, food preservatives linked to heart disease, and taurine's stress-protective effects in rats — closing with a reminder to audit the hidden downsides of any health intervention you're already doing. -
The Best Singular Hack To Change EVERYTHING About Your Life : 1543 24.09.2026 1j 13minDr. Robert Waldinger shares findings from the 85-year Harvard Study of Adult Development revealing that the quality of our relationships—not wealth, fame, or power—is the single greatest predictor of health, happiness, and longevity, and offers practical strategies for building "social fitness" at any life stage. -
15g Every Morning for Anti-Aging Mitochondria : 1541 22.09.2026 58minDave Asprey and Catharine Arnston explore how spirulina and chlorella may support mitochondrial function, cellular energy, detoxification, brain health, and healthy aging. -
I Wasted 10 Years Stuck With Brain Fog Until I Learned This : 1540 20.09.2026 20minA mold illness survivor explains how toxic mold in your home and body causes chronic brain fog, fatigue, and inflammation — and lays out a step-by-step plan to identify the source, remediate your environment, and detox what your body has already absorbed. -
Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539 18.09.2026 1j 2minDave Asprey sits down with spiritual teacher Teal Swan to explore narcissism, betrayal, extrasensory perception, the nature of ego, divine masculine and feminine energy, and whether humanity can heal its deepest wounds. -
How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538 17.09.2026 54minDave Asprey and neurobiologist Dr. Michael Leon explore how your sense of smell influences memory, sleep, brain aging, and longevity, and why olfactory enrichment may be one of the most overlooked tools for protecting cognitive health. -
Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537 16.09.2026 55minThis episode is a wide-ranging conversation covering testosterone and hormone replacement therapy, peptides, biohacking, psychedelics and spirituality, parenting, and building a health/longevity business, with the hosts sharing personal experiences throughout. -
The Peptide Secrets to a Youthful Face : 1536 15.09.2026 55minDave Asprey and Carolina Reis de Oliveira break down how senescent cells, menopause, hydration loss, and peptide science affect skin aging, and what the latest research suggests may help make skin function biologically younger. -
What 36 Hours Without Sugar Does to Your Body : 1535 13.09.2026 12minThis episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements. -
New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534 11.09.2026 9minThis week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat. -
Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533 08.09.2026 1j 9minDave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient. -
If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532 06.09.2026 10minDave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss. -
Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531 04.09.2026 7minThis episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through. -
Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530 03.09.2026 1j 58minJenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults. -
3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529 01.09.2026 35minDave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead. -
7 Brain Compounds I Take For Superhuman Focus : 1528 30.08.2026 9mincan you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll also learn" section based on this episode's content: You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties Want me to add this to the script, or adjust the tone or number of bullets? give me a dash in front of each bullet You'll also learn: Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulants The overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feels Why a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energy The orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirties can you give me timestamps for this episode. similar to this previous example: Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Timestamps: 00:00 – Intro & The Brain Fog Problem 01:12 – Fixing Brain Energy 01:41 – Sulbutiamine 03:00 – Sarcosine 04:14 – Uridine 05:08 – Thunbergia Laurifolia (Trumpet Vine) 05:55 – The Muscle-Energy Connection 06:38 – Dilucene 08:08 – TUDCA 09:06 – ACE 167 now i need a one sentence summary of this episode After overcoming his own brain fog, the creator breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance. -
Change Your Morning, Change Your Life! Hal Elrod : 1527 28.08.2026 1j 13minDave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance. -
Learn THIS And You’ll Become Impossible To Trigger : 1526 27.08.2026 1j 1minJonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity. -
Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525 25.08.2026 1j 1minJim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.
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