Analytically Speaking

Afleveringen

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  Ep. 48: From Fortran to Field Flow Fractionation 05.10.2026 54min

  Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy. In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Mark Schure, who has worked in separation science for over 35 years in both industry and academia. Over a 28-year period, he worked for Digital Equipment Corporation, the Rohm and Haas Company, and the Dow Chemical Company. Since then, he has served as Chief Technology Officer for Kroungold Analytical, and he has been an adjunct professor in the Department of Chemical and Biomolecular Engineering at the University of Delaware for over 20 years. Dr. Schure is a widely recognized expert in separation science who has published more than 110 papers, holds numerous patents, and edited the book Multidimensional Liquid Chromatography. His scientific interests encompass the fundamental separation science of complex molecules, polymers, and colloids, alongside 2D chromatography, retention mechanisms, and field flow fractionation. He has received numerous accolades, including the Eastern Analytical Symposium Award in Separation Science and the Uwe Neue Award from the HPLC conference. In a wide ranging conversation recorded live at the HPLC 2026 conference in Indianapolis following a memorial session for Prof. Peter Carr, we explore Mark’s unique entry into separation science, which benefited from prior experiences building amplifiers and electronics before transitioning to write Fortran software as a consultant for chemists at Northeastern University. We then discuss Mark’s foundational simulation work in field flow fractionation (FFF), including his approaches to modeling Coriolis effects and sedimentation. We also spend some time talking about Mark’s pioneering theoretical contributions to 2D chromatography on topics including sampling rate and detection limits. Finally, Mark shares his perspective on the intense inter-diffusion of information between his modeling group and Pete Carr and Ilja Siepmann at the University of Minnesota, the future of analytical chemistry, the need for improved analytical strategies for complex matrices like exosomes, and the potential for artificial intelligence to help identify unknown compounds in complex mixtures.
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  Ep 47: The Other Half of Beer’s Law 07.08.2026 1u 11min

  Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy. Here in Episode #47, podcast host Dr. Jerry Workman speaks with Dr. Thomas Mayerhöfer from the Leibniz Institute of Photonic Technology (Leibniz IPHT) in Jena, Germany, and Friedrich Schiller University Jena, about “the other half” of the Beer–Lambert law: dispersion theory, the concentration law of the refractive index, and refractive-index and complex-valued chemometrics. Dr. Mayerhöfer, who first joined the podcast for Episode #29 on the history and theory of infrared spectroscopy, returns to explain how Beer’s law falls out of dispersion theory as a limiting case, why the refractive index obeys a concentration law of its own that was mainstream physical chemistry before about 1920 (and helped confirm the Kekulé structure of benzene), and how new refractive-index and complex-valued chemometric methods — in combination with PLS — can outperform conventional absorbance-based calibration by up to an order of magnitude.
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  Ep. 46: Live from Pittcon with Award Winners Bob Pirok and Justin Godinho 07.07.2026 50min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with two recent award winners live from the Pittcon conference in San Antonio, Texas: Dr. Bob Pirok and Dr. Justin Godinho. Dr. Bob Pirok is an Associate Professor at the University of Amsterdam in the Netherlands, where he also completed his Ph.D. under the direction of Professor Peter Schoenmakers. He is an expert in multi-dimensional chromatography and the application of machine learning within the field. At Pittcon we celebrated his receipt of the Emerging Leader in Chromatography Award, presented by LCGC International Magazine. Dr. Justin Godinho is a Senior Principal Scientist at GlaxoSmithKline (GSK) in Upper Providence, Pennsylvania. He completed his undergraduate work at Davidson College and his Ph.D. under the direction of Professor Jim Jorgenson at the University of North Carolina at Chapel Hill. Before joining GSK, he worked in the column manufacturing business with Advanced Materials Technology. He is a recognized expert in column technology at both capillary and analytical scales, as well as the analysis of small and biotherapeutic molecules. At this year's conference, he received the Young Investigator in Separation Science Award, sponsored by the ACS Division of Analytical Chemistry. In the conversation, we discuss the recent award sessions for both guests and the evolution of their respective careers. We explore Justin’s transition from fundamental column packing research to biopharmaceutical applications at GSK, touching on the ongoing need for protein-suitable columns, capillary-scale techniques, and the Hydrophobic Subtraction Model column database. We then shift to Bob’s research on automated method development discussed at the meeting. This includes a deep dive into data-driven chromatography, the complexities involved in establishing effective Chromatographic Response Functions (CRFs), and why setting realistic expectations for artificial intelligence and automated method development is critical to avoiding a future "AI winter."
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  Ep 45: Overfitting in Chemometrics: Designing Models That Truly Work 15.05.2026 35min

  Ep 45: Overfitting in Chemometrics: Designing Models That Truly Work by LCGC & Spectroscopy
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  Ep. 44: Be a Nice Person 20.03.2026 50min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Pierre-Hugues (PH) Stefanuto who is an Associate Professor and Lead Scientist in the Molecular System Research Unit at University of Liège in Liège, Belgium. He previously received both his M.S. and Ph.D. degrees from the same institution. Following his graduate work in Liege he was a postdoctoral research fellow at Dartmouth College. He is a recognized world expert in multidimensional gas chromatography, where he focuses on profiling volatile organic compound mixtures in various life science samples. Currently, he is focused on developing multi-omics screening approaches to tackle biomedical challenges at the molecular level. He has received a number of accolades to date, including the John Phillips Award and Richard Sacks Award, which are two of the highest honors in the field of multidimensional gas chromatography. He is also one of the co-chairs of the ongoing Multidimensional Chromatography Workshop symposium series. In the conversation we talk about PH’s early experiences as a kid scientist, both experimenting in the kitchen at home, and as a laureate of the Chemistry Olympiad in Belgium. We then move on to discuss the Multidimensional Chromatography Workshop - the early days, the alignment with PH’s professional interests, the 17th annual workshop in Williamsburg, VA, and the upcoming 18th workshop in Liège in early 2027. We also talk about the “Century Mix” Project, which was discussed at the Williamsburg with guidance from PH and Dr. John Dimandjia, and has aims to democratize the characterization of GCxGC systems, and provide open datasets for anyone in the community to use. Later in the conversation we briefly discuss two of PH’s recent papers in the GCxGC field, both focused on aspects of data analysis. Finally, we finish with some quick hits, where PH has great advice for young scientists.
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  EP 43: An Introduction to Optical Photothermal Infrared (O-PTIR) Spectroscopy 02.02.2026 1u 5min

  Here in Episode #43, podcast host Dr. Jerry Workman speaks with Dr. Mustafa Kansiz, who is currently the Director of Product Management at Photothermal Spectroscopy Corporation in Santa Barbara, California. They will be discussing an introduction to optical photothermal infrared (O-PTIR) spectroscopy; the technique, its applications and the newest innovations in O-PTIR and even Photothermal Stimulated Raman Scattering (PT-SRS).
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  Ep. 42: Did You Look at the Raw Data? 06.01.2026 40min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Professor Kelly Hines. Dr. Hines is an associate professor in the Department of Chemistry at the University of Georgia in Athens. She received her B.S. degree in Chemistry from the University of Florida, and then completed the Ph.D. in Chemistry at Vanderbilt University. Her doctoral studies focused on monitoring biomolecular signatures of disease via ion mobility and mass spectrometry techniques, and then she moved on to post-doctoral experiences at two different institutions. The first stop was at the metabolomics resource core at the Mayo Clinic, and the second stop was in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. Kelly has won several awards in the field of chemical analysis, including recognition as a Female Role Model in Analytical Chemistry by Analytical and Bioanalytical Chemistry, as an Emerging Investigator by the Journal of the American Society for Mass Spectrometry, an ASMS Research Award (which is one of the top honors that young investigators in MS can receive), and very recently was named as the Chemist of the Year by the Northeast Georgia Section of the American Chemical Society. In a wide-ranging conversation, we discuss the early origins of Kelly’s interest in science rooted in her opportunity to explore the plant nursery managed by her father, and then her turn from civil engineering to analytical chemistry inspired by an early undergraduate course “Chemistry for Engineers”. We discuss Hines’ recent and ongoing work involving the use of ion mobility mass spectrometry (IMS-MS), with pre-separation using chromatography when appropriate, for multi-omics studies, aimed at deeper understanding of the biochemistry of organisms at the metabolite level. We also discuss Kelly’s positive experiences developing peer networks through regular attendance at conferences, particularly the American Society for Mass Spectrometry (ASMS) annual meeting, experiences in her second post-doctoral position that inspired her to pursue an academic position, and her approach to mentoring graduate students who show up in her laboratory with diverse backgrounds, interests, and abilities.
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  Ep 41: The Story of the Michelson Exhibit at the Angels Camp Museum 21.11.2025 52min

  Here in Episode #41, podcast host Dr. Jerry Workman speaks with Sunil Mehrotra and Doug Modlin, who are the project leaders of the Albert Michelson Exhibit at the Angels Camp Museum located in Angels Camp, California. They will be discussing the life and times of Albert Michelson and the creation of the Albert Michelson Angels Camp Museum Exhibit. Albert A. Michelson was the first Nobel Laureate in the sciences from the United States and the first physicist to accurately measure the speed of light, the size of stars, and more. References and Further Information for Albert A. Michelson’s Life and Angels Camp Museum Exhibit Life and Scientific Contributions (1) The Albert Michelson website landing page. https://albertmichelson.com/ (accessed 2025-09-30). (2) Michelson live interview film YouTube link: https://youtu.be/gQoNnu0n2lk (accessed 2025-09-30). (3) Workman, J., Jr. Albert A. Michelson: A Pioneer of Interferometry and Precision Optical Spectroscopy. Spectroscopy 2025, 40 (6), 22–26. https://doi.org/10.56530/spectroscopy.tz5770i4. (4) National Academy of Sciences (USA) Biographical Memoir of Albert Abraham Michelson PDF document. Available at: https://drive.google.com/file/d/1jd-yeTdj8y0kQVENLZkCXe8uoF3RX84E/view?usp=sharing (accessed 2025-09-30). (5) Albert A. Michelson, Recent advances in spectroscopy, Nobel Lecture, December 12, 1907. Available at: https://drive.google.com/file/d/1GeXXxuCoLbWVIfG8wS1XJ-kpY0ajBXEz/view?usp=sharing (accessed 2025-09-30). (6) Michelson featured in US Navy (USN) history video, YouTube link: https://youtu.be/-CbrVa9SrCI (accessed 2025-09-30). (7) Edna and Albert Michelson Family History. Available at: https://docs.google.com/document/d/1Kk_HpxnKjKbtHx9SPozM-jDbVFKc9L-_/edit?usp=sharing&ouid=100533588463446467177&rtpof=true&sd=true (accessed 2025-09-30). Albert Michelson exhibit at Angels Camp Museum (8) Albert Michelson exhibit unveiled at Angels Camp Museum article. Available at: https://drive.google.com/file/d/1VMjhYta7qfJbq95lKW2ftqPglJqCdhDO/view?usp=sharing (accessed 2025-09-30). (9) Albert Michelson Exhibit Inspires Young Minds at Angels Camp Museum Link: https://new.thepinetree.net/?p=179327 (accessed 2025-09-30). (10) Mark Twain Elementary Students Tour the Albert Michelson Exhibit YouTube link: https://youtu.be/hwpe-wkHtOo (accessed 2025-09-30). (11) A teacher and a student touring Albert Michelson exhibit at the Angels Camp Museum YouTube link: https://youtu.be/vdVJDkretU4 (accessed 2025-09-30). (12) Albert Michelson Exhibit at the Angels Camp Museum-spectrometer description YouTube link: https://youtu.be/Ed_-JSq_4pg (accessed 2025-09-30). (13). Virtual tour of the Albert Michelson Exhibit at the Angels Camp Museum link: https://tourmkr.com/F1SYh8VcsS/43684268p&273.03h&90t (14). The Albert Michelson Education Project supports the Learning Center at the Albert Michelson Exhibit and the Albert Michelson Science Fair Awards. Be sure to indicate that your donation is intended for the Albert Michelson Education Project and use the following link: https://www.m-otm.org/contribute (15). The Michelson STEAM Scholarship supports local high school students in Calaveras County pursue their education in STEAM related disciplines. Be sure to indicate that your donation is intended for the Michelon STEAM Scholarship and use the following link: https://calaverascommunityfoundation.org/ways-to-give/
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  Ep. 40: Curiosity, Collaboration, and Open-Mindnesses are the Keys 15.10.2025 52min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Professor Luis Colon. Dr. Colon is is the SUNY Distinguished Professor, A. Conger Goodyear Professor, and Associate Dean for Inclusive Excellence in the College of Arts and Sciences at the University at Buffalo. He received his bachelors degree from University of Puerto Rico at Cayey, and then received the Ph.D. from UMass Lowell. He also was a postdoctoral fellow in the Zare Group at Stanford where did groundbreaking work in detection for capillary electrophoresis. Colon has won numerous awards, including most recently the Kirkland Award in Chromatography (formerly known as the ACS Award in Chromatography), which we celebrated at the ACS Fall 2025 National Meeting. In a fascinating conversation, we discuss the influence of Luis’ father on his scientific career, by demonstrating to Luis (whether he realized it at the time or not) a physical separation of coffee shells and beans in the wind. Dr. Colon explains the origins of his interest in materials development for chromatography, which included observations he made on the relatively short lifetimes and fragility of silica-based materials while working in industry early in his career. We also spend a good bit of time discussing Prof. Colon’s motivations for an approach to mentoring younger scientists, as well as some of his thoughts about the future of the separation science field. Finally, Luis shares some of his wisdom gained over several decades as a successful and well recognized analytical scientist, emphasizing the importance of curiosity, collaboration, and open-mindedness.
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  Ep. 38: Being prepared isn’t just for Boy Scouts 08.09.2025 1u 2min

  Dr. Wilson is a research chemist and coordinator of the Cannabis Research Program in the Chemical Sciences Division at the National Institute of Standards & Technology (NIST) in Gaithersburg, Maryland. He received his B.S. degree in Chemistry from Greensboro College followed by a M.S. degree in Chemistry from the same institution. He then moved south to pursue a Ph.D. in Chemistry at the University of Central Florida, training in the lab of Prof. Andres D. Campiglia. In a wide-ranging conversation, we discuss the influence of 2000’s television shows such as CSI on Brent’s interest in forensic science and analytical chemistry, and how an informal interview at a poster session ultimately led to the position he now holds at NIST. Dr. Wilson shares how he navigated the educational landscapes in forensic science and chemistry, both at the undergraduate and graduate levels. We discuss the evolution of cannabis standards and analytical characterization in recent years, and Brent shares his perspective on the importance of standards in general, the birth of a reference material, and the significant effort it takes to bring these materials to the point where analytical scientists like us can purchase them. Dr. Wilson also describes some of his work on low-temperature emission spectroscopy techniques, where molecule exhibit much narrower and specific emission bands compared to room temperature detection. Brent also shares more about the life of a scientist within NIST, from day-to-day activities, competing for federal funding, and more. Finally, Dr. Wilson shares some professional advice, including the importance of being prepared and adaptable, the value of talking with people at conferences, and the importance of establishing and maintaining relationships over the course of one's career.
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  Ep 39: Space and Spectroscopy: Two Very Important Things 01.08.2025 46min

  Here in Episode #39, podcast host Dr. Jerry Workman speaks with Dr. Macarena Garcia Marin, who is an astrophysicist and instrument scientist for the European Space Agency based at the Space Telescope and Science Institute in Baltimore, MD USA. She will be discussing the highlights of the role of the James Webb Space Telescope, also known as JWST, and its abilities and discoveries using the science of spectroscopy in space, since performing spectroscopic research since its launch in 2021. We have invited Macarena to our Analytically Speaking podcast to discuss the current discoveries using JWST and what the future hopes are for a deeper understanding of the amazing universe that surrounds our home, planet Earth.
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  Ep 37: On the Subject of Flow Imaging Microscopy in Collaboration with the American Association of Pharmaceutical Scientists 06.06.2025 38min

  Here in Episode #37, podcast host Dr. Jerry Workman speaks with Dr. Austin Daniels, application scientist for Yokogawa Fluid Imaging Technologies. This Episode will focus on flow imaging microscopy (FIM), a new technology for subvisible particle characterization in biologics. We have invited Austin to our Analytically Speaking podcast to discuss the current trends and state of using FIM to ensure the quality and safety of biologics. This requires precise monitoring of subvisible particles, which can impact drug efficacy and patient health. Traditional analysis methods, such as light obscuration (LO) and membrane microscopy (MM), provide limited data on particle types and morphology, making it difficult to pinpoint contamination sources.
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  Ep. 36: A Day in the Life of a NIST Scientist 14.05.2025 49min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Alix Rodowa, Research Chemist within the Organic Chemical Metrology Group at the National Institute of Standards & Technology (NIST) in Gaithersburg, Maryland. At NIST, she is the Environmental Sector Task Lead for the Organic Analysis Working Group for the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (or CCQM). After discussing some of the events that sparked Dr. Rodowa’s interest in science, and analytical chemistry in particular, we discuss her path to a career as a NIST scientist, including cold-emailing potential research advisors, and an experience as a National Research Council (NRC) postdoctoral fellow. We then discuss her work on polyfluoroalkyl substances (PFAS), including the development of the PFAS Interference List - affectionately known as the “PIL” - and the development of a Standard Reference Material (SRM) for that research area. We also touch on emerging uses of machine learning in workflows for analytical target and suspect screening. Finally, Alix provides some insight into a day in the life of a NIST scientist, why she enjoys working in a government laboratory, and how aspiring scientists can explore this environment as a potential career option.
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  Ep 35: On the Subject of Continuing Education for Spectroscopists. 22.03.2025 32min

  Here in Episode #35, podcast host Dr. Jerry Workman speaks with Dr. Ellen V. Miseo, who has been active in vibrational spectroscopy and instrument development her entire career and is formally trained as a physical chemist. She has worked for instrument companies as well as run laboratory operations. She is past president of both the Coblentz Society and Society for Applied Spectroscopy and currently heads Miseo Consulting. We have invited Ellen to our Analytically Speaking podcast to discuss the current activities of SAS and Coblentz to foster further education in the essential aspects of spectroscopy for current and future practitioners.
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  Ep. 34: A Banner Year for Separation Science at Pittcon 2025 09.03.2025 36min

  Perrault Uptmor of William & Mary, and Dr. Emanuela Gionfriddo of SUNY at Buffalo. Kate and Emanuela are both returning guests of the pod (see episodes 2 and 14), and joined us on-site at the Boston Convention Center to reflect on what we saw and heard at Pittcon 2025. In a wide-ranging conversation, we touch on a variety of aspects of the Pittcon experience, including networking opportunities, award sessions recognizing both early-career scientists and achievements over lifetimes, and of course trends in various areas as observed from the numerous technical sessions and talks. Several notable award sessions honoring great work in separation science included: ● ACS Division of Analytical Chemistry Young Investigator in Separation Science - awarded to Prof. Xiao Su of the University of Illinois at Urbana-Champaign ● Pittcon Analytical Chemistry Award - awarded to Prof. Dan Armstrong of the University of Texas at Arlington ● LCGC Emerging Leader Award - awarded to Prof. Katelynn Perrault Uptmor of William & Mary ● LCGC Lifetime Achievement Award - awarded to Christopher Pohl of CAP Chromatography and Consulting ● Chromatography Forum of the Delaware Valley Dal Nogare Award - awarded to Terry Berger Some of the trends discussed during the episode include developments in the use of machine learning and artificial intelligence tools in our field, multi-dimensional separations, green chemistry, and more!
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  Ep. 32: Don’t skip seminar…you might miss a life-changing event 01.01.2025 49min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Benjamin Garcia. Dr. Garcia is the Raymond H. Wittcoff Distinguished Professor and Head of the Department of Biochemistry and Molecular Biophysics in the School of Medicine at Washington University in St. Louis. His research interests primarily focus on the development of mass spectrometry-based proteomic approaches for the analysis of post-translational modifications of proteins (PTMs) and modified proteomes. His group specializes in high-throughput and quantitative analysis of many classes of modified proteins, especially epigenetic histone PTMs. He is a prolific author and scientific leader, with an h-index approaching 120. He has received a LOT of awards to date, but we sat down with him at the Eastern Analytical Symposium where he was recognized for his recent EAS Award for Outstanding Achievement in Mass Spectrometry. In the conversation we talk about the origins of Dr. Garcia’s interests in analytical science, mass spectrometry, and biomedical research, and he shares his thoughts about the current state and near future for technologies used for biomolecule separations including peptides, proteins, and oligonucleotides. We also discuss Dr. Garcia’s highly impactful efforts to promote participation in the analytical sciences by people from all backgrounds, and he shares some thoughts about the “to-do list” for his upcoming term as chair of the ACS Division of Analytical Chemistry.
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  Ep 33: Automating Chemometrics for an Expert Calibration System 18.12.2024 1u 2min

  Here in Episode #33, podcast host Dr. Jerry Workman speaks with Dr. Brian G. Rohrback, President of Infometrix, Inc. in Bothell, WA, USA—who has been active in chemometrics research and creating software for complex calibrations and multivariate data analysis since 1983. Infometrix was founded by researchers Bruce Kowalski and Gerry Erickson in 1978. We have invited Brian to our Analytically Speaking podcast to discuss his research and experience in automating the process of building multivariate calibrations.
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  Ep 31: Clarifying the Meaning of Chemometrics in the World of Artificial Intelligence (AI) 02.12.2024 1u 14min

  Here in Episode #31, podcast host Dr. Jerry Workman speaks with Dr. Barry M. Wise, Founder and President of Eigenvector Research, Inc. about the meaning of the terms chemometrics, artificial intelligence (AI), machine learning (ML), and neural networks (NNs) within the context of analytical chemistry and process analysis.
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  Ep. 30: The Potential of Generative A.I. as a Research Assistant for Measurement Science 01.11.2024 41min

  In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Farooq Wahab, Research Engineering Scientist at the University of Texas at Arlington. Wahab has interests and expertise in chiral separations, improving the green-ness of chromatographic separations, new detectors for chromatography such as microwave rotational spectroscopy, and new techniques for signal processing in chromatography, among other areas. He and several coauthors recently published a paper in Analytical Chemistry discussing their experiences using generative artificial intelligence (i.e. chatGPT) as a research assistant when working on tasks in measurement science ranging from extraction of rotational microwave spectra from free induction decay signals, to baseline removal from chromatographic data. In the conversation we talk about the origins of this study, strengths and weaknesses of chatGPT as a research assistant in the analytical chemistry space, and the role of generative AI in chemistry teaching and learning. We also touch on tips and tricks also published by Wahab and coworkers for dealing with equations and symbol-heavy text when using generative AI tools. One very interesting application of these tricks is in the translation of relatively old (decades) papers that were published before English became the standard language for much of science publication.
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  Ep 29: Quantitative Spectroscopy and Wave Optics in Infrared Spectroscopy 01.10.2024 1u 3min

  Here in Episode #29, podcast host Dr. Jerry Workman speaks with Dr. Thomas Mayerhöfer from the Leibniz Institute of Photonic Technology in Jena, Germany, about quantitative spectroscopy and wave optics in infrared spectroscopy, including the theory, simulation, and modeling aspects.