The Human Upgrade: Biohacking for Longevity & Performance

Episoder

• Peptide Power Without Needles: Smarter Dosing for Longevity | Justin Kirkland : 1477 02.06.2026 54min

  Host Dave Asprey interviews Justin Kirkland of Amino Innovations and Precision Peptide Company, a chemist with 30 years of experience, about how peptides are synthesized, sourced safely in the US, and delivered through injections, microneedle patches, and nasal sprays, while discussing quality control issues in the gray market, which peptides are most promising or overhyped, and how genetics and gut bacteria influence individual responses.
• Brain Fog Starts in Your Feet (Scientifically Proven) : 1476 31.05.2026 8min

  I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet. In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness. Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – Personal Experience 00:47 – Root Cause: Not in Your Head 01:05 – Blood Flow and Brain Function 02:10 – The Calf Pump 03:52 – Foot Sensory Signals 04:26 – Nervous System Impact 06:22 – How to Fix It 07:51 – Personal Results Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
• NASCAR Death, Steroid Olympics, Genetic Age Truth, and Gut Depression... : 1475 29.05.2026 8min

  5:29 PMClaude responded: This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control…This week Dave Asprey covers the inaugural Enhanced Games, what Kyle Busch's death reveals about sepsis and inflammatory risk, a brain protein that may control the pace of aging, new evidence linking depression to immune biology, and a genetics paper that says half your lifespan was loaded before you were born.
• Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474 28.05.2026 1t 23min

  Dr. Andrew Salzman joins Dave Asprey to explain how gut barrier breakdown drives systemic aging through NAD depletion and inflammation, and why creatine and targeted NAD support are key to reversing it.
• The Doctor With Answers To Your Mystery Symptoms | Jessica Peatross : 1473 26.05.2026 1t 16min

  Dave Asprey and Dr. Jessica Peatross expose the root causes of chronic illness — parasites, toxic mold, histamine dysfunction, and cortisol imbalance — while challenging mainstream medicine's failures on everything from Lyme disease to the California Medical Board.
• The EXACT Japanese Formula To Live Past 100+ (Simple Steps) : 1471 24.05.2026 9min

  Drawing from Okinawa's blue zone lifestyle, this episode breaks down the five science-backed habits (mindful eating, purpose, staying active, strong social bonds, and stress resilience) that help people live past 100.
• This Epic Device Gives You A SUPERBRAIN : 1472 22.05.2026 15min

  9:03 PMClaude responded: Dr.Dr. Patrick Porter, PhD, founder of BrainTap, joins Host Dave Asprey to reveal how flickering light, 40 hertz gamma frequency, and brainwave entrainment technology backed by 72 peer-reviewed studies can break up amyloid plaque, reset your sleep, and rewire your brain for peak performance in as little as 10 minutes a day.
• The Biblical Anti-Aging Fruit That Scientists Are Obsessed With : 1470 21.05.2026 53min

  Chris Rinsch, co-founder and President of Timeline Longevity, joins Host Dave Asprey to reveal the 18-year science behind urolithin A, the postbiotic compound that outperforms rapamycin, triggers mitophagy, and is quietly becoming the most clinically validated longevity supplement on earth.
• How To Hack Your Brain's Missing Youth Molecule | Molly Maloof : 1469 19.05.2026 50min

  Claude responded: Dr.Dr. Molly Maloof, physician and former Stanford educator, joins Host Dave Asprey to reveal how human connection reshapes your biology at the cellular level, why longevity escape velocity is already here, and which peptides, psychedelics, and regenerative medicine breakthroughs are rewriting the rules of healthspan.
• The 4,000-Year-Old Asian Focus Drug That Is Not A Drug : 1468 17.05.2026 13min

  L-theanine, a 4,000-year-old amino acid found in tea, stacks with caffeine at a 2:1 ratio to create calm, focused alertness, and when combined with quality sleep, stress management, and clean coffee, it can deliver monk-like focus over the long term.
• Semen Switch, Chewing Gum, Creatine Cheat, Cancer Plants, and Bedtime Risk : 1467 15.05.2026 10min

  A single creatine dose sharpens your sleep-deprived brain, your gum is loading you with microplastics, irregular bedtimes may double your heart attack risk, scientists just decoded a plant molecule that kills cancer cells in the lab, and researchers built a reversible on/off switch for sperm production with no hormones required.
• Stop Wasting Your Gym Sweat (40 Minutes of This Wins Every Time) | Will Harlow : 1466 14.05.2026 1t 4min

  A UK physiotherapist (Will Harlow) joins Dave Asprey on the Human Upgrade podcast to debunk common fitness myths for people over 50, arguing that resistance training rather than cardio or walking alone is the key to building muscle, bone density, and long-term independence.
• The Real Reason She Loses Interest in Sex | John Gray : 1465 12.05.2026 1t 14min

  Your relational environment is a hormonal input, and John Gray breaks down the biology of attraction, testosterone, estrogen, and desire to show you exactly how to hack it.
• This Italian Fasting Hack Breaks All The Rules Of Fasting : 1464 10.05.2026 19min

  If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall. In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD). I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm. Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air -The One Device | Use code DAVE for $10 off at theonedevice.com/dave -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – Intro 00:40 – Gut Ecosystem 01:00 – Constant Snacking 02:57 – Gut-Brain Connection 03:40 – Why Standard Fasting Can Backfire 07:22 – The Fasting Sweet Spot 09:21 – Introducing the FMD 10:43 – Pre-Reset: Prep Days 13:24 – The 5-Day FMD Protocol 16:47 – Meal Timing & Circadian Rhythm 17:46 – Sleep, Stress & Recovery 18:22 – How Often to Do FMD 19:23 – Wrapup Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
• Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu : 1463 08.05.2026 10min

  Your hormones, your immune system, and your ability to act fast are the only things standing between you and a week that just proved institutions can't save you.
• iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade : 1462 07.05.2026 36min

  A former T-Mobile VP turned quantum tech founder explains how a remote energy field delivered over any distance produced measurable improvements in brain waves, HRV, and ATP production across 25 published studies — and why no sticker or passive device can protect you from what 5G, Starlink, and everyday EMF are actually doing to your mitochondria.
• Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald : 1461 05.05.2026 54min

  Dr. Kara Fitzgerald reveals how a targeted diet and supplement protocol reversed biological age by over three years in eight weeks, then goes deep on the Yamanaka factor science that could make that just the beginning.
• This 9,000-Year-Old Ritual Cleared 15 Years Of Brain Fog : 1460 03.05.2026 14min

  Brain fog isn't a willpower problem — it's a stressed nervous system, and ancient heat rituals like infrared sauna and contrast therapy are the most effective ways to reset it.
• Selfies Predict Cancer, Dirty Feed, Bone Vibration, and more... : 1459 01.05.2026 10min

  Dave Asprey breaks down five new research stories — from Finnish dirt playgrounds and exercise variety data to facial aging AI, bone-building wearables, and the raw milk H5N1 situation — and tells you exactly what to do with each one.
• The Strangest Thing I Do Every Morning for 15 Minutes | Brad Pitzele : 1458 30.04.2026 48min

  Dave Asprey and Brad Pizzoli discuss how combining Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges mitochondrial function, fights inflammation, and improves circulation to address chronic illness and slow aging.