We're not getting any younger... yet.

Odcinki

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  Q&A with Eric and Brianna 24.06.2026 40min

  In the final episode of season 3 we answer your biggest aging questions, from whether there is a single root cause of aging to why different organs fail in different ways. We also dig into what it would take to run human trials that prove real healthspan gains while staying honest about biomarkers, animal data, and online misinformation. Eric Verdin, MD and Brianna Stubbs, PhD Dr. Eric Verdin is President and CEO of the Buck Institute for Research on Aging and an internationally recognized p...
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  Brad Younggren: Filtering Out Aging 10.06.2026 42min

  What if removing and replacing part of your blood could turn back some of the measurable signs of aging? Brianna Stubbs talks with Dr. Brad Younggren — emergency physician, former Army doctor, and CEO of Circulate Health — about therapeutic plasma exchange (TPE). They cover how the procedure works, what the blinded Circulate trial found (including an average 2.6-year reduction in biological age over three months), TPE's unique potential to clear microplastics from the bloodstream, and the bro...
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  Hanadie Yousef: Cracking the Secretome Code 01.04.2026 35min

  In this episode, Buck scientist Brianna Stubbs joins Hanadie Yousef, Co-Founder of Juvena Therapeutics, to discuss the cutting-edge of longevity science. Dr. Yousef shares how Juvena is leveraging AI and the secretome—the proteins secreted by stem cells—to develop therapies that target muscle wasting and promote tissue regeneration. From the potential and risks of GLP-1 drugs to the role of AKT signaling in muscle health, this conversation explores how we can move beyond "snake oil" and into ...
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  Cynthia Kenyon: Switching on Resilience 18.03.2026 37min

  Eric Verdin sits down with Dr. Cynthia Kenyon, a true pioneer in the field of geroscience and the Vice President of Aging Research at Calico. Dr. Kenyon recounts the revolutionary discovery that aging is not merely a process of "wearing out," but is a genetically regulated biological program. In 1993, Cynthia’s pioneering discovery that a single-gene mutation could double the lifespan of C. elegans roundworms while preserving function sparked an intensive study of the molecular biology of agi...
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  Ana Maria Cuervo: Cellular Recycling 04.03.2026 46min

  What if the secret to a longer, healthier life isn’t found in a new supplement or a complex medical procedure, but in your cells' own innate ability to "take out the trash"? In this episode, host Eric Verdin is joined by Dr. Ana Maria Cuervo, a pioneer in the biology of aging and professor at the Albert Einstein College of Medicine. The conversation explores the critical roles of proteostasis—the cell's protein quality control factory—and autophagy, the body's natural recycling system. Dr. Cu...
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  Jamie Justice: The New Metrics of Functional Aging 18.02.2026 35min

  XPRIZE Healthspan Executive Director Jamie Justice joins Brianna Stubbs to discuss the $101 million race to restore 10 years of muscle, cognitive, and immune function within a single year. Moving past binary "alive or dead" metrics—famously called the "toes test" in animal research—the conversation focuses on reclaiming functional independence through clinical trial innovation. Together they explore the potential of accessible markers like RDW (Red Cell Distribution Width), the risks of overl...
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  Tony Wyss-Coray: Rejuvenating the Brain 04.02.2026 45min

  In this episode, Eric Verdin, CEO of the Buck Institute, and Stanford University’s Dr. Tony Wyss-Coray discuss the groundbreaking science of brain rejuvenation through heterochronic parabiosis, a process where young blood factors are shown to restore cognitive function and potentially extend lifespan. Moving from the lab to the clinic, they explore the next frontier: Proteomic Clocks. By measuring thousands of proteins, scientists can now determine the biological age of individual organs, all...
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  George Church: Rewriting The Rules of Aging 21.01.2026 39min

  What if aging is less a fate and more an engineering challenge? We sit down with George Church to unpack a future where gene therapy, cellular reprogramming, and AI-driven delivery systems converge to extend healthspan—and possibly lifespan—without sacrificing identity or safety. From bowhead whales and cancer risk to ethics, trial rigor, and how to deliver rejuvenation to the brain, this is a deep dive into what’s coming next and what it will take to get there. George Church is Professor of ...
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  Season 3 Trailer 14.01.2026

  We're back! Meet our new hosts Eric Verdin, CEO of the Buck Institute, and Brianna Stubbs, Director of Translational Science at the Buck. We're excited to bring you new insights into the fast-moving science of longevity with guests such as George Church, Jamie Justice, Peter Attia, and many more. Support the show
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  Nathan Price: Scientific Wellness and AI at the Forefront 24.07.2024 32min

  What do we really want from our healthcare system, and how can AI help us get it sooner? In our final episode of season two, Gordon talks with visionary systems biology expert Nathan Price about the emergence of scientific wellness, what we can learn from our digital twins, and how using AI to predict health outcomes can help us transform our understanding of aging and disease—potentially adding years of healthy life. Dr. Nathan Price is a distinguished scientist and leader in the field of h...
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  Luigi Ferrucci: Resilience as Medicine 10.07.2024 46min

  Few people have as much experience with patient care and long-term research as the celebrated geriatrician and epidemiologist Luigi Ferrucci. Listen in as he speaks with Gordon about his journey from acute care to population studies, the effective design of clinical trials, and moving towards predictive medicine so we can use our natural resilience to maintain health as we age. Dr. Luigi Ferrucci is a geriatrician and an epidemiologist who conducts research on the causal pathways leading to p...
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  Andrea Maier: From Potential to Practice 12.06.2024 36min

  The movement to integrate longevity treatments into clinical care is making strides. How can we ensure they are evidence-based, accessible, and personalized? World-renowned geroscientist Andrea Maier has been leading the way with innovative clinical trials and cutting edge research. In this episode, she talks with Gordon about the current state of the field, why we need a variety of clocks and interventions, what we can all do now to age better, and what the future of clinical practice looks ...
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  Daniel Belsky: Measuring the Pace of Aging 29.05.2024 38min

  Our chronological age doesn’t tell us much about how well our bodies are aging, but scientists have developed many ways to measure changes at the cellular and molecular levels, including the rate of change, that can suggest ways to improve health at every stage of life. Follow along as Gordon speaks with Daniel Belsky of Columbia University about DNA methylation, the effects of famine and poverty on aging biology, studying the exposome, and how to create equitable access to potential aging in...
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  Kristen Fortney: Finding Targets for Aging Interventions 15.05.2024 26min

  Of all the biochemical changes that occur with aging, what really matters? How can we use the incredible amount of health data available today to discover the best targets for interventions? In this episode, Kristen Fortney of BioAge talks with Gordon about the latest research in proteomics and metabolomics, the importance of muscle loss, and the challenge of measuring the right endpoints for effective treatment and regulatory approval. Kristen Fortney is the co-founder and CEO of BioAge, a ...
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  Valter Longo: Fasting for Health and Longevity 01.05.2024 29min

  What is the relationship between diet, chronic disease, and aging? Can we delay or reverse the effects of aging at the cellular level by following a fasting-mimicking diet? Listen in as Gordon speaks with Valter Longo of the Longevity Institute at USC about epigenetic reprogramming, turning on Yamanaka factors, and restoring our cells to a youthful state based on over 30 years of research on diet and fasting. Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Scienc...
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  Satchin Panda: The Age of Circadian Disruption 17.04.2024 31min

  Our modern world is full of potential disruptions to sleep. But as we learn more about circadian rhythm, we find that it influences everything from metabolism to mental health in different ways as we age. In this episode, Satchin Panda of the Salk Institute guides Gordon through the many interactions between sleep behavior and biology. Together they explore how new insights can help us improve our sleep health, and how researchers might target circadian rhythm to modulate the effects of aging...
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  Laura Carstensen: The Purpose and Promise of Longer Lives 03.04.2024 37min

  What is the goal of living longer? It’s not simply to celebrate a number, but to do something meaningful with that time. Renowned Stanford psychologist Laura Carstensen speaks with Gordon about the experience of aging, in the past and in the future, and why changes in culture must accompany changes in healthspan so we can flourish as a society. Laura L. Carstensen is Professor of Psychology at Stanford University where she is the Fairleigh S. Dickinson Jr. Professor in Public Policy and foun...
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  Season Two Coming Soon! 20.03.2024 1min

  We're back! In season one, we investigated the biology of aging in many different organisms to learn why and how we age. This season we'll take a close look at potential interventions that modify mechanisms of aging biology and may dramatically change the way we age in our lifetimes. Get ready for season two of the Buck's podcast We're not getting any younger... yet. with scientist Gordon Lithgow. Subscribe today! Support the show
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  Between the lines: Mobilizing the immune system 01.03.2023 12min

  Gordon and Stella revisit key concepts from the conversation with Arne Akbar, such as using sestrins to modulate T-cells and telomeres. Looking back over the course of season one, Stella and Gordon discuss the need to think about aging as an organizing principle, and how to deal with all the things we don't yet know. Stay tuned for season two! Support the show
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  Arne Akbar: Immunity and Beyond 15.02.2023 33min

  What role does the immune system play in aging? How do senescent cells evade it and promote inflammation? And what does it reveal about developing effective interventions? Immunologist Arne Akbar joins Gordon to break down the array of actors and pathways involved, including sestrins, immune memory, the gut microbiome, and more. Along the way, Arne highlights the need to connect across research areas, and shares why courage is the most important quality for a scientist to cultivate. Support t...