Longevity Optimization with Kayla Barnes-Lentz

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• Dr. Izabella Wentz: IBS Root Causes, Leaky Gut, Autoimmunity, and How To Start Healing Your Gut 28.05.2026 56min

  Less than 25% of people with IBS get real relief from conventional medicine. That number tells you everything about how the current approach is failing.Most people with IBS have been told it is stress, told to take medication, and sent home. But irritable bowel syndrome is not one condition, it is a label applied to a cluster of symptoms that can have 20 to 40 completely different root causes. And left unaddressed, it is one of the most reliable predictors of autoimmune disease down the line.In this episode I sit down with Dr. Izabella Wentz, clinical pharmacist, functional medicine expert, and NYT bestselling author known as the Thyroid Pharmacist. After her own IBS diagnosis in pharmacy school preceded her Hashimoto's diagnosis by six years, she has spent over a decade connecting the dots between gut dysfunction and autoimmunity for hundreds of thousands of people.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.https://branchbasics.com/KAYLA15Code: KAYLA15We explore:-Why IBS precedes autoimmune disease by 5 to 10 years-The three conditions that must all be present for autoimmunity to manifest-Why women are twice as likely to have IBS during their reproductive years and the specific hormonal and lifestyle drivers-The functional medicine testing approach versus what most GI doctors actually look at-Why gluten particles cross-react with thyroid tissue and what that means for anyone with Hashimoto's-How to actually get mold out of the body and why it disrupts the gut microbiome so severely-The gut healing protocol that got Dr. Izabella's husband into remission from ulcerative colitis in two monthsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Izabella:Instagram: https://www.instagram.com/izabellawentzpharmd/Website: https://thyroidpharmacist.com/Youtube: https://www.youtube.com/user/ThyroidPharmacist#guthealth #IBS #irritablebowelsyndrome #leakygut #autoimmune #hashimotos #thyroidhealth #womenshealth #femalelongevity #longevity #gutmicrobiome #functionalhealth #functionalmedicine #rootcause #parasites #SIBO #foodsensitivities #guthealing #healthoptimization #preventivemedicine
• Dr. Scott Sherr, MD: Why Stress Blocks Healing: Mitochondria, Immune Aging, Hyperbaric Oxygen, and Methylene Blue 21.05.2026 1godz 31min

  There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we break down exactly what it is, why so many people are stuck in it without knowing it, and the right sequence to actually get out.Dr. Scott is a board certified internal medicine physician, certified in hyperbaric oxygen therapy and health optimization medicine, and the chief medical officer of One Base Health, the company behind the hyperbaric chamber you see in every episode. He advises me personally on my hyperbaric protocols, including the ovarian longevity protocol I have been running, and this conversation goes deep into the science behind why that protocol makes sense and what we are actually trying to achieve.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.⁠https://zenbasil.com/shopzenbasil/zenbasilseedbag⁠Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityExplore Troscriptions’ mitochondrial, immune, and nervous system support products. Use code KAYLA10 at checkout for 10% off.https://troscriptions.comIn This Conversation:- Why Autoimmunity Risk Rises In Women During Perimenopause - Why The Body Can’t Heal When Stuck In Stress Mode- How Chronic Stress And Social Media Can Reduce Recovery Capacity- What Methylene Blue Does- Why The Gaba System Matters- When Hyperbaric Therapy HelpsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Scott Sherr and his work:Websites:drscottsherr.comhomehope.orgonebasehealth.comTroscriptions.comInstagram:https://www.instagram.com/troscriptions/https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/https://www.instagram.com/homehopeorg/Youtube:https://www.youtube.com/@troscriptionshttps://www.youtube.com/@drscottsherrLinkedIn:https://www.linkedin.com/in/drsherr/https://www.linkedin.com/company/troscriptions/https://www.linkedin.com/company/onebasehealth/
• Dr. Poonam Desai: The 5 Labs Women Need, Heart Disease Risk, Microplastics, and Perimenopause 14.05.2026 1godz 2min

  Most women have had bloodwork done. What most women haven't had is the right bloodwork. In this episode, Dr. Poonam Desai, double board certified in lifestyle and emergency medicine, NAM certified in menopause care, and founder of Longevity Place and Her Longevity, breaks down the five labs she runs on every female patient, the optimal values most physicians aren't targeting, and why the standard panel tells you almost nothing about long-term cardiovascular risk, metabolic health, or inflammation. This is one of the most practical longevity conversations I've had for women who want to know where they actually stand.We also go deep on the three female life phases medicine consistently underserves, how women's cardiac symptoms are still being dismissed in clinical settings, and what a real foundational protocol looks like before any advanced intervention enters the picture. The perimenopause section is worth your full attention, what is shifting hormonally and metabolically, why those symptoms should not be pushed through, and why the window for acting is earlier than most women are told.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.https://branchbasics.com/KAYLA15Code: KAYLA15In This Conversation:-Why women need a different longevity lens than men-The cardiovascular markers Dr. Desai wants women tracking early-Why blood pressure, resting heart rate, HRV, and snoring matter more than people think-How to use bowel movements as a simple gut-health signal-Why she starts with fiber before protein-The overlooked role of toxins, plastics, and hormone disruptors-What women should not ignore in perimenopause-Why knowing your numbers early changes everythingConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Poonam Desai:Instagram: https://www.instagram.com/drpoonamdesai/LinkedIn: https://www.linkedin.com/in/dr-poonam-desai/Website: https://www.drpoonamdesai.com/Her Substack: https://drpoonamdesai.substack.com/
• Prof. Belinda Beck, PhD: Bone Health: Building Strong Bones, Preventing Age-Related Loss, And Reversing Osteoporosis With Evidence-Based Exercise 07.05.2026 1godz 10min

  Most women are not thinking about their bones until a fracture happens or a scan comes back alarmingly. By then, the window for the most impactful intervention has often been narrowing for decades. Bone density peaks around age 18, not 30 as widely believed and the slow decline that follows is largely silent until it isn't.Professor Belinda Beck, PhD has spent more than two decades studying exactly what it takes to stop and reverse that decline. She is a professor at Griffith University, founder of the Bloom Clinic in Brisbane, and the principal investigator behind the LIFTMORE trials, a body of research that changed the scientific consensus on what is actually possible for women with osteoporosis and osteopenia. Her findings showed that heavy resistance and impact training twice weekly can safely grow bone mineral density in the spine and hip, even in women already diagnosed with very low bone mass and prior osteoporotic fractures. This was not what the medical establishment expected. And it fundamentally changed how serious practitioners now think about bone.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityIn this conversation we explore:- Why bone density peaks at 18 and what that means for every stage of life after- The LIFTMORE trial: what they did, who the participants were, and what the results showed- Why heavy lifting is the key variable and why conventional low-intensity exercise recommendations failed- What estrogen does to bone and why menopause causes such rapid loss- The truth about weighted vests, calcium supplements, and other popular bone health interventions- What GLP-1 drugs are doing to bone and muscle and what to do about it- Age-specific recommendations for women in their 20s to 30s, 40s to 50s, and postmenopauseConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn More About Prof. Belinda Beck and Her Work:LinkedIn: https://www.linkedin.com/company/the-bone-clinic/ ONERO® locations map:  https://onero.academy/locations/ONERO® Academy:  https://onero.academy/The Bone Clinic website:  https://theboneclinic.com.au/#bonehealth #bonedensity #osteoporosis #osteopenia #femalelongevity #womenshealth #heavylifting #strengthtraining #weighttraining #perimenopause #menopause #longevity #DEXA #LIFTMOREtrial #bonelosss #resistancetraining #healthoptimization #womenslongevity #exercisescience #preventivemedicine
• Dr. Dawn Mussallem, DO: Cancer Prevention, Early Detection, Exercise, Metabolic Health and Breast Cancer Screening 30.04.2026 1godz 24min

  In this episode, I’m joined by Dr. Dawn Mussallem, DO, an integrative oncologist, lifestyle medicine specialist, cancer survivor, heart transplant recipient, and the newly appointed Chief Medical Officer of Fountain Life.We talk about why cancer rates are rising, what we actually know about prevention, and why early detection matters so much when it comes to long-term outcomes. We also discuss the role of exercise, sleep, fiber, metabolic health, toxins, alcohol, gut health, screening tools, mammograms, full-body MRI, liquid biopsies, and why the basics still matter more than most people want to admit.Dr. Dawn also shares her extraordinary personal story: She is a stage 4 cancer survivor who went through chemotherapy and a bone marrow transplant at 26, developed cardiac toxicity from treatment 18 years later, received a heart transplant, and became the first person in the world to run a marathon within a year of receiving a new heart. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIf you’re already paying attention to protein, blood sugar, and longevity nutrition, fiber is one of the biggest gaps to fix. Zen Basil makes it simple to add more fiber, minerals, and prebiotic support into your routine with certified edible basil seeds that are tested for glyphosate and over 400 pesticides.Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagIn this episode:- Why cancer is rising in younger people- The lifestyle factors linked to cancer prevention- Why exercise matters during and after cancer treatment- The role of sleep, insulin, and metabolic health- Fiber, gut health, and the microbiome- Mammograms, breast MRI, full-body MRI, and liquid biopsies- Soy, breast cancer myths, and plant protei- Hormone therapy, breast cancer risk, and screening- Why connection and purpose matter for longevityConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Dawn Mussallem:Instagram: https://www.instagram.com/drdawnmussallem/LinkedIn: https://www.linkedin.com/in/dawn-mussallem-do-dipablm-2b360b57/Website: https://www.fountainlife.com/#cancerprevention #breastcancer #femalelongevity #womenshealth #longevity #integrativeoncology #cancersurvivorship #earlydetection #breastcancerawareness #hormonehealth #metabolichealth #exerciseandcancer #soyandcancer #perimenopause #menopause #cancerresearch #preventivemedicine #healthoptimization #womenslongevity #fountainlife
• Dr. Brian Kennedy, PhD: The Real Science of Longevity: mTOR, Rapamycin & How to Measure Biological Age 23.04.2026 2godz 33min

  Brian Kennedy is one of the world’s leading researchers studying the biology of aging.In this conversation, we break down what longevity science actually shows about extending healthy lifespan and the everyday habits that appear to influence how we age.Dr. Brian shares insights from decades of aging research, explaining how scientists study longevity, how interventions like rapamycin and biological age testing are evaluated, and how lifestyle factors such as exercise, nutrition, fasting, and sleep continue to shape the foundation of long-term health.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member5 key longevity habits discussed in this episode:- Exercise and physical activity- Nutrition and metabolic health- Energy balance and fasting- Sleep and recovery- Longevity interventions and emerging therapiesTogether, these factors form the foundation researchers believe will have the greatest impact on healthspan as longevity science continues to evolve.Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Brian Kennedy:LinkedIn: https://www.linkedin.com/in/brian-kennedy-69777318/Website: https://medicine.nus.edu.sg/trp/healthy-longevity/
• GLP-1 Crisis for Women, Gut Health, Bone Loss with Dr. Sara Szal, MD 16.04.2026 1godz 13min

  We're back with Dr. Szal! Today we are discussing a variety of topics: Gut health, peptides, hormone health , GLP-1's, bone health and so much more!In this conversation, Dr. Sara G dives into the gut-brain connection and explains how disrupting the microbiome can directly affect mood, anxiety, and overall mental resilience. She breaks down why even a single course of antibiotics can shift the balance of your gut in ways most people never consider, and what that means for how you feel day to day.This is where the gut-brain connection becomes practical, not theoretical. Instead of treating symptoms in isolation, understanding how the microbiome regulates neurotransmitters and inflammation changes the way these issues are approached.Rebuilding that system requires more than random probiotics or diet changes. The Weed, Seed, Feed framework focuses on restoring gut balance in the right order, removing what doesn’t belong, reintroducing beneficial bacteria, and supporting their growth long-term.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityIn this conversation:-Antibiotics and anxiety (25–50% increase)-The gut-brain connection explained simply-What happens when the microbiome is disrupted-Why most gut protocols don’t work-Weed, Seed, Feed framework-How to rebuild gut health properlyConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Sara:Instagram: https://www.instagram.com/saragottfriedmd/Website: https://saraszalmd.com/YouTube: www.youtube.com/@SaraSzalMDFollow her on Substack:https://saraszalmd.substack.com/
• Dr. Bérénice Benayoun, PhD: Why Your Ovaries Age (And the Gut Connection) 09.04.2026 1godz 32min

  Bérénice Benayoun, PhD, explains why ovarian aging may be one of the earliest and most important drivers of female aging, influencing the brain, immune system, metabolism, and long-term disease risk far beyond reproduction. She breaks down what we actually know so far, including DNA damage, mitochondrial dysfunction, fibrosis, hormonal signaling, and why the ovary appears to age faster than other tissues.We also get into one of the most surprising findings in the field right now: a brand new study from her lab found that post-reproductive gut microbiota unexpectedly improved ovarian reserve and lowered inflammatory signals in young mice, raising a completely new set of questions about the gut-ovary connection and what may eventually be possible for ovarian health.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityIn this conversation:-Why the ovary may be the fastest aging organ in the female body-Why menopause is a healthspan issue, not just a fertility issue-DNA damage, mitochondria, fibrosis, and the hallmarks of ovarian aging-The new microbiome finding that surprised even the researchers-Why later menopause predicts longer and healthier life-Rapamycin, hormone therapy, and what may actually helpIf you’re already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.Check them out: https://branchbasics.com/KAYLA15For 15% off use code: KAYLA15Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Bérénice Benayoun:LinkedIn: https://www.linkedin.com/in/b%C3%A9r%C3%A9nice-benayoun-a374a74b/en/Website: https://gero.usc.edu/labs/benayounlab/Her New Study (Estropausal gut microbiota transplant improves measures of ovarian function in adult mice): https://pubmed.ncbi.nlm.nih.gov/41776310/
• Dr. Deb Rivera, PhD: The Missing Link Between Stress, Aging, and Resilience 02.04.2026 1godz 32min

  Most people can feel when stress is affecting them. Far fewer know whether their body is adapting well or quietly being pushed toward dysfunction.In this episode, Dr. Deb Rivera, PhD in neuroengineering, explains the hidden biological system that helps determine how well your body handles stress. Her research focuses on redox balance and the glutathione ratio, a biomarker that may reveal whether your body is adapting to stress or slowly moving toward dysfunction.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn This Conversation-How to tell whether stress is helping or harming the body-The glutathione ratio and what it reveals about resilience-The role of redox balance in aging and metabolic health-Why recovery capacity determines how you respond to stress-How lifestyle factors influence mitochondrial and cellular health-Microplastics, environmental stressors, and biological resilience-Practical ways to support your body’s stress-adaptation systemConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Deb Rivera:LinkedIn: https://www.linkedin.com/in/journeymetrics/Website: https://journeymetrics.io/
• Dr. Eboni Cornish, MD: Brain Longevity, Neuroinflammation, and What Quietly Damages the Brain 26.03.2026 1godz 39min

  Brain health problems rarely begin where most people look. Memory issues, low mood, poor focus, anxiety, and even early cognitive decline can be driven by hidden inflammation and root-cause imbalances long before they show up the way most people expect.In this episode, Dr. Eboni Cornish explains how chronic infections, mold, toxins, hormones, gut dysfunction, and oral or nasal microbial imbalances can all affect the brain, and why “mental health” often needs to be approached as brain health first.She also shares how tools like brain imaging, inflammation markers, and functional testing can uncover patterns that are often missed in standard workups, while outlining the core foundations that support long-term brain health, including sleep, exercise, omega-3s, vitamin D, hormone balance, gut health, and detox capacity.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn This Conversation:- Why brain symptoms can start outside the brain- How neuroinflammation can affect mood, focus, and memory- Mold, Lyme, Epstein-Barr, and other overlooked brain disruptors- Why gut, oral, and nasal health matter for cognition- The tests and markers that can reveal early brain stress- The foundations that support brain longevityConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/YouTube: www.youtube.com/@KaylaBarnesLentzSpotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Eboni Cornish:Instagram: https://www.instagram.com/dr.ebonicornish/TikTok: https://www.tiktok.com/@drebonicornishWebsite: https://www.drebonicornish.com/Amen Clinics: https://www.amenclinics.com/team/eboni-cornish-md/
• Jessie Inchauspé Glucose Goddess on CGMs, Crashes & The Biggest Glucose Mistakes 19.03.2026 51min

  Blood sugar stability may be one of the most important levers for long term health, yet most people never look at it.In this episode, I am joined by Jessie Inchauspé, widely known as the Glucose Goddess, to examine what glucose spikes are actually doing inside the body and why they matter even if you are not diabetic.We unpack how glucose spikes can influence your mood, focus, cravings, and energy levels, why blood sugar stability matters even if you are not diabetic, and how seeing your own patterns can completely change the way you approach food.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberWe also cover:- The biggest glucose mistakes most people make- Why “healthy” breakfasts often lead to energy crashes- How dinner timing impacts deep sleep- The connection between glucose spikes and skin aging through glycation- Simple strategies like food order and walking after meals- How a mother’s glucose levels can influence her baby’s long term metabolic riskUnderstanding your glucose patterns gives you leverage, and small, strategic shifts can compound into measurable long term health improvements.Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comConnect with Glucose Goddess:Website: https://www.glucosegoddess.com/YouTube: https://www.youtube.com/@GlucoseRevolutionInstagram: https://www.instagram.com/glucosegoddess/TikTok: https://www.tiktok.com/@glucosegoddess_Pre-order her new book: https://www.glucosegoddess.com/pages/9-months-that-count-forever
• Dr. Deanna Minich, PhD: How Women Should Structure Macros in Their Meals 12.03.2026 1godz 45min

  Women are told to fast, cut carbs, eat high protein, avoid seed oils, and track macros, but most of that advice ignores female physiology.In this episode, I’m joined by Dr. Deanna Minich, PhD, certified functional medicine practitioner and nutrition scientist. We walk through the Female Longevity Nutrition Protocol she created, including circadian timing, macro ranges by life stage, and how to stop getting whiplash from internet nutrition trends.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn This Conversation:The “breakfast myth” and why your ovaries won’t shrinkEating earlier in the day, circadian timing, and appetite regulationMacro ranges by life stage and why Deanna uses ranges, not rigid targetsPerimenopause and postmenopause macro shiftsOmega Index testing and why it mattersFiber, fats, seed oils, and what the research actually supportsMicronutrient testing and how to personalize nutrition and supplementsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...YouTube: www.youtube.com/@KaylaBarnesLentzApple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Deanna Minich:Instagram: https://www.instagram.com/deannaminich/Website: https://deannaminich.com/YouTube: www.youtube.com/@foodandspirit
• Dr. Susanna Søberg, PhD: The Science of Cold Plunges for Women 05.03.2026 1godz 21min

  Cold exposure is not a badge of toughness. It’s a stressor.And if you do it wrong, you can absolutely overdo it.In this episode, I’m joined by Dr. Susanna Søberg, PhD, scientist and educator specializing in metabolism, cold and heat exposure, and longevity. We break down what cold exposure is actually doing in the body, why brown fat matters for metabolic health, and how women should think about timing cold exposure around PMS, luteal phase, and menstruation.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn This Conversation:-Why cold exposure works best when it’s short and strategic-Brown fat, insulin sensitivity, and why it doesn’t have to be “that cold” -Cold vs heat for women, and why “better” depends on the outcome-PMS timing and when to pull back on stressors-Temperature, time, and the real dose-response of cold exposure-How to spot viral claims that sound exciting but aren’t scienceConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Susanna Søberg, PhD:Instagram: https://www.instagram.com/susanna_soebergWebsite: https://soeberginstitute.com/Thermalist Women’s Retreat With Dr. Susanna Søberg: https://soeberginstitute.com/pages/thermalist%C2%AE-women-s-retreat
• Dr. Stephanie Riley Hahn: Pelvic Floor Optimization, Leaks, Sex, And Prolapse 26.02.2026 1godz 35min

  Pelvic floor problems are not a “just do more kegels” issue.For a lot of women, kegels are either not specific enough, or they make symptoms worse.In this episode, Dr. Stephanie Riley Hahn, pelvic floor physical therapist and founder of Longevity and Pilates, breaks down what pelvic floor dysfunction actually is, how to tell weakness from tightness, and why pressure management and breathing mechanics often matter more than squeezing harder.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberIn this conversation:Why pelvic floor tightness can drive pain, irritation and symptomsThe difference between weakness and tension, and how to tellHow breathing and pressure management change everythingWhat downtraining involves, and what tends to backfireProlapse support options, and when to seek helpOveractive bladder and constipation patterns that keep symptoms aliveConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...YouTube: www.youtube.com/@KaylaBarnesLentzFollow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about StephanieInstagram: https://www.instagram.com/longevityptpilates/Website: https://www.longevityptandpilates.com/Shownotes:Pelvic floor PT locator: https://www.aptapelvichealth.org/ptlocator
• Dr. Aimie Apigian, MD: The Biology of Trauma + Nervous System Safety 19.02.2026 1godz 54min

  Longevity isn’t just workouts, supplements, and recovery tools, it starts with nervous system health. In this episode, Dr. Aimie Apigian explains what trauma actually is (not a label, but a measurable physiological response), how the body shifts from stress into overwhelm, and why “pushing through” often turns into years of avoidance, numbing, and hidden internal strain.She breaks down the biology behind the trauma response, including the role of adrenaline, cortisol timing, and how mitochondrial capacity influences resilience. You’ll also learn her practical, body-based approach to creating “safe enough” in real time, plus the three phases of healing: safety, support, and expansion, so you don’t stay stuck avoiding triggers forever.In this conversation:Stress vs trauma response (and what changes physiologically)Why adrenaline drives the response and cortisol arrives laterHow the body stores trauma as patterns, not just memoriesThe 3 nervous system states and the thoughts they generateA simple somatic exercise to build safety in the bodyWhy devices/meds can be bridges, not the destinationUsing biomarkers + wearables without fooling yourselfWhy modern media can create vicarious traumaJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/YouTube: www.youtube.com/@KaylaBarnesLentzSpotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Aimie Apigian, MD:Instagram: https://www.instagram.com/draimie/YouTube: https://www.youtube.com/c/DrAimieApigianWebsite: https://www.biologyoftrauma.com/Order her Book “The Biology of Trauma”: https://www.biologyoftrauma.com/book
• I Became the First Woman in the World to Test Her Ovarian Age 14.02.2026 18min

  For the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test.Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on over 40,000 real women across different life stages, analyzes hormone biomarkers, body composition, and reproductive history to estimate ovarian age relative to chronological age.This is a massive step forward in female longevity science.In this episode, I walk through what the test measures, how the algorithm works, and what becoming the first data point actually means, not just for me, but for women collectively. We also explore what may be driving ovarian aging in the first place.I also share how I’m now testing specific interventions in isolation, including hyperbaric oxygen therapy, to determine whether we can meaningfully influence ovarian aging over time.Ovarian lifespan is significantly shorter than overall lifespan and once we can measure it, we can begin to understand it.This is only the first step in redefining female longevity.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member*Kayla's social + website:*Instagram:  https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQApple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comSHOW NOTES:00:01:03 Timeless Biotech Website:https://timelessbiotech.com/00:01:13 Podcast With The Founder of Timeless Biotech:https://www.youtube.com/watch?v=s-_EuNUwjsM&t=57s00:04:12 Kayla’s Protocols:https://www.protocol.kaylabarnes.com/00:09:58 Podcast With Dr. Chris Masterjohn:https://www.youtube.com/watch?v=z3quYW_pCDU00:10:48 Study About Ovarian Stiffness Increasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7681059/#acel13259-sec-000200:16:22 Study For Increased PFAShttps://pubmed.ncbi.nlm.nih.gov/41620147/00:17:56 Red Light Therapy Study:https://www.sciencedirect.com/science/article/abs/pii/S1011134424001842?via=ihub
• Cynthia Thurlow, NP: Perimenopause, Insulin Resistance and Midlife Metabolism 12.02.2026 58min

  Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk.In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause.She breaks down how perimenopause can begin earlier than most women expect, why symptoms vary so widely, and how lifestyle factors like fasting, exercise intensity, sleep, alcohol, and chronic stress interact with hormones during this transition.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberThis conversation explores:Why insulin resistance often emerges in perimenopauseHow stress and trauma shape metabolic and hormonal healthThe role of gut health in PMS, mood, and estrogen balanceWhen fasting helps women and when it makes things worseWhy “doing everything right” can still lead to symptomsHow to individualize nutrition, training, and recovery in midlifeConnect with Kayla:Instagram:https://www.instagram.com/kaylabarnes/TikTok:https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/YouTube: www.youtube.com/@KaylaBarnesLentzApple: https://podcasts.apple.com/us/podcast...Website:https://www.protocol.kaylabarnes.comLearn more about Cynthia ThurlowInstagram: https://www.instagram.com/cynthia_thurlow_/YouTube: https://www.youtube.com/cynthiathurlowWebsite: https://www.cynthiathurlow.com/Pre-order her upcoming book: The Menopause Gut (28th of April 2026):https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/?mcp…ACE (Adverse Childhood Experiences) questionnaire:https://www.acesaware.org/wp-content/uploads/2022/07/ACE-Questionnaire-for-Adults-Identified-English-rev.7.26.22.pdf
• Dr. Chris Masterjohn, PhD - Mitochondria, Micronutrients, and How Nutrition Actually Drives Longevity 05.02.2026 2godz 39min

  When cellular energy production is impaired, no diet, supplement, or health protocol can work as intended.In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress, persistent fatigue, and supplements that stop working over time.He breaks down why vitamin D supplementation often creates new problems when it is taken without proper nutrient balance, how high doses can disrupt other systems in the body, and why sunlight has biological effects that vitamin D pills alone cannot replicate.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberThis conversation explores:Why mitochondrial bottlenecks explain most energy and health plateausHow micronutrient deficiencies undermine supplements and biohacksWhen creatine supports cellular energy and why it works differently than most supplementsWhy vitamin D supplementation can backfire without context and balanceWhy sunlight affects biology in ways supplements cannot replaceHow diet, fasting, and exercise interact with mitochondrial capacityWhy optimizing one system often breaks another without proper foundationsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr Chris Masterjohn’s work:Website: https://www.chrismasterjohn-phd.com/Instagram: https://www.instagram.com/chrismasterjohn/YouTube: https://www.youtube.com/@chrismasterjohn
• Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy and Bone Health 29.01.2026 49min

  In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause.Kayla's social + website:Instagram:  kaylabarnesTikTok:  femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Jessica Shepherd's social + website:Website: https://www.jessicashepherdmd.com/Instagram: https://www.instagram.com/jessicashepherdmd/Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd
• Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are Replacing Your Plasma With THIS 22.01.2026 1godz 9min

  What if your blood is what’s making you sick and the key to reversing it is removing it?In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/...Kayla's social + website:Instagram:  kaylabarnesTikTok:  femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Khanh's social + website:Instagram: https://www.instagram.com/regenwithdrnguyen/ Website: Austin Regenerative Therapy