Hart2Heart with Dr. Mike Hart

Episódios

• 
  #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati 17.09.2026 1h 9min

  In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function.   Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening 10.09.2026 1h 25min

  Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers. Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.   NOBS Toothpaste Tablets — NOBS https://nobsroutines.com/products/nobs-toothpaste-tablets NOBS Herbal Mouthwash — NOBS https://nobsroutines.com/products/nobs-herbal-mouthwash Atomic Habits — James Clear https://jamesclear.com/atomic-habits Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter https://music.youtube.com/podcast/Vn-SH7qbvkw Relative Dentin Abrasivity (RDA) Explained — American Dental Association https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:08 Why Oral Health Matters 04:35 Choosing The Right Toothpaste 09:15 Why Whitening Toothpaste Fails 13:58 Key Toothpaste Ingredients 22:49 Hydroxyapatite And Fluoride 28:31 Electric Brushes And Technique 30:56 Waterpik Versus Flossing 34:32 Mouthwash Myths And Safer Picks 40:24 Acidic Mouthwash Risks 41:00 Tongue Scraping Basics 44:21 Nighttime Snacking Rules 45:48 Carbonated Drinks and pH 47:43 Mouth Breathing and Dry Mouth 50:39 Teeth Whitening Science 54:00 Whitening Options and Longevity 01:00:25 Dental Cleaning Ingredients 01:01:54 Fillings Materials and Safety 01:06:53 Root Canals Mythbusting 01:11:34 Veneers Hype and Downsides 01:16:37 Gum Disease and Heart Health 01:20:19 Ideal Oral Hygiene Plan 01:24:10 Where to Find NOBS   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims 03.09.2026 1h 24min

  In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition offers, while Dr. Price separates what he has personally observed from what has yet to be established through rigorous research. The conversation explores cannabinoids, THC, CBD, terpenes, chemotherapy and radiation, pathology and imaging, the limitations of anecdotal evidence, and the regulatory, funding, and data-access barriers standing between individual case reports and credible clinical trials.  Lee Whitley is an entrepreneur and the creator of Lee's Oil and Lee Helps, a cannabis-based project that grew out of his personal experience with cancer and his years of developing and refining a proprietary cannabis formulation. He has since become an outspoken advocate for studying the results he says he has observed through formal clinical research. Dr. Ira Price is a physician with nearly two decades of experience prescribing cannabinoids and researching medical cannabis, including published work on cannabis for opioid substitution and years of lecturing internationally on cannabinoid medicine. Together, Whitley and Dr. Price bring two very different perspectives to the conversation—one shaped by personal experience and unconventional experimentation, and the other by clinical practice, scientific skepticism, and a focus on evidence, regulation, and properly designed trials. Lee Helps / Lee's Oil — Lee Whitley https://leehelps.com/ Cannabis for Opioid Substitution Trial (COST) — Dr. Ira Price / Cannabis Research Associates https://clinicaltrials.gov/study/NCT03859089 Cannabis Research Licensing — Health Canada https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/industry-licensees-applicants/research-licensing-application.html   Clinical Trials With Cannabis — Health Canada https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/notice-clarification-requirements-conducting-clinical-trials-cannabis.html Human Health Therapeutics Research Centre — National Research Council Canada https://www.nrc.canada.ca/en/research-development/research-collaboration/research-centres/human-health-therapeutics-research-centre   Prescribing Drugs Policy — College of Physicians and Surgeons of Ontario (CPSO) https://www.cpso.on.ca/physicians/policies-guidance/policies/prescribing-drugs 4-Year-Old Cancer Case With 132 Tumors — Lee Whitley / Shit My Dad Taught Me https://www.iheart.com/podcast/1323-shit-my-dad-taught-me-264023145/episode/ep-22-lee-whitley-286273525/ Lee Helps Cancer & Melanoma Testimonials — Lee Whitley / Lee Helps Oil https://www.leehelpsoil.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Claimed Cure Rates 01:59 Doctor Skepticism 03:47 Four Year Old Case 06:40 Colon Cancer Testimonial 09:43 Lee Cancer Story 14:28 Injection Timeline 16:00 Formula Breakdown 18:28 Terpenes Explained 21:29 Rick Simpson Comparison 24:52 How It Works 27:43 Chemo Radiation Debate 33:20 Injections Vs Pills 36:42 Research Roadblocks 44:03 Trial Plans Abroad 44:34 30 Women Trial Plan 46:02 Study Design Debate 47:23 Dosing Protocol Details 48:43 Big Pharma Buyout Claims 51:50 Suppression And Threats 55:12 What Happens After Success 57:59 Finding Patients And Reach 59:48 Treating More Than Cancer 01:06:51 How The Plant Was Found 01:13:47 Chemo Radiation Clash 01:17:59 Timeline And Publication 01:20:27 Closing Advice And Wrap   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #235 Dr. Kenealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors 27.08.2026 1h 6min

  In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial function. They also discuss fasting and ketogenic diets, cancer screening, GLP-1 medications, aspirin, peptides, medicinal mushrooms, IV vitamin C, and other integrative approaches, along with Dr. Connealy's concerns about conventional screening and treatment practices. Throughout the conversation, she emphasizes individualized care and looking beyond a diagnosis to understand the broader conditions affecting each patient.   Dr. Leigh Erin Connealy is a medical doctor with four decades of experience who takes a prevention-focused, whole-person approach to health, longevity, and complex chronic disease. Her work spans human optimization through advanced conditions including cancer, dementia, autoimmune disease, and Parkinson's, with an emphasis on identifying and addressing factors that may interfere with the body's ability to function optimally. Her approach was shaped in part by her own health journey after learning that she had been exposed before birth to DES (diethylstilbestrol), which led her to undergo ongoing evaluations at MD Anderson and explore medicine beyond conventional symptom-based care. Over her career, she has incorporated individualized laboratory assessment, natural hormones, nutrition, peptides, and other integrative strategies while emphasizing what she describes as "creating health" rather than simply treating a diagnosis.    [The Cancer Revolution] — Leigh Erin Connealy, MD / Hachette Book Group https://www.hachettebookgroup.com/titles/leigh-erin-connealy/the-cancer-revolution/9780306836688/ [Be Perfectly Healthy] — Leigh Erin Connealy, MD / Perfectly Healthy https://perfectlyhealthy.com/products/be-perfectly-healthy-1 [Celluverse Podcast] — Dr. Leigh Erin Connealy, Alannah Connealy & Jess Donovan https://podcasts.apple.com/us/podcast/celluverse/id1836455844 [Dr. Leigh Erin Connealy Instagram — @connealymd] — Leigh Erin Connealy, MD https://www.instagram.com/connealymd/ [Cologuard Plus] — Exact Sciences Corporation https://www.cologuard.com/resources [QTI Breast Acoustic CT Scanner] — QT Imaging Holdings, Inc. https://www.qtimaging.com/breast-acoustic-ct-scanner/ [UT MD Anderson Cancer Center] — The University of Texas MD Anderson Cancer Center https://www.mdanderson.org/ [Eminence Organic Skin Care — Sun Care] — Eminence Organic Skin Care https://eminenceorganics.com/us/face/sun-care [Primally Pure Sunscreen] — Primally Pure https://primallypure.com/pages/sunscreen [COOLA Sunscreen] — COOLA https://coola.com/collections/sunscreen   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:07 Root Cause Medicine 02:29 Is Cancer Preventable 05:42 Biggest Risk Factors 09:51 Toxins And Detox Testing 12:26 Sweating And Detox Baths 00:00 Doctors Not Listening 16:58 Does Sugar Feed Cancer 22:37 Fasting And Keto Strategies 26:05 Mushrooms And Supplements 27:21 Thiamine And Nutrient Gaps 29:35 Hormones And Cancer Risk 35:42 Complete Hormone Panels 38:02 GLP-1s and Cancer Risk 39:18 Daily Aspirin Debate 41:12 Peptides to Avoid 43:20 Russian Peptides Cycling 45:43 Non Toxic Sunscreen Choices 47:14 Deodorants and Aluminum 48:18 AirPods and Brain Health 50:26 Cancer Screening Strategy 54:30 Breast Imaging Options 56:05 Biopsy Spread Concerns 58:09 Why Medicine Misses Prevention 01:01:55 Personal DES Cancer Journey 01:03:10 IV Vitamin C for Cancer 01:04:26 Where to Follow and Book   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #234 Navigating Weight Loss: Breaking Down Barriers with Dan Go 20.08.2026 1h 1min

  After a five-year hiatus, Dan Go returns to break down a sustainable approach to fat loss for busy people who do not have hours to spend in the gym. He explains why identifying the main physiological or psychological bottleneck—such as late-night eating, stress, grazing, or weekend overeating—can matter more than simply handing someone a meal plan. The conversation covers calorie tracking for awareness, protein and fiber for satiety, meal timing, restaurant strategies, preserving muscle with low-volume strength training, FFMI as an alternative to BMI, and a balanced view of GLP-1 medications that considers both their benefits and trade-offs. Dan Go is a fitness coach and entrepreneur whose work focuses on helping busy professionals, founders, and entrepreneurs improve their body composition, health, and performance through sustainable nutrition, behavior change, and efficient training. His coaching approach emphasizes identifying the specific habits, beliefs, and environmental factors that make fat loss difficult, then building practical systems and guardrails that clients can maintain long term. Rather than relying on extreme diets or high-volume workouts, he focuses on awareness, consistency, adequate protein, structured eating, and time-efficient strength training to help clients lose fat while preserving muscle. [Dan Go Official Website] — Dan Go (Dan Go) https://www.dango.co/ [The High Performance Journal] — Dan Go (Dan Go) https://www.dango.co/newsletter [Dan Go on X] — Dan Go (X (formerly Twitter)) https://x.com/CoachDanGo [Dan Go on Instagram] — Dan Go (Instagram) https://www.instagram.com/coachdango/ [Dan Go Private Coaching] — High Performance Founder / Dan Go (High Performance Founder) https://highperformancefounder.com/private-coaching [Why I Quit Drinking Alcohol] — Mark Manson (Mark Manson) https://markmanson.net/why-i-quit-drinking-alcohol [A Satiety Index of Common Foods] — S. H. Holt, J. C. Miller, P. Petocz & E. Farmakalidis (PubMed) https://pubmed.ncbi.nlm.nih.gov/7498104/ [Fat-Free Mass Index (FFMI) Research] — Loenneke et al. (PubMed Central (PMC)) https://pmc.ncbi.nlm.nih.gov/articles/PMC3445648/ [ChatGPT] — OpenAI (ChatGPT) https://chatgpt.com/ [Claude] — Anthropic (Claude) https://claude.com/ [Mounjaro (tirzepatide)] — Eli Lilly and Company (Mounjaro) https://mounjaro.lilly.com/ [Ozempic (semaglutide)] — Novo Nordisk (Ozempic) https://www.ozempic.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:49 Rapid Fat Loss Setup 01:11 Find The Bottleneck 02:38 Late Night Eating Roots 04:21 Mark Manson Case Study 05:55 Metabolic Reset Phase 06:38 After Weight Loss Plan 09:29 Remove Obstacles First 10:59 Sustainable Diet Rules 13:03 No Cheat Meals 13:15 90 10 Ratio Diet 15:27 Tracking For Awareness 18:12 Calorie Blind Spots 19:45 Guardrails Not Counting 21:43 Satiety And Fiber 24:24 GLOP Protein Breakfast 28:36 Why Eat Breakfast 30:14 Breakfast Beats Stress 31:22 Night Eating Guardrails 32:53 Sleep and Late Meals 34:15 Restaurant Ordering Hacks 38:49 Keep Muscle While Cutting 45:30 FFMI Over BMI 47:31 GLP-1s Balanced Take 54:25 Dosing and Nutrition Guardrails 57:50 Men vs Women Fat Loss 59:58 Where to Find Dan Go   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #233 Understanding NAD+: Insights with Dr. Charles Brenner 13.08.2026 1h 1min

  Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.   Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/   Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies   Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/   This is the PAD study discussed in the episode where NR improved six-minute walking performance.   NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968   This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.   Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext   This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.   NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/   This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.   Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/   This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.   Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner   Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
• 
  #233 Understanding NAD+: Insights with Dr. Charles Brenner 13.08.2026 1h 1min

  Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.   Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/   Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies   Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/   This is the PAD study discussed in the episode where NR improved six-minute walking performance.   NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968   This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.   Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext   This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.   NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/   This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.   Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/   This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.   Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner   Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #232 Testosterone Screening, Metabolic Health, and Hormone Optimization: Free T, SHBG, hCG, and Body Composition 06.08.2026 55min

  This episode explores the opportunities and risks of testosterone optimization, beginning with the US military's decision to screen men over 30 for low testosterone. Dr. Mike Hart and Dr. Jonathan Schoeff discuss why symptoms such as fatigue, low libido, and difficulty changing body composition cannot be interpreted from a single lab value. They examine the importance of free testosterone, SHBG, insulin resistance, visceral fat, estradiol, DHT, fertility, and individualized dosing. The conversation also challenges common measures such as BMI and body fat percentage, emphasizing skeletal muscle mass, visceral adiposity, sustainable health goals, and the minimum effective intervention.   Dr. Jonathan Schoeff is a spinal surgeon and longevity medicine practitioner whose work focuses on hormone health, metabolic optimization, body composition, and individualized health strategy. Through comprehensive laboratory testing, clinical assessment, and personalized treatment planning, he helps clients understand how hormones, insulin sensitivity, muscle mass, visceral fat, lifestyle, and long-term health goals interact. Describing his role as that of a "biological strategist," Dr. Schoeff emphasizes precision over standardized protocols and develops practical plans designed around each person's biology, priorities, and daily life.   Health and Human Performance Optimization to Enhance Military Readiness — U.S. Department of War https://media.defense.gov/2026/Jul/15/2003961654/-1/-1/1/HEALTH%20AND%20HUMAN%20PERFORMANCE%20OPTIMIZATION%20TO%20ENHANCE%20MILITARY%20READINESS%20OSD004430-26%20RES%20FINAL.PDF   Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action — Giacomo Tirabassi et al. https://pubmed.ncbi.nlm.nih.gov/26421011/   Comparative Effects of Daily and Weekly Boron Supplementation on Plasma Steroid Hormones and Proinflammatory Cytokines — Mohammad Reza Naghii et al. https://pubmed.ncbi.nlm.nih.gov/21129941/   Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi   Surviving Sepsis Campaign Adult Guidelines — Society of Critical Care Medicine https://www.sccm.org/survivingsepsiscampaign/guidelines-and-resources/surviving-sepsis-campaign-adult-guidelines   The Longevity Lab — Dr. Jonathan Schoeff and Candace Schoeff https://longevitylabwellness.com/   Jonathan Schoeff on Instagram — Dr. Jonathan Schoeff https://www.instagram.com/jonschoeff/   Jonathan Schoeff on YouTube — Dr. Jonathan Schoeff https://www.youtube.com/@drjonschoeff   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:42 Military Low T Screening 04:32 Normal Ranges and Treatment 08:19 Free Testosterone and Insulin 12:35 High SHBG and Enclomiphene 15:54 hCG Fertility and Protocols 19:35 Obesity Low T Strategy 23:26 Aromatase Inhibitors and Estrogen 26:51 DHT Mood and Libido Balance 28:57 DHT Balance Risks 30:10 Minimum Effective Dose 31:55 Longevity Strategy Mindset 33:31 Clinic Cuts Alcohol Use 35:40 Goals Drive Strategy 38:06 Body Fat Targets Debate 41:54 Sustainable Leanness 45:33 Personalized Nutrition Plans 48:09 Beyond Body Fat Metrics 52:29 Rules Not Regulations 53:31 Wrap Up And Where To Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #231 Dr. Kyle Gillett on Nootropics, Peptides, GLP-1 Side Effects, Hair Loss, and Microplastics 30.07.2026 1h 11min

  Dr. Kyle Gillett joins Dr. Mike Hart to discuss safer, more practical approaches to biohacking, performance, and longevity. They cover indoor microplastic exposure, bromantane, low-dose nicotine, healing peptides, BPC-157 safety, tesamorelin, growth hormone, GLP-1 digestive side effects, NAD support, carnitine, hair loss, sleep medications, and longevity treatments. Dr. Gillett separates promising interventions from overhyped protocols while emphasizing evidence, appropriate dosing, consistency, and individual risk. Dr. Kyle Gillett is a physician and founder of Gillett Health whose work focuses on personalized hormone care, metabolic health, performance, and longevity. He uses laboratory results, symptoms, medical history, lifestyle, and treatment response to guide decisions about hormones, medications, peptides, and supplements. He also hosts the Gillett Health Podcast and founded Sage Bio.   [Gillett Health] — Dr. Kyle Gillett and James O'Hara https://gilletthealth.com/ [The Gillett Health Podcast] — Dr. Kyle Gillett and James O'Hara https://podcasts.apple.com/us/podcast/the-gillett-health-podcast/id1631735999 [Sage Bio Laboratory Testing] — Sage Bio, Inc. https://www.sagebio.com/ [AirDoctor Air Purifiers] — AirDoctor and Ideal Living https://airdoctorpro.com/ [Consensus Research Search] — Consensus https://consensus.app/ [Google Scholar] — Google https://scholar.google.com/ [Cravv Cytisine Product Information] — Health Canada https://health-products.canada.ca/lnhpd-bdpsnh/info?licence=80072525 [Juven Therapeutic Nutrition] — Abbott Nutrition https://www.abbottnutrition.com/our-products/juven [EGRIFTA WR Tesamorelin Prescribing Information] — U.S. Food and Drug Administration https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf [QUVIVIQ Daridorexant Information] — Idorsia Pharmaceuticals https://www.quviviq.com/ [DAYVIGO Lemborexant Information] — Eisai https://www.dayvigo.com/ [Micro- and Nanoplastics in Coronary Circulation Study] — Pasquale Paolisso and colleagues, European Heart Journal https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag447/8725569 [CJC-1295 FDA Review Materials] — U.S. Food and Drug Administration, Pharmacy Compounding Advisory Committee https://www.fda.gov/advisory-committees/advisory-committee-calendar/updated-meeting-time-and-public-participation-information-december-4-2024-meeting-pharmacy [Kyle Gillett, MD on Instagram] — Dr. Kyle Gillett https://www.instagram.com/kylegillettmd/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Bromantane Overview 02:16 How Bromantane Works 04:45 Trump Debate Stack 06:03 Nicotine Microdosing 08:39 Cartilax vs BPC 12:06 Ultimate Healing Stack 14:09 Healing Supplements 16:26 Tesamorelin Benefits 21:09 Growth Hormone Dosing 22:54 Kids and Height 25:13 Selank and Benzo Taper 28:59 Best Time for BPC 31:03 BPC Safety Risks 33:00 GLP1 Motility Fixes 34:39 Low Dose Naltrexone Uses 36:06 LDN and Alcohol Effects 37:10 GLP-1 Heartburn Fixes 38:42 GLP-1s and Drinking 40:18 Hangover Supplement Stack 42:55 Oral vs Injectable Carnitine 45:27 NAD+ Shots vs Precursors 47:35 Hair Loss Stack for Men 50:44 Topical Dutasteride Strategy 56:06 Hair Loss Stack for Women 56:59 Top Longevity Meds 01:00:28 Aspirin Nuance and Lp 01:02:25 TUDCA for Gallbladder 01:04:36 Leptin Resistance Basics 01:06:33 Microplastics and Indoor Air 01:10:03 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #230 Progesterone for Sleep, GLP-1 Microdosing, and HRT/Peptide Insights with Dr. K 23.07.2026 1h 9min

  Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims. Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.   Quick Coherence Technique — HeartMath https://help.heartmath.com/introduction/quick-coherence-technique/ The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al. https://pubmed.ncbi.nlm.nih.gov/36142272/ Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific https://www.quicksilverscientific.com/products/facial-beauty-serum Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri Vladimir Khavinson Publications — Professor Vladimir Khavinson https://khavinson.info/publications   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:57 GLP-1 Starting Doses 03:39 GLP-1 Anti Inflammation Aging 07:15 Motility Supplements Side Effects 09:02 Tirzepatide vs Semaglutide 11:46 Adrenal Fatigue Myth 13:23 Fatigue Bloodwork Checklist 16:16 TRT Hematocrit Sleep Apnea 19:01 Underrated Blood Tests 20:06 Womens HRT Basics 22:21 Testosterone for Women 25:19 Thyroid Treatment LDN NAD 29:31 Progesterone GABA Sleep 32:25 Progesterone for Men Debate 33:43 Testosterone Injection Frequency 36:05 TRT Dosing Frequency 36:45 Why TRT Stops Working 37:50 Creams vs Injections 39:08 Fertility and HCG 41:46 Peptides vs Pharma 44:17 HGH and Secretagogues 45:12 5-Amino-1-MQ Hype 48:15 Topical GHK-Cu Skincare 50:25 Injectable Copper Peptide Hair 52:26 BPC 157 and TB500 58:25 Thymosin Alpha 1 Immunity 01:01:13 Mitochondrial Peptides 01:03:20 Endo 205 and New Peptides 01:04:17 Kavinson and Epitalon 01:08:21 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #229 Supplements, Methylation, and Genetics: Why "Healthy" Stacks Can Trigger Anxiety 16.07.2026 1h 22min

  Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status. Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.   Work with Dr. Tyler Panzner! Unlock Your Genetic Potential — Dr. Tyler Panzner https://drtylerpanzner.com/ Dr. Tyler Panzner on Instagram — Tyler Panzner https://www.instagram.com/drtylerpanzner/ Quieting an Overactive Mind Webinar — Tyler Panzner https://overstimulated.drtylerpanzner.com/webinar-registration-page   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:47 MTHFR Hype vs Reality 02:14 Methylated Bs and Anxiety 03:48 Creatine Choline and SAMe 07:43 Beyond One Gene Test 11:14 Lithium Orotate Basics 15:18 Supplements That Backfire 17:36 Antioxidant Overload Effects 21:01 Melatonin Dose Debate 23:56 Antioxidants Around Workouts 26:48 Collagen What Actually Works 30:07 SSRIs and Genetic Fit 34:23 Herbal SSRI Alternatives 37:18 DHT Lowering Side Effects 41:54 Biohacking Marketing Hype 43:25 Fish Oil Mood Ratios 46:16 Oral Nicotine Tradeoffs 52:03 Methylene Blue Risks 54:46 Mitochondria Boosters Anxiety 57:13 Greens Powders Overstimulation 01:01:04 Magnesium Forms For Sleep 01:04:51 DNA Testing And ChatGPT 01:12:23 Genetics For Caffeine Sensitivity 01:16:23 Psychedelics And DNA 01:18:50 Coaching Logistics Wrap Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #228 Minoxidil for Hair Loss: Topical vs Oral, Tretinoin, and Microneedling 09.07.2026 31min

  The episode explains how to use minoxidil for hair loss, emphasizing that it supports follicles and prolongs the anagen phase but does not block DHT (with topical dutasteride mentioned as a scalp-focused DHT option). It reviews evidence that 5% topical minoxidil is optimal (better than 2% and superior to 10%), works best on the crown/vertex, and should be applied to the scalp—not the hair—with expectations set for gradual results and possible early shedding. Twice-daily topical use is recommended unless combined with 0.01% tretinoin, which can make once-daily use similarly effective, though irritation can occur. Microneedling combined with minoxidil is strongly recommended based on a 2013 RCT, with guidance on depth (0.5–1.0 mm), frequency, and waiting 12–24 hours (or longer with tretinoin) before applying minoxidil. The episode also compares oral minoxidil dosing, notes a 2024 RCT showing similar outcomes to topical at 5 mg, and details systemic side effects, monitoring, and cautions including pet toxicity with topical use.   Full Hair Loss Podcast — Wnt vs DHT https://www.youtube.com/watch?v=bswq-Qhfebs   Minoxidil + Microneedling — 2013 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC3746236/   5% vs 2% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/12196747/   5% vs 10% Topical Minoxidil https://pubmed.ncbi.nlm.nih.gov/31403367/   Minoxidil + 0.01% Tretinoin Study https://pubmed.ncbi.nlm.nih.gov/17902730/   Oral vs Topical Minoxidil — 2024 Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11007651/   Topical Dutasteride Study https://pmc.ncbi.nlm.nih.gov/articles/PMC12405733/   Topical Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a689003.html   Oral Minoxidil Drug Information https://medlineplus.gov/druginfo/meds/a682608.html   Tretinoin Drug Information https://medlineplus.gov/druginfo/meds/a682437.html   Dutasteride Drug Information https://medlineplus.gov/druginfo/meds/a603001.html   Minoxidil Toxicity in Dogs and Cats https://pubmed.ncbi.nlm.nih.gov/34370845/   Sildenafil / Viagra Drug Information https://medlineplus.gov/druginfo/meds/a699015.html   Tadalafil / Cialis Drug Information https://medlineplus.gov/druginfo/meds/a604008.html   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:45 Minoxidil Basics 01:43 DHT And What It Misses 03:07 How Minoxidil Works 03:55 Best Areas To Treat 04:30 Choosing The Right Strength 05:55 Once Or Twice Daily 08:28 Applying It Correctly 10:10 Microneedling Protocol 15:17 Formulations And Routine 18:14 Topical Side Effects 19:34 Shedding And Pet Safety 20:44 Oral Minoxidil Overview 22:53 Dosing And Risks 27:39 Combining Oral And Topical 28:36 Final Takeaways The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #227 Diet Update: High-Protein, High-Fiber Meal Plan Built for Training and Consistency 02.07.2026 29min

  The speaker shares a structured, consistent diet designed to support hard training (three strength sessions, Norwegian 4x4, Zone 2 cardio, and one MMA session weekly), reduce "food noise," and stay full with high protein and fiber. He explains cooling/freezing rice to increase resistant starch and lower glycemic impact, then details his daily routine: a morning shake with creatine, collagen peptides, greens/red powder, and beta-alanine; four eggs mid-morning; high-protein Greek yogurt mixed with psyllium husk and acacia fiber; a pre-workout oats-and-whey bowl; a post-workout shake with whey, berries, vegetables, and sauerkraut; and a batch-prepped dinner of extra-lean ground beef, basmati rice, avocado, and sauce, plus a small yogurt-and-berries snack. Daily totals are about 2600 calories with ~260g protein, ~262g carbs, ~62–80g fat, and ~42g fiber, with weekend flexibility including two gin martinis and restaurant meals like steak or occasional pasta.   Norwegian 4x4 Protocol https://www.ntnu.edu/cerg/advice   VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio   Creatine / Athletic Performance https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/   Creatine / Sleep Deprivation Study https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/   Multi Collagen Peptides https://pmc.ncbi.nlm.nih.gov/articles/PMC8521576/   Collagen Before Exercise Study https://pmc.ncbi.nlm.nih.gov/articles/PMC5183725/   ATP Labs Greens & Reds https://atplab.com/products/green-red-whole-foods-100-organic   Beta-Alanine https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/   Coenzyme Q10 https://www.nccih.nih.gov/health/coenzyme-q10   Fish Oil / Omega-3 https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/   Oikos High Protein Greek Yogurt https://www.oikos.ca/en/oikos-high-protein   Psyllium Husk / LDL Cholesterol https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/assessments/psyllium-products-blood-cholesterol-lowering-nutrition-health-claims-food-labelling.html   Acacia Fiber / Gut Microbiome https://pmc.ncbi.nlm.nih.gov/articles/PMC8296006/   Short-Chain Fatty Acids / Butyrate https://pmc.ncbi.nlm.nih.gov/articles/PMC8153313/   Grass-Fed Whey Protein https://atplab.com/products/grass-fed-whey   Fermented Foods / Sauerkraut https://pmc.ncbi.nlm.nih.gov/articles/PMC9020749/   Resistant Starch / Cooled Rice Study https://pmc.ncbi.nlm.nih.gov/articles/PMC9013350/   Quest Protein Bars https://www.questnutrition.com/collections/protein-bars   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:45 Diet Goals and Structure 01:58 Training Schedule and Carbs 03:42 Morning Supplements Stack 07:19 First Meal Eggs and Fats 09:00 Greek Yogurt Fiber Snack 11:26 Pre Workout Oats and Whey 13:22 Post Workout Shake and Gut Health 15:19 Dinner Meal Prep Beef Rice Avocado 18:40 Evening Snack and Sleep Timing 19:58 Daily Macros and Protein Targets 20:58 Weekend Flex Meals and Alcohol 24:30 Extra Foods and Final Takeaways 28:23 Wrap Up and Thanks   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #226 Viewpoint Diversity, Physician-Assisted Suicide, AI, and Human Dignity in Medicine 25.06.2026 1h 1min

  Dr. Kristin Collier joins Dr. Mike Hart to discuss the ethical, cultural, and technological forces reshaping modern medicine. Reflecting on the 2022 white coat speech walkout, she explores viewpoint diversity, self-censorship, moral courage, and the importance of cultivating wisdom alongside technical skill in medical education. The conversation also examines physician-assisted suicide, its relationship to suicide prevention, mental illness, disability, chronic disease, palliative care, healthcare funding, and the protection of vulnerable patients. They also discuss the promise and risks of artificial intelligence in medicine, including concerns about weakened clinical reasoning and the loss of person-to-person care, as well as spirituality, meaning, reproductive ethics, IVF, abortion, and human dignity. Dr. Kristin Collier is a physician, medical educator, and bioethics scholar whose work focuses on medical education, spirituality in healthcare, human dignity, and the moral responsibilities of physicians. Drawing from her experience teaching future doctors and caring for patients, she examines how wisdom, compassion, intellectual freedom, and ethical reflection can help medicine remain both scientifically rigorous and deeply human. Truth Matters — Robert P. George and Cornel West https://www.simonandschuster.com/books/Truth-Matters/Robert-P-George/9798888451700 The Age of Feelings: Recovering the Truth https://robertpgeorge.com/articles/the-age-of-feelings-recovering-the-truth/ Meditations — Marcus Aurelius https://www.gutenberg.org/ebooks/2680 Medical Wisdom with Kristin Collier https://community.hippsoc.org/podcasts/the-hippocratic-society-podcast/episodes/2149039113 Moral Diversity for Medical Trainees https://pubmed.ncbi.nlm.nih.gov/39247933/ Moral Diversity for Medical Trainees — DOI https://doi.org/10.1353/pbm.2024.a936219 Professionalism in Modern Medicine: Does the Emperor Have Any Clothes? https://pubmed.ncbi.nlm.nih.gov/17198290/ The Patient as a Person — Abraham Joshua Heschel https://pubmed.ncbi.nlm.nih.gov/30411181/ Physician-Assisted Suicide Isn't Healthcare https://www.wsj.com/opinion/free-expression/physician-assisted-suicide-isnt-healthcare-0a9141c6 AMA Code of Medical Ethics — Physician-Assisted Suicide https://code-medical-ethics.ama-assn.org/ethics-opinions/physician-assisted-suicide AMA Report on Assisted-Suicide Terminology https://councilreports.ama-assn.org/councilreports/downloadreport?uri=%2Fcouncilreports%2FA_25_ceja_report_3.pdf AMA Physician-Assisted Suicide Report https://www.ama-assn.org/system/files/2019-05/a19-ceja2.pdf Stephanie Packer's Story https://patientsrightsaction.org/stephanie-packer/ Oregon Death With Dignity Act Reports https://www.oregon.gov/oha/ph/providerpartnerresources/evaluationresearch/deathwithdignityact/pages/ar-index.aspx Oregon Death With Dignity Act 2025 Report https://www.oregon.gov/oha/PH/PROVIDERPARTNERRESOURCES/EVALUATIONRESEARCH/DEATHWITHDIGNITYACT/Documents/year28.pdf The Death Treatment — Rachel Aviv https://www.newyorker.com/magazine/2015/06/22/the-death-treatment Canadian MAID Public-Opinion Survey https://researchco.ca/2023/05/05/maid-canada-2023/ Health Canada Annual MAID Report https://www.canada.ca/en/health-canada/services/publications/health-system-services/annual-report-medical-assistance-dying-2024.html Physician-Assisted Suicide and MAID Debate https://www.youtube.com/watch?v=fhT2eLrTq_Y In Vitro Fertilization: A Good End by Bad Means https://pubmed.ncbi.nlm.nih.gov/41909105/ In Vitro Fertilization Article — DOI https://doi.org/10.1177/00243639261421221 Roe v. Wade https://www.oyez.org/cases/1971/70-18 Kristin Collier — University of Michigan https://medschool.umich.edu/profile/4378/kristin-m-collier Kristin Collier X / Twitter https://x.com/HSRDirector Kristin Collier — PubMed Publications https://pubmed.ncbi.nlm.nih.gov/?term=Kristin+M+Collier%5BAuthor%5D Kristin Collier — Google Scholar https://scholar.google.com/scholar?q=%22Kristin+M.+Collier%22 Kristin Collier — Apple Podcasts https://podcasts.apple.com/us/search?term=Kristin%20Collier   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:44 Patients React to Intolerance 04:14 Cancel Culture in Medicine 08:05 Private Support and Fear 09:22 Moral Courage in Academia 11:17 Courage Versus Conformity 13:30 Why Medicine Needs Wisdom 16:45 Viewpoint Diversity in Training 22:29 Stoicism and Detached Concern 25:36 Physician Assisted Suicide Debate 29:51 Is It Ever Compassionate 31:49 Hard Cases and Suffering Care 32:20 Compassion Beyond Killing 33:09 Why People Request MAID 33:56 Suicide Prevention Paradox 37:00 Mental Illness and Euthanasia 40:02 Psychedelics Versus MAID 42:12 Euthanasia as a Hammer 46:23 AI Threats to Medicine 51:40 AI in Training Today 52:45 Spirituality and Meaning 56:11 Pro Life Pro Woman 58:33 Human Dignity Closing The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #225 GLP-1 Masterclass: Dosing, Optimal Use, Lifestyle Changes, and Benefits Beyond Weight Loss 18.06.2026 59min

  This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication. Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results. Dr. Christle Guevarra Website https://www.drchristle.com/ Dr. Christle's Free GLP-1 Guide https://www.drchristle.com/glp1-guide Dr. Christle Instagram https://www.instagram.com/dr.christle/ Ozempic — semaglutide https://www.ozempic.com/ Wegovy — semaglutide for weight management https://www.wegovy.com/ Mounjaro — tirzepatide https://mounjaro.lilly.com/ Zepbound — tirzepatide for weight management / sleep apnea https://zepbound.lilly.com/ FDA: Concerns With Unapproved GLP-1 Drugs https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Retatrutide Clinical Trial Info https://clinicaltrials.gov/study/NCT05882045 Vyvanse — lisdexamfetamine https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Creatine — NIH Supplement Info https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Psyllium Husk / Fiber — MedlinePlus https://medlineplus.gov/druginfo/meds/a601104.html Berberine — NCCIH https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know Tesamorelin — MedlinePlus https://medlineplus.gov/druginfo/meds/a611035.html CJC-1295 — PubMed Research https://pubmed.ncbi.nlm.nih.gov/16352683/ Ipamorelin — PubMed Research https://pubmed.ncbi.nlm.nih.gov/9849822/ FDA: Peptides / Compounding Safety Concerns https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Oura Ring https://ouraring.com/ White Claw https://www.whiteclaw.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Weekly Dosing Debate 03:41 Starting Dose Basics 06:28 Pens vs Vials Safety 08:37 Finding Your Sweet Spot 11:01 Nighttime Binge Window 13:32 Lifestyle Work Still Matters 14:30 Benefits Beyond Weight 17:27 Libido and Low Calories 22:26 Alcohol Hits Different 24:59 Cancer Claims Reality Check 26:59 Strength Training Priority 29:06 Supplements and Creatine 29:38 Creatine Protein Fiber Basics 31:50 Berberine Pros and Cons 32:37 Peptides Sleep and Muscle 35:28 Too Lean for GLP-1 38:52 Cycles PCOS and Fertility 40:45 Food Noise vs Appetite 44:42 Staying On or Stopping 49:19 Heart Rate and HRV Concerns 51:38 Ozempic vs Mounjaro Choices 54:45 Sleep Apnea and Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #224 Dr. Alex Tatum on Peptides, FDA Crackdowns, TRT Nuance, and Safe Penis Enhancement 11.06.2026 1h 6min

  Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC meeting. He explains most peptide APIs and many compounded GLP-1 ingredients come from China, while pharma-grade GLP-1s have more U.S. production. The discussion covers retatrutide's potential biologic classification (40–amino acid rule) and pricing implications, MOTS-c as an adjunct for low energy on GLP-1s, skepticism about cardarine, growth hormone secretagogues and cancer fears, TRT dosing frequency, sleep apnea screening, HCG's roles, and penis enhancement via traction for length and hyaluronic acid filler for girth, emphasizing expectations and mental health. Dr. Alex Tatem is a board-certified urologist focused on men's health, hormone optimization, male fertility, and sexual wellness. In this episode, he joins Dr. Mike Hart to discuss the changing landscape of peptide therapy, including FDA restrictions, compounding pharmacies, drug supply chains, and the growing debate around access to treatments such as BPC-157, MOTS-c, and retatrutide. He also breaks down practical considerations for men using testosterone replacement therapy, including HCG, fertility preservation, dosing frequency, estrogen-related side effects, and sleep apnea risk. Drawing from his experience treating a wide range of patients, he shares a harm-reduction approach to performance medicine and explains what men should understand before considering growth hormone peptides, GLP-1 medications, or penile enhancement procedures. Dr. Alex Tatem Website https://dralextatem.com/ Dr. Alex Tatem Instagram https://www.instagram.com/dralextatem/ Huberman Lab — Peptides: The Science, Uses & Safety | Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri FDA Pharmacy Compounding Advisory Committee Meeting — July 23–24, 2026 https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026 FDA Bulk Drug Substances Under Section 503A https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act FDA Compounding Safety Risks https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Semaglutide / Ozempic https://medlineplus.gov/druginfo/meds/a618008.html Tirzepatide / Mounjaro https://medlineplus.gov/druginfo/meds/a622044.html Retatrutide Clinical Trial https://clinicaltrials.gov/study/NCT05929066 Testosterone Cypionate https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=testosterone%20cypionate Human Chorionic Gonadotropin / HCG https://pubmed.ncbi.nlm.nih.gov/?term=human+chorionic+gonadotropin BPC-157 https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157 KPV Peptide https://pubmed.ncbi.nlm.nih.gov/?term=KPV+peptide TB-500 / Thymosin Beta-4 https://pubmed.ncbi.nlm.nih.gov/?term=thymosin+beta-4 MOTS-c https://pubmed.ncbi.nlm.nih.gov/?term=MOTS-c CJC-1295 https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295 Ibutamoren / MK-677 https://pubmed.ncbi.nlm.nih.gov/?term=ibutamoren+MK-677 Cardarine / GW501516 https://pubmed.ncbi.nlm.nih.gov/?term=GW501516+cardarine PhalloFILL at Urology of Indiana https://menshealthin.com/services/phallofill/ Hyaluronic Acid Penile Girth Enhancement Overview https://auanews.net/issues/articles/2024/august-extra-2024/office-and-surgical-technologies-the-evolving-landscape-of-penile-girth-enhancement   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 Are Peptides Threatening Pharma 01:17 Patent Law and FDA Categories 02:19 The 2023 Peptide Ban Fallout 03:59 Safety or Money Debate 06:09 China Supply Chain Exposed 11:33 RFK Jr Peptide Messaging 16:01 Retatrutide Biologic Fight 20:51 What Biologic Status Costs 25:27 MOTS-c as GLP-1 Booster 28:43 Growth Hormone Cancer Myth 32:18 Sleep Effects and Bryan Johnson 35:04 Microplastics and Saunas 36:48 Cardarine Cancer Risk 40:07 TRT and HCG Basics 45:08 HCG Dosing Nuance 49:06 Daily TRT Microdosing 52:03 Sleep Apnea on TRT 56:34 Penis Enhancement Options 01:02:54 Realistic Expectations 01:04:46 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #223 How I Increased My VO2 Max at 41 With the Norwegian 4x4 Protocol 28.05.2026 34min

  The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus weekly MMA, he shifted to one zone 2 session, one Norwegian 4x4 VO2 max workout, and one MMA session weekly. He defines VO2 max and details the 4x4 protocol (4 minutes hard/3 minutes easy for 4 rounds plus brief warmup/cooldown), using a COROS heart rate monitor to track significant zone 5 time. Starting at 8.0 mph, he increased treadmill speed by 0.1 mph weekly to 9.3 mph, discussing deload weeks, fatigue limits, body weight changes, footwear, sauna frequency, and mixed views on supplements like beta-alanine, beetroot, and ketones.   Norwegian 4x4 Protocol https://www.myworkout.com/en/4x4-intervals VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio Stats Canada VO2 Max Percentile Table https://www150.statcan.gc.ca/n1/pub/82-003-x/2019010/article/00002/tbl/tbl02-eng.htm Oura Ring https://ouraring.com/ COROS Heart Rate Monitor https://coros.com/heart-rate-monitor Freak Athlete Nordic Hyper / Hyper Pro https://freakathlete.co/products/hyper-pro HOKA Clifton 10 https://www.hoka.com/en/ph/clifton-10-run-smooth/ Nike Zoom Fly https://www.nike.com/ph/w/nike-zoom-fly-running-shoes-37v7jz7oc5azy7ok Post-Exercise Sauna Bathing Study https://pubmed.ncbi.nlm.nih.gov/16877041/ Urolithin A https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 Beetroot / Dietary Nitrate https://www.ausport.gov.au/ais/nutrition/supplements/group_a/performance-supplements2/beetroot-juicenitrate Ketone-IQ https://ketone.com/ Beta-Hydroxybutyrate / BHB Ketones https://www.ncbi.nlm.nih.gov/books/NBK493179/ L-Citrulline https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Creatine https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Beta-Alanine https://examine.com/supplements/beta-alanine/ MOTS-c https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/ Cardarine / GW501516 https://www.wada-ama.org/en/news/wada-issues-alert-gw501516 Brady Holmer https://www.bradyholmer.com/ Hart2Heart Episode with Brady Holmer https://open.spotify.com/episode/0DxQVb0Mkah57ZgHbWmWUy   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 VO2 Max Story Setup 01:27 Baseline Training Split 02:58 What VO2 Max Means 05:10 Why Add Structure 06:01 Norwegian 4x4 Explained 06:49 Starting Speeds Recovery 08:07 Zone 5 Targets 10:55 Tracking Heart Rate 12:23 Estimating VO2 Max 14:37 Zone 2 And MMA Role 17:20 Bodyweight And Running 19:46 Shoes Sauna Supplements 24:44 Progressive Overload Plan 29:34 Deloads Plateaus Mindset 31:29 Final Takeaways Encouragement   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia 21.05.2026 1h 3min

  Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) PT-141 / Bremelanotide [https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html) GHK-Cu copper peptide https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) Tretinoin / Retin-A https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html) NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/) Nicotinamide Riboside / NR https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/) Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/) GLP-1 drugs https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Tirzepatide https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html) BPC-157 https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/) TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/) Tesamorelin https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)   Thymosin Alpha-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/) SS-31 / Elamipretide https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/) Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html) Psyllium husk https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #221 Acute vs. Chronic Inflammation: Causes, Biomarkers, and How to Lower It 14.05.2026 58min

  The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin resistance), poor sleep and sleep apnea, ultra-processed foods, sedentary behavior, overtraining, chronic psychological stress, poor oral health, gut dysbiosis/barrier issues, smoking, alcohol, pollution, autoimmune disease, and chronic infection. The host reviews biomarkers to discuss with a physician such as high-sensitivity CRP, ESR, ferritin, WBC and neutrophil-to-lymphocyte ratio, fasting insulin, ApoB, omega-3 index/omega-6:omega-3 ratio, and homocysteine. Chronic inflammation is linked to cardiovascular disease, depression/anhedonia, brain fog, autoimmune disease risk, cancer mechanisms, skin aging, erectile dysfunction, and chronic pain. Treatment focuses on lifestyle (notably treating sleep apnea, sleep optimization, fat loss, exercise, oral health, omega-3 intake, sauna, stress regulation, circadian rhythm), selected supplements (vitamin D if deficient, curcumin, boswellia, ginger, garlic, olive oil polyphenols, sulforaphane, magnesium/glycine, taurine, NAC, quercetin, probiotics, creatine), and brief discussion of drugs including GLP-1 agonists, colchicine, NSAIDs, corticosteroids, and biologics.   Chronic inflammation https://www.ncbi.nlm.nih.gov/books/NBK493173/ C-reactive protein test https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/ ESR blood test https://medlineplus.gov/lab-tests/erythrocyte-sedimentation-rate-esr/ Ferritin blood test https://medlineplus.gov/lab-tests/ferritin-blood-test/ Homocysteine test https://medlineplus.gov/lab-tests/homocysteine-test/ ApoB test https://my.clevelandclinic.org/health/diagnostics/24992-apolipoprotein-b-test Insulin resistance https://www.ncbi.nlm.nih.gov/books/NBK507839/ Obstructive sleep apnea https://medlineplus.gov/ency/article/000811.htm CPAP therapy https://medlineplus.gov/ency/article/001916.htm Sleep hygiene https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.html Physical activity guidelines https://www.cdc.gov/physical-activity-basics/guidelines/adults.html Ultra-processed foods https://pmc.ncbi.nlm.nih.gov/articles/PMC10831891/ Gum disease https://www.cdc.gov/oral-health/about/gum-periodontal-disease.html Gut microbiome https://www.nccih.nih.gov/health/gut-microbiome-what-you-need-to-know Fiber https://www.hsph.harvard.edu/nutritionsource/carbohydrates/fiber/ Autoimmune diseases https://medlineplus.gov/autoimmunediseases.html Inflammation and heart disease https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease Inflammation and depression https://pmc.ncbi.nlm.nih.gov/articles/PMC4566946/ Cancer and chronic inflammation https://www.cancer.gov/about-cancer/causes-prevention/risk/chronic-inflammation Omega-3 supplements https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 Inflammation Basics 01:24 Acute Versus Chronic 03:29 Chronic Disease Link 03:52 Visceral Fat Driver 06:06 Sleep And Apnea 12:33 Food And Movement 16:02 Stress And Oral Health 18:17 Gut And Fiber 21:17 Toxins Autoimmune Infection 26:05 Inflammation Biomarkers 27:13 Inflammation Blood Markers 28:37 Ferritin Iron Balance 30:07 Metabolic Cardio Labs 32:08 Omega 3 Index Insights 34:07 Homocysteine Risks 34:58 Why Inflammation Matters 41:07 Lifestyle Fixes 46:24 Supplement Options 54:36 Medication Overview 57:36 Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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  #220 Wnt vs DHT: Understanding Androgenic Alopecia and the Top Treatments to Slow Hair Loss 07.05.2026 41min

  In this solo episode on androgenic alopecia, the host explains that hair loss is slow and progressive, driven largely by genetics and DHT-mediated miniaturization of follicles across the anagen, catagen, and telogen cycle, and stresses early detection using periodic photos of the temples, hairline/vertex, and crown. He frames hair growth as a "battle" between Wnt signaling (promotes growth and anagen entry via stem cell activation) and DHT signaling (suppresses Wnt and increases inhibitors like DKK, TGF-beta, and PGD2), noting advanced loss involves inflammation, fibrosis, and irreversible follicle loss. He reviews contributors like poor scalp blood flow, iron deficiency (most evidence), possible zinc/B12/folate deficiency, thyroid dysfunction, and insulin resistance, then covers treatments: finasteride (oral and topical) and dutasteride as DHT blockers with potential systemic side effects, plus minoxidil and microneedling (home vs professional) as key options, with add-ons like ketoconazole shampoo, PRP, red light, and cautions about anabolic steroids and high-dose testosterone increasing DHT pressure.   Hair loss diagnosis and treatment https://www.aad.org/public/diseases/hair-loss/treatment/diagnosis-treat Androgenetic alopecia https://medlineplus.gov/genetics/condition/androgenetic-alopecia/ DHT and WNT signaling https://pubmed.ncbi.nlm.nih.gov/29549490/ Finasteride https://medlineplus.gov/druginfo/meds/a698016.html Topical finasteride https://pmc.ncbi.nlm.nih.gov/articles/PMC6609098/ FDA warning on compounded topical finasteride https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-providers-compounders-and-consumers-potential-risks-associated-compounded Post-finasteride syndrome https://pubmed.ncbi.nlm.nih.gov/35983808/ Dutasteride https://medlineplus.gov/druginfo/meds/a603001.html Minoxidil https://www.aad.org/public/diseases/hair-loss/treatment/diagnosis-treat Microneedling for hair loss https://pubmed.ncbi.nlm.nih.gov/23960389/ Ketoconazole shampoo https://pubmed.ncbi.nlm.nih.gov/31858672/ Topical caffeine https://pubmed.ncbi.nlm.nih.gov/39997270/ Pumpkin seed oil https://pubmed.ncbi.nlm.nih.gov/24864154/ PRP for hair loss https://pubmed.ncbi.nlm.nih.gov/30882509/ Red light / low-level light therapy https://pmc.ncbi.nlm.nih.gov/articles/PMC8906269/ Stem cells / exosomes for hair growth https://pmc.ncbi.nlm.nih.gov/articles/PMC12433634/ Iron, zinc, B12, and folate deficiencies https://pmc.ncbi.nlm.nih.gov/articles/PMC6380979/ Thyroid testing https://medlineplus.gov/thyroidtests.html Insulin resistance / metabolic syndrome https://medlineplus.gov/metabolicsyndrome.html Testosterone / TRT https://medlineplus.gov/druginfo/meds/a605020.html Tretinoin https://medlineplus.gov/druginfo/meds/a682437.html Anastrozole / Arimidex https://medlineplus.gov/druginfo/meds/a696018.html Anabolic steroids https://nida.nih.gov/research-topics/anabolic-steroids   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:56 What Is Androgenic Alopecia 02:17 Hair Follicle Life Cycle 03:55 Miniaturization and Early Detection 06:51 DHT Basics and Other Causes 09:27 WNT Versus DHT Explained 13:10 Nutrients Thyroid and Insulin 16:26 Finasteride Benefits and Risks 19:21 Topical Finasteride and Dutasteride 25:01 Minoxidil Growth Booster 27:19 Microneedling for WNT Activation 30:21 Extra Treatments and Add Ons 37:04 Testosterone TRT and Steroids 40:16 Wrap Up and Key Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart