The College of Glycation with Dr. Paul Reynolds

Эпизоды

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  Fatty Liver and MASLD 12.08.2026 25мин

  In this episode of the College of Glycation, Professor Paul Reynolds explains why the liver sits at the center of systemic glycation. The same organ that clears advanced glycation end-products from the bloodstream is also the one that accumulates them when burdened with fat and inflammation, creating a self-reinforcing loop. Fructose is the key substrate: it bypasses the main regulatory brake of glycolysis, flooding the liver with both new fat (de novo lipogenesis) and methylglyoxal, the most aggressive endogenous glycating agent. RAGE, activated by AGEs and the danger signal HMGB1, is required for hepatic stellate cells to produce scar tissue; once collagen is deposited, AGE crosslinks make that scar resistant to breakdown. The 2023 renaming to metabolic dysfunction-associated steatotic liver disease (MASLD) correctly places insulin resistance and glycemic burden at the center of the diagnosis.Reynolds covers practical measurement tools (FIB-4, FibroScan, and supportive skin autofluorescence) and the specific weight-loss thresholds that matter: steatosis improves at 3–5 %, steatohepatitis at 7–10 %, and meaningful fibrosis regression mainly at 10 % or more. Fructose restriction produces rapid measurable benefits even without calorie reduction, and emerging histology data from GLP-1 therapies further support intervention while the process is still reversible. Fatty liver is a flux problem, not merely a storage problem—and every major point in the loop remains under your influence if addressed early enough.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Lipoxidation and ALEs 05.08.2026 26мин

  In this episode of the College of Glycation, Professor Paul Reynolds expands the conversation beyond sugar into the parallel chemistry of lipoxidation. Polyunsaturated fats in cell membranes undergo radical chain peroxidation, breaking into highly reactive aldehydes such as 4-hydroxynonenal, malondialdehyde, and acrolein. These form permanent advanced lipoxidation end-products (ALEs) on proteins — nearly identical in mechanism and consequence to advanced glycation end-products. Landmark experiments showed that carboxymethyllysine, one of the most measured “AGEs,” readily forms from oxidized polyunsaturated fats even without any sugar present. ALEs also bind RAGE and drive the same NF-κB inflammatory pathway, contributing to atherosclerotic plaque, fatty liver, neurodegeneration, and chronic lung disease.Reynolds emphasizes that glycation was never only a sugar story; it is a story of reactive carbonyls arriving from two major inputs. Clearance capacity varies between people (notably with the common ALDH2 variant), and practical protection includes choosing more stable fats for high-heat cooking, protecting polyunsaturated oils from heat, light, and oxygen, supporting carbonyl scavengers such as carnosine, and matching vitamin E intake to polyunsaturated fat load. If you have been managing metabolic health by watching glucose alone, this episode shows why you need to widen the frame to include oxidant exposures, fat quality, and carbonyl clearance.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  How to Measure Glycation 29.07.2026 23мин

  In this episode of the College of Glycation, Professor Paul Reynolds finally answers the question that arrives after every previous episode: “How do I actually measure my own glycation?” He walks through the practical toolkit that reveals tissue damage even when standard labs look perfect. Hemoglobin A1c gives a two-to-three-month average but can be distorted by red-blood-cell lifespan and other confounders. Fructosamine and glycated albumin offer a faster two-to-four-week window and strongly predict diabetes risk and complications. Continuous glucose monitoring turns the average into a real-time movie, exposing the spikes and glycemic variability that drive oxidative stress and glycation — even in people told they are “normal.” Skin autofluorescence, measured noninvasively in seconds with an AGE Reader, estimates long-term tissue accumulation of advanced glycation end-products and has been shown to predict type 2 diabetes, cardiovascular disease, and mortality independently of glucose and A1c.Reynolds frames these markers as clocks running at different speeds and shows how to close the test-intervene-retest loop on the right timescale. A landmark Weizmann Institute study of personalized nutrition based on individual continuous glucose data proves that your own measurements outperform generic dietary advice. The goal is not anxiety but agency: trade the vague fear of a once-a-year number for specific knowledge you can act on, becoming the scientist studying the most important subject you will ever have.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Glycation and Your Bones and Muscles 22.07.2026 22мин

  In this episode of the College of Glycation, Professor Paul Reynolds explains why bone strength is not the same as bone density and how glycation quietly sabotages both your skeleton and your muscles. Bone is a composite material — mineral provides stiffness while collagen acts as the flexible rebar that absorbs impact. Glycation creates random AGE crosslinks like pentosidine that weld collagen strands together, turning tough, energy-dissipating bone into rigid, brittle material that snaps instead of bending. This is the hidden reason people with type 2 diabetes fracture far more often (especially at the hip) despite normal or even high bone density on scans, and why tools like FRAX underestimate their risk. The same process stiffens muscle’s collagen scaffold and overactivates RAGE signaling, impairing satellite cell repair and driving muscle atrophy. The result is accelerated sarcopenia and frailty — brittle bones plus weak, poorly repairing muscle that makes falls more likely and more devastating.The good news is that this damage is not inevitable. Reynolds shows how controlling blood sugar slows glycation at the source, why aging bodies need higher protein intake to support muscle repair, and why resistance training is the single most powerful intervention — it strengthens both bone and muscle while improving glucose control in a virtuous cycle. Skin autofluorescence even offers a noninvasive way to track tissue AGE burden. Your bones and muscles are living, collagen-rich tissues that sugar can quietly sabotage, but the same habits that protect your metabolism also keep you strong, mobile, and independent for decades.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Methylglyoxal and the Glyoxylase System (GLO1) 15.07.2026 22мин

  In this episode of the College of Glycation, Professor Paul Reynolds uncovers methylglyoxal (MGO) as the real culprit behind most glycation damage — a highly reactive molecule your body produces every second as an unavoidable byproduct of glycolysis, and even more aggressively from fructose metabolism. Far more potent than glucose itself, MGO drives “dicarbonyl stress,” the upstream process that leads to advanced glycation end-products (AGEs) and contributes to aging and metabolic disease across the body. Your primary defense is the ancient glyoxalase system, led by the enzyme GLO1, which uses glutathione to neutralize MGO before it can harm proteins and DNA. GLO1 is controlled by Nrf2, the master regulator of cellular protection, meaning this defense system can be upregulated when needed.Reynolds explains how to strengthen your defenses in practical ways: activate Nrf2 with sulforaphane from broccoli sprouts (shown in a human clinical trial to improve blood sugar control in type 2 diabetes), support glutathione and NAD status through better sleep and lower inflammation, and use direct scavengers like carnosine to intercept MGO. He ties MGO and the glyoxalase system to every previous topic in the series — from blood vessels and kidneys to the brain, skin, and insulin resistance — revealing it as the unifying thread. The great news is that this system is responsive to how you eat and live, giving you real leverage to reduce production of MGO while boosting your body’s ability to clear it.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Glycation and the Lungs 10.07.2026 22мин

  In this episode of the College of Glycation, Professor Paul Reynolds explores the lung as the ultimate proof-of-concept organ for the AGE-RAGE axis. Unlike most tissues where RAGE appears only during injury, the lung expresses the highest baseline levels of RAGE in the body from birth, where it normally plays a structural role helping alveolar type I cells maintain the delicate gas-exchange surface. When AGEs — whether inhaled from cigarette smoke, e-cigarette vapor, air pollution, or generated internally through high blood sugar — engage this abundant receptor, they trigger a powerful feed-forward inflammatory loop via NF-κB. This drives emphysema (RAGE knockout mice are largely protected from smoke-induced destruction), amplifies allergic asthma through HMGB1, and promotes pulmonary fibrosis by glycation-mediated collagen crosslinking that stiffens the lung matrix and pushes fibroblasts into scar-producing myofibroblasts. Lower circulating sRAGE also strongly tracks with worse COPD and emphysema in humans.The lung makes the chemistry visible in real time: inhaled exposures plug directly into the receptor that the rest of the body only activates under stress. Reynolds shows that the same metabolic strategies discussed throughout the series — steady blood glucose, reduced dietary AGEs, and supporting your body’s sRAGE “sponge” — protect lung health just as powerfully as avoiding direct inhalation of AGEs. The lesson is clear: an organ built almost entirely around reading sugar damage as fire deserves to be protected from it.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds Full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Glycated LDL and Cardiovascular Health 01.07.2026 20мин

  In this episode of the College of Glycation, Professor Paul Reynolds challenges the decades-old story that heart disease risk is simply a matter of lowering your LDL cholesterol number. He explains how glycation — driven by glucose, fructose, and especially methylglyoxal — chemically modifies LDL particles, turning ordinary LDL into small, dense, sticky versions with defaced apoB that the liver can no longer clear efficiently. These modified particles are instead taken up by scavenger receptors on macrophages, creating foam cells that build atherosclerotic plaque. At the same time, high blood sugar and glycated LDL strip away the protective endothelial glycocalyx, the slippery non-stick coating that normally keeps LDL particles from sticking to artery walls, creating a self-reinforcing vicious cycle of damage and inflammation mediated by RAGE.Drawing on key studies showing that methylglyoxal alone can convert LDL into its most atherogenic form, that blocking RAGE dramatically reduces plaque even without lowering glucose or lipids, and that modified LDL in circulation predicts real cardiovascular events, Reynolds reframes heart disease as a metabolic and glycation problem rather than purely a cholesterol quantity problem. The practical takeaway is clear: instead of obsessing only over the LDL number, focus on tightening glucose control, reducing sugar and fructose load, and using the triglyceride-to-HDL ratio as a readily available proxy for the small, dense, glycation-prone LDL particles that actually drive disease. The most powerful protection for your heart comes from controlling the chemistry that turns normal LDL into a weapon.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Leaky Gut Meets RAGE 24.06.2026 23мин

  In this episode of the College of Glycation, Professor Paul Reynolds reveals how glycation and leaky gut don’t just coexist — they actively multiply each other’s damage. A diet high in heat-generated advanced glycation end-products (AGEs) reshapes the gut microbiome, weakens the intestinal barrier, and allows bacterial lipopolysaccharide (LPS) to leak into the bloodstream in a state called metabolic endotoxemia. At the same time, elevated glucose and dietary AGEs keep the RAGE receptor constantly engaged. Because RAGE and TLR4 (the LPS receptor) physically interact and upregulate one another in a feed-forward loop, the leaked LPS lands on an immune system that glycation has already primed — dramatically amplifying inflammation and insulin resistance through shared NF-κB signaling.Drawing on landmark studies from Cani, Qu, Snelson & Coughlan, Yan, Uribarri, and others, Reynolds shows that this synergy is not additive but multiplicative. The same modern dietary pattern that generates AGEs also opens the door for LPS and then lowers the threshold for its inflammatory effects. Practical takeaways include shifting to gentler, moisture-based cooking methods to slash dietary AGEs, feeding butyrate-producing bacteria with fiber and dairy fats to strengthen tight junctions, and controlling blood glucose and insulin to disengage RAGE and raise the inflammatory threshold. Ultimately, glycation is reframed not merely as tissue damage, but as a recalibration of immune judgment — turning an ordinary bacterial leak into the spark that meets the gasoline.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Glycocalyx and the Role of Glycation 17.06.2026 22мин

  In this episode of the College of Glycation, Paul Reynolds flips the script on sugar. While glycation is usually portrayed as the villain that damages proteins, lipids, and DNA through advanced glycation end products, today he reveals a place where sugar is actually the hero: the glycocalyx. This dense, gel-like sugar coat covers nearly every cell in your body, with its most important version lining the inside of all your blood vessels like an invisible protective forest.Paul explains the structure of the glycocalyx, its surprising thickness, and its four critical roles as a selective filter, a shear-stress sensor that triggers nitric oxide release, a physical and electrical barrier against clotting and inflammation, and a non-stick coating for smooth blood flow. He then shows how high blood sugar rapidly destroys this layer—halving its volume in just six hours through oxidative stress and the AGE-RAGE pathway that activates heparanase. The breakdown of the glycocalyx appears to be one of the earliest events in vascular dysfunction, atherosclerosis, and kidney disease, while also contributing to leaky gut. The solution, Paul argues, is the same approach that protects the rest of the body: keeping blood glucose stable and low so the cell can build and maintain this life-saving sugar coat instead of tearing it down.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Adipose Glycation and Fat Cell Hypertrophy 10.06.2026 23мин

  Podcast Episode Description:In this eye-opening episode of the College of Glycation, Professor Paul Reynolds explores adipose glycation — the hidden process where fat cells themselves become chemically modified by sugar, turning them into drivers of metabolic dysfunction. Far from being passive storage tanks, hypertrophic adipocytes generate their own glycating agents like methylglyoxal (MGO), activating the AGE-RAGE axis, inflammation, hypoxia, and fibrosis. This creates a self-reinforcing loop that promotes insulin resistance, cytokine release, and impaired fat expandability — explaining why fat cell size and behavior matter far more than total body fat.Drawing on key studies, Reynolds connects the dots between chronic hyperinsulinemia, fructose intake, RAGE-driven hypertrophy, and the breakdown of healthy adipose remodeling. The episode reveals why some people develop metabolic disease at lower BMIs and offers practical, empowering strategies: lower insulin through carb restriction and time-restricted eating, minimize fructose, support the glyoxalase system, and stay active to keep fat cells healthy and quiet. A must-listen for anyone interested in body composition, inflammation, and breaking the cycle of metabolic illness.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  GLP-1 Beyond Glucose 03.06.2026 26мин

  In this eye-opening episode of the College of Glycation, biomedical scientist and Professor of Cell Biology Paul Reynolds goes beyond the headlines on the blockbuster GLP-1 receptor agonists—semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). While everyone talks about dramatic weight loss, Reynolds reveals what these drugs are actually doing at the cellular level: directly downregulating the RAGE receptor, suppressing AGE-induced inflammation, and powerfully activating autophagy. Drawing on landmark trials like SELECT (which showed a 20% drop in major cardiovascular events even in people without diabetes), he demonstrates how these benefits stem from four overlapping anti-glycation mechanisms that go far deeper than glucose control or appetite suppression.Reynolds walks listeners through the full family of incretin therapies, the science of the dangerous AGE-RAGE-NF-κB axis, and how GLP-1 agonists restore cellular recycling by shifting the AMPK-mTOR balance—clearing damaged, glycated proteins in ways that explain their impressive tissue-protective effects. He closes with a balanced, practical perspective: these are powerful pharmacologic tools that mimic healthy metabolic states, but they work best as temporary bridges to real food, movement, sleep, and fasting rather than lifelong crutches. If you want to truly understand why metabolic dysfunction drives chronic disease—and what the GLP-1 story teaches us about fixing it at the root—this episode is essential listening.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Autophagy and Glycation 27.05.2026 19мин

  In this episode of the College of Glycation, Dr. Paul Reynolds explores autophagy—one of the body’s most powerful yet underappreciated defenses against aging. Autophagy, the Nobel Prize-winning cellular “self-eating” process, allows cells to identify, package, and recycle damaged proteins, dysfunctional mitochondria, misfolded molecules, and glycated junk before they mature into advanced glycation end-products (AGEs). These sugar-modified compounds stiffen tissues, impair insulin signaling, promote inflammation, and accelerate chronic disease. Dr. Reynolds explains how constant eating and elevated insulin keep autophagy suppressed, trapping cells in perpetual “build and store” mode and allowing glycation damage to accumulate.Intermittent fasting changes everything by lowering insulin, suppressing mTOR, and activating AMPK—triggering the metabolic switch that rapidly ramps up autophagy and delivers a true glycation reset. Drawing on landmark research, Dr. Reynolds shows how even short fasting windows (like 16:8) can clear glycated proteins, improve metabolic health, and support cellular renewal. He offers practical, step-by-step guidance for beginners through advanced fasters, while clearly outlining who should avoid fasting and how to combine it with smart eating and exercise for maximum benefit. This episode delivers the science and the actionable strategy to harness your body’s built-in cellular housekeeping system.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  The Sugar Diet and Glycation 20.05.2026 17мин

  In this episode of the College of Glycation, Dr. Paul Reynolds takes a clear-eyed look at the viral “sugar diet” trend sweeping social media — where people are eating bowls of sugar, drinking large amounts of fruit juice and honey, and eliminating fat while claiming major improvements in energy, mood, and metabolism. He asks the question almost no one else is asking: what does this dietary pattern actually do to glycation? Drawing on peer-reviewed research, Dr. Reynolds explains why fructose is dramatically more glycating than glucose, how it drives rapid methylglyoxal formation and advanced glycation end product (AGE) accumulation, and why even short-term high-fructose intake can increase liver fat, visceral adiposity, and insulin resistance within days to weeks.While acknowledging the real short-term effects some people experience (such as feeling warmer or more energetic), Dr. Reynolds shows why these acute benefits do not reflect long-term safety. He highlights the critical gap between normal fasting glucose and hidden glycation damage, the complete lack of long-term clinical trials on sugar-dominant diets, and why this approach ultimately maximizes the very biochemical pathways that accelerate tissue aging, vascular stiffening, and chronic disease. The episode offers a science-based alternative perspective for anyone prioritizing metabolic health and longevity over trending dietary extremes.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Fermentation and Glycation 13.05.2026 23мин

  In this episode of the College of Glycation, Dr. Paul Reynolds reveals why traditional fermented foods—staples of every human culture for thousands of years—may be one of the most powerful, yet underused tools for lowering your glycation burden and resetting metabolic health. He explains how fermentation pre-digests sugars, delivers living microbes and bioactive compounds (lactic acid, acetic acid, short-chain fatty acids, and peptides), and counteracts the modern Western diet’s relentless drive toward advanced glycation end products (AGEs), chronic inflammation, and insulin resistance.Drawing on landmark research including the 2021 Stanford study, Dr. Reynolds walks through the five key mechanisms by which real fermented foods boost gut microbial diversity, blunt post-meal glucose spikes, inhibit AGE formation and RAGE signaling, improve insulin sensitivity, and strengthen the intestinal barrier. He also shares a clear, practical protocol: which foods matter most, how much to eat, smart timing strategies, and important cautions for getting the maximum benefit. If you’re serious about reducing glycation and reclaiming the metabolic protection our ancestors took for granted, this episode shows you exactly how to make fermented foods a daily, non-negotiable habit.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
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  Fasting and Glycation 06.05.2026 18мин

  In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—explains how fasting is one of the most powerful and underutilized tools for resetting the glycation burden your body carries. He breaks down how the standard modern eating pattern of frequent, carbohydrate-rich meals drives near-constant glucose and insulin elevations that accelerate the formation of advanced glycation end products (AGEs). These permanent molecular modifications stiffen tissues, trigger inflammation through the RAGE receptor, and fuel the chronic diseases we associate with aging. Dr. Reynolds shows why this damage isn’t inevitable and how fasting interrupts the cycle at its root.He details the profound metabolic shifts that occur when you stop eating insulin drops, the body flips the “metabolic switch” to fat-burning and ketone production, and autophagy—the cellular recycling program—ramps up to clear out damaged, glycated proteins. Drawing on key research, he covers practical approaches including time-restricted eating, early time-restricted feeding, alternate-day fasting, extended fasts, and fasting-mimicking diets. You’ll also learn why how you break a fast matter and how these strategies improve insulin sensitivity, reduce oxidative stress, and enhance metabolic flexibility—independent of weight loss. Whether you’re new to fasting or looking to deepen your practice, this episode delivers a clear, science-backed roadmap for using one of the body’s own repair mechanisms to fight glycation and support long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Glycation and Your Mouth as a Metabolic Canary 29.04.2026 25мин

  Your gums may be telling you something critical about your metabolic health. In this episode of the College of Glycation, Dr. Paul Reynolds explores the overlooked connection between gum disease, glycation, and systemic inflammation. He explains how Advanced Glycation End Products (AGEs) form and accumulate—and how periodontal disease doesn’t just result from metabolic dysfunction, but can actively drive it. From inflammatory signaling to insulin resistance, this episode reveals how the mouth plays a central role in whole-body health. If you’re interested in metabolism, aging, or the deeper biochemical drivers of chronic disease, this episode offers a powerful new perspective on why oral health is far more than cosmetic—it’s metabolic.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Glycation and Your Hormones 22.04.2026 28мин

  In this episode of the College of Glycation series, Dr. Paul Reynolds explores how advanced glycation end-products (AGEs) quietly disrupt the body’s hormonal systems. Moving beyond blood sugar alone, he explains how glycation damages key proteins involved in hormone production, transport, and signaling—affecting thyroid function, testosterone levels, insulin sensitivity, and fertility. Even when lab results appear normal, these molecular changes can impair how hormones actually function at the tissue level.Dr. Reynolds connects the chemistry of glycation to real-world conditions like hypothyroidism, PCOS, infertility, and metabolic dysfunction, while introducing the RAGE pathway as a major driver of chronic inflammation and hormonal imbalance. This episode offers a deeper framework for understanding the link between diet, metabolic health, and endocrine function—and what you can do to reduce glycation and protect long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  Fructose is a Glycation Accelerant 15.04.2026 24мин

  In this episode of the College of Glycation, Dr. Paul Reynolds explores a major blind spot in metabolic health: fructose. While most discussions around sugar focus on glucose and blood sugar levels, this episode reveals why fructose may be even more damaging. Dr. Reynolds explains how fructose is metabolized almost entirely in the liver, bypassing key regulatory systems and driving fat production, insulin resistance, and oxidative stress. More importantly, fructose is significantly more reactive in the glycation process—accelerating the formation of advanced glycation end-products (AGEs) that damage tissues and promote chronic disease.Building on foundational glycation science, this episode uncovers how fructose not only glycates proteins faster than glucose but also generates highly reactive compounds like methylglyoxal, amplifying cellular damage. Dr. Reynolds challenges common assumptions about “healthy” sugars found in fruit juice and natural sweeteners, offering a clearer understanding of how modern dietary patterns contribute to long-term metabolic dysfunction. Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  AGEs 101: The Basics of Glycation 08.04.2026 31мин

  In this episode of the College of Glycation, Dr. Paul Reynolds introduces the foundational science of glycation—one of the most important and underrecognized processes driving aging and chronic disease. He explains how glucose, while essential for energy, can also react with proteins in the body through a non-enzymatic process that gradually leads to the formation of advanced glycation end-products (AGEs). Using clear analogies and step-by-step explanations, Dr. Reynolds walks through how glycation begins, how it progresses, and why its effects accumulate silently over time in tissues like blood vessels, kidneys, nerves, and eyes. This episode also explores the real-world implications of glycation in modern health, highlighting how lifestyle factors—such as diet, cooking methods, physical inactivity, and chronically elevated blood sugar—accelerate the process beyond what the body can manage. Dr. Reynolds outlines the body’s natural defense systems and, more importantly, the practical steps individuals can take to reduce glycation burden, improve metabolic health, and slow the long-term trajectory of aging and disease.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
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  How Reversible is Glycation? 01.04.2026 33мин

  In this episode of the College of Glycation, Dr. Paul Reynolds explores one of the most important questions in metabolic health: Is glycation reversible? While some damage—especially in long-lived tissues like collagen—can persist for decades, this episode reveals that the body is far from helpless. Dr. Reynolds breaks down the science of how glycation forms, why certain stages are more reversible than others, and the built-in systems your body uses to defend against and clear this damage.More importantly, he translates that science into practical strategies you can use right away. From improving blood sugar control and reducing dietary AGEs to leveraging fasting, exercise, and targeted supplementation, this episode reframes the goal—not as fully reversing damage, but as slowing its accumulation and changing your long-term health trajectory.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)