The Open Loop with Chay Carter

Эпизоды

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  At-Home Brain Stimulation for Depression with Daniel Månsson 23.07.2026 34мин

  In this episode of The Open Loop, Chay Carter is joined by Daniel Månsson, Chief Scientific Officer and Founder at Flow Neuroscience. Daniel shares his journey from clinical psychology and computer science into building one of the most recognised at-home neurostimulation companies for depression. This is a practical conversation about tDCS, treatment-resistant depression, clinical evidence, and what it takes to bring brain stimulation out of the clinic and into the hands of patients. We explore why Flow chose transcranial direct current stimulation, how the company built its evidence base across Europe and the UK, and what its FDA approval means for the next stage of growth in the US. We also discuss the challenge of separating clinically validated neurotechnology from wellness products, the role of doctors in at-home treatment pathways, and how precision psychiatry could shape the next generation of depression care. Key takeaways:🔹 Why Flow Neuroscience chose tDCS for at-home depression treatment🔹 How the company built clinical evidence through real-world data and RCTs🔹 Why patient access is central to Flow’s approach🔹 How at-home neurostimulation can balance accessibility with medical oversight🔹 Why precision psychiatry could help match the right patients to the right treatments Host: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Daniel MånssonChief Scientific Officer and Founder at Flow Neuroscience.LinkedIn: https://www.linkedin.com/in/danielmanss/Learn more about Flow Neuroscience: https://www.flowneuroscience.com/Key Chapters:00:39 Daniel’s Journey from Psychology to Neurotech04:09 Building Flow Neuroscience for Depression Treatment07:47 From European Regulation to FDA Approval11:00 Insights from 60,000 Patients14:26 Preparing for Flow’s US Launch18:14 How the Flow tDCS Device Works21:47 Expanding Indications and Next-Generation Devices25:32 Balancing Patient Access, Safety, and Medical OversightSponsor:This episode is sponsored by Reccy Neuro — the home of neurotech. Jobs, companies, investors, events, Cortex industry intelligence, and specialist resources for the neurotech market.Learn more about Reccy Neuro: https://neuro.reccy.dev/The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, operators, and industry leaders building what comes next in brain health, medicine, and technology.If you enjoyed this episode, please subscribe, leave a review, and share it with someone interested in neurotechnology.New episodes of The Open Loop drop every week.
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  How Spark Biomedical Is Expanding Auricular Neurostimulation with Daniel Powell 08.07.2026 34мин

  In this episode of The Open Loop, Chay Carter is joined by Daniel Powell, Founder of Spark Biomedical. Daniel shares his journey from consulting into more than two decades in neuromodulation, with experience across spinal cord stimulation, DBS, vagus nerve stimulation, and non-invasive auricular neurostimulation. This is a practical conversation about building clinically validated neurotechnology and taking one platform into multiple high-need areas. We explore Spark Biomedical’s work across opioid withdrawal, surgical blood loss, and women’s health, as well as the challenges of reimbursement, clinical evidence, form factor, and scaling wearable neuromodulation into real-world care.Key takeaways:🔹 How Spark Biomedical is using auricular neurostimulation across multiple clinical applications🔹 Why opioid withdrawal is a powerful but commercially challenging indication🔹 How the “neural tourniquet” could help reduce blood loss in surgery and trauma🔹 Why OhmBody is applying neurostimulation to heavy menstrual bleeding and women’s health🔹 Why clinical evidence matters as wearable neurotechnology becomes more accessibleHost: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Daniel PowellFounder, Spark Biomedical IncLinkedIn: https://www.linkedin.com/in/daniel-powell-a377055/The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, operators, and industry leaders building what comes next in brain health, medicine, and technology.If you enjoyed this episode, please subscribe, leave a review, and share it with someone interested in the future of neurotechnology.Sponsor:This episode is sponsored by Reccy Neuro — the home of neurotech. Jobs, companies, investors, events, Cortex industry intelligence, and specialist resources for the neurotech market.
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  Personalised Neuromodulation for Alzheimer’s with Ken Mariash 02.07.2026 36мин

  In this episode of The Open Loop, Chay Carter is joined by Ken Mariash, CEO of Sinaptica Therapeutics.Ken shares how Sinaptica is developing a non-invasive, personalised neuromodulation therapy designed to slow the progression of Alzheimer’s disease by targeting the brain networks involved in memory.This is a practical conversation about moving beyond amyloid-only thinking and looking at Alzheimer’s as a disease of network dysfunction.We also explore Ken’s background in medtech, biopharma, and neuromodulation, as well as Sinaptica’s Phase 2 data, pivotal trial plans, reimbursement strategy, and vision for biomarker-led Alzheimer’s care.Key takeaways:🔹 Why Alzheimer’s may need to be understood as a disease of network dysfunction🔹 How Sinaptica is combining TMS and EEG to personalise neuromodulation🔹 Why traditional TMS can be limited by targeting and dosing uncertainty🔹 How biomarker-led therapy could help clinicians understand whether treatment is working🔹 Why non-invasive, personalised brain stimulation could become part of the future Alzheimer’s treatment pathwayGuest: Ken MariashCEO of Sinaptica TherapeuticsLinkedIn: https://www.linkedin.com/in/kenmariash/Host: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, and operators building what comes next in brain health, medicine, and technology.If you enjoyed this episode, please subscribe, leave a review, and share it with someone interested in the future of neurotechnology.New episodes of The Open Loop drop every week.Sponsor:This episode is sponsored by ReccyNeuro — the home of neurotech. Jobs, companies, investors, events, Cortex industry intelligence, and specialist resources for the neurotech market.Learn more about ReccyNeuro here: https://neuro.reccy.dev/
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  The Future of Audio Medicine with Laura Avonius, Founder of Audicin 24.06.2026 47мин

  In this episode of The Open Loop, Chay Carter is joined by Laura Avonius, Founder and CEO of Audicin.Laura is a Finnish entrepreneur, composer, and digital health leader building at the intersection of music, neuroscience, and nervous system regulation.She shares how her journey from behavioural science, tech, and music led to the creation of Audicin, a company developing neuroscience-based audio journeys designed to help people focus, recharge, and sleep better.This is a fascinating conversation about audio medicine, binaural beats, brain entrainment, and the challenge of building evidence-based products in a market crowded with overclaiming and questionable content.We explore how sound can influence brainwave states, why the listening experience matters, how Audicin is approaching sleep and daytime regulation, and why the future of neurotech may depend on giving people real help, not just more measurement.Key takeaways:🔹 How Audicin is using neuroscience-based audio to support focus, relaxation, and sleep🔹 Why many binaural beat tracks online may not be what they claim to be🔹 How brain entrainment works through frequency differences between the left and right ear🔹 Why form factor matters when building sleep technology people will actually use🔹 Why neurotech products need to prioritise real-world support, not just data and measurementHost: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Laura AvoniusFounder and CEO of AudicinLinkedIn: https://www.linkedin.com/in/laura-avonius-398a8617/ Chapters:00:39 Introduction to Audicin and Audio Medicine06:34 Finding Calm in Busy Urban Life09:23 How Binaural Beats Influence Brain States12:26 The Science and Skepticism Around Binaural Beats18:37 Building the Audicin Sleep Headband21:34 Expanding Beyond Sleep into Nervous System Regulation28:21 Why People Need Help, Not Just More Measurement37:54 Audicin’s Neurotech Business Strategy and Market VisionIf you enjoyed this episode, please subscribe, leave a review, and share it with someone interested in the future of neurotechnology.New episodes of The Open Loop drop every Wednesday, with conversations featuring the founders, researchers, operators, and industry leaders shaping what comes next in brain health, medicine, and technology.Sponsor:This episode is sponsored by Reccy Neuro — the home of neurotech. Jobs, companies, investors, events, Cortex industry intelligence, and specialist resources for the neurotech market.
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  The Future of CSF Modulation with Pharaoh Neuro 17.06.2026 25мин

  In this episode of The Open Loop, Chay Carter is joined by Dr Nandan Lad and Amaza Reitmeier, the executive leaders behind Pharaoh Neuro.Nandan is a neurosurgeon at Duke and the inventor behind Neurapheresis, while Amaza brings nearly 25 years of leadership experience from Medtronic, including deep experience in brain therapies and DBS.This is a practical conversation about Pharaoh Neuro’s mission to create a new category in brain care: CSF modulation, or what Nandan describes as “neurodialysis”.We explore how Neurapheresis could change the treatment pathway for subarachnoid haemorrhage and hemorrhagic stroke by actively filtering cerebrospinal fluid, removing blood and inflammatory material, and helping reduce devastating downstream complications.We also discuss the company’s clinical data, Series A raise, regulatory pathway, reimbursement strategy, and the broader platform potential across neuroinflammatory conditions.Key takeaways:🔹 Why hemorrhagic stroke remains a major unmet need in brain care🔹 How Neurapheresis works as a closed-loop CSF filtration system🔹 Why Pharaoh Neuro is building a new therapeutic category, not just a device🔹 What early clinical studies showed in blood and protein clearance🔹 How CSF modulation could expand into meningitis, ALS, MS, leptomeningeal disease, and other neuroinflammatory conditionsHost: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Amaza ReitmeierCEO & Director, Pharaoh NeuroLinkedIn: https://www.linkedin.com/in/amaza-reitmeier/ Guest: Nandan LadChief Medical Officer & Co-Founder​LinkedIn: https://www.linkedin.com/in/nandan-lad-6262805/ Key Chapters:00:00 Introduction to Pharaoh Neuro and Its Founders02:39 The Origin Story of Neurapheresis05:27 How Neurapheresis and CSF Modulation Work10:20 Clinical Validation and Early Patient Results13:31 Regulatory Pathways and Creating a New Category15:25 Platform Potential Beyond Hemorrhagic Stroke20:18 Pharaoh Neuro and the Broader Neurotech Landscape23:36 Restoring CSF Balance and What Comes NextThe Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, and operators building what comes next in brain health, medicine, and technology.
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  Building a Nervous System OS with Anoop Antony 10.06.2026 31мин

  In this episode of The Open Loop, Chay Carter is joined by Anoop Antony, Founder and CEO of NeuroX.Anoop shares his journey from psychology and cognitive neuroscience into EEG, brain health, neurofeedback, photobiomodulation, and wearable neurotechnology.This is a practical conversation about making brain health more accessible, understandable, and useful outside traditional clinical and research settings.We explore how NeuroX is combining EEG, HRV, wearable data, and clinical services to build a more complete view of the nervous system, from brain scans and neurofeedback to in-ear EEG and the NEVE platform.We also discuss the future of EEG wearables, why form factor matters, how brain data could support elite performance and everyday cognitive health, and what it takes to communicate neurotechnology to people outside the neuroscience bubble.Key takeaways:🔹 Why EEG is moving beyond hospitals and research labs🔹 How NeuroX is building a nervous system dashboard combining brain and body data🔹 Why in-ear EEG could help make brain monitoring more wearable and accessible🔹 How neurofeedback and photobiomodulation are being used in brain health clinics🔹 Why translating brain data into simple, actionable insights is key to public adoptionHost: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Anoop AntonyFounder and CEO of NeuroXLinkedIn: https://www.linkedin.com/in/anoop-antony-529a72181/ Key Chapters:00:00 Introduction to NeuroX and Anoop Antony03:46 The Evolution of EEG Technology06:32 NeuroX’s Vision for Accessible Brain Health09:09 In-Ear EEG and Wearable Brain Monitoring12:14 Neurofeedback and Photobiomodulation14:54 Who Is Using Brain Health Technology?17:48 Communicating Neurotechnology Beyond the Science Bubble23:31 Product Roadmap and the Future of NeuroXThe Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, and operators building what comes next in brain health, medicine, and technology.
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  The Future of Neurotech Investing with Jordi Parramon 01.06.2026 36мин

  In this episode of The Open Loop, Chay Carter is joined by Jordi Parramon, a neurotechnology operator, investor, and founder of Nexus NeuroTech Ventures. Jordi brings more than 27 years of experience across medical devices, health tech, and venture, with leadership roles spanning Boston Scientific, Verily, and a portfolio of neurotech companies including Cala Health, INSIGHTEC, Rune Labs, Lotus Neuro, and Galvani. This is a practical conversation about what neurotech needs next, from patient access and indication expansion to reimbursement, market access, consumer devices, and smarter investment thinking. We also explore Jordi’s perspective on the future of neuromodulation, brain data, wearable technologies, BCI, focused ultrasound, and why the next phase of the industry will depend on connecting innovation across the full patient journey. Key takeaways: 🔹 Why neurotech still needs to solve its patient access and penetration problem🔹 How consumer and regulated devices could work together across the healthcare journey🔹 What early-stage neurotech investors look for beyond financial modelling🔹 Why reimbursement and market access are becoming central to funding and M&A🔹 Where Jordi sees the next major opportunities in neuromodulation and neuropsychiatric care Host:Chay CarterFounder, Carter SciencesCo-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest:Jordi ParramonNeurotechnology investor, operator, and founder of Nexus NeuroTech VenturesLinkedIn: https://www.linkedin.com/in/jordi-parramon-50b2158/ Key Chapters:00:00 Introduction to Jordi Parramon01:16 From Implantable Devices to Neurotech Investment04:28 M&A, Platforms, and Early Neuromodulation Innovation08:57 Patient Access and Indication Diversification11:19 Wearables, Consumer Devices, and Neurohealth16:43 EEG, Brain Data, and the Future of Digital Health18:05 What Investors Look for in Neurotech28:22 Emerging Opportunities and the Future of Neuromodulation The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology. 🔔 Subscribe for weekly conversations with the founders, researchers, and operators building what comes next in brain health, medicine, and technology.
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  Inside the Tivic Health Journey with Jennifer Ernst 01.06.2026 38мин

  In this episode of The Open Loop, Chay Carter is joined by Jennifer Ernst, founder and former CEO of Tivic Health (now Valion Bio). Jennifer shares the story behind Tivic’s journey, from consumer bioelectronics and non-invasive stimulation to FDA clearance, retail launch, IPO, supply chain disruption, and a major pivot into biopharma. This is a practical conversation about the rollercoaster journey of building regulated consumer neurotechnology, bringing a new category to market, and navigating the strategic decisions founders face when timing, capital, and market conditions change. We also look ahead to the future of bioelectronic medicine, including peripheral nerve stimulation, AI-native company building, and how electrical and pharmaceutical approaches could eventually work together. Key takeaways: 🔹 Why “going consumer” is not always the easier route for neurotech companies🔹 What founders need to understand about category creation, claims, and customer acquisition🔹 How Tivic navigated FDA clearance, retail launch, IPO, and supply chain disruption🔹 Why remote monitoring, reimbursement, and physician incentives matter for device adoption🔹 How AI, peripheral nerve stimulation, and bioelectronic medicine could shape the next phase of neurotech Host:Chay CarterFounder, Carter SciencesCo-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest:Jennifer ErnstFounder and former CEO of Tivic Health (now Valion Bio)LinkedIn: https://www.linkedin.com/in/jenniferernst/ Key Chapters: 00:00 Introduction to Jennifer Ernst and Tivik Health03:28 The Journey into Bioelectronics and Neurotechnology07:01 Consumer Market Challenges in Neurotechnology10:02 Navigating the IPO Process and Supply Chain Issues14:01 Lessons Learned from the Tivik Experience17:39 The Future of Neurotechnology and AI Integration23:09 Vagus Nerve Stimulation and Its Potential28:51 Transitioning to Biopharmaceuticals and Future Directions The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.
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  How Brainomix Is Bringing AI Into Stroke and Lung Care 27.05.2026 38мин

  In this episode of The Open Loop, Chay Carter is joined by Dr George Harston, Chief Medical and Innovation Officer at Brainomix. George shares how Brainomix is building clinical AI software to support treatment decisions in stroke and fibrosing lung disease, helping clinicians extract meaningful information from medical scans and use it in time-critical patient pathways. This is a practical conversation about what it takes to move healthcare AI from algorithm performance into real clinical adoption. We explore why AI is only valuable when it integrates into workflows, supports clinician decision-making, and improves patient outcomes. We also discuss Brainomix’s journey from Oxford spinout to NHS adoption, Series C growth, and US expansion, as well as the company’s work with hospitals, pharma partners, and clinical trials. Key takeaways: 🔹 Why stroke care depends on faster identification and treatment decisions🔹 Why clinical AI needs workflow integration, not just strong algorithms🔹 How Brainomix is applying imaging AI across stroke and fibrosing lung disease🔹 What it takes to drive adoption across hospitals, healthcare systems, and the US market🔹 Why the future of healthcare AI will depend on evidence, implementation, and patient impact Host:Chay CarterFounder, Carter SciencesCo-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest:Dr. George HarstonChief Medical and Innovation Officer at BrainomixLinkedIn: https://www.linkedin.com/in/george-harston-3b9496b1/Key Chapters:00:00 Introduction to Brainomix and Dr George Harston04:01 From Stroke Medicine to Clinical AI06:54 Why AI Needs to Fit the Clinical Workflow12:30 How Imaging AI Can Improve Patient Outcomes18:25 Expanding AI Support into Fibrosing Lung Disease24:19 Navigating US Healthcare, Reimbursement, and Adoption30:09 The Future of Stroke Treatment and Clinical AI36:23 Brain Data, Personalised Medicine, and What Comes Next The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.
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  Restoring Memory with BCIs - Dan Rizzuto 20.05.2026 27мин

  In this episode of The Open Loop, Chay Carter is joined by Dan Rizzuto, President and CTO at Nia Therapeutics. Dan shares how Nia is developing a closed-loop neurostimulation system designed to help patients with memory loss, combining implantable sensing, machine learning, wearable components, and personalised stimulation. This is a practical conversation about the future of cognitive BCIs, what it takes to move neurotechnology from academic research into clinical development, and why memory restoration could become one of the most important frontiers in the field. We also explore Nia’s FDA Breakthrough Device Designation for TBI-related memory loss, the evolution of BCI over the last 20 years, the reality behind cognitive enhancement hype, and why efficacy matters more than form factor when building neurotechnology for patients. Key takeaways: 🔹 How Nia Therapeutics is developing closed-loop neurostimulation for memory loss🔹 Why cognitive BCIs could become a major new category in neurotechnology🔹 What FDA Breakthrough Device Designation means for clinical development🔹 Why direct-to-consumer cognitive enhancement still needs stronger evidence🔹 How the neurotech field is evolving from research breakthroughs to real patient impactHost:Chay CarterFounder, Carter SciencesCo-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/Guest:Dr. Dan RizzutoPresident and Chief Technology Officer at Nia TherapeuticsLinkedIn: https://www.linkedin.com/in/rizzuto/Key Chapters:00:00 Introduction to Dan Rizzuto and Nia Therapeutics02:23 Closed-Loop Neurostimulation for Memory Loss05:09 From Motor BCIs to Cognitive Applications09:40 How Nia’s Implantable and Wearable System Works12:00 Cognitive Enhancement, Ethics, and Future Possibilities14:09 FDA Breakthrough Device Designation and Regulatory Pathways16:18 Fundraising, Clinical Trials, and What Comes Next21:22 Emerging Modalities, Brain Data, and the Future of Neurotech The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.
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  The Future of Brain Medicine with Owen Muir 13.05.2026 56мин

  In the first episode of The Open Loop, Chay Carter, Founder of Carter Sciences and Reccy Neuro is joined by Dr. Owen Scott Muir, Interventional Psychiatrist, Co-founder & Chief Medical Officer at Radial. Owen shares his personal journey through bipolar disorder, his experience as a clinical trial participant, and how those experiences shaped his mission to build the future of “brain medicine”. This is a wide-ranging conversation on transcranial magnetic stimulation (TMS), neurotechnology, AI biomarkers, precision psychiatry, and what it really takes to scale brain-based treatments in the real world. We also explore the future of neuromodulation, patient-centred care, and why Owen believes psychiatry is evolving into a much broader field of brain medicine. Key takeaways: 🔸 How Owen’s personal experience with bipolar disorder led him into neurotechnology🔸 Why TMS changed his view of mental health treatment🔸 How AI biomarkers could help predict which treatments work for patients🔸 Why Owen believes “mental health” should be reframed as “brain medicine”🔸 What it takes to scale patient-centred neurotechnology in the real world Host:Chay CarterFounder, Carter SciencesCo-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest:Dr. Owen Scott Muir MD, DFAACAPInterventional PsychiatristCo-founder & Chief Medical OfficerLinkedIn: https://www.linkedin.com/in/owen-muir-md-dfaacap-fctmss-53345b7/ Key Chapters:00:00 Introduction to Dr. Owen Scott Muir02:21 Personal Journey and Mental Health Experiences05:57 Clinical Trials and the Future of Mental Health Treatment09:49 Understanding Transcranial Magnetic Stimulation (TMS)13:06 The Evolution of TMS Treatments26:57 AI Biomarkers and Precision Psychiatry35:58 Building a Patient-Centric Brain Medicine Company46:22 The Future of Neurotechnology and Brain Medicine The Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology. 🔔 Subscribe for more conversations with the founders, researchers, and operators building the future of brain medicine. #Neurotechnology #Neurotech #BrainMedicine #TMS #Neuromodulation #MentalHealth #PrecisionPsychiatry #AIHealthcare #BrainComputerInterface #Neuroscience #HealthcareInnovation #ClinicalResearch #DigitalHealth #TheOpenLoop #LifeScience #Podcast