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  Dr Robert Kushner on GLP-1s, appetite biology and coming off the drug 16.09.2026 1ч 11мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzEpisode SummaryThis week Mikki talks with Dr Robert Kushner, an obesity medicine physician, educator and researcher with over four decades in the field. He is Professor Emeritus at Northwestern University Feinberg School of Medicine, a founder and the first chair of the American Board of Obesity Medicine, and a past president of The Obesity Society. He was also the corresponding author on the STEP 1 semaglutide trial published in the New England Journal of Medicine in 2021, and sat on the steering committee for SELECT — so he has watched this field from the inside, before and after GLP-1 receptor agonists arrived.The conversation traces what clinicians actually understood about obesity in the 1980s and 90s, Bob's own leptin trial and why it did not deliver, and how reframing obesity as a biological disease led researchers to the gut hormones. From there it moves into the practical territory: how the clinical conversation has shifted from counting calories to diet quality, which side effects are real and which are social media noise, what happens to muscle mass and physical function, how dose escalation should actually work, why hunger returning is not the same as weight regain, and what the evidence says about stopping. Bob is careful throughout to separate what the trials show from what is still unknown, which makes this a useful listen whether you work with clients on these medications or are weighing them up yourself.Key TopicsWhat clinicians believed about obesity three decades ago — excess body fat was known to cause system-wide harm, but the mechanisms, and appetite dysregulation in particular, were not understood, and weight regain after lifestyle intervention was already expectedBob's own leptin trial in the 1990s, published in JAMA, and why leptin turned out to be a useful biological signal rather than a treatment — it defends against weight loss but was never built to stop overeatingThe STEP 1 result and why it changed the field: 15% average weight loss at 68 weeks against a previous benchmark of 6–9%, with a third of participants losing 20%How the clinical conversation shifted from quantity to quality — when the medication does the heavy lifting, the questions become whether someone is eating enough, staying hydrated and getting sufficient protein, rather than how to control cravingsWhich side effects are real and which are overstated: GI effects are the genuine shared profile and can be substantially reduced through diet during dose escalation, while hair thinning and facial fat loss follow large weight loss by any routeMuscle mass, sarcopenia and the groups who need watching, alongside the consistent finding that physical function and quality of life improve in trials — possibly because fatty infiltration of muscle resolvesDose escalation in the real world versus the trial protocol, and why there are still no pretreatment predictors of who will respondWhy appetite drifting back is normal and not a failure — Bob's framing of restored appetite regulation at a lower body weight, with "the amplitude smaller than it was before"Benefits beyond weight loss, including SELECT's 20% reduction in cardiovascular events on top of standard care, plus sleep apnoea, knee osteoarthritis, MASH and psoriasis — driven both by weight loss and by independent mechanismsCost and access, microdosing, extending the interval between injections, and where bariatric surgery still fitsChapters00:00 Introduction05:13 Obesity medicine before GLP-1s13:34 Gut hormones and the STEP 1 result21:00 From calorie counting to diet quality25:00 Side effects and social media myths29:54 Muscle mass, function and exercise35:08 Dose escalation and who responds40:30 When hunger comes back46:37 Stopping the drug, cost and access52:24 Benefits beyond weight loss57:37 Long-term safety and microdosing1:01:10 Coming off, surgery and what's nextGuest / ResourcesDr Robert KushnerProfessor Emeritus, Northwestern University Feinberg School of MedicineFounder and first chair of the American Board of Obesity MedicinePast president of The Obesity SocietyAuthor or editor of 15 books, 56 book chapters and 230 original and review articlesWebsite: drrobertkushner.comBooksSix Factors to Fit: Weight Loss that Works for You! — written for the patientPatient-Centered Weight Management: The Six Factor Professional Program and Toolkit — written for the clinicianTrials and studies discussedSTEP 1 — once-weekly subcutaneous semaglutide, New England Journal of Medicine, 2021. 1,961 adults, 68 weeks, ~15% average weight loss. Bob was the corresponding authorSTEP 1 extension — the off-treatment follow-up showing weight regain after stoppingSELECT — semaglutide versus placebo in 17,000 people with obesity or overweight and pre-existing cardiovascular disease but no diabetes, over nearly four years. A 20% reduction in second heart attack, stroke or cardiovascular death, on top of standard care. Bob sat on the steering committeeSURMOUNT-1 extension — participants with pre-diabetes maintained on treatment for three years, with weight remaining stableLook AHEAD — an intensive behavioural therapy trial in diabetes; of those who lost 10% of body weight, around 40% maintained it for about four years without medicationKushner's leptin trial (1990s) — placebo versus leptin injections, published in JAMAA tirzepatide dose-reduction study — 15mg reduced to 5mg, with partial weight regainA randomised microdosing study in people with diabetes — standard monthly dose escalation versus gradual weekly escalation to the same final dose, showing better tolerability and fewer dropouts. Bob refers to this study but does not name it, so it is referred-to-but-not-identifiedResearchers mentionedAndres Acosta, Mayo Clinic — phenotype and biomarker work on predicting treatment responseOrganisationsNorthwestern University Feinberg School of MedicineAmerican Board of Obesity MedicineThe Obesity SocietyObesity Action CoalitionNovo Nordisk — the sponsor of STEP 1Mayo ClinicMedications and hormones discussed GLP-1 receptor agonists; semaglutide; liraglutide; tirzepatide; phentermine; topiramate; naltrexone; bupropion. Gut hormones: GLP-1, GIP, glucagon, amylin. Also leptin, insulin, statins, beta blockers, testosterone and oestrogen.Terms that come up Appetite dysregulation; food noise; leptin resistance; medu...
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  A Normal HbA1c Can Hide a Decade of Insulin Resistance 14.09.2026 22мин

  Episode SummaryHbA1c turns up on almost every routine blood panel, and in this Monday mini episode Mikki looks at how much it can genuinely tell you. She starts with the physiology — haemoglobin picks up glucose non-enzymatically, red cells live 100 to 120 days, and the result is a weighted average of glucose exposure that leans heavily on the most recent month. That matters more than it first appears, because anything that shortens or lengthens red cell lifespan moves the number without blood glucose changing at all. Iron deficiency, heavy menstrual bleeding, foot strike haemolysis in runners, thalassaemia and sickle trait, recent blood donation and B12 deficiency can each push a result in one direction or the other.From there Mikki works through the research-based critiques: insulin resistance and beta cell decline can precede an abnormal HbA1c by many years, the test is highly specific but only about 50 per cent sensitive against an oral glucose tolerance test, an average conceals the shape of the glucose curve, and both genetics and ordinary measurement noise move the number independently of glucose. She closes on the practical side — where HbA1c does earn its place, why she still thinks a result of 40 or 41 deserves a conversation with your doctor, and which markers are worth reading alongside it.Key TopicsWhat HbA1c actually measures. Glycation is non-enzymatic with no regulatory brake, so it proceeds in proportion to how much glucose is around and how long the cell is exposed. A red cell cannot repair it, making it a passive record of the preceding 8 to 12 weeks.The "three-month average" is weighted, not even. About 50 per cent of the movement toward a new value happens in the first month, which is why a result can shift over six weeks.Falsely low results. Haemolysis of any cause, haemoglobinopathies such as sickle trait and thalassaemia trait, ongoing blood loss, blood donation, recent transfusion, advanced liver disease, and starting iron treatment in someone iron deficient.Falsely high results. Untreated iron deficiency anaemia, B12 and folate deficiency, splenectomy or functional asplenia, and aplastic anaemia.Athletes get it from both directions. Foot strike haemolysis lowers A1c relative to true glucose exposure, while the iron deficiency common in female athletes raises it — and the two distortions can partly cancel out, so the number alone will not tell you which is happening.Correcting iron can drop A1c without any dietary change. Mikki's worked example is a woman going from 42 to 37 mmol/mol once her iron is sorted, and her concern is that the change gets credited to a nutrition intervention she never needed.The cut-offs, in New Zealand and US units. Roughly 30 to 39 mmol/mol normal, 41 mmol/mol pre-diabetes and 50 mmol/mol diabetes locally, against WHO and ADA thresholds of 42 and 48 mmol/mol. Type 2 diabetes throughout, not type 1.HbA1c is a lagging signal. Insulin markers can diverge from controls up to 20 years before diagnosis, and beta cell function is already down around 50 per cent by the time someone meets diagnostic criteria — so a normal HbA1c is compatible with a long stretch of compensated insulin resistance.Specific but not sensitive. Against an oral glucose tolerance test, sensitivity of about 50 per cent with specificity around 97 per cent, and screening work in which the HbA1c criteria missed a large majority of pre-diabetes.What to read alongside it. Fasting glucose, ideally fasting insulin, waist-to-height ratio, triglyceride-to-HDL ratio and a fasted lipid panel — plus your own historic trend rather than the population cut-off.Chapters00:00 How HbA1c works and what distorts it03:41 Athletes, foot strike haemolysis and iron06:23 New Zealand and US cut-offs08:40 Why HbA1c lags insulin resistance12:12 Averages, genetics and measurement noise15:41 Your own trend, and ethnic differences18:41 Where HbA1c earns its place21:31 Sign-off and new recipesGuest / ResourcesSolo episode — no guest.Referenced in the episodeWorld Health Organization — pre-diabetes around 42 mmol/mol (6%), diabetes at 48 mmol/mol (6.5%)American Diabetes Association — diabetes at 48 mmol/mol (6.5%)Mikki discusses findings from a number of published studies through the episode. They are described in the audio rather than cited by name, so no reference list is given here.Tests and markers discussedHbA1c · fasting glucose · fasting insulin · oral glucose tolerance test · continuous glucose monitor · HOMA2-IR · HOMA2-B · ferritin · fasted lipid panel · triglyceride-to-HDL ratio · waist-to-height ratioFind MikkiInstagram, Threads and X — Mikki WillidenFacebook — Mikki Williden NutritionWebsite — mikkiwilliden.com — one-on-one calls and the recipe portal Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  What Are Trainers For in the GLP-1 Era? with Dr Eric Helms 09.09.2026 1ч

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comEpisode SummaryDr Eric Helms returns to Mikkipedia for an unscripted conversation about GLP-1 medications and what they mean for anyone working in nutrition and fitness. Eric is a coach, athlete, author and educator, part of the 3DMJ coaching team, co-founder of the MASS research review, and co-director of the Sports Performance Research Institute New Zealand (SPRINZ) at AUT, where he is also a senior research fellow. Mikki opens with a personal trainer who was accused of stepping outside her lane for talking about GLP-1s, and the two of them work outwards from there.The conversation covers whether coaches and nutritionists are within their scope supporting people on these medications, what obesity medicine can miss when a patient's weight loss stalls, and why reduced everyday movement belongs under the heading of metabolic adaptation rather than being treated as a separate problem. Eric separates appetite into distinct drivers — energy signalling, hedonic food seeking and food noise — and explains why that distinction matters clinically. The second half turns to protein, where Eric makes the case that it is a minor player for most people's health outcomes unless intake is genuinely low, and that "which macronutrient is most satiating" is the wrong question in the first place. He is candid throughout about the limits of what is currently known, including several things he says he cannot answer. The episode closes on his argument that trainers have an opportunity to stop being weight loss coaches and get back to promoting health, fitness and movement.Key TopicsScope of practice. Eric argues the behavioural, lifestyle, nutrition and exercise side of GLP-1 use is squarely within a personal trainer's remit — while cautioning that nobody yet has the twenty years of practitioner experience we have with medications like exogenous insulin.Where the usual trainer skill set doesn't transfer. Most trainers are practised at helping clients restrain appetite. Clients on GLP-1s often have the opposite problem: struggling to eat enough, and needing nutrient quality raised on a low intake.What a stall actually signals. When someone stops tracking calories and their weight loss plateaus, Eric's first read is not under-fuelling — it is that tracking had become tedious and unsustainable, and no second skill set has replaced it. He treats the stall as an opportunity to build other skills rather than a reason to resume tracking.Movement, NEAT and metabolic adaptation. Reductions in spontaneous physical activity and non-exercise activity thermogenesis come from the same mechanisms as the older, narrower idea of a falling metabolic rate. Eric's view is that most of the "side effects" attributed to these drugs are the side effects of successful weight loss.Appetite is not one thing. Eric separates energy signalling (feeling depleted), hedonic food seeking (actively wanting a particular food or experience) and food noise (constant, distracting preoccupation) — then notes satiety has several definitions of its own on top of that.Why near-universal drug response is interesting. In trials of a newer triple-agonist medication, every participant in the higher dose groups lost at least 5–10% of body weight. Eric speculates — and flags it clearly as speculation — that this implies the drug targets more than food noise alone.How much protein actually matters. Eric's position is that protein is a minor player for general population health outcomes unless someone is starting low. Moving from around 0.8–1.1 g/kg to 1.3–1.5 g/kg has a reasonably moderate effect; moving from 1.6 to 2.2 g/kg is minor outside physique sport, where it is "a game of inches".Meeting people where they are. Someone on an intermittent eating pattern may be reaching only 1.1 g/kg, and a poorly constructed plant-based diet 0.9 g/kg. Telling them to double it can read as an impossible barrier. Mikki describes targeting 1.2 g/kg for GLP-1 clients against the 1.8–2.2 g/kg circulating online.Satiety is a meal question, not a macronutrient question. Food weight and volume, texture, hardness, eating rate, energy density, fibre and fluid all matter, and Eric raises an open question he says he cannot answer: whether those levers become more effective in someone on a GLP-1 once the environmental drivers of overeating are suppressed.What trainers are for. Eric suggests fear of professional redundancy drives some anti-GLP-1 feeling in the industry, argues obesity is primarily a built-environment problem needing a societal-scale solution, and makes the case that trainers should return to promoting health, fitness and movement.Chapters00:00 Introduction03:36 No small talk and no script06:59 Are trainers in their lane on GLP-1s?12:17 Low carb pushback and the naturalistic fallacy14:38 When weight loss stalls21:18 Reduced movement, NEAT and metabolic adaptation24:36 Food noise, hedonic eating and appetite29:36 What personal trainers are actually for32:31 Bodybuilding, diet culture and physical culture38:55 How much protein do we really need?46:36 What actually drives satiety55:57 Where to find EricGuest / ResourcesDr Eric HelmsCoach, athlete, author and educator; a personal trainer since the early 2000s, with a background in the US Air Force and commercial gyms.Part of 3DMJ, coaching drug-free strength and physique competitors.Co-founder of the MASS research review (Monthly Applications in Strength Sport), produced with Dr Eric Trexler, Dr Lauren Colenso-Semple and Dr Michael Zourdos, running since 2017 — massresearchreview.comCo-director of the Sports Performance Research Institute New Zealand (SPRINZ) at AUT, and a senior research fellow supervising Masters and PhD students.Instagram: @Helms3DMJCo-host of the Iron Culture podcast.Also mentionedMikkipedia episode 390 — "Living the Bodybuilding Lifestyle with Eric Helms", the previous conversation Mikki refers to: podcast.mikkiwilliden.com/390Docs Who Lift — the podcast from Dr Spencer Nadolsky and Dr Karl Nadolsky, recommended by Eric.Barbell Medicine — Dr Austin Baraki and Dr Jordan Feigenbaum, recommended by Eric for their work on HRT, testosterone replacement therapy and GLP-1 medications.The protein leverage hypothesis — the idea that people keep eating until they reach a protein threshold; Eric notes that threshold sits around 12–13% of energy.The Minnesota semi-starvation study — referenced by Eric as background on the transient, biologically driven effects of dieting.The physical culture movement of the early 1900s, and Bernarr Macfadden as a figure within it.A recent conference abstract indicating people on GLP-1s may be less active than they ...
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  Is It Emotional Eating, or Are You Just Under-Fuelled? 07.09.2026 20мин

  Episode SummaryThis is a solo Mini Mikkipedia on emotional eating, prompted by a practitioner who asked Mikki how to help a client who describes herself as a lifelong emotional eater — someone who eats when she is stressed, eats when the day has been long and she finally sits down, and has tried everything she has read about without anything sticking. Rather than going straight to coping strategies, Mikki starts by asking whether it is emotional eating at all.The answer she gives is careful. Emotional eating is measured by questionnaires like the Dutch Eating Behaviour Questionnaire and the Emotional Eating Scale, but when high scorers are put in a lab under a genuinely induced negative mood, they largely do not eat more than anyone else — and the group that reliably does eat more is restrained eaters, meaning dieters. That does not make emotional eating imaginary: it shows up consistently in clinical binge eating, and phone-based sampling in ordinary life does show boredom, stress and low mood preceding craving. Mikki's position is that someone calling themselves an emotional eater is describing something real but may have the mechanism wrong. A large share of it, she argues, is under-fuelling, chaotic eating and under-sleeping with an emotional trigger sitting on top — so the mechanical causes come first, and only what survives that audit is worth treating as an emotional problem. The second half is practical: regular eating structure, tracking the trigger rather than the food, one if-then plan, affect labelling, and letting a self-limiting urge pass. Useful if you work with clients who use this label about themselves, or you use it about yourself.Key TopicsWhy the emotional eating questionnaires may not measure what they claim — high scorers largely do not eat more than anyone else when negative mood is genuinely induced in a lab, and across a meta-analysis of 56 experimental studies in nearly 3,700 participants the group who reliably ate more were dieters, not self-identified emotional eatersWhere emotional eating does hold up: clinical binge eating, and real-life phone sampling showing boredom, stress and low mood preceding cravingRestraint as a driver — attempted restriction predicting the next loss-of-control episode better than actual restriction did, and why the attempt matters more than the achieved deficitThe mechanical audit to run first: enough food earlier in the day, protein at each meal, satiety signals like volume, speed, texture and flavour, long gaps without eating, and sleepHow sleep restriction raises ghrelin, lowers leptin and shifts brain activity away from the frontal and insular regions towards the amygdala — and why someone on six hours of sleep presents identically to an emotional eater but needs a different interventionThe two patterns worth distinguishing: clock-locked eating that goes sideways between five and ten at night regardless of the day, and situation-locked eating that tracks events insteadWhy a regular eating structure removes the physiological amplifier and makes the emotional signal visibleTracking the trigger rather than the food for two weeks, why most people find their triggers far narrower than they assumed, and why an if-then plan works better when it adds a behaviour than when it removes oneAffect labelling, and urges being self-limiting — rising, peaking and falling within about 10 to 20 minutes whether or not you act on themSelf-criticism after an episode reliably predicting more eating, and self-compassion tested as the alternativeChapters00:00 Introduction and the emotional eating label04:00 Ruling out under-fuelling and sleep06:59 Clock-locked versus situation-locked eating09:52 Building a regular eating structure11:55 Tracking the trigger and if-then plans14:09 Affect labelling and riding out the urge16:27 Self-compassion and when to refer on18:33 Recap and closeQuestionnaires discussedDutch Eating Behaviour Questionnaire (DEBQ) — van Strien, T., Frijters, J. E. R., Bergers, G. P. A., & Defares, P. B. (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders, 5(2), 295–315.Emotional Eating Scale (EES) — Arnow, B., Kenardy, J., & Agras, W. S. (1995). The Emotional Eating Scale: the development of a measure to assess coping with negative affect by eating. International Journal of Eating Disorders, 18(1), 79–90.Studies and research discussedReferenced in the order they come up in the episode. Mikki describes each by its finding rather than by citation, so these have been identified afterwards and matched on population, design and reported numbers.Whether the emotional eating scales measure what they claim (01:36, 02:19) — Bongers, P., & Jansen, A. (2016). Emotional eating is not what you think it is and emotional eating scales do not measure what you think they measure. Frontiers in Psychology, 7, 1932. Concludes the scales lack predictive and discriminative validity, and may instead capture how people think about the relationship between mood and eating rather than what they actually eat.The meta-analysis of 56 experimental studies (02:35, 03:12) — Evers, C., Dingemans, A., Junghans, A. F., & Boevé, A. (2018). Feeling bad or feeling good, does emotion affect your consumption of food? A meta-analysis of the experimental evidence. Neuroscience & Biobehavioral Reviews, 92, 195–208. Fifty-six experimental studies, 3,670 participants. Negative emotion increased eating in restrained eaters; it did not increase eating in people with overweight or obesity, in people with eating disorders, or in self-assessed emotional eaters.Attempted restraint versus actual restriction (04:20) — Manasse, S. M., et al. (2023). Differentiating types of dietary restraint and their momentary relations with loss-of-control eating. International Journal of Eating Disorders, 56(4). Ecological momentary assessment over 7–14 days in 96 adults with binge-spectrum eating disorders.Brain imaging after sleep deprivation (05:38) — Greer, S. M., Goldstein, A. N., & Walker, M. P. (2013). The impact of sleep deprivation on food desire in the human brain. Nature Communications, 4, 2259. Reduced activity in frontal and insular evaluation regions alongside amplified amygdala activity, with increased desire for high-calorie food tracking the subjective severity of sleep loss.The single night of sleep curtailment (06:06) — Yang, C.-L., Schnepp, J., & Tucker, R. M. (2019). Increased hunger, food cravings, food reward, and portion size selection after sleep curtailment in women without obesity. Nutrients, 11(3), 663. Habitual seven-to-nine-hour sleepers, time in bed cut by a third for one night; more hunger and cravings, more chocolate consumed on a progressive ratio task, and larger self-selected lunch portions.Affect and craving in daily life (08:34) — Aulbach, M. B., Bamberg, C., Reichenberger, J., Arend, A.-K., & Blechert, J. (2025). Bidirectional associations between affect and food craving within and between individuals: A mega-analysis. Appetite, 209, 107936. Eight pooled ecological momentary assessment studies, 764 participants, four to six daily questionnaires over 7–20 days. Negative momentary states were associated with more craving at the same moment; the mega-analysis did not find a sign...
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  Why Fat Loss Gets Harder in Menopause with Dr. Bill Campbell 02.09.2026 57мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzIn this episode of Mikkipedia, Mikki speaks with returning guest Dr Bill Campbell, professor of exercise science and leading body composition researcher, about the emerging question of weight loss resistance during perimenopause and menopause. Bill shares how his wife’s own experience prompted him to investigate why previously effective calorie deficits may produce very different results during the menopause transition.They discuss the limits of existing fat-loss research, why tracking accuracy still matters, and Bill’s current study comparing weight-loss responses in premenopausal versus peri- and early postmenopausal women. Bill also unpacks his fascinating case series using an extremely aggressive four-day, high-protein fat-loss protocol, where resistance-trained women lost fat while largely maintaining lean mass—and maintained that fat loss a month later. Highlights What Bill means by “weight loss resistance”—and why it doesn’t mean calories no longer matter  Why menopause-specific fat-loss research is still surprisingly limited  Bill’s wife’s experience with perimenopause, HRT and changing body composition  The four-day rapid fat-loss protocol: very low calories, high protein and six hours of walking daily  Why short, aggressive dieting may differ dramatically from prolonged crash dietingDr. Bill Campbell is a Professor of Exercise Science and the Director of The Performance and Physique Enhancement Lab at the University of South Florida. He has his PhD in Exercise, Nutrition, and Preventive Health, he's authored 3 books on sports nutrition and over 200 scientific abstracts and manuscripts focused on the topics of sports nutrition and exercise science and is previous president of the international society of sports nutrition.Dr Campbell uses his education background to provide an informational channel on IG that busts myths on dieting and helps inform people on best practice. Highly worth a follow.https://www.billcampbellphd.com/On IG: https://www.instagram.com/billcampbellphd/?hl=enhttps://podcast.mikkiwilliden.com/66 Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Why More Fibre Isn’t Fixing Your Constipation Still Constipated? Here’s What You Might Be Missing 31.08.2026 25мин

  Constipation is often met with the same advice: eat more fibre, drink more water and move more. But what if you’re already doing all of that and still struggling? In this Mini Mikkipedia episode, Mikki explores why constipation isn’t one single problem — and why piling on more fibre can sometimes make things worse. She breaks down the differences between slow-transit constipation, IBS-related symptoms and pelvic floor dysfunction, including dyssynergic defecation. Mikki also looks at why the type of fibre matters, the evidence for psyllium, kiwifruit, prunes and magnesium oxide, and when supplements or medications may actually be contributing to the problem. Plus, she explains the signs that suggest it may be time to look beyond nutrition and seek medical or pelvic health support.In this episode:Why more fibre can sometimes worsen bloating and constipationPsyllium versus inulin, chicory root and insoluble fibresThe overlooked role of pelvic floor dysfunction and outlet obstructionEvidence for two kiwifruit daily, prunes and magnesium oxideOther contributors including medications, supplements, thyroid function, under-eating, stress and poor sleep Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Carbs, Fat Oxidation and Finding Your Fueling Sweet Spot with Prof. Paul Laursen 26.08.2026 1ч 6мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comThis week on the podcast, Mikki speaks with Paul Laursen about the science of training, nutrition, and what it really means to take a personalised approach to athletic performance.Paul and Mikki explore metabolic flexibility, fat oxidation, carbohydrate availability, and how the way an athlete fuels can influence both training adaptations and performance. They discuss why there is rarely one nutritional strategy that works for everyone, and why individual experimentation, alongside good physiological principles, remains so important.The conversation also covers pre-training nutrition and insulin responses, carbohydrate loading, low-carbohydrate versus high-carbohydrate approaches, and how training load should influence fuelling decisions. Paul shares his perspective on the growing use of continuous glucose monitors and other personal data, including where these tools can provide useful insight and where the numbers may be easy to overinterpret.They also touch on nutrition for youth athletes, the physiological changes that occur through puberty, and why fuelling strategies need to evolve with both the athlete and the demands of their sport.It’s a wide-ranging discussion that brings together physiology, practical nutrition, and the importance of looking beyond blanket recommendations to understand what works best for the individual.Dr. Paul Laursen is a world-renowned sports scientist, endurance coach, and co-founder of Athletica AI, an innovative platform leveraging artificial intelligence to optimize endurance training. With a PhD in Exercise Physiology and years of research experience, Dr. Laursen has published extensively on topics including high-intensity interval training (HIIT), endurance performance, and sports nutrition. His work bridges the gap between cutting-edge science and practical application for athletes at all levels.Dr. Laursen has worked with elite athletes across disciplines, helping them achieve peak performance through personalized training and nutrition strategies. He’s also a passionate educator, co-authoring the influential book The Science and Application of High-Intensity Interval Training and contributing to the evolution of endurance sports practices. Known for his holistic approach, Dr. Laursen focuses on the interplay between fueling, recovery, and overall athlete health, making him a leading voice in the field of endurance sports.When he’s not advancing endurance science, Dr. Laursen is often found testing his own limits in the field as an endurance athlete, embodying the principles he teaches. His unique blend of scientific expertise and real-world experience continues to shape the way athletes train, fuel, and performhttps://podcast.mikkiwilliden.com/46https://podcast.mikkiwilliden.com/3 https://podcast.mikkiwilliden.com/330https://www.paullaursen.com/ https://athletica.ai/ https://hiitscience.com/ https://athletica.ai/podcast Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Where Did the Crunch Go? Fat Loss-Friendly Fixes 24.08.2026 11мин

  When you’re focused on fat loss, sometimes it isn’t more food you’re craving — it’s texture. In this Mini Mikkipedia episode, Mikki tackles one of the most common complaints she hears: where did all the crunch go? She shares 27 low-calorie ways to add crunch, freshness and satisfaction back into meals without relying on calorie-dense extras that can quickly eat into your budget. From cabbage, radish and sugar snap peas to crispy air-fried vegetables, pickles, sauerkraut, nori and edamame, there are plenty of options beyond crackers and nuts. Mikki also explains how preparation methods, different vegetable cuts and clever use of seasonings can completely change the eating experience — proving that a fat-loss meal doesn’t have to be soft, sad or boring.In this episode27 low-calorie foods that bring crunch and texture to mealsWhy nuts, seeds and crispy chickpeas can be harder to budget during fat lossSimple air-fryer, roasting and quick-pickling ideasHow different cuts and textures make salads and bowls more satisfyingUsing seasonings to make the same basic ingredients taste completely different Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Iron, Infants and the First 1,000 Days - with Gina Ulrich 19.08.2026 55мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzThis week on the podcast Mikki speaks to Gina Urlich, clinical nutritionist and founder of Odi Nutrition. Mikki and Gina dive into why iron deficiency is such an important issue in babies and young children, and why iron needs increase so dramatically from around six months of age.They unpack the difference between low iron stores, iron deficiency and iron deficiency anaemia, why iron matters so much for brain development, behaviour, immunity and growth, and some of the signs that might warrant further investigation.They also get very practical about feeding. Gina explains haem versus non-haem iron, the best iron-rich foods for babies and toddlers, how to improve absorption, and why meeting iron requirements can be surprisingly difficult when you are dealing with small appetites and picky eaters.They also discuss the baby and toddler food environment, what parents should know about common packaging claims, and the gap Gina saw in the market that ultimately led her to create Odi Nutrition.This is a really practical episode for parents, grandparents and practitioners who want to better understand how to support iron status during these critical early years.Gina Urlich is a clinical nutritionist, former nurse, mother of four and the founder of Odi Nutrition. She holds a Bachelor of Health Science in Nutritional Medicine and has spent much of her career working in women’s health and infant nutrition.Her interest in early childhood nutrition grew through both her clinical work and her own experience as a mum. After creating resources to help parents navigate introducing solids, Gina saw just how much confusion there was around feeding babies well, particularly when it came to balancing good nutrition with the realities of busy family life.That ultimately led her to create Odi Nutrition, a New Zealand baby and children’s food company focused on convenient, nutrient-dense wholefood options for growing children.https://odinutrition.com/https://www.instagram.com/gina.urlich/?hl=en  Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Is Tracking Your Food Really Obsessive? 17.08.2026 20мин

  Food tracking, weighing portions and stepping on the scales are increasingly framed as obsessive behaviours—but are the tools themselves really the problem? In this Mini Mikkipedia episode, Mikki explores what the research actually says about self-monitoring for weight loss and maintenance. She looks at evidence showing that regular weighing and food tracking can improve awareness, support behaviour change and help people catch weight regain early, while also acknowledging that tracking can become problematic for some people. The crucial distinction appears to be how and why the tool is being used. Mikki discusses autonomous versus guilt-driven motivation, the importance of self-talk, and when numbers can shift from useful information to a measure of self-worth. The takeaway: tracking can be incredibly useful—but it should serve you, not control you. In this episode: Why self-monitoring is consistently associated with successful weight management  What research says about daily weighing, food logging and disordered eating  When tracking shifts from useful feedback to unhealthy fixation  Why motivation and self-talk can completely change the tracking experience  How to use tracking temporarily, strategically and without needing to log forever Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Rapid Fat Loss: When Faster Can Be Smarter - with Brandon DaCruz 12.08.2026 1ч 35мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comThis week on Mikkipedia Mikki is joined by Brandon DaCruz, host of the Chasing Clarity podcast, for the first episode in a new collaborative series bringing together their perspectives on nutrition, fat loss and body composition.They kick things off with a deep dive into rapid fat loss and protein-sparing modified fasting, starting with what a PSMF actually is and how each of them defines rapid fat loss in practice.Mikki and Brandon explore the potential benefits of taking a more aggressive approach to fat loss, alongside the physiological, psychological and behavioural drawbacks that need to be considered.They also get into how these strategies look with real clients. Brandon shares how he uses rapid fat-loss days, deficit deloads and high-carbohydrate refeeds, while Mikki explains how PSMF days and structured diet breaks are incorporated into Mondays Matter.Finally, they discuss who rapid fat-loss strategies are not appropriate for, including circumstances where hormonal health, energy availability, training demands or physique goals mean a more conservative approach is warranted.It’s a practical and nuanced discussion about when rapid fat loss can be a useful tool, when it can become counterproductive, and why context matters far more than simply labelling an approach as good or bad.Brandon DaCruz at his website https://www.brandondacruzfit.com/, and on Instagram @brandondacruz_Chasing Clarity https://podcasts.apple.com/us/podcast/chasing-clarity-health-fitness-podcast/id1619611966 Brandon DaCruz is an online nutrition and physique coach, accredited nutritionist, functional nutrition and metabolism specialist, and health and fitness educator with over 16 years of coaching experience.Throughout his career, Brandon has helped more than 1,200 clients ranging from Olympia-level physique competitors and competitive athletes to business owners, executives, and lifestyle clients improve their body composition, optimize performance, and enhance their overall health. His coaching philosophy is rooted in an evidence-informed approach that combines the best available research with real-world coaching experience gained from working directly with clients in the trenches for over a decade and a half.Brandon has been featured in leading industry publications including Men’s Fitness Magazine, Muscular Development, Bodybuilding.com, and the Alan Aragon Research Review, where he served as a contributing author.Known for his ability to translate complex scientific concepts into practical, actionable strategies, Brandon specializes in helping clients lose body fat, build muscle, improve metabolic health, and create sustainable long-term results without relying on extremes or quick fixes.Brandon is also the host of the Chasing Clarity Health & Fitness Podcast, a show ranked in the top 5% of all podcasts on Spotify. Through both solo episodes and conversations with many of the industry’s leading researchers, and educators, the podcast aims to bridge the gap between complexity and clarity in health, fitness, nutrition, and physique development. Each episode is designed to empower listeners through education and provide the tools needed to make informed decisions about their health and physique goals.https://podcast.mikkiwilliden.com/270https://podcast.mikkiwilliden.com/226 https://podcast.mikkiwilliden.com/300 https://podcast.mikkiwilliden.com/368 https://podcast.mikkiwilliden.com/416 https://podcast.mikkiwilliden.com/422 https://podcast.mikkiwilliden.com/458  Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Why Men and Women Store Fat Differently 10.08.2026 22мин

  wo people can have the same body weight and BMI yet face very different metabolic risks. In this episode, Mikki explores the biological reasons men and women store fat differently and why location matters more than the number on the scale. She explains how oestrogen directs fat towards the hips and thighs before menopause, why declining oestrogen can shift fat towards the abdomen, and how immune signalling, liver function and cholesterol patterns differ between the sexes. Mikki also examines women’s surprising advantage in insulin sensitivity, the role of skeletal muscle in glucose control, and why waist circumference may predict cardiovascular risk better than BMI. This episode offers a nuanced look at fat distribution, menopause and metabolic health, while reinforcing the powerful role of nutrition, exercise and lifestyle.Topics covered:Why equal body weight does not mean equal metabolic riskHow oestrogen influences fat storage and fat releaseWhy visceral fat often increases through menopauseSex differences in inflammation, liver health and cholesterolThe roles of muscle mass and insulin sensitivity Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Medical Astrology: An Ancestral Lens on Health with Kira Sutherland 05.08.2026 1ч 11мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzIn this episode, Kira joins Mikki to explore medical astrology through the broader lens of ancestral medicine. They discuss how astrology once sat alongside herbal medicine, food, seasonal living and close observation of the natural world as part of a practitioner’s medical map.This is not a conversation about newspaper horoscopes or using a birth chart to diagnose disease. Instead, Kira explains how medical astrology may be used as a constitutional and reflective framework for considering temperament, health patterns, resilience, vulnerability and timing. They explore the roles of the four elements, the relationship between planetary cycles and the body, and whether astrology can sometimes provide language for experiences that are not easily captured by standard testing.Drawing on Kira’s background in naturopathy and nutrition, they also examine how ancestral knowledge might complement modern healthcare without romanticising the past or abandoning scientific scrutiny. Ultimately, the conversation asks whether health is only about identifying what is wrong with the body, or whether it can also involve understanding the patterns the body may be expressing.Kira is an Australian Naturopath, Nutritionist, Herbalist and Medical Astrologer. Known for her vibrant, straight-forward teaching style, Kira has lectured in Medical Astrology within Australia, North America and Europe.In private practice for over 25 years, Kira combines her knowledge in Natural Medicine with her passion for Medical Astrology into a wonderful mix of mind/body medicine. Kira's Medical Astrology training and mentoring programs attract hundreds of students every year from around the world, with rave reviews about her teaching style and breadth of knowledge and application. In her free time, she competes in endurance sport and skis with her family as much as possible.Follow Kira online: https://www.kirasutherland.com.au https://www.astrologyofhealth.com/abouthttps://podcast.mikkiwilliden.com/154 Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Food Noise, Hunger and Cravings: Know the Difference 03.08.2026 22мин

  Food noise, hunger and cravings are often treated as interchangeable, but they arise from different biological and psychological systems. In this episode, Mikki explains how physiological hunger develops gradually in response to the body’s energy needs, while cravings are shorter, cue-driven urges for specific foods. Food noise is different again: a persistent background hum of food-related thoughts linked to reward circuitry, rumination and heightened responsiveness to food cues.Mikki explores why GLP-1 medications can dramatically quiet food noise, how stress, poor sleep and highly palatable foods can amplify it, and why intuitive eating may improve calmness around food without necessarily producing fat loss. She also outlines practical strategies, including improving protein and fibre intake, reducing easy access to trigger foods, addressing stress and sleep, and recognising when medical support may be appropriate.Topics coveredThe biological differences between hunger, cravings and food noiseWhy food noise feels intrusive and repetitiveHow GLP-1 medications affect food reward pathwaysThe role of stress, sleep and ultra-processed foodsPractical strategies for reducing appetite-related noise Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Mobility, Strength and Staying Capable as You Age with Darren Ellis 29.07.2026 1ч 6мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comThis week on the podcast Mikki chats to Darren Ellis about movement, mobility and function as we age. As always, a grounding conversation that speaks to Darren’s passion in the fitness world and helping us live our best most awesome lives.Darren Ellis, MSc, has an aim to share what he’s learned with as many people as possible, teaching them that there are no shortcuts with exercise, but that it can be achievable, and even fun, with good coaching and a supportive peer group. He is a regular contributor to a variety of popular print and web based health and fitness magazines, public speaker, and consultant to sporting organisations, businesses, universities and television.Specialties: Strength training and nutrition for fitness, sport, weight loss, muscle gain, longevity.Darren can be found at: https://www.darrenellis.coach/  Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Why Perfectionism Sabotages Your Fat Loss Progress 27.07.2026 24мин

  Perfectionism can look like discipline, but when it comes to fat loss, it often creates the exact opposite result. In this episode, Mikki explores why capable, high-achieving people can be disciplined in every area of life yet struggle to stay consistent with food and exercise. She explains the difference between rigid and flexible dietary restraint, why one unplanned meal can trigger an all-or-nothing spiral, and how self-criticism makes it harder to recover from normal setbacks. Drawing on research into self-efficacy, dichotomous thinking and self-compassion, Mikki shares practical ways to build systems that reduce reliance on willpower. The goal is not to follow a plan perfectly. It is to interpret setbacks more constructively, make the next useful decision and keep showing up often enough for consistency to become routine.Topics coveredWhy discipline is context-specific rather than a fixed personality traitHow rigid restraint can increase food preoccupation and loss-of-control eatingWhy the story you tell yourself after a lapse matters more than the lapseHow self-compassion supports control, confidence and continued effortPractical systems for replacing willpower with structure Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  HRT, Tirzepatide and Weight Loss After Menopause with Professor Daniela Hurtado and Dr Regina Castaneda 22.07.2026 51мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzThis week on the podcast Mikki speaks to two researchers, Professor Daniela Hurtado and Dr Regina Castaneda about the interaction between HRT and tirzepatide use. In a conversation led by Regina, they talk about differences that occur as women head through menopause, the role of HRT at mitigating some of these changes and the findings from their paper looking at how hormone therapy might enhance the therapeutic effects of tirzepatide in a postmenopausal population - discussing sex related differences.Maria Daniela Hurtado Andrade, M.D., Ph.D., is from Ecuador where she completed her medical degree at the Pontifical Catholic University. Her curiosity about the causes of obesity led her to pursue doctorate-level training in Physiology and Pharmacology at the University of Florida. Her research focused on the brain's regulation of food intake. After her doctoral training, she completed Internal Medicine training at the University of Pittsburgh Medical Center in Pittsburgh, PA, and Endocrinology Fellowship specialty training at Mayo Clinic in Rochester, MN. She joined Mayo Clinic Staff in 2019.Dr. Hurtado Andrade is interested in understanding obesity's pathophysiology to develop more effective therapeutic interventions. She is part of the Mayo Clinic Precision Medicine for Obesity program. This program aims at developing an individualized approach to the management of obesity and its complications with the goal of improving outcomes. To facilitate the generation of this new knowledge, she has focused her clinical and research efforts on specific populations: perimenopausal women and breast cancer survivors. Dr. Hurtado's contributions and expertise to the field of obesity have been recognized nationally and internationally.Regina Castaneda, MD, serves as a postdoctoral research fellow at Mayo Clinic in Florida. She is also an MSc candidate at Mayo Clinic College of Medicine and Science. Her work centres on women's health topics including obesity, diabetes, and menopause-related metabolic changes.Dr Castaneda has contributed to research examining the effects of tirzepatide on weight loss in postmenopausal women and the potential influence of hormone therapy. She is affiliated with the Division of Endocrinology, Diabetes and Metabolism at Mayo Clinichttps://www.mayoclinic.org/biographies/hurtado-andrade-maria-daniela-m-d-ph-d/bio-20539671https://www.linkedin.com/in/regina-castaneda-md-8b2371358/ Paper: https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(25)00145-1/abstract Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - When GLP-1 Weight Loss Dims Motivation 20.07.2026 22мин

  This episode explores emerging evidence that high-dose tirzepatide may reduce more than appetite and food noise in some people. Mikki breaks down a new case series involving three women who experienced anhedonia, a loss of motivation or interest in previously rewarding activities, despite achieving substantial weight loss. She explains the difference between “wanting” and “liking,” how GLP-1 medications may influence dopamine reward pathways, and why symptoms can feel different from depression or early medication side effects. The cases suggest that dose reduction may restore motivation without necessarily compromising weight-loss maintenance. While three cases cannot establish causation or prevalence, the findings highlight the importance of monitoring exercise, hobbies, social engagement, and overall enjoyment alongside weight, appetite, and gastrointestinal symptoms.Topics CoveredWhat anhedonia is and how it differs from depressionThree cases involving high-dose tirzepatideThe potential role of dopamine and reward pathwaysWhy dose reduction improved symptoms in these casesPractical considerations for patients and prescribers Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order
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  Fueled or Fooled? Rethinking Ultra-High Carbohydrate Fuelling with Dr Dan Plews 15.07.2026 1ч 3мин

  Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comThis week on the podcast Mikki speaks to Dan Plews about his new paper ‘fuelled or fooled’ Examining the Evidence and Mechanisms Behind Ultra‑High Carbohydrate Intake in Endurance Athletes - and they discuss the latest research on carbohydrate fuelling (from the very low to the very high) and the evidence base to support ultra high carb fuelling.Dr Dan Plews is an applied sports scientist, exercise physiologist, researcher, coach and accomplished endurance athlete with more than 17 years of experience working at the highest levels of international sport.Dan is the founder of Endure IQ, an endurance education and coaching platform designed to help athletes and coaches apply sports science in the real world. He is also the co-founder of Endurox alongside Dr Adam Storey, providing evidence-based HYROX coaching and programming that combines endurance development, strength training and race-specific preparation. In addition, Dan is Science Lead at Pillar Performance Supplements, where he helps translate emerging research into practical supplementation strategies for athletes.Dan’s work brings together scientific rigour, elite-level coaching experience and first-hand understanding of what it takes to perform. His approach is centred on giving athletes the “why” behind the “what” and helping them apply science-driven strategies to train smarter and perform at their best.Paper Examining the Evidence and Mechanisms Behind Ultra‑High Carbohydrate Intake in Endurance Athletes https://link.springer.com/article/10.1007/s40279-026-02462-zhttps://www.endureiq.com/. https://www.endurox.co/about Previous appearanceshttps://podcast.mikkiwilliden.com/360https://podcast.mikkiwilliden.com/198 https://podcast.mikkiwilliden.com/107 https://podcast.mikkiwilliden.com/47 https://podcast.mikkiwilliden.com/31  Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden
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  Mini Mikkipedia - Why Diets Fall Apart After Week Three 13.07.2026 29мин

  Why do people start a fat loss plan with a hiss and a roar, only to fall off a few weeks later? In this episode, Mikki unpacks the real reasons diets often derail once the novelty wears off. It is not just boredom or lack of discipline. Early scale loss slows, hunger increases, rigid rules become harder to sustain, and motivation naturally fades. Mikki explains why sustainable fat loss requires structure, flexibility, realistic expectations, and systems that work when life gets busy. She also shares practical strategies to stay consistent, including planning weekends, using simple meal templates, tracking behaviours instead of obsessing over the scale, and shifting identity from “trying to lose weight” to becoming someone who lives a fitness lifestyle.Highlights:Why motivation drops after the first few weeks of dietingHow water weight, glycogen, and scale expectations affect adherenceWhy overly rigid or repetitive plans often backfirePractical strategies for weekends, busy days, and off-plan mealsThe importance of identity, systems, and behavioural consistency Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order