The College of Glycation with Dr. Paul Reynolds

Epizode

• Leaky Gut Meets RAGE 24.06.2026 23min

  In this episode of the College of Glycation, Professor Paul Reynolds reveals how glycation and leaky gut don’t just coexist — they actively multiply each other’s damage. A diet high in heat-generated advanced glycation end-products (AGEs) reshapes the gut microbiome, weakens the intestinal barrier, and allows bacterial lipopolysaccharide (LPS) to leak into the bloodstream in a state called metabolic endotoxemia. At the same time, elevated glucose and dietary AGEs keep the RAGE receptor constantly engaged. Because RAGE and TLR4 (the LPS receptor) physically interact and upregulate one another in a feed-forward loop, the leaked LPS lands on an immune system that glycation has already primed — dramatically amplifying inflammation and insulin resistance through shared NF-κB signaling.Drawing on landmark studies from Cani, Qu, Snelson & Coughlan, Yan, Uribarri, and others, Reynolds shows that this synergy is not additive but multiplicative. The same modern dietary pattern that generates AGEs also opens the door for LPS and then lowers the threshold for its inflammatory effects. Practical takeaways include shifting to gentler, moisture-based cooking methods to slash dietary AGEs, feeding butyrate-producing bacteria with fiber and dairy fats to strengthen tight junctions, and controlling blood glucose and insulin to disengage RAGE and raise the inflammatory threshold. Ultimately, glycation is reframed not merely as tissue damage, but as a recalibration of immune judgment — turning an ordinary bacterial leak into the spark that meets the gasoline.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Glycocalyx and the Role of Glycation 17.06.2026 22min

  In this episode of the College of Glycation, Paul Reynolds flips the script on sugar. While glycation is usually portrayed as the villain that damages proteins, lipids, and DNA through advanced glycation end products, today he reveals a place where sugar is actually the hero: the glycocalyx. This dense, gel-like sugar coat covers nearly every cell in your body, with its most important version lining the inside of all your blood vessels like an invisible protective forest.Paul explains the structure of the glycocalyx, its surprising thickness, and its four critical roles as a selective filter, a shear-stress sensor that triggers nitric oxide release, a physical and electrical barrier against clotting and inflammation, and a non-stick coating for smooth blood flow. He then shows how high blood sugar rapidly destroys this layer—halving its volume in just six hours through oxidative stress and the AGE-RAGE pathway that activates heparanase. The breakdown of the glycocalyx appears to be one of the earliest events in vascular dysfunction, atherosclerosis, and kidney disease, while also contributing to leaky gut. The solution, Paul argues, is the same approach that protects the rest of the body: keeping blood glucose stable and low so the cell can build and maintain this life-saving sugar coat instead of tearing it down.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• Adipose Glycation and Fat Cell Hypertrophy 10.06.2026 23min

  Podcast Episode Description:In this eye-opening episode of the College of Glycation, Professor Paul Reynolds explores adipose glycation — the hidden process where fat cells themselves become chemically modified by sugar, turning them into drivers of metabolic dysfunction. Far from being passive storage tanks, hypertrophic adipocytes generate their own glycating agents like methylglyoxal (MGO), activating the AGE-RAGE axis, inflammation, hypoxia, and fibrosis. This creates a self-reinforcing loop that promotes insulin resistance, cytokine release, and impaired fat expandability — explaining why fat cell size and behavior matter far more than total body fat.Drawing on key studies, Reynolds connects the dots between chronic hyperinsulinemia, fructose intake, RAGE-driven hypertrophy, and the breakdown of healthy adipose remodeling. The episode reveals why some people develop metabolic disease at lower BMIs and offers practical, empowering strategies: lower insulin through carb restriction and time-restricted eating, minimize fructose, support the glyoxalase system, and stay active to keep fat cells healthy and quiet. A must-listen for anyone interested in body composition, inflammation, and breaking the cycle of metabolic illness.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• GLP-1 Beyond Glucose 03.06.2026 26min

  In this eye-opening episode of the College of Glycation, biomedical scientist and Professor of Cell Biology Paul Reynolds goes beyond the headlines on the blockbuster GLP-1 receptor agonists—semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). While everyone talks about dramatic weight loss, Reynolds reveals what these drugs are actually doing at the cellular level: directly downregulating the RAGE receptor, suppressing AGE-induced inflammation, and powerfully activating autophagy. Drawing on landmark trials like SELECT (which showed a 20% drop in major cardiovascular events even in people without diabetes), he demonstrates how these benefits stem from four overlapping anti-glycation mechanisms that go far deeper than glucose control or appetite suppression.Reynolds walks listeners through the full family of incretin therapies, the science of the dangerous AGE-RAGE-NF-κB axis, and how GLP-1 agonists restore cellular recycling by shifting the AMPK-mTOR balance—clearing damaged, glycated proteins in ways that explain their impressive tissue-protective effects. He closes with a balanced, practical perspective: these are powerful pharmacologic tools that mimic healthy metabolic states, but they work best as temporary bridges to real food, movement, sleep, and fasting rather than lifelong crutches. If you want to truly understand why metabolic dysfunction drives chronic disease—and what the GLP-1 story teaches us about fixing it at the root—this episode is essential listening.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Autophagy and Glycation 27.05.2026 19min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores autophagy—one of the body’s most powerful yet underappreciated defenses against aging. Autophagy, the Nobel Prize-winning cellular “self-eating” process, allows cells to identify, package, and recycle damaged proteins, dysfunctional mitochondria, misfolded molecules, and glycated junk before they mature into advanced glycation end-products (AGEs). These sugar-modified compounds stiffen tissues, impair insulin signaling, promote inflammation, and accelerate chronic disease. Dr. Reynolds explains how constant eating and elevated insulin keep autophagy suppressed, trapping cells in perpetual “build and store” mode and allowing glycation damage to accumulate.Intermittent fasting changes everything by lowering insulin, suppressing mTOR, and activating AMPK—triggering the metabolic switch that rapidly ramps up autophagy and delivers a true glycation reset. Drawing on landmark research, Dr. Reynolds shows how even short fasting windows (like 16:8) can clear glycated proteins, improve metabolic health, and support cellular renewal. He offers practical, step-by-step guidance for beginners through advanced fasters, while clearly outlining who should avoid fasting and how to combine it with smart eating and exercise for maximum benefit. This episode delivers the science and the actionable strategy to harness your body’s built-in cellular housekeeping system.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• The Sugar Diet and Glycation 20.05.2026 17min

  In this episode of the College of Glycation, Dr. Paul Reynolds takes a clear-eyed look at the viral “sugar diet” trend sweeping social media — where people are eating bowls of sugar, drinking large amounts of fruit juice and honey, and eliminating fat while claiming major improvements in energy, mood, and metabolism. He asks the question almost no one else is asking: what does this dietary pattern actually do to glycation? Drawing on peer-reviewed research, Dr. Reynolds explains why fructose is dramatically more glycating than glucose, how it drives rapid methylglyoxal formation and advanced glycation end product (AGE) accumulation, and why even short-term high-fructose intake can increase liver fat, visceral adiposity, and insulin resistance within days to weeks.While acknowledging the real short-term effects some people experience (such as feeling warmer or more energetic), Dr. Reynolds shows why these acute benefits do not reflect long-term safety. He highlights the critical gap between normal fasting glucose and hidden glycation damage, the complete lack of long-term clinical trials on sugar-dominant diets, and why this approach ultimately maximizes the very biochemical pathways that accelerate tissue aging, vascular stiffening, and chronic disease. The episode offers a science-based alternative perspective for anyone prioritizing metabolic health and longevity over trending dietary extremes.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• Fermentation and Glycation 13.05.2026 23min

  In this episode of the College of Glycation, Dr. Paul Reynolds reveals why traditional fermented foods—staples of every human culture for thousands of years—may be one of the most powerful, yet underused tools for lowering your glycation burden and resetting metabolic health. He explains how fermentation pre-digests sugars, delivers living microbes and bioactive compounds (lactic acid, acetic acid, short-chain fatty acids, and peptides), and counteracts the modern Western diet’s relentless drive toward advanced glycation end products (AGEs), chronic inflammation, and insulin resistance.Drawing on landmark research including the 2021 Stanford study, Dr. Reynolds walks through the five key mechanisms by which real fermented foods boost gut microbial diversity, blunt post-meal glucose spikes, inhibit AGE formation and RAGE signaling, improve insulin sensitivity, and strengthen the intestinal barrier. He also shares a clear, practical protocol: which foods matter most, how much to eat, smart timing strategies, and important cautions for getting the maximum benefit. If you’re serious about reducing glycation and reclaiming the metabolic protection our ancestors took for granted, this episode shows you exactly how to make fermented foods a daily, non-negotiable habit.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• Fasting and Glycation 06.05.2026 18min

  In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—explains how fasting is one of the most powerful and underutilized tools for resetting the glycation burden your body carries. He breaks down how the standard modern eating pattern of frequent, carbohydrate-rich meals drives near-constant glucose and insulin elevations that accelerate the formation of advanced glycation end products (AGEs). These permanent molecular modifications stiffen tissues, trigger inflammation through the RAGE receptor, and fuel the chronic diseases we associate with aging. Dr. Reynolds shows why this damage isn’t inevitable and how fasting interrupts the cycle at its root.He details the profound metabolic shifts that occur when you stop eating insulin drops, the body flips the “metabolic switch” to fat-burning and ketone production, and autophagy—the cellular recycling program—ramps up to clear out damaged, glycated proteins. Drawing on key research, he covers practical approaches including time-restricted eating, early time-restricted feeding, alternate-day fasting, extended fasts, and fasting-mimicking diets. You’ll also learn why how you break a fast matter and how these strategies improve insulin sensitivity, reduce oxidative stress, and enhance metabolic flexibility—independent of weight loss. Whether you’re new to fasting or looking to deepen your practice, this episode delivers a clear, science-backed roadmap for using one of the body’s own repair mechanisms to fight glycation and support long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Glycation and Your Mouth as a Metabolic Canary 29.04.2026 25min

  Your gums may be telling you something critical about your metabolic health. In this episode of the College of Glycation, Dr. Paul Reynolds explores the overlooked connection between gum disease, glycation, and systemic inflammation. He explains how Advanced Glycation End Products (AGEs) form and accumulate—and how periodontal disease doesn’t just result from metabolic dysfunction, but can actively drive it. From inflammatory signaling to insulin resistance, this episode reveals how the mouth plays a central role in whole-body health. If you’re interested in metabolism, aging, or the deeper biochemical drivers of chronic disease, this episode offers a powerful new perspective on why oral health is far more than cosmetic—it’s metabolic.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Glycation and Your Hormones 22.04.2026 28min

  In this episode of the College of Glycation series, Dr. Paul Reynolds explores how advanced glycation end-products (AGEs) quietly disrupt the body’s hormonal systems. Moving beyond blood sugar alone, he explains how glycation damages key proteins involved in hormone production, transport, and signaling—affecting thyroid function, testosterone levels, insulin sensitivity, and fertility. Even when lab results appear normal, these molecular changes can impair how hormones actually function at the tissue level.Dr. Reynolds connects the chemistry of glycation to real-world conditions like hypothyroidism, PCOS, infertility, and metabolic dysfunction, while introducing the RAGE pathway as a major driver of chronic inflammation and hormonal imbalance. This episode offers a deeper framework for understanding the link between diet, metabolic health, and endocrine function—and what you can do to reduce glycation and protect long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Fructose is a Glycation Accelerant 15.04.2026 24min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores a major blind spot in metabolic health: fructose. While most discussions around sugar focus on glucose and blood sugar levels, this episode reveals why fructose may be even more damaging. Dr. Reynolds explains how fructose is metabolized almost entirely in the liver, bypassing key regulatory systems and driving fat production, insulin resistance, and oxidative stress. More importantly, fructose is significantly more reactive in the glycation process—accelerating the formation of advanced glycation end-products (AGEs) that damage tissues and promote chronic disease.Building on foundational glycation science, this episode uncovers how fructose not only glycates proteins faster than glucose but also generates highly reactive compounds like methylglyoxal, amplifying cellular damage. Dr. Reynolds challenges common assumptions about “healthy” sugars found in fruit juice and natural sweeteners, offering a clearer understanding of how modern dietary patterns contribute to long-term metabolic dysfunction. Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• AGEs 101: The Basics of Glycation 08.04.2026 31min

  In this episode of the College of Glycation, Dr. Paul Reynolds introduces the foundational science of glycation—one of the most important and underrecognized processes driving aging and chronic disease. He explains how glucose, while essential for energy, can also react with proteins in the body through a non-enzymatic process that gradually leads to the formation of advanced glycation end-products (AGEs). Using clear analogies and step-by-step explanations, Dr. Reynolds walks through how glycation begins, how it progresses, and why its effects accumulate silently over time in tissues like blood vessels, kidneys, nerves, and eyes. This episode also explores the real-world implications of glycation in modern health, highlighting how lifestyle factors—such as diet, cooking methods, physical inactivity, and chronically elevated blood sugar—accelerate the process beyond what the body can manage. Dr. Reynolds outlines the body’s natural defense systems and, more importantly, the practical steps individuals can take to reduce glycation burden, improve metabolic health, and slow the long-term trajectory of aging and disease.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• How Reversible is Glycation? 01.04.2026 33min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores one of the most important questions in metabolic health: Is glycation reversible? While some damage—especially in long-lived tissues like collagen—can persist for decades, this episode reveals that the body is far from helpless. Dr. Reynolds breaks down the science of how glycation forms, why certain stages are more reversible than others, and the built-in systems your body uses to defend against and clear this damage.More importantly, he translates that science into practical strategies you can use right away. From improving blood sugar control and reducing dietary AGEs to leveraging fasting, exercise, and targeted supplementation, this episode reframes the goal—not as fully reversing damage, but as slowing its accumulation and changing your long-term health trajectory.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• Hidden AGEs in Health Foods 25.03.2026 28min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores a growing concern among health-conscious individuals: whether even “healthy” foods may be contributing to glycation and long-term metabolic damage. Prompted by real audience questions, he unpacks the science of advanced glycation end products (AGEs) with a focus on those introduced through diet, revealing that the true driver of AGE content is often not the food itself—but how it’s prepared.Drawing on decades of research, Dr. Reynolds explains how cooking methods like roasting and grilling dramatically increase AGE formation compared to lower-temperature, moisture-rich methods like boiling or steaming. He also breaks down how the body absorbs, processes, and clears dietary AGEs, and why metabolic health plays a central role in determining overall AGE burden. The episode delivers practical, evidence-based strategies to reduce glycation exposure—offering clarity and control to anyone looking to support long-term health and reduce inflammation at the molecular level.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Health Conditions Including Vertigo, MTHFR, and more 18.03.2026 28min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation—long understood as a driver of aging and metabolic disease—may also underlie a range of specialized health conditions that often go unexplained. Moving beyond theory, he connects the biochemical process of advanced glycation end product (AGE) formation to real-world issues like frozen shoulder, vertigo, and MTHFR-related metabolic dysfunction. By breaking down how glycation alters long-lived proteins such as collagen, myelin, and vascular tissues, Dr. Reynolds reveals how a single molecular process can manifest across joints, nerves, and the inner ear.Drawing on peer-reviewed research and clear physiological explanations, this episode reframes seemingly unrelated diagnoses through a unified metabolic lens. You’ll gain insight into how glycation and homocysteine-driven protein damage may work together to accelerate dysfunction, why these processes often go undetected in standard clinical testing, and what this means for long-term health. Whether you’re dealing with chronic joint pain, unexplained neurological symptoms, or genetic findings like MTHFR, this conversation offers a deeper understanding of the hidden biochemical patterns shaping your health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Practical Glycation Busters and Supplements 11.03.2026 24min

  In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—shifts from explaining the science of glycation to exploring practical strategies for fighting it. Glycation and the buildup of advanced glycation end products (AGEs) contribute to aging, inflammation, and many chronic diseases, but there are evidence-based ways to slow this process. Dr. Reynolds breaks down the research behind several powerful tools that may help reduce glycation damage and improve metabolic health.This episode highlights supplements and dietary strategies that target glycation at multiple stages, including L-carnosine, pyridoxamine, GlyNAC (glycine + NAC), beta-hydroxybutyrate (BHB), and the polyphenols found in yerba mate. Dr. Reynolds also discusses the potential role of allulose as a lower-glycation sugar alternative and explains why improving insulin sensitivity and reducing blood glucose are foundational for protecting long-term cellular health. If you’re interested in slowing the molecular processes that contribute to aging and chronic disease, this episode provides practical, science-backed insights you can start applying today.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhbPaul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)
• Keto & Carnivore Diets 04.03.2026 24min

  In this episode of the College of Glycation, Dr. Paul Reynolds examines one of the most debated questions in metabolic health: do ketogenic and carnivore diets worsen glycation—or help prevent it? Breaking down the biochemistry, he explains how glycation forms advanced glycation end products (AGEs) that drive inflammation, oxidative stress, and accelerated aging, and why chronically elevated blood glucose is the primary trigger behind this damage.Dr. Reynolds explores how carbohydrate restriction lowers HbA1c and reduces endogenous AGE formation, while addressing concerns about dietary AGEs from cooked meat and methylglyoxal production during ketosis. He also highlights the protective role of beta-hydroxybutyrate (BHB), the body’s glyoxalase detoxification system, and the often-overlooked impact of fructose in accelerating glycation. The result is a clear, evidence-based look at how ketogenic and carnivore diets intersect with metabolic chemistry—and what that means for long-term health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Reproductive System and Glycation 25.02.2026 29min

  In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation impacts one of the most metabolically sensitive systems in the body: the reproductive system. From PCOS and ovarian dysfunction to erectile dysfunction and impaired nitric oxide signaling, this episode connects advanced glycation end products (AGEs) to hormonal imbalance, vascular damage, and chronic inflammation. Dr. Reynolds also examines gestational diabetes, placental dysfunction, and the emerging science of transgenerational metabolic programming—revealing how a mother’s metabolic health may influence not only her child, but potentially future generations.Grounded in peer-reviewed research, this conversation makes a compelling case that fertility and sexual health are not isolated issues—they are reflections of metabolic integrity. If you care about hormones, pregnancy, longevity, or preventing chronic disease, this episode underscores a powerful principle: protecting your metabolism protects everything downstream.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Integument System Physiology and Glycation 18.02.2026 28min

  In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—dives into the integumentary system and explains why your skin is one of the most revealing indicators of metabolic health. Unlike internal organs you can’t see, the effects of glycation and chronic inflammation show up directly on your face, hands, and body. Dr. Reynolds breaks down how advanced glycation end products (AGEs) form when sugars bind to proteins, and why long-lived structural proteins like collagen and elastin are especially vulnerable to becoming stiff, cross-linked, and dysfunctional over time.This lecture connects the biochemistry of glycation to real-world outcomes like wrinkles, sagging, dull or yellowed skin tone, barrier breakdown, increased infection risk, and delayed wound healing—especially in diabetes. You’ll also learn why skin autofluorescence is emerging as a powerful marker of AGE burden, even in non-diabetics, and how daily lifestyle choices can reduce glycation load and protect skin integrity as you age.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 
• Sensory Organ Physiology and Glycation 11.02.2026 22min

  In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how glycation quietly damages two of the body’s most delicate and essential systems: the eyes and the ears. While most people associate diabetes-related damage with the heart or kidneys, this lecture shows how advanced glycation end products (AGEs) progressively harm the retina, lens, and cochlea through microvascular breakdown, oxidative stress, inflammation, and mitochondrial dysfunction—often long before someone is formally diagnosed with diabetes.You’ll learn why sensory organs are uniquely vulnerable due to their extreme metabolic demand, fragile end-artery circulation, and limited regenerative capacity. From pericyte loss and blood-retinal barrier failure in diabetic retinopathy, to crystallin protein cross-linking in cataracts, to the underrecognized connection between rising A1c and hearing loss, this episode connects molecular biochemistry to real-world outcomes—and highlights why reducing glycation through metabolic health is one of the most powerful strategies for protecting vision and hearing over a lifetime.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)