The Proof with Simon Hill

Епизоде

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  The Liver Disease 30% of Us Have and Never Feel | Prof Aleksander Krag 14.09.2026 1ч 20мин

  Around 30% of the world's population has too much fat in their liver, and almost none of them know it. Liver disease stays silent until it is very advanced, which is exactly why so many people are found too late. In this episode I sit down with Prof Aleksander Krag, professor and department chair of gastroenterology and hepatology at Odense University Hospital and former Secretary General of the European Association for the Study of the Liver, to separate the frightening headline number from the thing that actually determines risk. It is not the fat. It is the scarring, and there is a simple test that can tell you whether you have any. What we cover Why a third of us have fat in our liver, and why that alone is not the thing to worry about Steatosis versus fibrosis, and why only scarring predicts clinical liver disease What blood-based alcohol biomarkers revealed about self-reported drinking The single home measurement that tracks liver risk best FIB-4, FibroScan, elastography, and ELF, explained plainly How reversible liver damage really is, and where semaglutide and resmetirom fit The policy levers Aleksander argues would prevent more disease than any clinic can If you have ever wondered whether your drinking, your waistline, or your last set of liver enzymes is worth acting on, this conversation gives you a clear place to start. To connect with Prof Aleksander Krag, visit the Centre for Liver Research (FLASH) at the University of Southern Denmark, follow him on X, or find him on LinkedIn. If this episode was useful, please leave a rating and review on Apple Podcasts or Spotify. It genuinely helps more people find the show. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  The Case for Treating Cholesterol Before Plaque Appears | Dr Thomas Dayspring and Dr Dan Soffer 07.09.2026 1ч 42мин

  Almost all of us have atherosclerosis, and almost none of us are told so, because "normal" cholesterol is a population average rather than a physiological target. Dr Thomas Dayspring and Dr Dan Soffer, both Masters of the National Lipid Association, join me for a conversation devoted entirely to primary prevention. They do not agree on everything, and that is the point. Tom argues ApoB is the cause of atherosclerosis. Dan calls it the necessary substrate. Between them you get an unusually honest look at how two experienced clinicians weigh evidence, uncertainty, and their own bias when treating someone who feels perfectly well. What We Cover: Why genes matter less for atherosclerosis than most people assume Is ApoB causal, or simply necessary? The disagreement, in full What "normal" cholesterol means, and the levels we are born with LDL-C years: a five-second calculation you can run on yourself What the 2026 dyslipidemia guideline changed How they would manage a healthy man in his thirties with a family history and an ApoB of 100 Statin muscle symptoms, and the simple test that settles it If you have ever been told your cholesterol is fine and wondered what that actually means, start here. To connect with Dr Thomas Dayspring, find him on X, where he posts as @Drlipid. To connect with Dr Daniel Soffer, visit his Penn Medicine profile. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Skylight Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF. Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  Bone Health, Falls, Medications & Healthy Longevity | Dr Deborah Kado 31.08.2026 1ч 35мин

  Everyone wants to talk about longevity. Almost no one wants to talk about gerontology, the field that has been studying how to age well for a century. Dr Deborah Kado, Stanford professor of medicine and geriatrician, joins me to bridge that gap. From bone health and balance to deprescribing, gut microbiome research, and the surprising power of your attitude towards ageing, this is a masterclass in what actually matters for a long, well-lived life. What We Cover: Why "longevity science" is largely gerontology rebranded A positive attitude towards ageing and its link to lower dementia risk Balance, power training, and preventing falls and fractures The truth about osteoporosis medications and the scare that drove millions away Why extra weight after menopause can be protective Vitamin D, sleep regularity, and the gut microbiome This one will change how you think about growing older, whatever your age. To connect with Dr Deborah Kado, visit her Stanford profile or find her on LinkedIn. Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. ProLon ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF. ProLon ships within the United States. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  Type 2 Diabetes Remission in the GLP-1 Era | Prof Roy Taylor 25.08.2026 1ч 24мин

  Professor Roy Taylor returns, three years after his first appearance, with the five-year DiRECT trial results and a clear-eyed assessment of where diet-driven type 2 diabetes remission stands in the GLP-1 era. The evidence is now solid: type 2 diabetes is, for many, a reversible condition of excess fat in the liver and pancreas. But keeping it in remission demands keeping the weight off, and the new generation of weight loss drugs comes with marketing claims that Roy says have no evidence behind them. What We Cover: The Twin Cycle Hypothesis and personal fat threshold Five-year DiRECT data: durable remission, halved hospital admissions, fewer cancers Why regaining the weight means the diabetes returns GLP-1s: what they genuinely do, and what's marketing The muscle loss panic, put in perspective Gestational diabetes and pre-pregnancy weight Whether you have type 2 diabetes, care for someone who does, or simply want to understand one of the biggest shifts in modern medicine, this conversation delivers. To learn more about Professor Roy Taylor's work, visit his research site at Newcastle University or read his book Life Without Diabetes. Clinicians can also explore his type 2 diabetes remission toolkit for general practice. Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Upwork Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. HomeServe Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you. HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs. Skylight Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF. Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess 17.08.2026 1ч 8мин

  Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, registered dietitian and Senior Research Fellow at the University of Oxford, says the evidence is clear: a higher-protein, lower-carbohydrate diet can lower post-meal glucose by more than medication, no weight loss required. We also tackle the noisier end of the blood sugar conversation: glucose spikes, fruit fear, insulin-first theories of obesity, and the panic about GLP-1s and muscle loss. What We Cover: Why glucose only causes direct harm at diabetic levels How protein wakes up "sleepy" beta cells What overfeeding trials reveal about insulin and obesity Fruit, fibre, and fat quality: what matters and what doesn't Menopause, PCOS, and shift work The truth about GLP-1s and muscle loss If you want a clear-eyed guide to metabolic health without the hype, this episode delivers. To connect with Dr Nicola Guess, visit nicolaguess.com or find her on Instagram and YouTube. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford 10.08.2026 2ч 3мин

  About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly evaluated. In this episode I sit down with Dr Michael Eisenberg, a urologist, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, and Dr Natalie Crawford, a reproductive endocrinologist and co-founder of Fora Fertility in Austin, Texas. This is the comprehensive male fertility resource I went looking for and couldn't find, and I have a personal stake in it. What surprised me most is that sperm health appears to be about much more than conception. It tracks with metabolic health, immune health, pregnancy outcomes, and in one Danish cohort, with age of death decades later. What We Cover What a semen analysis measures, and why ejaculating normally tells you nothing Semen quality as a sixth vital sign, and the Danish study linking it to lifespan Testosterone therapy, why it functions as a contraceptive, and how long recovery takes Whether sperm counts are really declining, and the likely drivers Cannabis, alcohol, heat, cycling, sleep, and body weight Total motile sperm count, DNA fragmentation, and what to ask your lab for Paternal age, sperm freezing, and timing your decisions Sperm turn over roughly every three months, which makes this one of the most movable metrics in health. Whichever stage of life you're at, this conversation is worth your time. To connect with Dr Michael Eisenberg, find him on Instagram or LinkedIn. To connect with Dr Natalie Crawford, you can find her book The Fertility Formula at nataliecrawfordmd.com/book, listen to her podcast As a Woman, or follow her on Instagram, TikTok, YouTube, and LinkedIn. If this episode was useful, please leave a rating and review on Apple Podcasts. It genuinely helps more people find the show. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Skylight Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF. Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson 04.08.2026 1ч 53мин

  Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from confident hype, and in this conversation we tackle everything from new cholesterol-lowering drugs to gene editing, cognitive ageing, and the lean mass hyperresponder debate. Along the way we get a few things off our chests about the misinformation that spreads faster than the careful answer ever can. What We Cover Why healthy ageing brains owe more to lifestyle than to genetics How PCSK9 inhibitors work, and why plaque is more like geology than plumbing Gene editing for cholesterol and functional cures for type 1 diabetes The lean mass hyperresponder debate and what the Keto-CTA re-analysis shows Why colorectal cancer is rising in younger adults The 2026 dyslipidemia guidelines and why you should test your Lp(a) once This is a grounded, evidence-first conversation, and I hope it helps you feel clearer and more confident about the decisions that actually move the needle. If you enjoy the episode, please take a moment to rate and review the show, it genuinely helps more people find it. To connect with Dr Terry Simpson, visit terrysimpson.com, where you will find his bio, recipes, and plenty more. You can also follow him on Instagram, X, and TikTok, and read his writing on Substack. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass 27.07.2026 2ч 20мин

  Metabolic dysfunction rarely announces itself. We tend to think of metabolic health as a line you cross the day you are diagnosed with type 2 diabetes, but the decay usually begins years earlier, at the level of the cell. In this masterclass I bring together Dr Iñigo San Millán, Dr Alan Flanagan, Dr Kevin Hall, Dr Robert Eckel, Professor Roy Taylor, and Dr Christos Mantzoros to explain what metabolic flexibility is, why your mitochondria sit at the centre of it, and what you can actually do about it. What We Cover Why lactate is a fuel and a signal, not a waste product, and our best non-invasive window into mitochondrial function Whether a calorie really is a calorie, and what the controlled chamber studies found The twin cycle hypothesis, and why type 2 diabetes is more reversible than we were taught The personal fat threshold, and why a normal BMI can still hide a problem Whether sugar or saturated fat does more to drive fat in the liver Why Zone 2 earns its reputation, and how much of it you actually need Metabolic health is not fixed, and it is rarely too late to move in a better direction. I hope this conversation gives you a clearer picture of what is happening beneath the surface, and a few levers you can start pulling today. To learn more from the experts featured in this masterclass, you can follow Dr Iñigo San Millán on Instagram and Twitter, explore Professor Roy Taylor's work on type 2 diabetes remission at Newcastle University, read more from Dr Kevin Hall at kevinhallphd.com or on LinkedIn, and find Dr Alan Flanagan on Instagram and through Alinea Nutrition. The masterclass also features insights from Dr Robert Eckel and Dr Christos Mantzoros. If you are enjoying The Proof, please take a moment to rate and review the show on Apple Podcasts. It genuinely helps more people find these conversations. The 81-Year-Old Who Reversed 30 Years of Damage (00:00) What Metabolic Health Actually Means Now (01:57) Why Mitochondria Decide Your Disease Risk (06:01) What Is Metabolic Flexibility? (12:47) Hepatic Fat Oxidation and the Sex Difference (15:20) Is a Calorie Really a Calorie? (18:29) You Can Be Sick Before You're Diagnosed (28:41) Why Lactate Is the Biomarker to Watch (29:20) Lactate Is Not a Waste Product (31:03) Is Lactic Acid Burn a Myth? (36:42) Why Athletes Clear Lactate and You Don't (40:34) When High Lactate Predicts Death (43:01) The Study That Found Damage in Healthy People (47:13) The Lactate Test That Beats Blood Sugar (54:31) Training Zones 1 to 6 Explained by Fuel (58:50) Why Zone 2 Builds Mitochondria Best (1:09:18) How to Know You're in Zone 2 Without a Lab (1:16:50) Is 150 Minutes a Week Enough? (1:23:39) Why You Still Need High Intensity Training (1:28:10) What Obesity Research Got Wrong (1:31:44) The Twin Cycle Hypothesis of Type 2 Diabetes (1:35:04) Your Personal Fat Threshold Explained (1:42:26) Why Some People Store Fat Safely (1:45:45) Why BMI Fails as a Health Measure (1:51:29) Sugar or Saturated Fat: What Drives Liver Fat? (1:55:07) 15kg Weight Loss and Diabetes Remission (2:01:05) Does Weight Loss Really Destroy Muscle? (2:04:39) Why Exercise Alone Doesn't Drop Weight (2:07:05) 3 Tests That Reveal Your Metabolic Health (2:11:14) What Blue Zones Get Right About Movement (2:17:40) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  New Science of Weight Loss | A Masterclass 20.07.2026 1ч 54мин

  GLP-1 medications are transforming obesity treatment, but they're only one piece of the puzzle. In this masterclass, I bring together insights from Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gonzalez, Dr Christos Mantzoros, and Dr Stephan Guyenet to explain how these medications work, why "food noise" matters, and what it really takes to improve long-term metabolic health. What We Cover How GLP-1 medications regulate appetite and food noise Why obesity is more complex than willpower Semaglutide vs tirzepatide and newer medications Nutrition and resistance training while taking GLP-1s The role of fibre, protein, and Mediterranean-style eating Common misconceptions and side effects I hope this episode helps you better understand both the promise and the limitations of GLP-1 medications, while highlighting the importance of lifestyle alongside any medical treatment. Why Terry Simpson Started Taking a GLP-1 (00:00) What Is Food Noise, Really? (04:59) Why GLP-1 Drugs Work So Well (10:16) What Actually Causes Obesity (17:37) How GLP-1 Medications Work in the Body (21:22) The Strange Lizard Behind GLP-1 Drugs (25:56) 3 Types of Hunger You Didn't Know About (28:41) How to Naturally Boost Fullness Signals (37:08) How Doctors Choose Which GLP-1 to Prescribe (45:10) Why Some People Don't Respond to GLP-1s (53:09) GLP-1 Side Effects, Guilt, and Eating Right (58:12) Mediterranean Diet's Effect on Long-Term Weight Loss (01:10:29) The Shame Around Taking GLP-1 Medications (01:20:00) Being Called a Pharma Shill (01:32:39) The History Behind GLP-1 Drugs (01:38:18) Will You Need GLP-1s Forever? (01:47:04) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. ProLon ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF. ProLon ships within the United States. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Fertility, Sperm Health, and Nutrition Before and During Pregnancy | Dr Federica Amati 13.07.2026 1ч 23мин

  We tend to treat pregnancy as the starting line for a child's health. In this episode, Dr Federica Amati, Head Nutritionist at ZOE, makes the evidence-based case that the window opens earlier, in the months before conception, and that it shapes fertility and lifelong health in ways most of us were never told. What I valued most is her balance. The science is striking, but she frames it as information to act on rather than a reason for guilt, and she is honest about how much sits with environment and policy rather than individual choice. What we cover: Why the first 1,000 days may be the longevity lever almost no one talks about How a father's metabolic health links to his child's brain, and a mother's to their metabolism The 90-day preconception window, and what both partners can do What the decline in sperm counts really means for individuals GLP-1 medications, fertility, and a contraception detail too few people hear Protein, eggs, soy, and choosing a prenatal supplement, myths included Whether you are planning a pregnancy, supporting a partner, or simply curious about how much of our health is set before birth, I think this one will stay with you. To connect with Dr Federica Amati, follow her on Instagram and explore her work at ZOE. If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify. It genuinely helps more people find these conversations. Intro (00:00) Why Your Baby's Health Is Set Before Birth (03:13) Dr. Federica Amati's Background in Maternal Nutrition (07:41) What 48 of 52 Cell Differentiations Means for Your Baby (15:33) How Egg and Sperm Health Drive Conception Outcomes (21:40) Does What You Do Preconception Affect the Baby Too (26:09) Sperm DNA and Placental Health: The Father's Hidden Role (30:39) Heat, Laptops, and Sauna: What Kills Sperm Quality (32:56) Is the 50% Sperm Count Decline Real (39:32) Soy Foods, Testosterone, and Male Fertility Myths Debunked (44:30) Foods to Avoid in the 90-Day Preconception Window (48:10) GLP-1 Drugs, Fertility, and Unplanned Pregnancies (54:28) First Trimester Nausea: What Actually Helps (59:42) How to Choose a Prenatal Supplement (01:04:34) How Much Protein Do You Actually Need in Pregnancy (01:07:30) Can a Plant-Based Diet Work During Pregnancy (01:11:59) Tylenol in Pregnancy: Is It Safe (01:15:55) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. We'd love your feedback. Complete our quick 2-minute audience survey to help us better understand what content, topics, and guests you enjoy most. Take the survey at voicingchange.media/simon. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Can You Reverse Heart Disease? What My Plaque Scans Showed | Dr Campbell Rogers 06.07.2026 1ч 15мин

  In late 2024 a CT scan revealed a small amount of soft plaque in my arteries. Sixteen months later I scanned again, and my plaque volume had dropped by around forty percent. In this episode I ask the cardiologist behind the technology whether a result like that can really be trusted. Dr Campbell Rogers is an interventional cardiologist, a former Harvard faculty member who ran the cath lab at Brigham and Women's Hospital, and now Chief Medical Officer at Heartflow. What we cover: The difference between a calcium score, a CT coronary angiogram, and AI plaque analysis Why a calcium score of zero does not mean you are free of disease What my own scans showed, and why Campbell believes the result Soft versus calcified plaque, and why calcification can be a sign of stabilisation Treating the plaque you can see rather than just an ApoB number Who should consider getting scanned, and the honest trade-offs This is a conversation about seeing a disease we used to only guess at, held with the right amount of scientific humility. If you want to understand your own heart health, I think it is well worth your time. If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify. It genuinely helps more people find these conversations. To connect with Dr Campbell Rogers, visit Heartflow. How Campbell Rogers went from cardiologist to Heartflow (00:00) What Heartflow is and how it works (07:26) Coronary CT angiogram vs. stress test (11:54) Why symptoms alone miss early heart disease (13:18) How Heartflow analyzes CT scans in 90 minutes (15:58) Calcified vs. non-calcified plaque: which is riskier (21:28) Why calcium score zero doesn't mean no heart disease (28:45) Who should get a CT angiogram with AI plaque analysis (31:09) Why seeing your plaque improves medication adherence (34:04) Simon's 2024 Heartflow scan results (39:12) How plaque rupture triggers a heart attack (43:25) Simon's 2026 Heartflow scan: 40% plaque reduction in 16 months (45:43) How long to wait between CT scans (51:14) Heartflow vs. Cleerly vs. QAngio (53:12) How Heartflow results led Simon to start statins (58:21) JAMA study: Heartflow tracks plaque in prostate cancer patients (1:00:10) What is low attenuation plaque and why it's high risk (1:02:53) Who should ask their doctor about a coronary CT angiogram (1:07:37) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. We'd love your feedback. Complete our quick 2-minute audience survey to help us better understand what content, topics, and guests you enjoy most. Take the survey at voicingchange.media/simon. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $500 off. The 4th of July sale ends July 12, and you get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Reversing Artery Plaque: 8 Supplements Ranked by the Evidence | Simon Hill, MSc 29.06.2026 1ч 1мин

  Can a supplement actually reverse the plaque in your arteries, or only slow it down? It is the question I am asked most, and after a 2024 scan revealed early plaque in my own left anterior descending artery, it became a personal one too. This is part two of my three-part series on reversing atherosclerosis. In this solo episode I work through eight of the most popular supplements and rank them by the strength of the human evidence, not the strength of the marketing. What we cover: Why pure EPA has by far the strongest evidence for regressing plaque, and what EVAPORATE, CHERRY, JELIS, and REDUCE-IT showed The REDUCE-IT versus STRENGTH debate, and why the form of omega-3 may matter as much as the dose Aged garlic extract and vitamin K2: what the imaging and calcification data suggest Niacin and the biomarker trap: raising "good" cholesterol without lowering risk Where CoQ10, berberine, nattokinase, and pomegranate extract really sit, plus a fact-check of a popular nattokinase claim My own plan after that scan, and a preview of part three on the pharmaceuticals Only one of these eight has strong evidence behind it, and even then it is a prescription rather than a tub from the supplement aisle. Supplements can be useful additions, but never a replacement for the proven basics. You can see exactly what I take over at my personal supplement stack. If you are enjoying the series, the simplest way to help is to leave a quick rating and review on Apple Podcasts, and to share this episode with someone whose heart health you care about. Can Supplements Actually Reverse Arterial Plaque? (00:00) EVAPORATE Trial: High-Dose EPA Reversed Plaque by 9% (02:09) Why Pure EPA Outperforms Standard Fish Oil (07:22) JELIS to REDUCE-IT: EPA Cuts Cardiac Events by 25% (10:10) REDUCE-IT Controversy and RESPECT-EPA 2024 (13:47) VITAL Trial: Omega-3 for Healthy Adults + 2026 Lp(a) Data (16:51) Aged Garlic Extract: 3 Trials on Plaque and Calcification (20:09) Vitamin K2: Does Redirecting Calcium Lower Heart Risk? (23:17) Niacin Failed: Why Raising HDL Didn't Save Lives (27:50) CoQ10: Promising Mechanism, No Plaque Imaging Proof (33:18) Berberine: The Gut Pathway No Other Supplement Uses (38:21) Nattokinase: One Study Says 36% Drop, One Says Zero (41:16) Pomegranate Extract: Strong Animal Data, Weak Human Trials (49:16) Which Supplements Can Actually Reverse Atherosclerosis? (53:18) Simon's Personal Protocol for Reversing LAD Plaque (55:24) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. We'd love your feedback. Complete our quick 2-minute audience survey to help us better understand what content, topics, and guests you enjoy most. Take the survey at voicingchange.media/simon. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. HomeServe Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you. HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  How to Lose Weight and Fix Your Metabolism in 2026 | Dr Mauricio Gonzalez 22.06.2026 1ч 29мин

  For decades we have treated the number on the scale as the goal of metabolic health. Dr Mauricio Gonzalez, a triple board-certified physician and endocrinology fellow practising in New York, makes the case that we have been measuring the wrong thing. In this conversation we explore why liver fat, not body weight, is becoming the real target, what the latest weight-loss medications can and cannot do, and how to cut through the hype and dogma that surround this field. What we cover: Why isolated blood tests and blood pressure readings tell you very little The myth that GLP-1 medications are "the easy way out" Why liver fat may matter more than body weight How diabetes clinics now remove medications instead of adding them Which supplements earn their place, and which Mauricio has cooled on The minimum effective dose for exercise, and knowing when "enough" is enough A grounded, practical conversation with a doctor who meets people where they are. If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify, it genuinely helps more people find these conversations. To connect with Dr Mauricio Gonzalez, follow him on Instagram, X, and YouTube, or visit his website at drmauriciogonzalez.com. Intro (00:00) Minimum Effective Dose for Exercise (01:38) Why Continuity of Care Reduces Mortality (07:09) How Type 2 Diabetes Silently Develops Over 12 Years (09:23) Statin vs. PCSK9 Inhibitor: How Doctors Choose (12:45) How GLP-1 Drugs Transformed the Diabetes Clinic (21:46) Why Doctors Now Measure Organ Fat, Not Body Weight (30:25) How Fatty Liver Disease Is Diagnosed (34:05) How Liver Fat Drives Insulin Resistance (40:47) Wegovy vs. Zepbound: How to Choose a GLP-1 (48:18) Should Lean People Use GLP-1s for Metabolic Health? (51:53) Why Patients Feel Guilty Taking GLP-1s (54:13) How Mauricio’s Nutrition Advice Has Evolved Over a Decade (01:04:35) Supplements on GLP-1s: What's Worth Taking (01:09:42) Minimum Effective Dose for Resistance Training (01:16:52) When Health Optimization Becomes Counterproductive (01:21:20) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Use code THEPROOF at eightsleep.com/theproof for up to $500 off. The 4th of July sale ends July 12, and you get 30 days to try it at home and return it if you don't love it. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. ProLon ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF. ProLon ships within the United States. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Evidence-Based Exercise in Pregnancy and Postpartum | Dr Margie Davenport 15.06.2026 1ч 33мин

  In this episode, exercise physiologist Dr Margie Davenport walks me through what the evidence actually shows about exercise during pregnancy and the postpartum period. Margie chaired the 2019 Canadian Guideline for Physical Activity throughout Pregnancy, the 2025 Canadian postpartum guideline, and the upcoming International Olympic Committee consensus statement on athletes through pregnancy and postpartum. We cover where the 140 bpm rule came from, the scale of the benefits at the population level, what direct fetal monitoring during HIIT and heavy lifting really shows, the new postpartum data, and why so many of the historical prohibitions do not survive contact with the data. What we cover: Where the 1985 "stay below 140 bpm" rule came from, and why it has long outlived its evidence Around 40 percent fewer cases of preeclampsia and gestational diabetes, and around 67 percent fewer cases of depression during pregnancy HIIT, heavy resistance training, and what fetal monitoring shows The 51 percent reduction in complications among women who kept lifting heavy Postpartum: the six-week myth, breastfeeding and injury risk, and a 45 percent reduction in postpartum depression The short list of actual "don'ts": scuba diving, and a few situational cautions The paradigm shift from prohibition to shared decision-making If this episode is useful, please leave a rating and review on Apple Podcasts or Spotify, and share it with someone in your life who is trying to make sense of conflicting advice. To connect with Dr Margie Davenport, visit exerciseandpregnancy.ca, follow her on Instagram at @DrMargieDavenport, or find her on LinkedIn and YouTube. Intro (00:00) Why Pregnancy Exercise Advice Feels So Confusing (01:15) The Most Damaging Myth About Exercise In Pregnancy (03:08) How Exercise Cuts Pregnancy Complications By 40% (05:05) Why Pregnant Women Were Excluded From Research (07:46) Can You Do High Intensity Workouts While Pregnant (12:49) How Exercise Lowers Preeclampsia And Diabetes Risk (16:43) How Much Exercise Is Safe During Pregnancy (27:03) Is Heavy Lifting Safe During Pregnancy (32:10) What You Should Never Do While Pregnant (40:41) Pelvic Floor Exercises Every Pregnant Woman Needs (47:41) How To Know If You're Overexerting While Pregnant (56:12) Does Exercise Affect Fertility And Conception (1:00:42) Why The 140 BPM Myth Still Exists (1:04:52) How Exercise Improves Postpartum Mental Health And Sleep (1:09:28) The Truth About The 6 Week Postpartum Rule (1:11:32) Does Breastfeeding Increase Your Risk Of Injury (1:17:13) Why Pregnant Athletes Need Better Policy Support (1:19:56) What Future Pregnancy Exercise Research Will Reveal (1:24:50) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38TERA ships to the United States, Australia, and New Zealand. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. ProLon ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF. ProLon ships within the United States. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. WHOOP WHOOP, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. WHOOP ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Nutrition for satiety and weight loss | Dr Federica Amati 09.06.2026 1ч 32мин

  GLP-1 medications are now part of the mainstream conversation, but the biology of appetite and satiety, the system these drugs operate within, gets far less attention than the drugs themselves. In this episode, I sit down with Dr Federica Amati, Head Nutritionist at ZOE and author of the new book The Appetite Reset, to explore what's actually happening in the gut and brain when appetite signals do their job, and what that means for everyone, on or off medication. Federica brings a rare combination of pharmacology, clinical nutrition, and public health expertise to a subject that rarely receives this level of nuance. This is a conversation about understanding your biology well enough to work with it. What we cover: How GLP-1 works naturally in the body, why the natural peptide lasts minutes while the drug version lasts days, and why this matters for anyone using or considering these medications The three types of hunger (hedonic, homeostatic, and microbiota-driven) and how to tell them apart in practice Why GLP-1 supplements don't replicate what the medications do "Prehab" before starting medication: gut microbiome diversity, fibre intake, and nutrient status as the foundation Why the 30g daily fibre target doesn't drop when calorie intake does on medication Protein targets of 1.2 to 1.6g per kilogram and resistance training three times a week as the most critical protective interventions for muscle and bone health The science on shame, weight stigma, and why treating obesity as a lifestyle choice is both inaccurate and actively harmful If this episode was useful, a review on Apple Podcasts or a follow on Spotify makes a genuine difference. To connect with Dr Federica Amati, follow her on Instagram at  ⁠instagram.com/dr.fede.amati⁠ or explore her work through ZOE at zoe.com⁠. Her new book, The Appetite Reset⁠, will be released on June 25 and is available to pre-order now. Intro (00:00) Why Everyone Needs to Understand Appetite Biology (01:14) How Dr. Federica Amati Became a Nutrition Expert (03:06) Why GLP-1 Drugs Are Different From Any Supplement (11:29) The Gila Monster That Led to Ozempic (17:44) What Is Food Noise and Why It Controls You (20:20) Why Willpower Isn't the Problem: Genetics and Epigenetics (24:06) How GLP-1s Change Your Relationship With Food and Joy (30:54) Lowest Effective Dose: Why More Isn't Better (34:08) The Muscle Loss Risk Nobody Warns You About (39:34) Microdosing GLP-1s: Does It Work or Is It Dangerous (41:59) The Three Types of Hunger and How to Tell Them Apart (44:51) How Your Gut Microbes Drive Cravings and Leptin Resistance (50:17) Why Calories Alone Don't Explain Appetite (58:07) How to Manage Food Noise Without a GLP-1 (01:04:46) Prehab Before GLP-1s (01:11:09) The Fiber, Fat, and Gut Prep Protocol for GLP-1 Users (01:13:56) What Clinical Trials Actually Include That Real-World Use Doesn't (01:21:41) Do You Need Supplements on a GLP-1? (01:27:15) Obesity Is Not a Lifestyle Choice: Shame, Stigma, and GLP-1s (01:29:49) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. WHOOP WHOOP, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. WHOOP ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  The Surgeon Defending Statins, GLP-1s, and Ancel Keys | Dr Terry Simpson 01.06.2026 1ч 42мин

  In this episode, I sit down with bariatric surgeon and science communicator Dr Terry Simpson for a wide-ranging conversation about health misinformation, GLP-1 medications, statins, ApoB, the Mediterranean diet, and the loud contrarians who dominate social media. Terry has familial hypercholesterolemia, a family history of premature cardiovascular disease, and lost 50 pounds on tirzepatide, all of which give him unusual personal stakes in these debates. What we cover: How to think about uncertainty in science, and Terry's heuristic for spotting misinformation The Gila monster origin story of GLP-1 medications, and the difference between native and pharmacological GLP-1 What food noise actually is, and Terry's own experience on tirzepatide His personal case for statins, an LDL of 190 brought into the 40s, and an ApoB in the 40s A defence of Ancel Keys and the Mediterranean diet Where the carnivore, anti-statin, seed oil, and nattokinase narratives fall apart Compounded GLP-1s, peptide deregulation, and why the FDA still matters If you find this episode useful, please leave a rating and review on Apple Podcasts or Spotify and share it with someone who might benefit. To connect with Dr Terry Simpson, visit terrysimpson.com, find him on TikTok at @drterrysimpson, Instagram at @drterrysimpsonmd, X at @drterrysimpson, and Substack at @drsimpson. His podcast is The Unfiltered MD. Intro (00:00) Why Carnivore and Anti-Vax Are Today's Biggest Health Lies (01:02) Doctors, COVID and the Cost of Speaking Up Online (03:58) How to Spot a Health Huckster (13:25) Will GLP-1 Drugs Make Bariatric Surgery Obsolete (19:12) A Bariatric Surgeon's Personal Decision to Take a GLP-1 Drug (22:54) Willpower Is Not the Problem: What Food Noise Actually Feels Like (26:23) Why Ancel Keys Was Right and Low Carb Got It Wrong (32:51) Mediterranean Diet Results That Stopped a Trial Early (39:50) Are GLP-1 Drugs the Greatest Medical Breakthrough This Century (47:38) The Real Danger of Buying Compounded GLP-1 Drugs Online (51:27) BPC-157 and Peptides: Why FDA Guardrails Actually Matter (59:42) Familial Hypercholesterolemia, Statins and a Personal Wake Up Call (01:04:69) Inflammation vs. ApoB: What Actually Causes a Heart Attack (01:13:04) CT Angiogram Results and Keto CTA Data Explained (01:16:33) Fish Oil vs. Eating Fish: Why the Supplement Doesn't Replicate the Food (01:24:35) Simon's Plant Based Diet, Seed Oils and Cooking with Olive Oil (01:28:07) The Seed Oil Debate: Are People Just Afraid of Modern Chemistry (01:33:17) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38TERA ships to the United States, Australia, and New Zealand. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. LMNT Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked. LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S. WHOOP WHOOP, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. WHOOP ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  Has Optimisation Culture Gone Too Far? | Sarah Ann Macklin 28.05.2026 1ч 10мин

  In this episode, I’m joined by Sarah Ann Macklin to explore the hidden psychological costs of modern wellness culture and why pursuing health can sometimes leave us feeling more anxious, overwhelmed, and disconnected. Sarah shares insights from her new book, Healthy Shouldn’t Be This Hard, as we unpack self-compassion, perfectionism, body image, mindset, and the pressure to constantly optimise every aspect of our lives. What We Cover Why wellness culture can become emotionally exhausting The difference between self-esteem and self-compassion How mindset shapes long-term health behaviours The psychological side of food, body image, and self-worth Why optimisation culture can backfire Practical ways to build a healthier relationship with yourself I really enjoyed this conversation with Sarah and appreciated her thoughtful, balanced perspective on what genuine wellbeing actually looks like in practice. Pre-order Sarah’s new book, Healthy Shouldn’t Be This Hard, and follow her on Instagram, subscribe to her YouTube channel, and read her writing on Substack. You can also learn more about Sarah and her work on her website. Intro (00:00) What Wellness Culture Is Getting Wrong Right Now (01:16) The Chambermaid Study: How Mindset Changes Your Body (05:48) The Milkshake Study: Your Perception Affects Your Metabolism (07:06) Sarah's Modeling Career, Collapse, and ER Wake-Up Call (09:11) How Social Media Weaponizes Self-Comparison (14:01) Has Optimization Culture Gone Too Far? (17:58) How to Know When Health Habits Become Counterproductive (22:36) Self-Compassion Is a Muscle — Here's How to Build It (27:28) How Common Is Beating Yourself Up Over Health? (30:26) The Chocolate Bar Test: Audit Your Self-Compassion (36:33) How to Reconnect with Your Real Hunger Signals (39:36) The 3-Step Compassion Framework for Eating Decisions (40:57) Discipline vs. Self-Compassion: They're Not Opposites (43:44) The "Friend Filter": The Simplest Self-Compassion Tool (57:12) What Better Wellness Culture Looks Like in 5 Years (01:02:17) Where to Find Sarah's Book "Healthy Shouldn't Be This Hard” (01:04:48) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
• 
  What the Headlines Get Wrong About the Future of Meat | Bruce Friedrich 26.05.2026 1ч 47мин

  Six years on from our first conversation, global meat consumption is at a record high, and the harms of industrial animal agriculture have only deepened. Bruce Friedrich, founder of the Good Food Institute, is back on the podcast to argue that the answer is not asking people to eat less, but rebuilding meat itself from the ground up. Bruce is the author of the new book Meat: How the Next Agricultural Revolution Will Transform Humanity's Favorite Food and Our Future, and one of the most thoughtful voices working on alternative proteins anywhere in the world. What we cover: Why public health messaging on meat has not changed consumption since the 1960s The four harms of industrial animal agriculture An honest post-mortem on Beyond Meat and the plant-based industry Where cultivated meat actually sits in 2026 Why this transition needs governments, not only venture capital The ultra-processed food backlash and what the science really shows To connect with Bruce Friedrich, you can find his book at meatbook.org, learn more about the Good Food Institute at gfi.org, follow him on X at x.com/BruceGFriedrich, or connect with him on LinkedIn at linkedin.com/in/brucegfriedrich. Support the work of the Good Food Institute. Listener donations will be matched dollar-for-dollar up to $30,000: gfidonorportal.donorsupport.co Intro (00:00) Why Feeding Crops to Animals Is Destroying the Planet (02:02) Is Everything Getting Worse? A 6-Year Update (07:33) Plant-Based Meat: Honest Assessment of What Went Wrong (13:42) Did These Products Come to Market Too Early? (19:42) What US Government Support for Alt Proteins Should Look Like (25:56) 35 Governments Are Now Funding This Research (33:12) Why Conservative States Banned Cultured Meat (36:42) Are Traditional Meat Companies Actually on Board? (40:07) Why Meat Consumption Will Keep Rising Until 2050 (47:06) Is Innovation Actually Stalling? The Real Picture (52:10) Why Cultivated Meat May Beat Plant-Based to the Finish Line (56:47) The Science of Plant Fats vs. Animal Fats Explained (01:00:22) The Biggest Blind Spot in Plant-Based Meat Today (01:07:35) Cultivated Meat Regulatory Milestones: From Zero to 5 Countries (01:14:13) The Only Engineering Challenge That Could Doom Cultured Meat (01:18:05) FDA Approval, Chicken with Cancer, and Why Cultured Meat Is Safer (01:20:30) Cultured Meat Prices Dropped 100,000x in 12 Years (01:25:21) Vow Foods' SpaceX-Inspired Bioreactor Breakthrough (01:30:42) How GFI Raises Money And a $30K Donation Match (01:34:55) The Protein Myth: Why Impossible Burgers Beat Beef on Nutrition (01:39:31) This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. ProLon ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF. ProLon ships within the United States. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Cozy Earth This spring, give yourself the kind of comfort that lives with you all day - not just the moment you get home. Head to cozyearth.com and use my code THEPROOF for an exclusive 20% off. Cozy Earth ships worldwide. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.
• 
  Improving cholesterol and blood pressure with diet | A Masterclass 18.05.2026 1ч 57мин

  Cardiovascular disease is the world's leading killer, and yet the prevention conversation has become noisier and more confused than ever. In this Masterclass I bring together the evidence-first material I think is most useful for understanding cholesterol, blood pressure, and long-term heart health. You will hear from Dr Walter Willett at Harvard, cardiology dietitian Michelle Routhenstein, and nephrologist Dr Raymond Townsend, alongside my own deep dives on plaque regression, the Portfolio Diet, and six landmark trials. What we cover: Legumes as the most underrated longevity food The Portfolio Diet and a 30% LDL reduction without statins What six trials tell us about diet, plaque progression, and regression Dr Walter Willett on saturated fat, seed oils, and dairy Sodium, potassium, and the DASH diet for blood pressure Why diet, exercise, and medications work best together The earlier you start, the more leverage you have. This Masterclass is meant to give you a clearer map of what actually works. If this episode was useful, please consider leaving a rating or review on Apple or Spotify. It helps more than you might think. Most Underrated Foods for Long-Term Health (00:00) Can You Actually Reverse Artery Plaque? (03:07) How to Lower ApoB Without Statins (07:19) The Portfolio Diet: Cut LDL by 30% (09:11) 6 Trials That Changed Heart Disease Science (16:30) Michelle Routhenstein: Why Doctors Skip ApoB Testing (20:07) Best Food Swaps to Lower ApoB (27:04) RFK Jr, Seed Oils, and the Saturated Fat Debate (35:48) Full-Fat vs. Low-Fat Dairy and Your Heart (38:27) Blood Pressure: Why the Sodium-Potassium Ratio Matters (43:08) Walter Willett: The True Mediterranean Diet (45:19) Are Seed Oils Inflammatory? The Science (50:50) Should You Cook with Olive Oil or Not (57:44) Full-Fat vs. Low-Fat Dairy: 2025 Research (01:03:00) Dairy vs. Soy Milk: Health and Planet (01:09:32) Plant Protein vs. Animal Protein: The Data (01:14:52) Raymond Townsend: Top Levers for Lowering Blood Pressure (01:16:38) Best Exercise Type for Blood Pressure (01:20:13) How Sodium Raises Blood Pressure Over Time (01:24:48) Potassium vs. Sodium: Why the Ratio Is Everything (01:30:40) Should You Watch Salt with Normal Blood Pressure (01:43:51) Why the DASH Diet Works as Well as a Drug (01:48:31) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com. Momentous ships to many countries worldwide depending on local import regulations. SwimClub SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF. HomeServe Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you. HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.
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  The Peptides Quietly Accelerating Aging | Dr Valter Longo 11.05.2026 1ч 47мин

  The peptide and GLP-1 conversation has reached a fever pitch. Growth-hormone-releasing peptides are being marketed as longevity tools, GLP-1s are being treated as a default rather than a last resort, and a wellness aesthetic of higher IGF-1, more muscle, and less fat is being sold as the route to a longer life. In this episode, I sit down with Dr Valter Longo, Professor of Gerontology at USC and Director of the USC Longevity Institute, to look at what the data actually says. Valter developed the Fasting-Mimicking Diet, has led foundational work on the growth hormone, IGF-1, insulin, and TOR axis across yeast, mice, and humans, and runs non-profit longevity foundation clinics in Europe and the US. He calls himself the anti-biohacker and makes the case using the totality of evidence rather than the loudest claim. What we cover: The peptide boom and why every line of evidence cuts the other way The body composition reality of GLP-1s after 3 to 4 years The optimal IGF-1 range and how to land there with food and timing The Fasting-Mimicking Diet across more than 47 clinical trials, including the biological-age reduction studies The Harvard plant-versus-animal protein data, properly read A grounded case against ketogenic patterns for longevity and what to eat instead If this conversation lands, a quick rating or review on Apple Podcasts or Spotify makes a real difference. To follow more of Dr Valter Longo's work, visit his website, find him on Instagram, and explore the work of the Create Cures Foundation, the Valter Longo Foundation, the Longevity Technology Institute, and the European Longevity Institute through his published research and his book The Longevity Diet. Intro (00:00) The Peptide Boom and What Is Actually Being Sold (00:01) GLP-1s: 92 Per Cent Drop-Out and the Body Composition Math (00:02) The Fasting-Mimicking Diet Reverses Western-Diet Damage (00:13) Snell, Ames, and Laron Dwarf Mice (00:18) The Laron Syndrome Cohort in Ecuador (00:24) Acromegaly and the Cost of High Growth Hormone (00:28) The Optimal IGF-1 Range: 120 to 160 ng/mL (00:50) Plant vs Animal Protein, Properly Read (00:57) The Anti-Keto Case from Okinawa to Loma Linda (01:08) Stanford Crohn's, Miami UC, and Rome Kidney Disease (01:22) Biological Age Reduction After Three FMD Cycles (01:25) FMD Safety Across More Than a Million Users (01:31) The Longevity Diet: Eat More, Eat Better (01:43) This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. 38Tera ships to the United States, Australia, and New Zealand. Pique Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON. Pique ships within the U.S. and to Australia, Canada, and select EU countries. Function Health Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States. Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico. Truemed Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars. IM8 With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com. IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America. WHOOP WHOOP, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. WHOOP ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @theproof Twitter: @theproof Facebook: The Proof with Simon Hill