Brave & Curious with Dr Lora Shahine

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• Ep 173 Ovarian Rejuvenation: The Race to Extend Fertility with Roohi Jeelani, MD 02.06.2026 1h 1min

  What if the "final frontier" of fertility care is not IVF technology, but the aging ovary itself? Can science help improve egg quality, mitochondrial function, and reproductive lifespan? And how do patients sort through what is proven, what is promising, and what is still very much in the "ask your doctor before you try this" category? In this episode of Brave & Curious, Dr. Lora Shahine welcomes reproductive endocrinologist Dr. Roohi Jeelani for a fascinating conversation about ovarian rejuvenation, age-related fertility decline, and the future of fertility treatment.  Together, they discuss why age remains one of the biggest factors in IVF success, how egg quality changes over time, and why topics like oxidative stress, mitochondrial health, inflammation, and lifestyle optimization are becoming such important parts of the fertility conversation. In this episode you'll hear: [1:07] Meet Dr. Roohi Jeelani [2:32] Age and fertility [4:23] Egg quality basics [8:06] Sleep and fertility [9:35] Stress and cortisol [14:58] Movement and PCOS [16:54] Nutrition for fertility [18:51] Trimester zero prep: Small, sustainable changes [29:25] CoQ10, Inositol, Melatonin [35:38] NAD and egg quality [43:56] GLP-1 fertility questions [47:22] Peptides and PRP [55:33] Ovarian rejuvenation research [1:01:04] Future fertility medicine Resources mentioned:  onto.health @roohijeelanimd on Instagram | LinkedIn @onto-health-co on LinkedIn Your Leggings Could be Causing Infertility? with Dr. Lora Shahine on YouTube Can CoQ10 Improve Egg Quality and Sperm Health for TTC? with Dr. Lora Shahine on YouTube Does Growth Hormone Improve IVF Outcomes? with Dr. Lora Shahine on YouTube Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.  
• Ep172 Unexplained Infertility: Finally Explained 19.05.2026 33min

  Have you been told your fertility tests are normal, but pregnancy still isn't happening? What does unexplained infertility actually mean when it clearly feels like something is going on? And how do age, egg quality, sperm function, endometriosis, inflammation, and implantation issues factor into a diagnosis that can feel more frustrating than reassuring? In this episode of Brave & Curious, Dr. Lora Shahine takes a compassionate deep dive into unexplained infertility to explain how it's diagnosed, why it affects so many patients, and what may be happening behind the scenes when standard fertility testing does not reveal a clear answer. Listeners will learn the most common hidden contributors to unexplained infertility, treatment options, and when moving to IVF may be the most effective path forward. In this episode you'll hear: [0:49] Dr. Lora Shahine's personal fertility story [3:06] How Diagnosis Works [4:31] How Common is Unexplained Infertility? [8:07] Possible Cause #1: Age & Fertility [11:51] Possible Cause #2: Hidden Sperm Factors [13:48] Possible Cause #3: Egg Quality Unknowns [14:13] Possible Cause #4: Implantation Mysteries [15:19] Possible Cause #5: Tubal Function Problems [16:49] Possible Cause #6: Endometriosis Link [19:233 Possible Cause #7: Inflammation and Lifestyle [20:39] What to Do Next [23:38] Treatment Plans: IUI vs IVF [31:31] Wrap up and next steps   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.  
• Ep 171 What Your Semen Analysis is Not Telling You with Jeff Lysiak, PhD 05.05.2026 35min

  Are you frustrated by a diagnosis of unexplained infertility? What if a "normal" semen analysis is not telling the whole story about sperm health? Could a new male fertility test help explain why fertilization is not happening, even when sperm count, motility, and morphology look fine? In this episode of Brave & Curious, Dr. Lora Shahine welcomes Jeff Lysiak, PhD. He is a reproductive biologist, and co-founder and Chief Science Officer of PS Fertility. He is here to to talk about what standard semen analysis may miss.  Together, Dr. Shahine and Dr. Lysiak explore the science behind sperm fertilization competence, the role of phosphatidylserine (PS) on live sperm, and how Dr. Lysiak's research led to PS Direct, a diagnostic test designed to measure sperm's ability to bind and fertilize an egg beyond traditional semen parameters. Dr. Shahine and Dr. Lysiak also discuss the future of male reproductive health research, including lifestyle factors, environmental exposures, and the growing need for more precise answers earlier in the fertility journey. In this episode you'll hear: [0:39] Meet Jeff Lysiak, PhD [2:01] From Placenta to Sperm [3:24] PS Discovery Explained [5:01] How Sperm Meets Egg [9:02] From Lab to Clinic [10:19] Limits of Semen Analysis [12:46] PS Score and Misdiagnosis [14:12] At Home PS Test Kit [18:20] Where PS Fits Clinically [21:13] Varicocele & Repair Surgery [24:14] Using PS to Guide Care [27:26] Lifestyle Factors [33:006] Future Research Directions [34:21] Where to Find the Test & Connect with Jeff   Resources mentioned:  PSFertility.com   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was sponsored by PS Fertility. This episode was produced by Audiotocracy Podcast Production.  
• Ep 170 Cost of Fertility Care: Solutions with Angela Rastegar from Sunfish 22.04.2026 37min

  What if the hardest part of your fertility journey isn't the medicine, it's affording the best treatment? How do you plan for IVF costs when coverage is unclear or incomplete? And is there a smarter, more supported way to navigate the financial stress of building a family?  In this episode of Brave & Curious, Angela Rastegar, CEO and founder of Sunfish, joins Dr. Lora Shahine. They are honoring National Fertility Week through their conversation that explores the real cost of fertility care and why financial planning is just as critical as medical care. Angela shares her deeply personal fertility journey, including multiple rounds of egg freezing without financial support, and how that experience led her to build a platform designed to support patients through every step of their family-building journey, from egg freezing and IVF to surrogacy. Dr. Shahine and Angela talk about the hidden gaps in insurance coverage, the rising reality of fertility-related debt, and how Sunfish's data-driven, AI-powered programs aim to reduce uncertainty with personalized care plans, cost transparency, and even financial protections for IVF and egg freezing outcomes. In this episode you'll hear: [0:34] Angela Rastegar's personal journey, without financial support [3:28] Along comes Sunfish [5:45] The IVF Success Program [8:35] The hidden costs of IVF [13:40] Common misconceptions with insurance coverage [19:53] Step-by-step breakdown of cost [23:01] Grants, loans, and creative solutions [27:08] New AI-powered egg freezing program [30:55]The "silent tax" of egg freezing [37:00] Getting connected to Sunfish Resources mentioned:  joinsunfish.com Sunfish provides personalized financial plans using proprietary software to estimate costs for each Program. If actual costs exceed projections, eligible patients may receive a partial refund under program terms. Sunfish is not a medical provider. Terms and conditions apply.   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.  
• BONUS Ep 169 Fighting for Fertility with RESOLVE CEO Danielle Melfi 19.04.2026 40min

  IVF is under fire. So, what happens when access to IVF is suddenly at risk? How much power should policy have over your ability to build a family? And what can one voice, or one story, really do to protect fertility care for millions?  In this timely episode of Brave & Curious, Dr. Lora Shahine is joined by Danielle Melfi, the new CEO of RESOLVE, who brings a powerful blend of policy expertise, personal fertility experience, and a deep commitment to family-building equity.  Airing at the start of National Infertility Awareness Week, Dr. Lora Shahine and Danielle are talking about the real-world impact of recent legislative threats to IVF, including the Alabama ruling that temporarily halted treatment. They explore how advocacy organizations mobilize quickly to protect patients.  Danielle shares her own egg freezing journey, her background in government and healthcare advocacy, and how RESOLVE is working to expand access, improve patient education, and fight misinformation in an increasingly complex fertility landscape. In this episode you'll hear: [1:41] Meet Danielle Melfi, CEO of RESOLVE [5:45] Why IVF Stopped in Alabama [10:55] What RESOLVE Does [14:15] Fertility Care Coverage in California and Recent Advocacy Wins [19:29] The Power of Fertility Stories [21:48] Restorative Reproductive Medicine Movement: A Threat in Disguise? [23:12] Personhood Bills Explained [36:55] RESOLVE's Strategic Plan [38:31] Get Involved   Resources mentioned:  resolve.org @resolveorg on Instagram   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.
• Ep 168 Taking Charge of Your PCOS with Cory Ruth, RDN 07.04.2026 46min

  What if your PCOS diagnosis is about more than fertility? What if the symptoms you've been told to "just manage" are actually your body asking for deeper support? And what if you could take back control in a way that feels empowering rather than restrictive? In this episode of Brave & Curious, Dr. Lora Shahine sits down with registered dietitian and author of PCOS is My Power Cory Ruth, RDN  to explain all about Polycystic Ovary Syndrome (PCOS) and why it's often misunderstood. Cory shares her personal journey to diagnosis and how it shaped her mission to help women better understand the metabolic, hormonal, and reproductive components of PCOS.  Dr. Shahine and Cory cover the diagnostic criteria, common misconceptions (like "just lose weight"), and the evolving science around lifestyle interventions, blood sugar regulation, and long-term health outcomes. This episode will give listeners a clearer understanding of how to manage PCOS through sustainable nutrition, movement, and mindset shifts, without falling into restrictive or shame-based approaches. Cory's refreshing expertise helps us reframe PCOS as a potential catalyst for lifelong health—giving you the tools to feel informed, supported, and back in the driver's seat. In this episode you'll hear: [1:56] PCOS "triple threat": reproductive, metabolic, & hormonal [5:40] Cory Ruth's personal journey [8:01] Early signs of PCOS [11:43] The Rotterdam criteria [17:33] PCOS is a weight issue: MYTH [19:09] Nutrition is the foundation of PCOS management [22:24] Simple, realistic meal ideas to support PCOS [31:25] Intermittent fasting & PCOS [34:27] Mental health & PCOS [37:35] Long-term risks of PCOS [40:10] Sustainable lifestyle changes that actually work [43:05] Reframing PCOS as an opportunity for lifelong health   Resources mentioned:  www.thewomensdietitian.com @thewomensdietition on Instagram Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.
• Ep 167 Endometriosis Diagnosis Without Surgery? Dr. Bruce Lessey 24.03.2026 45min

  Are you struggling with unexplained infertility and wondering if endometriosis could be the missing piece? Have you been told that surgery is the only way to get a diagnosis? What if a simple test could offer answers without going into the operating room?  In this episode of Brave & Curious, Dr. Lora Shahine welcomes guest Dr. Bruce Lessey, a double board certified OBGYN and Reproductive Endocrinologist with decades of research experience and over 150 peer-reviewed publications. Together they explore a groundbreaking question in reproductive medicine: can we diagnose endometriosis without invasive surgery? Dr. Lessey and Dr. Shahine explain the science behind BCL6 testing, a biomarker found in the uterine lining that may signal inflammation linked to endometriosis. Dr. Lessey also shares how this research evolved from studying implantation markers to developing a potential non-invasive diagnostic tool, and why timing in the menstrual cycle is critical for accurate results.  They also discuss the realities of delayed diagnosis, the connection between endometriosis and unexplained infertility, and how this test is already being used in clinical settings. In this episode you'll hear: [1:21] Meet Dr. Bruce Lessey [4:27] Why does diagnosing endometriosis take years? [7:16] Introducing BCL6 testing [16:20] Timing the biopsy window [22:51] IVF outcomes study [25:42] Fresh vs. frozen transfers [27:22] Treating expected endometriosis [28:44] Lupron and surgery explained [30:42] BCL6 in recurrent pregnancy loss and recurrent implantation failure [33:04] Progesterone resistance and benefits of letrozole [40:48] Timing and testing pitfalls [43:02] Future research and wrap up Resources mentioned:  Overexpression in Eutopic Endometrium of Women With Endometriosis. doi: 10.1177/1933719116649711.   Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. doi: 10.1016/j.fertnstert.2017.09.017.   Unexplained recurrent pregnancy loss and unexplained infertility: twins in disguise. doi: 10.1093/hropen/hoz021.   This episode is sponsored by Cicero Diagnostics. Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.  
• Ep 166 Is Inflammation Hijacking Your Fertility? Answers from Natalie Crawford, MD 10.03.2026 55min

  What if inflammation is quietly affecting your fertility? What if the key to improving egg quality and hormonal balance isn't just medical treatment, but the everyday choices you make? And what if understanding your body earlier could change your entire fertility journey?  In this episode of Brave & Curious, Dr. Lora Shahine welcomes fertility specialist Dr. Natalie Crawford to explore how inflammation influences reproductive health and what women can do to support fertility from the inside out. Dr. Natalie Crawford is the author of The Fertility Formula, and she is here to share how her own experience with infertility and pregnancy loss shaped her passion for empowering patients with science-based fertility education.  Together, she and Dr. Shahine discuss the growing role of chronic inflammation, insulin resistance, environmental exposures, and lifestyle factors in fertility challenges. Dr. Crawford explains why fertility medicine often reacts too late in the process and why understanding hormones, ovarian reserve, and reproductive health earlier can help people advocate for themselves and make informed decisions. In this episode you'll hear: [2:32] Dr. Natalie Crawford's fertility journey [7:00] Chronic inflammation and fertility [20:59] Insulin resistance impacts hormones, ovulation, & egg quality [26:34] The connection between stress, cortisol, and fertility outcomes [28:09] Sleep is an important fertility-supporting habit [32:41] Strength training to improve hormone health [41:23] Nutrition basics that work [48:25] Dr. Crawford's framework: Educate, Advocate, Optimize [54:26] Connecting with Natalie Resources mentioned:  nataliecrawfordmd.com As A Woman Podcast @nataliecrawfordmd Instagram | TikTok | LinkedIn | YouTube   Ep 157 Why Sleep is the Most Powerful Habit You Can't Ignore with Dr. Meredith Broderick Dr. Shahine's Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.
• Ep 165 Do Progesterone Shots Improve Frozen Embryo Transfer Success? 03.03.2026 17min

  Are progesterone shots really necessary for a frozen embryo transfer? Why would your doctor recommend intramuscular injections over suppositories or other less painful options? And could the type of progesterone you use actually affect implantation, miscarriage risk, or live birth rates? In this episode of Brave & Curious, Dr. Lora Shahine explains the science behind progesterone support in frozen embryo transfer (FET) cycles, especially why intramuscular (IM) progesterone is often recommended in certain programmed cycle protocols.  Dr. Shahine explains how progesterone supports implantation and early pregnancy, the key differences between programmed or medicated and natural or ovulatory FET protocols, and why not all progesterone options perform the same way.  Listeners will learn how IM progesterone compares to other forms and when IM progesterone may meaningfully improve FET success. You'll get some practical guidance on how to talk with your doctor about choosing the right progesterone protocol for your body and your treatment plan.  In this episode you'll hear: [1:11] Progesterone shot fears [2:30] Why progesterone matters [4:22] Why supplement in treatment [5:22] Programmed vs. ovulatory FET [7:31] Progesterone options explained [11:07] Landmark 2021 trial set up [13:08] Results: live birth miscarriage [15:14] Next steps   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode! This episode was produced by Audiotocracy Podcast Production.  
• Ep 164 Taking Charge of Cycle Tracking with Author Dr. Toni Weschler 24.02.2026 49min

  Are ovulation predictor kits enough to time intercourse? Can an app really tell you when you're fertile? And what if your body has been giving you the answers all along?  In this episode of Brave & Curious, Dr. Lora Shahine is talking to fertility awareness pioneer Dr.  Are ovulation predictor kits enough to time intercourse? Can an app really tell you when you're fertile? And what if your body has been giving you the answers all along?  In this episode of Brave & Curious, Dr. Lora Shahine is talking to fertility awareness pioneer Toni Weschler, author of Taking Charge of Your Fertility, and her niece, software engineer, Sabrina Nowicki. These three women explore how women can confidently track ovulation, understand cervical fluid, and take charge of their reproductive health with both education and technology. Toni Weschler shares the powerful origin story behind her decades of paper charting and why she once resisted fertility apps altogether. She believed that a thermometer, a pen, and knowledge of your own body were enough.  Sabrina explains how that philosophy evolved into Cyclisity, an educational cycle tracking app designed as the perfect companion to the book. Unlike predictive period apps that rely on algorithms and "average" 28-day cycles, Cyclisity follows the sympto-thermal method exactly as taught in Toni's work. It will finally make sense why basal body temperature confirms ovulation but doesn't predict it, how cervical fluid signals approaching fertility, why ovulation predictor kits can miss critical timing, and how improper app use can delay fertility diagnosis or lead to unintended pregnancy.  This conversation is a masterclass in reproductive education and body literacy while blending science, privacy, and modern technology. In this episode you'll hear: [0:39] Meet the guests: Author Toni Weschler and Sabrina Nowicki [2:36] Why track your cycle? [4:03] Understanding ovulation and health [6:49] Sabrina's personal journey [10:29] Toni's period story [13:10] The push for technology [14:52] Early software resistance [18:35] The perfect team forms [22:03] Creating Cyclisity [27:07] Using book and app together [31:41] Temperature vs cervical fluid [32:53] Checking cervical fluid Resources mentioned:  cyclisity.com tcoyf.com @cyclisity on IG @cyclisityapp on TikTok @wanderingsabrina on IG | on TikTok Ep 50 Over 25 Years of Taking Charge of Your Fertility with Author Toni Weschler Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode!  
• Ep 163 C-Section Scar and Fertility: Should Isthmocele Be Treated? 17.02.2026 15min

  Did you have a C-section and now notice spotting that won't quit? Are you dealing with pelvic pain, confusing symptoms, or trouble getting pregnant, and wondering if they're connected? Has anyone ever mentioned the word isthmocele to you… or is this the first time you're hearing it? In this episode of Brave & Curious, Dr. Lora Shahine explains a condition many patients are never warned about after a C-section: an isthmocele. She tells us what an isthmocele is, how it can form in a prior C-section scar, and why it can sometimes lead to unexpected bleeding, pain, or fertility challenges.  You'll learn the five key symptoms that may signal an isthmocele, how this condition can affect fertility and future pregnancy plans, and the pros and cons of monitoring versus treating. Dr. Shahine also talks us through when surgical repair may be helpful, and the exact questions to ask your doctor so you can advocate for informed, personalized care.  If you've had a C-section and feel like something isn't quite right, this episode offers knowledge, reassurance, and a clear path forward. In this episode you'll hear: [0:46] Understanding C-section scars: Isthnocele [2:21] What is an isthmocele? [3:24] How common? [4:18] Getting diagnosed [6:06] Symptoms [7:36] Treatment options [9:21] Observation vs. surgical management [14:01] Important questions to ask your doctor [14:57] Conclusion & final thoughts Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app to earn FREE CE Credit for listening to this episode
• Ep 162 Optimizing Embryo Transfer Success: Your Questions Answered 10.02.2026 29min

  How do you make an embryo stick? Is there anything you can do to improve embryo transfer success? And how do you know which advice is science-backed versus fertility folklore?  In this special solo Q&A episode of Brave & Curious, Dr. Lora Shahine answers the questions patients ask most often when preparing for an embryo transfer. What really matters during an IVF embryo transfer? Using real questions from Instagram, YouTube, and her own practice, she walks listeners through fresh vs. frozen embryo transfer, what happens on transfer day, whether you need a full bladder, lying down afterward, Valium use, pineapple cores, French fries, genetic testing, ERA testing, and how uterine lining preparation actually works. Listeners will come away with a clearer understanding of embryo transfer success rates, frozen embryo transfer protocols, and implantation timing, and get their real questions answered. In this episode you'll hear: [1:27] What should I expect on transfer day? [8:00] What happens post-transfer? [9:35] Funny myths: pineapple cores & McDonalds french fries [13:46] Fresh vs. frozen transfer myths [20:18] Pre-transfer testing and ERA [24:37] Natural vs. medicated transfer protocols [28:30] Conclusion & final thoughts Links and Resources: Embryo Transfer: What to Expect on YouTube Does the Embryo Fall Out: Embryo Transfer Tips on YouTube Fresh vs. Frozen Transfers: Pros and Cons on YouTue Studies Mentioned: Randomized Controlled Trial for FET Protocols: PMID: 38944045 Retrospective analysis Perinatal Outcomes with FET protocols PMID:33926401 Randomized Controlled Trial for ERA before FET PMID: 36472596 Randomized Controlled Trial Bedrest after embryo transfer: PMID:31520259 Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Join the Learn at Pinnacle app ⁠to earn FREE CE Credit for listening to this episode!
• Ep 161 Understanding Fertility Testing: A Step-by-Step Guide for Couples 03.02.2026 24min

  Are you starting to think about fertility testing? Have you been trying to conceive and wondering which tests actually matter? Or are you overwhelmed by conflicting advice  and unsure where to begin?  In this episode of Brave & Curious, Dr. Lora Shahine breaks down fertility testing with clarity, compassion, and evidence. Now you can move forward feeling informed instead of intimidated. Dr. Shahine covers the basics of fertility testing including the essentials of a thorough health history. She also explains how menstrual cycles, ovulation patterns, pain, PCOS, endometriosis, lifestyle factors, and mental health all shape a fertility workup.  This episode empowers couples with realistic expectations, evidence-based guidance, and the confidence to advocate for personalized fertility care, because understanding your options is the first step to feeling as ready as you can for what comes next. In this episode you'll hear: [1:36] Key fertility tests for women: AMH, FSH, estradiol, ultrasound, and HSG [3:42]] The full work up: lifestyle, medical history, menstrual cycles, and past pregnancies  [7:54] Ovarian reserve and AMH explained [13:19] Fertility tests for men: semen analysis and hormone evaluation [16:13] Preconception testing including genetic carrier screening [21:48] When to see a fertility specialist and what to ask your doctor after testing   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 160 Age, Fertility, and Pregnancy: What's Possible and What's Safe 27.01.2026 15min

  Can you really get pregnant after menopause? Why do celebrities seem to defy biology when it comes to age and fertility? And just because pregnancy is possible at later ages, is it actually safe?  In this episode of Brave & Curious, Dr. Lora Shahine explores the questions so many people are quietly asking as they navigate fertility, aging, and family-building decisions. Dr. Shahine breaks down what the science actually says about age and fertility, including why it becomes harder to conceive with age, how eggs and sperm age differently, and what role options like IVF, egg freezing, and donor eggs play.  She also reviews headline-making cases of pregnancy at advanced reproductive age and explains why these headlines, while eye-catching, don't always tell the full medical story. She explains how clinicians think about risk, safety, and counseling for pregnancy later in life. This episode offers evidence-based clarity, compassionate context, and practical guidance to help you make informed decisions. At any age. In this episode you'll hear: [1:22] What record-breaking pregnancies really tell us [3:00] Understanding age & fertility [7:19] Health risks of pregnancy at 40s, 50s, and beyond [9:28] Men's reproductive age & health of pregnancy  [10:21] Ethical considerations for older parents [11:27] Updated ASRM recommendations [13:35] Final thoughts   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 159 How Your Genetics Can Guide Your Nutrition with Dr. Steven Zeisel 20.01.2026 47min

  Could your DNA explain why one-size-fits-all nutrition advice doesn't always work? Why do some people thrive on certain diets while others struggle, even when they're "doing everything right"? What if your genetics could help guide smarter nutrition choices before pregnancy, during pregnancy, and across your entire lifespan?  In this episode of Brave & Curious, Dr. Lora Shahine explores how genetics, nutrition, and reproductive health are deeply intertwined. She is joined by Dr. Steven Zeisel, a physician-scientist whose groundbreaking research helped redefine choline as an essential nutrient.  Their discussion traces how decades of work in biochemistry, genetics, and medicine led to the concept of precision nutrition. Dr. Zeisel explains how nutrients like choline, folate, methylfolate, betaine, and vitamin B12 interact with our genes. And he explains why common genetic variants can change how much of these nutrients our bodies actually need.  They also touch on why pregnancy, estrogen, fertility, and even sperm health are profoundly influenced by these metabolic pathways, and why traditional nutrition guidelines may miss the mark for many people. Listeners will learn how emerging genetic tests can help identify individual "roadblocks" in metabolism. This episode is a powerful reminder that when it comes to nutrition, personalized science matters. In this episode you'll hear: [0:48]Why one-size-fits-all nutrition advice doesn't work [2:19] Choline goes from non-essential to critical [8:16] The surprising role of estrogen [10:11] What can genetics influence? [15:33] Precision nutrition testing and what it can reveal [28:06] Challenges and acceptance in nutritional science [33:29] Genetic testing for personalized nutrition [45:56] What does all this research mean? Resources mentioned:  genate.com @TheGenateTest on Facebook   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books Disclaimer: This episode is sponsored by SNP Therapeutics. All opinions and thoughts expressed are our own and were not influenced by the sponsor.
• Ep 158 How a C-section May Impact Your Future Fertility: What the Evidence Shows 13.01.2026 23min

  Have you had a C-section and now you're wondering if it could affect future conception? Are you planning one and feeling unsure how it may influence your reproductive health?  In this episode of Brave & Curious, Dr. Lora Shahine goes beyond headlines and reviews a landmark study to better understand how C-sections may impact future fertility, miscarriage rates, and pregnancy complications.  This episode will arm you with three essential questions to ask your provider and help you make informed decisions and have empowered conversations, all grounded in clarity, not fear. In this episode you'll hear: [0:50] Overview of C-section impact study [1:08] Fertility after C-section [7:59] Pregnancy risks after C-section [18:36] Benefits of a C-Section [19:45] FAQ [21:14] Advocating for your care [22:51] Final thoughts Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 157 Why Sleep Is the Most Powerful Health Habit You Can't Ignore with Dr. Meredith Broderick 06.01.2026 38min

  Are you exhausted but still can't sleep through the night? Do you wake up feeling unrefreshed, foggy, or wired-tired no matter how early you go to bed? Could your sleep habits—or an undiagnosed sleep disorder—be quietly impacting your hormones, mental health, fertility, and long-term wellbeing?  In this episode of Brave & Curious, Dr. Lora Shahine and her guest, Dr. Meredith Broderick, invite you to rethink everything you've been told about sleep and why "pushing through" exhaustion is not a badge of honor.  Dr. Broderick shares how her own experience with sleep deprivation led her into sleep medicine, why sleep disorders are vastly underdiagnosed in women, and how poor sleep is linked to conditions like depression, migraines, cardiovascular disease, metabolic dysfunction, and infertility.  Together, they explain the difference between true sleep and sedation, why sleeping pills and alcohol disrupt restorative sleep, and how sleep apnea and chronic insomnia show up differently in women. You'll learn when to ask for a sleep study, common red flags you shouldn't ignore (like morning headaches and daytime fatigue), and practical, evidence-based steps to start improving your sleep—without shame, perfection, or fear. In this episode you'll hear: [1:23] Sleep is a non-negotiable pillar of health [5:10] Recognizing sleep disorders [12:59] The science behind sleep [14:19] Sleep & reproductive health [19:04] Practical sleep solutions [27:52] Understanding mid-night awakenings [29:21] Cultural variations in sleep patterns [31:23] Sleep trackers [33:20] Key reasons to consider a sleep study [36:50] Conclusion & final thoughts Resources mentioned:  soundsleepguru.com @sleepdoctormer on Instagram Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 156 The Fertility Reset: How You Can Eat, Exercise, and Maximize Your Reproductive Health for the New Year 30.12.2025 25min

  How can you give yourself the best chance of conceiving in the year ahead? Which habits truly influence fertility? And when is it appropriate to seek additional support or consult a specialist? In this New Year episode of Brave & Curious, Dr. Lora Shahine shares a practical and compassionate Fertility Reset—a clear roadmap for anyone preparing to conceive or looking for guidance after months of trying. She reviews the foundations of cycle tracking and timed intercourse, strategies for reducing harmful exposures, and lifestyle and nutrition changes that can support reproductive health. Dr. Shahine also explains how stopping birth control varies by method, why understanding ovulation is essential, and how to decide whether at-home testing or a medical evaluation is the next right step. This episode offers an evidence-based guide to enhancing fertility, improving overall wellness, and approaching the year ahead with clarity and confidence. In this episode you'll hear: [0:32] Kicking off a fertility reset [1:27] Get your health in check [2:59] Stopping birth control [5:08] Cycle tracking [7:19] Timing intercourse [9:25] Lifestyle changes: what to stop and what to start [20:31] Prenatal vitamins [21:55] When to see a fertility specialist   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 155 Miscarriage and Recurrent Pregnancy Loss: Is IVF the right step for you? 23.12.2025 33min

  Is IVF the answer for recurrent pregnancy loss? Why would IVF with genetic testing of embryo be helpful for people that are 'getting' pregnant but can 'stay' pregnant?  In this educational episode, Dr. Lora Shahine explains the complex relationship between IVF, genetics, and recurrent pregnancy loss. She reviews the science behind why chromosomal imbalances are one of the most common causes of first-trimester miscarriage and discusses how preimplantation genetic testing for aneuploidy (PGT-A) may help select embryos with the highest chance of success for some patients. Through real patient examples and evidence-based guidance, this episode explores the nuances of testing, timing, emotional well-being, and the ethical and financial considerations that shape decision-making. Listeners will walk away informed, empowered, and reminded that no matter their fertility path, they are not alone. In this episode you'll hear: [2:03] Why consider IVF for recurrent pregnancy loss? [4:10] IVF process & genetic testing [11:02] Real world counseling & patient scenarios [16:12] Pros & cons of IVF for recurrent pregnancy loss [24:58] Key considerations for IVF [28:15] Patient examples and recommendations [31:12] Final thoughts Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
• Ep 154 Folic Acid vs. Folate: Why the Controversy? with Dr. Prati Sharma 16.12.2025 30min

  Are you confused about prenatal vitamins? Wondering whether folic acid or folate is best? And what about those MTHFR conversations on the internet? Should you be worried?  In this episode of Brave & Curious, Dr. Lora Shahine is asking the questions so many people have but rarely get clear answers to. Her guest is fertility expert Dr. Prati Sharma who is here to address the fear, the science, and the nuance behind one of the most debated supplements in pregnancy health. Folate and folic acid may sound interchangeable, but as Dr. Shahine and Dr. Sharma explain, the topic gets complicated fast — especially once genetics, supplements, and internet opinions enter the chat.  Together they explain the definitions, evidence-based guidelines, genetic polymorphisms like MTHFR, and how the supplement market (and sometimes fear-based messaging) can mislead patients.  Listeners will hear balanced, thoughtful insight rooted in reproductive endocrinology, science-backed recommendations, and compassionate care, not panic or overwhelm. And most importantly, you'll leave feeling calmer, more empowered, and equipped with the right questions instead of fear. In this episode you'll hear: [1:25] Why is folate vs. folic acid such a heated topic? [3:37] What is folate? [4:067 What is folic acid? [5:35] MTHFR gene variant explained [6:40] The history & science behind the recommendations [9:58] How much folic acid do you actually need? [12:56] What newer studies show [20:23] How to choose a prenatal [28:06] Final takeaways and connecting with Dr. Sharma   Resources mentioned:  @drpratiaharma on IG createivf.com/about/prati-sharma-fertility-doctor birdandbe.com ABOG Folic Acid Recommendations Review from Integrative Medicine Journal Review by Jen Gunter, MD   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books