632nm

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• The Atomic Physics Behind Neutral Atom Computers | Mark Saffman 30.06.2026 1t 23min

  Why are so many companies betting on neutral atoms to build the first useful quantum computers?In this episode, we speak with Mark Saffman, professor at the University of Wisconsin–Madison and one of the pioneers of neutral atom quantum computing. Over the past two decades, Saffman has helped transform Rydberg atoms from a theoretical idea into one of the leading architectures for scalable, fault-tolerant quantum computing.We explore the physics of optical tweezers and Rydberg blockade, how neutral atoms perform quantum logic and create entanglement, and why this platform offers unique advantages in connectivity and scalability. Saffman also discusses the engineering challenges of improving gate fidelity, implementing quantum error correction, and scaling from small laboratory experiments to processors containing millions of qubits.We also discuss the origins of companies like Infleqtion, the rapid growth of the neutral atom ecosystem, and what it will take for quantum computers to solve meaningful scientific and industrial problems.Whether you're interested in quantum computing, atomic physics, quantum error correction, computer architecture, or the future of information processing, this episode provides a deep technical look at one of the most promising paths toward practical quantum computers.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Michael Dubrovsky: https://www.linkedin.com/in/michael-dubrovsky/Xinghui Yin: https://www.linkedin.com/in/xinghui-yin/Subscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro and Reads02:45 - Neutral Atoms vs Superconductors and Ions07:30 - Rydberg Atoms12:49 - Practical Considerations for Rydberg Atoms19:04 - From Atomic Physics to Quantum Gates29:49 - Increasing Trap Loading38:27 - Evolution of Rydberg Gates45:05 - Limits of Rydberg Fidelity49:49 - Scaling Neutral Atom Arrays53:47 - Atomic Species and QEC1:03:38 - History of Infleqtion1:10:27 - Mark’s Outlook on the Future1:15:08 - Caltech and Peter Shor1:20:00 - Advice for Young Scientists#quantumphysics #quantumcomputing #physics #computerscience
• Silicon Photonics and the Future of AI Scaling | John Bowers 16.06.2026 1t 39min

  Why are some of the world's largest technology companies betting on silicon photonics?In this episode, we speak with John Bowers, professor at UC Santa Barbara and one of the pioneers of silicon photonics, about the technologies that are transforming AI infrastructure and modern data centers. Bowers explains why moving data has become one of the central challenges in computing, how optical communication is overcoming the limitations of traditional electrical interconnects, and why light is increasingly being used to connect processors, servers, and entire data centers.We explore the origins of silicon photonics, from early optical communications research to the development of integrated photonic devices that can be manufactured using semiconductor processes. Bowers discusses the engineering challenges of combining lasers with silicon, the breakthroughs that enabled heterogeneous integration, and how decades of research helped turn silicon photonics into a commercial technology deployed at global scale.We examine the growing demands of artificial intelligence, where the movement of information between processors has become just as important as computation itself. Bowers explains why bandwidth, power consumption, and interconnect density are emerging as critical bottlenecks for AI systems, and how optical links are enabling the next generation of large-scale computing architectures.We also discuss data center networking, optical interconnects, co-packaged optics, heterogeneous integration, semiconductor manufacturing, photonic integrated circuits, telecommunications, AI hardware, and the future of warehouse-scale computing. Throughout the episode, Bowers provides an inside look at how advances in photonics are reshaping the infrastructure that powers modern computing.Whether you're interested in silicon photonics, optical communications, semiconductor engineering, computer architecture, AI hardware, data center design, networking, integrated photonics, electrical engineering, or the future of computing, this episode provides a deep technical exploration of one of the most important technologies behind the AI revolution.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Michael Dubrovsky: https://www.linkedin.com/in/michael-dubrovsky/Xinghui Yin: https://www.linkedin.com/in/xinghui-yin-168b94130/Subscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:19 - Why Data Centers Need Photonics05:28 - Bowers's Interest in Physics10:09 - Lessons From Bell Labs12:58 - Semiconductor Lasers18:31 - Teaching Entrepreneurship23:21 - Heterogeneous Integration29:40 - Why Silicon Photonics Needed Better Light Sources32:00 - Heterogeneous Integration vs Direct Growth44:04 - The Packing Problem in Photonics47:49 - Narrow Linewidth Lasers51:31 - Data Centers in Space59:19 - Lessons from the Telecom Bubble1:02:17 - Recent Breakthroughs in Photonics1:04:32 - What is a Frequency Comb?1:07:07 - Solitons and Microcombs1:14:48 - Optical Computing and AI1:19:09 - How Bowers Starts Companies1:21:56 - Was Bowers Late to Any Trends?1:22:51 - What would Bowers Build with Unlimited Resources?1:24:38 - Creating Bell Labs for AI1:26:35 - Competition, Endurance, and Personality1:30:41 - The Best Problems for Young Scientists to Tackle1:37:47 - Advice for Researchers Who Want to Keep Real Depth#photonics #datacenter #siliconphotonics #computerscience #artificialintelligence
• Bioelectricity, Morphogenesis, and Two-Headed Worms | Michael Levin 02.06.2026 1t 27min

  How can a flatworm regenerate a complete head after being cut in half?In this episode, we speak with Michael Levin, developmental biologist and director of the Allen Discovery Center at Tufts University, about the emerging field of developmental bioelectricity. Levin explains how voltage gradients, ion channels, and gap junctions form a layer of biological control that operates alongside genetics and biochemistry to regulate embryonic development, regeneration, and anatomical patterning.We explore the experimental foundations of bioelectricity research, including the use of voltage-sensitive dyes, ion channel manipulation, and computational models to read and write electrical information in living tissues. Levin discusses how bioelectric signals help establish left-right asymmetry in embryos, coordinate communication across developing tissues, and encode large-scale anatomical information that individual cells cannot possess on their own.The conversation examines classic and surprising experiments from the field, including the creation of two-headed planarian worms, the induction of ectopic eyes in frog embryos, and the restoration of normal development after severe genetic and environmental disruptions. Levin explains how bioelectric circuits can act as a control architecture for morphogenesis, allowing tissues to make collective decisions about growth, form, and regeneration.We also discuss voltage gradients, membrane potentials, gap junction networks, developmental pattern formation, regenerative medicine, collective cellular intelligence, and the relationship between electrophysiology and gene regulation. Throughout the episode, Levin argues that understanding development requires looking beyond genes alone to the dynamic electrical communication networks that coordinate living systems across scales.Whether you're interested in developmental biology, embryology, regeneration, electrophysiology, bioelectricity, morphogenesis, systems biology, ion channels, pattern formation, or the future of regenerative medicine, this episode provides a deep technical exploration of how electrical signals help shape living organisms.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Michael Dubrovsky: https://www.linkedin.com/in/michael-dubrovsky/Xinghui Yin: https://www.linkedin.com/in/xinghui-yin-168b94130/Subscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:40 - Early Interest in Bioelectricity05:22 - External Electric Stimulation19:54 - Two-Headed Planarians31:40 - Designing Bioelectric Experimental Methods56:37 - Different Model Organisms1:07:34 - TAME Theory1:24:16 - Xenobots and Advice for Young Scientists#planaria #morphology #neuroscience #biology #bioelectricity
• Quantum Architecture, QAOA, and Cancer Biomarkers | Fred Chong 19.05.2026 1t 59min

  Are quantum computers changing the way we discover cancer treatments?In this episode, Misha and Yudong spoke with Fred Chong, Seymour Goodman Professor at the University of Chicago, about the future of quantum computer architecture and how quantum algorithms could eventually help solve real-world problems in medicine, optimization, and scientific computing.Chong explains the transition from the NISQ era toward fault-tolerant quantum computing, why hardware-aware software design remains essential, and how compiler architectures, error correction, and quantum system design all interact across the full computing stack. The conversation explores the challenges of building scalable quantum machines, the tradeoffs between superconducting qubits, trapped ions, and neutral atoms, and why many quantum systems may ultimately function as specialized accelerators alongside classical computers.We also discuss quantum optimization algorithms like QAOA and how Chong’s group is applying them to cancer biomarker discovery and treatment prediction. By analyzing complex multimodal biological data, including DNA, mRNA, and pathology imaging, these methods aim to uncover patterns that are difficult for conventional machine learning systems to identify without overfitting.Along the way, Fred shares stories from the early days of supercomputing at Thinking Machines, the origins of his quantum research career, the founding of Super.tech, and his perspective on where quantum computing is genuinely making progress versus where hype still dominates the conversation.Topics include quantum computing, QAOA, fault-tolerant quantum computing, quantum error correction, quantum compilers, NISQ systems, neutral atoms, superconducting qubits, quantum architecture, cancer biomarkers, biomedical optimization, hybrid quantum-classical systems, and the future of quantum software and hardware co-design.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Yudong Cao: https://www.linkedin.com/in/yudong-cao-25b6a929/Subscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:34 - From Jurassic Park to Quantum Computing10:13 - Modernizing NISQ Research13:45 - Designing Around Quantum Hardware20:30 - Variational Quantum Algorithms23:07 - Quantum Computers for Cancer Research30:35 - How Q4Bio Began37:20 -  Will We Need QEC in the Future?40:25 - What Quantum Computers Can Learn from Classical Architecture43:08 - Would Fred Return to Classical Computing?46:11 - Quantum Software and Quantum Compilers55:19 - Starting Super.tech1:01:43 - Classical Analogs to Quantum Hardware1:12:21 - Advice for Young Scientists1:17:43 - Is AI Impacting Quantum Research?1:22:38 - Importance of Formal Verification1:30:40 - QLDPC Codes1:35:48 - Fred’s Beginnings in Computer Science1:42:48 - Chicago vs Silicon Valley1:46:27 - Do We Need More Quantum Software Companies?1:53:17 - Future of Quantum Computing and Cryptography#quantumcomputing #quantumalgorithms #cancerresearch #computerscience
• How Quantum Sensors Can Measure Single Electrons | Amir Yacoby 05.05.2026 2t 1min

  How do you measure something as small as a single electron or map quantum behavior at the nanoscale?In this episode, Misha spoke with Amir Yacoby, professor at Harvard University, about the cutting edge of quantum sensing and the experimental tools redefining how we probe the quantum world.Yacoby explains how physicists build ultra-sensitive detectors, from single-electron transistors to quantum dots and NV centers in diamond, that can measure charge, spin, and magnetic fields with extraordinary precision. These tools make it possible to study both strongly correlated systems, like those exhibiting the fractional quantum Hall effect, and isolated quantum systems used as qubits.We explore how accidental discoveries in the lab can evolve into entirely new sensing techniques, including momentum-resolved tunneling and nanoscale imaging methods. The conversation also highlights how quantum sensors are enabling researchers to bridge two regimes: complex many-body systems and controllable quantum devices, opening the door to new insights in topological physics and quantum information processing.Whether you're interested in quantum measurement, nanoscale imaging, or the future of quantum technologies, this episode offers a detailed look at how new instruments are driving discovery at the frontiers of physics.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:23 - The Process of Creating Quantum Tools11:28 - Graduate School at Weizmann14:51 - From Aerospace to Condensed Matter26:53 - Starting at Harvard39:44 - Working at Bell Labs47:42 - Diamond NV Centers1:00:52 - Spin Waves1:16:10 - SQUIDs1:29:57 - State of the Art Sensors1:33:08 - Motivations for Building Better Sensors1:36:52 - Fabrication Challenges1:40:14 - New Sensors1:45:49 - Majoranas1:53:25 - Finding New Applications for Sensors1:57:16 - The Use of AI in Physics1:58:55 - Advice for Young Scientists 
• The Physics of Un-Hackable Face Recognition | Rob Devlin on Metalenz 21.04.2026 1t 13min

  How do you turn a flat piece of nanostructured material into a secure biometric sensor?In this episode, we speak with Rob Devlin, co-founder and CEO of Metalenz, about how metasurfaces are transforming optics and enabling a new generation of biosecure sensing. Devlin explains how engineers can control light at the subwavelength scale to replace bulky lens stacks with a single flat surface, and why the real breakthrough isn’t just miniaturization, but the ability to mass-produce optics in semiconductor fabs.We explore how Metalenz scaled metasurfaces from academic prototypes into millions of devices, and what it takes to design optics for manufacturing. Devlin breaks down the transition from building one perfect device in a cleanroom to producing millions that all meet tight specifications.The conversation focuses on polarization imaging as a new information channel in consumer devices. Unlike traditional cameras that capture only intensity and color, polarization reveals material properties. This enables a new approach to facial recognition that is both more secure and more compact than existing systems.Rob also shares the story behind Metalenz, from its origins in a Harvard lab to partnerships with major semiconductor manufacturers, and how the company navigated the challenges of finding product-market fit, scaling fabrication, and building a new sensing stack from scratch.Whether you’re interested in optics, nanofabrication, consumer electronics, or the future of biometric security, this episode explores how controlling light at the nanoscale is opening entirely new possibilities for sensing and identity verification.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:22 - Making Metalenses Mass-Producible10:58 - Metasurfaces for Polarimetry17:10 - Face ID Security and Pitfalls24:47 - Polar ID Principles29:02 - Polar ID Demo39:58 - Meeting Federico Capasso50:43 - Developing Metasurface Fabrication Techniques55:58 - Founding Metalenz 1:11:44 - Future of Metalenz and Metasurfaces#photonics #faceid #biometrics #metasurface #biosecurity #optics
• The Real Economics of Data Centers in Space | Starcloud CEO Philip Johnston 01.04.2026 1t 37min

  Are data centers in space physically possible, or just another overhyped idea?In this episode, we speak with Philip Johnston, CEO of Starcloud, about the technical and economic case for putting AI infrastructure in orbit. The idea has gone viral in recent months, drawing strong criticism from science communicators like Scott Manley, Kyle Hill, and Hank Green, but rarely with detailed engagement on the underlying assumptions.We examine whether space-based data centers can compete with terrestrial infrastructure, and what constraints actually matter: energy generation, cooling, launch costs, and manufacturing at scale. Johnston walks through the core economic model behind Starcloud, including assumptions about SpaceX’s Starship, the cost of solar power in orbit, and why removing terrestrial constraints like land use, permitting, and energy storage could fundamentally change how compute is deployed.We discuss the physics of radiative cooling in space, the challenges of operating GPUs in a radiation environment, and how orbital systems compare to Earth-based data centers in terms of efficiency and cost structure. The conversation also explores broader questions around AI’s growing energy demands, the limits of terrestrial infrastructure, and whether shifting compute off-world is a niche solution or a long-term inevitability.Whether you’re interested in space technology, AI infrastructure, energy systems, or the economics of large-scale computing, this episode offers a detailed look at one of the most debated ideas in modern engineering, and a rare opportunity to hear its strongest arguments laid out in full.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Michael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:12 - What is Starcloud?02:44 - Why do data centers need to go to space?06:15 - Can’t we just build more solar panels on earth?11:10 - Economic analysis of Starcloud19:56 - How does Starcloud’s cooling work?28:26 - Training an LLM in space32:07 - Addressing critics on space Twitter34:23 - Is Starcloud overfunded?35:59 - Will demand for data centers keep going up?38:11 - GPU lifespan and disposal in space39:47 - Bus structures41:43 - Starcloud’s origin and founders49:29 - Fundraising, Competition, and Meeting Expectations53:29 - Satellite size and collisions56:29 - Manufacturing Bottlenecks1:00:20 - Starcloud 1 tests1:01:57 - Acceleration after YC1:03:43 - Testing on Earth1:05:06 - Motivations for Starcloud1:06:45 - Data centers on the Moon1:08:12 - Interacting with AI companies1:08:18 - What’s next for Starcloud?1:14:01 - Other uses for Starcloud satellites1:17:56 - Lunar hotels and space elevators1:24:28 - Complementary business ideas to Starcloud1:29:51 - Philip’s competitive twin1:32:18 - Philip and Mike’s thoughts on YC1:34:45 - Advice for young entrepreneurs#datacenter #aidatacenter #starlink #spacex #falcon9 #starcloud
• How To Make Quantum Algorithms Cheaper | Craig Gidney on Magic-State Factories, Resource Estimates 27.03.2026 2t 3min

  How do you actually make quantum algorithms work on real hardware?Build your own quantum circuits in Crumble: https://algassert.com/crumbleIn this episode, we speak with Craig Gidney of Google Quantum AI, whose work focuses on the practical realities of building fault-tolerant quantum computers. Gidney explains how seemingly small implementation choices, like how you perform arithmetic, can dominate the cost of entire quantum algorithms.We explore why factoring small numbers like 15 in Shor's algorithm can be misleadingly easy, and why scaling to larger numbers requires dramatically more resources due to operations like modular multiplication. He breaks down how quantum circuits are often dominated by classical reversible logic, and why optimizing these routines is critical for making quantum computing viable.The conversation covers quantum error correction, including why T gates are especially expensive, how magic state factories works, and how different hardware architectures change what “cost” even means. Gidney also explains how resource estimates for breaking cryptography have dropped by orders of magnitude and what drove those improvements.We also dive into the tools he built, including Stim, Quirk, and Crumble, which help researchers simulate noise, visualize circuits, and track how errors propagate through complex systems. Gidney shares his unconventional path into the field, the role of intuition and tooling in discovery, and how software engineering shapes modern quantum research.Whether you’re interested in quantum computing, error correction, cryptography, or the engineering challenges behind scalable quantum systems, this episode offers a clear and grounded look at what it really takes to turn quantum algorithms into reality.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://www.linkedin.com/in/mikhail-shalaginov/Yudong Cao: https://www.linkedin.com/in/yudong-cao-25b6a929/Subscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:22 - Shor’s Algorithm04:02 - Why are Arithmetic Operations Important?08:35 - Why are T-Gates Important for QEC?13:47 - Motivations for Creating Crumble and STIM18:40 - Can AI Code Quantum Simulators?22:32 - Journey into Learning Quantum26:50 - How to Enter the Field of Quantum Computing31:16 - From Starcraft to Software Engineering36:05 - Crumble Demo53:18 - Quirk Demo1:00:48 - Estimating Resources for Quantum Computation1:08:58 - Optimizing Measurements for Computation1:16:40 - How Many Qubits Do We Actually Need?1:30:49 - Other Research Areas for Improving Fault Tolerance1:41:23 - Elliptic Curve Discrete Logarithm Problem1:46:55 - New Tools for Quantum Computing1:50:23 - What Would Craig Do with Unlimited Funding?1:52:28 - How Learning Has Changed for Craig with Experience1:57:31 - Riding the Wave of Innovation vs Sticking to One Idea1:59:53 - Advice for Young Scientists#quantumcomputing #quantumphysics #computerscience #googleai #googlequantum
• How Neurons Translate Electricity into Chemistry | Tom Südhof 10.03.2026 1t 30min

  How do neurons convert electrical signals into chemical messages in under a millisecond?In this episode, we speak with Thomas Südhof, Stanford neuroscientist and Nobel laureate whose discoveries revealed the molecular machinery that allows neurons to communicate at synapses. Südhof explains how an electrical impulse traveling down a neuron triggers the rapid release of neurotransmitters, transforming an electrical signal into a chemical one that can be received by the next cell.We explore the remarkable precision of synaptic transmission, including how calcium ions trigger vesicle fusion, how specialized proteins organize the release machinery, and why this entire process unfolds on the timescale of a single millisecond. Südhof walks us through the molecular components that make this possible, including the proteins that dock neurotransmitter-filled vesicles and control their release.The conversation also examines how these discoveries reshaped modern neuroscience by revealing the fundamental mechanisms underlying neuronal communication. Südhof discusses how synapses operate as highly specialized molecular machines and how disruptions in synaptic signaling are linked to neurological and psychiatric disorders.Whether you’re interested in neuroscience, synapses, brain signaling, neurotransmitters, or the molecular basis of thought, this episode offers a clear explanation of how neurons translate electricity into chemistry, and how this microscopic process makes brain communication possibleFollow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 - Intro01:23 - What is a Synapse?07:01 - History of Synapse Discovery12:54 - How Electron Microscopy Helped Neuroscience15:11 - Early Electrophysiological Experiments18:31 - Why are Neurotransmitters Needed At All?21:25 - Electrical Connections Between Cells22:48 - How Signal Diversity is Created in Synapses29:04 - Why are Synapses Chemical?31:06 - How Tom Began his Neuroscience Career39:32 - Emerging Tools that Allowed for Researching Synapses44:16 - Discerning Protein Function49:36 - Discovering Mechanism through Data52:15 - Isolating Membrane Proteins55:09 - Voltage Gates57:50 - How Synapses Change Over Time1:02:14 - How are Synapses Formed?1:10:22 - The Need for New Tools1:11:53 - Implications for Drug Discovery1:17:07 - Exploring the Mouse Hippocampus1:22:35 - Tom’s Work on LDL Receptors1:26:33 - Understanding Molecular Logic#neuroscience #neuroplasticity #nobelprize #hubermanlab #neurobiology 
• How Engineers Solve “Impossible” Problems | Dan Gelbart 17.02.2026 2t 3min

  How do engineers solve problems that seem to violate the laws of physics?In this episode, we speak with Dan Gelbart, a prolific inventor and precision engineer, about what it really means to work at the limits of physical law. From lasers and optical systems to ultra-precision manufacturing and semiconductor tools, Gelbart has spent decades designing systems where nanometers, noise, and nonlinearities matter, and where small misunderstandings of physics can block real progress.We discuss the story of the first working laser, built by Theodore Maiman, and why it succeeded only after questioning widely accepted assumptions. Gelbart explains how many “impossible” engineering problems aren’t forbidden by physics at all: they’re constrained by measurement errors, incomplete models, or failure to explore edge cases like pulsed operation, material effects, and boundary conditions.We explore precision metrology, high-resolution imaging for satellite systems, the culture of engineering education, and the difference between a true physical limit and a design constraint. Gelbart reflects on why mastering fundamentals, mechanics, optics, electromagnetism, matters more than chasing trends, and how breakthroughs often come from carefully re-examining what others assume cannot be done.Whether you’re interested in physics, engineering, semiconductor manufacturing, lasers, or the philosophy of technological innovation, this conversation offers a rigorous look at how engineers operate at the edge of what nature allows, and sometimes push beyond what others think is possible.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 - Intro01:35 - The World’s First Laser07:53 - Solving Impossible Problems23:37 - Underestimated Problems39:36 - Dan’s Backstory43:33 - How to Teach Yourself Anything47:03 - Shortcomings of Modern Education53:19 - Developing the Optical Tape Recorder1:01:39 - Machine Obsolescence1:08:04 - Why are Scientists Often Bad Businessmen?1:15:17 - Developing Medical Devices1:24:52 - Untapped Potential of Materials Science1:30:47 - Accidental Inventions1:35:37 - Surviving Bureaucracy1:42:27 - Humanoid Robots1:44:11 - Managing an Engineering Team1:50:06 - Developing the First Good Mobile Data Terminal1:54:15 - Building an Environment for Solving Problems2:02:18 - Why Aren’t We Inventing New Things?#machining #cnc #precisionengineering #metrology #machineshop
• How Visual Experience Rewires the Brain | Mark Bear on Neuroplasticity 03.02.2026 1t 55min

  How does experience rewire the brain—and why is vision the ideal system for understanding neuroplasticity?In this episode, we speak with Mark Bear, MIT neuroscientist and a pioneer in the study of experience-dependent plasticity. Bear explains how the visual cortex became a model system for uncovering the synaptic mechanisms that allow the brain to change, adapt, and learn, especially during early development.We explore how visual experience shapes neural circuits, why the brain undergoes critical periods of heightened plasticity, and what classic experiments in visual deprivation revealed about how connections are strengthened or lost. Bear walks us through the discovery of binocular vision in the cortex, the role of inhibition in closing critical periods, and how these ideas reshaped our understanding of learning and memory.The conversation also covers modern views of cortical plasticity, including perceptual learning, visual recognition memory, and how the brain distinguishes familiar from novel stimuli. Bear discusses how insights from vision extend to broader questions about brain development, neurological disorders such as amblyopia, and whether adult plasticity can be reopened.Whether you’re interested in neuroscience, brain development, neuroplasticity, learning and memory, or the biology of vision, this episode offers a clear and authoritative look at how experience shapes the brain at the level of neural circuits and synapses.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro00:54 - Neuroplasticity in the Visual Cortex05:45 - Critical Periods for Neuroplasticity16:50 - Brain Development in Blind People19:25 - Hallucinations and Sensory Deprivation25:36 - How Mark’s Vision Disorder Led Him to a Career in Neuroscience31:35 - Intro to the Visual System35:52 - Visual System Processing40:52 - Pop Science Neuroplasticity45:00 - Memory Enhancing Pharmaceuticals50:18 - Other Ways of Modifying the Visual Cortex1:14:50 - Declarative vs Procedural Memory1:22:36 - Neural Networks and Memory Degradation1:25:16 - Neuron Transplants and Neurogenesis1:28:58 - Brain-Machine Interfaces1:33:46 - Most Prominent Issues in the Field1:40:47 - Fragile X Syndrome1:51:10 - Advice for Young Scientists#neuroplasticity #neuroscience #hubermanlab #braindevelopment #brainplasticity
• Snell's Law, Metasurfaces, and Metalenses | Federico Capasso 20.01.2026 2t 13min

  How can flat surfaces shape light as powerfully as bulky lenses?In this episode, we speak with Federico Capasso, Harvard physicist and pioneer of metasurfaces, metalenses, and nanophotonics. Capasso traces the path from his work at Bell Labs on quantum cascade lasers to the invention of metasurface optics, showing how a practical challenge—collimating light without traditional lenses—sparked a new way to control light.We explore the physics behind metasurfaces and generalized Snell’s law, explaining how subwavelength structures enable precise control of wavefronts, phase, and polarization beyond what conventional diffractive optics or Fresnel lenses allow. Capasso clarifies common misconceptions, contrasts metasurfaces with diffraction gratings and phased arrays, and emphasizes the importance of physical intuition and simplicity.The conversation covers metalenses, polarization optics, holography, and how these ideas moved from theory to large-scale manufacturing in semiconductor foundries, ultimately appearing in consumer devices like smartphones. Capasso also reflects on commercialization, the legacy of Bell Labs, and the blurred boundary between basic science and real-world technology.Whether you’re interested in metasurfaces, metalenses, nanophotonics, optics, or the process behind breakthrough discoveries, this episode offers a clear and insightful look at how modern optical physics becomes transformative technology.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 - Intro01:53 - Transition from Bell Labs to Harvard09:45 - Generalized Snell's Law21:25 - Facing the Diffractive Optics Community31:07 - Benefits of Well-Rounded Education45:16 - Metalenses55:55 - Can AI do Physics?1:07:39 - Industry vs Academia1:11:44 - Nanophotonics1:14:44 - What Allowed for the First Metalenses?1:17:38 - 632nm and Other Lasers1:20:47 - Quantum applications of Metalenses1:30:14 - Quantum Entanglement Redefines Spacetime1:43:22 - Stokes Parameters1:48:28 - Limits of Metasurface Pixel Size1:55:20 - Advice for Young Scientists2:01:45 - Critique of the H Index#metasurface #metalenses #quantumphysics #materialscience #optics  #photonics
• Graphene, Nanotubes, and Quantum Hall Physics | Philip Kim 06.01.2026 2t 47min

  How do electrons behave when they’re confined to a single layer, and why do entirely new laws of physics emerge when dimensions shrink?Papers discussed in this episode:Experimental observation of the quantum Hall effect and Berry's phase in graphene: https://www.nature.com/articles/nature04235Tunable Fractional Quantum Hall Phases in Bilayer Graphene: https://arxiv.org/abs/1403.2112Room-Temperature Quantum Hall Effect in Graphene: https://arxiv.org/abs/cond-mat/0702408In this episode, we speak with Philip Kim, Harvard physicist and a leading experimentalist in low-dimensional quantum materials. Kim traces the experimental path from high-temperature superconductors and charge-density waves to carbon nanotubes and the earliest graphene devices, revealing how advances in nanofabrication and quantum transport opened the door to modern 2D materials physics.We dive deep into the Hall effect and quantum Hall effect, from their 19th-century origins to the discovery of quantized and fractional conductance, and explain why these effects were found experimentally before they were fully understood theoretically. Kim shares behind-the-scenes stories of early graphene experiments, mechanical exfoliation, Shubnikov–de Haas oscillations, and what it was like to be scooped by the work that launched graphene into the spotlight.Along the way, we explore how disorder, dimensionality, and magnetic fields shape electronic behavior; why carbon nanotubes paved the way for graphene; and how many of the most important discoveries in condensed matter physics arise from intuition, timing, and new experimental tools.Whether you’re interested in graphene, quantum transport, the quantum Hall effect, nanofabrication, superconductors, or the real stories behind breakthrough discoveries, this conversation offers a rare, technically rich look at how modern quantum materials research actually unfolds.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 - Intro01:15 - How Philip Began Studying Graphene20:06 - Old Methods of Creating Graphene32:33 - Hall Effect and Quantum Hall Effect48:29 - Philip's Work at Columbia52:33 - Philip's First Experiments with Graphene1:06:43 - Did Philip Get Scooped from a Discovery?1:09:40 - The Power of Scotch Tape1:24:57 - High Temperature Quantum Hall Effect1:30:18 - Fractional Quantum Hall Effect1:41:17 - Collaboration with Particle Physicists1:54:13 - Single Layer Graphene1:59:44 - Next Gen Electronics with 2D Materials2:03:23 - Graphene Twisting2:14:48 - Superconductivity in Other Materials2:20:06 - Anyons2:30:00 - Fault-Tolerant Quantum Computing2:36:05 - Can AI and Big Data Help Physicists?2:40:47 - What Would Philip Do with Unlimited Resources?2:43:44 - Optimizing the Education System#graphene #quantumphysics #materialscience #halleffect #electromagnetism
• Quantum Matter, Super-conductors, and Black Holes | Subir Sachdev on the SYK Model 23.12.2025 2t 34min

  What makes high-temperature superconductors and “strange metals” some of the most perplexing systems in modern physics?In this episode, we speak with Dr. Subir Sachdev: Harvard physicist and one of the leading architects of today’s understanding of quantum matter. Sachdev explains why strange metals refuse to behave like ordinary conductors, how quantum entanglement reshapes the landscape of many-body physics, and why the quest to understand cuprate superconductors continues to push both theory and experiment to their limits.We explore the physics of the cuprate phase diagram, the collapse of quasiparticles, and the role of quantum criticality in creating universal, linear-in-temperature behavior. Sachdev walks us through the origins of the SYK model, its surprising connections to black-hole thermodynamics and holography, and how new lattice-based models may finally bridge the gap between solvable theory and real materials.Whether you’re curious about superconductivity, quantum criticality, black-hole analogies, emergent gauge fields, or the deep physics behind strongly correlated electrons, this conversation offers a rare, accessible look at how frontier theoretical work is redefining our picture of quantum matter—from the lab bench to the edge of spacetime.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Mikhail Shalaginov: https://x.com/MYShalaginovMichael Dubrovsky: https://x.com/MikeDubrovskyXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:01:22 - Subir’s Path to Condensed Matter Physics06:24 - Challenges in Discovering Cuprates09:53 - History of Superconductivity20:07 - Subir's PhD work27:09 - Development of the SYK model41:09 - Strange Metals56:43 - Derivation of SYK Model1:03:53 - Signatures of Strange Metals1:09:58 - How Quantum Mechanics Affects Black Holes1:17:10 - What Brought Subir to Black Holes?1:19:43 - Black Hole Connections to SYK1:29:28 - ADS CFT Correspondence1:37:04 - Can Quantum Computers Help Advance the SYK Model?1:40:17 - Is AI Useful for Theoretical Physics?1:46:40 - How does Quantum Criticality Play into Superconductivity?1:49:11 - Derivation Quantum Criticality1:52:49 -  What is Holography?1:55:07 - Holography2:00:19 - Green’s Function2:08:46 - Green’s equation slides2:13:23 - Yukawa Model vs SYK2:17:30 - Can AI Brute Force Physics Discoveries?2:23:51 - What Would Subir Do With Unlimited Funding?2:36:33 - Dissecting the Hype of Superconductivity2:31:15 - Raising the Next Generation of Great Physicists#theoreticalphysics #quantummaterials #astrophysics #superconductivity #superconductor #blackhole #quantumphysics #quantummechanics
• How to Build Fault-Tolerant Quantum Computers | Austin Fowler on Surface Codes + TQEC 09.12.2025 1t 50min

  Would we get a quantum computer sooner if everything was open source?In this episode, we speak with Austin Fowler, one of the architects of quantum error correction and a pioneer of the surface code used in today’s leading quantum computers. Fowler helped lay the groundwork for scalable, fault-tolerant computation at Google Quantum AI, before leaving to advocate for a more open and collaborative model of research.He explains why building a useful quantum computer will require millions of reliable qubits, why no known algorithm yet clearly outperforms classical computation, and why the field’s current competitive funding model may be slowing progress instead of accelerating it. From the engineering challenges of superconducting qubits to the economics of global research, Fowler offers a candid, inside look at the state of quantum technology.We explore the history and promise of quantum error correction, the software bottlenecks that still stand in the way, and how an open-source, international approach — modeled on CERN or the International Space Station — could transform the field. Along the way, Fowler reflects on his time at Google, the importance of collaboration, and what it will really take to make quantum computing practical.Whether you’re interested in quantum hardware, physics, computer science, or research policy, this conversation reveals the technical, ethical, and economic realities behind one of today’s most ambitious scientific pursuits.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 - Intro01:40 - Austin’s Longevity in Quantum02:31 - What’s the Goal of Quantum Computing?05:01 - Creating Fault-Tolerant Qubits06:55 - Advantages of 2D Surface Code08:47 - Austin’s Journey into Quantum16:32 - Working at Google20:14 - Alternatives to Surface Codes22:18 - Should Quantum Computing Be Open Source?25:20 - Quantum Computing is Eating Itself30:52 - Open Source as a Mission35:46 - Advice for People Getting into TQEC39:03 - Bit Flips vs Phase Flips45:43 - History of Surface Codes49:05 - From Surface Code to Fault Tolerance57:19 - What Software do Quantum Computers Need?1:00:17 - Quantum vs Classical Error Correction1:05:57 - Manufacturing Superconducting Qubits1:12:02 - Noise Models in Software1:21:21 - How do NISQ Experiments help us Build Better Computers?1:24:01 - State of the Art Topological QEC1:31:38 - How did the TQEC Community Begin?1:34:46 - Future of TQEC1:36:03 - Quantum AI1:37:58 - Advice for Young Scientists1:41:35 - Underrated Quantum Research1:47:21 - What are the Most Important Upcoming Developments?
• Why Syncing Atomic Clocks is Virtually Impossible | Judah Levine on UTC 26.11.2025 2t 4min

  Why is syncing atomic clocks still one of the hardest problems in physics and engineering?In this episode, we speak with Judah Levine—legendary NIST physicist and one of the key architects of modern timekeeping—about the invisible systems that hold the digital world together. Levine explains why synchronizing atomic clocks across the planet is far more complex than the clocks themselves, and why seemingly simple ideas like “round-trip delay” break down in real-world media such as fiber optics and the internet.We explore how UTC is built from hundreds of atomic clocks, the difference between keeping time and *transferring* time, and the surprising challenges introduced by asymmetric delays, chromatic dispersion, and environmental noise. Levine walks us through the evolution of cesium clocks, the rise of optical clocks, and the technologies that make GPS, finance, power grids, and global communication possible.Along the way, we discuss the history of time synchronization, from railroad schedules to radio frequencies to modern satellite systems; the ongoing debate over leap seconds; and why the future of precision timing depends not just on better clocks, but on better *engineering* to deliver those clocks’ performance to the real world.Whether you’re curious about atomic clocks, relativity, fiber optics, GPS, the structure of time itself, or the hidden physics behind everyday technology, this conversation offers a rare look at how science, engineering, and careful statistical thinking keep modern civilization in sync—down to the nanosecond.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: [https://www.632nm.com](https://www.632nm.com/)Timestamps:00:00 – Intro01:03 – What is UTC?05:50 – Timekeeping for Satellites07:08 – How Radio Created Better Clocks18:32 – From Astronomy to Atoms25:25 – Why are there 24 Hours in a Day?29:55 – Why Synchronizing Clocks is so Hard47:09 – How did Judah get into Clocks?53:29 – Is UTC Vulnerable to Hackers?1:06:41 – Cesium vs Optical Atomic Clocks1:11:23 – How Cesium Clocks Work1:23:35 – Why Cesium Clocks are Imperfect1:26:17 – Judah’s 3 Year Experiment1:29:30 – Statistics with Clocks1:33:40 – Is Time Real?1:36:29 – Is the Universe Slowing Down?1:40:29 – Atomic Time and General Relativity1:42:17 – What’s Left for Atomic Clocks?1:54:34 – What would Judah do with Unlimited Funding?1:58:57 – Judah's Past in Programming2:02:55 – Advice for Young Scientists
• Can We Predict History Like the Weather? | Peter Turchin on Cliodynamics 04.11.2025 1t 18min

  Why do civilizations rise, prosper, and then collapse? Here's what the math tells us.In this episode, we sit down with Peter Turchin, complexity scientist and founder of the field of cliodynamics, which uses data and mathematical models to study the long-term cycles of history. Turchin explains his theory of elite overproduction, how societies generate too many ambitious, educated elites competing for too few positions, and why this dynamic reliably leads to polarization, inequality, and political turmoil.We explore how his structural-demographic theory maps the recurring “boom and bust” rhythms that have shaped civilizations from ancient Rome to modern America, the role of military competition in driving cooperation and social complexity, and how new tools—from AI-assisted historical databases to ancient DNA and LiDAR—are transforming the study of the past.Whether you’re drawn to history, sociology, complexity science, or the fate of modern democracies, this conversation reveals how Turchin’s quantitative approach offers a new way to understand—and maybe even forecast—the forces that make societies rise and fall.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:48 - Overproduction of Elites10:56 - Did Models Predict the Rise of Trump?20:43 - Is Russian History Repeating in the US?26:48 - How Competition Stabilizes Societies32:14 - What Data Goes into Cliodynamic Models?38:13 - How New Technologies Shaped Archaeology43:28 - Can Historians Build Mathematical Intuitions?47:59 - What Questions can be Answered with Cliodynamics?52:23 - Does the NYC Mayoral Race Fit into Turchin's Theory?56:37 - Is Fear of China Bringing Us Together?58:29 - Do Historians Reject Turchin’s Work?1:00:03 - Trends in Civilizations and Outliers1:03:29 - Calvary and the Evolution of Societies1:10:03 - Is Evolution via Natural Selection a Suitable Analog for History?1:15:16 - Could Turchin's Ideas Be Misinterpreted Dangerously?
• Why Do Quantum Computers Make So Many Mistakes? | Mikhail Lukin on Quantum Error Correction 21.10.2025 1t

  You can’t copy a qubit. So how do quantum computers remember anything?In this episode, we sit down with Mikhail Lukin, Harvard physicist and co-director of the Harvard Quantum Initiative, whose lab is building quantum computers from arrays of individually trapped atoms. Lukin explains the paradox of quantum error correction—how you can safeguard quantum information even though it can’t be copied or measured directly—and why this breakthrough may be the key to making large-scale quantum computers possible.We dive into the strange logic of superposition, entanglement, and “small cat states,” explore what makes quantum evolution inherently analog, and learn how Lukin’s team uses optical tweezers and Rydberg interactions to engineer stable, reconfigurable qubits—atoms literally held and moved by light.Whether you’re fascinated by quantum mechanics, computing, Schrödinger’s cat, or the future of information, this conversation reveals how physicists are turning the weirdness of quantum physics into working technology—and why building a fault-tolerant quantum computer is one of the hardest and most exciting challenges in science today.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:32 - Fundamentals of Quantum Computers04:09 - Transistors vs Quantum Gates10:07 - What is Quantum Error Correction?14:23 - State of the Art QEC22:19 - Quantum Research Before Lukin27:35 - Lukin’s Breakout Work31:10 - From Quantum Optics to Quantum Computing36:59 - Working with Neutral Atoms48:17 - Funding Quantum Computers50:00 - Transverse Gate Operations58:22 - Is Quantum Computing All Hype?#quantumcomputing #quantumerrorcorrection #mikhaillukin #qubits  #schrodingerscat  #entanglement #superposition #quantumphysics
• We Interviewed the Winners of the Ig Nobel Prize | Ig Nobel 2025 09.10.2025 1t 5min

  The scientific stories behind this year's research that made people LAUGH, then THINK.Watch the 2025 Ig Nobel Ceremony here: https://youtu.be/z1cP4xKd_L4In this episode, we bring together three of this year’s Ig Nobel winners whose research spans psychology, food science and human biology. You’ll hear how a team of psychologists devised a counter-intuitive way to boost a narcissist’s self-confidence; how two physicists uncovered the “mozzarella phase” of pecorino cheese while perfecting cacio e pepe; and how a group studying lactation discovered that garlic changes breast-milk’s aroma and baby behavior.We explore the playful setups, surprising results and serious science behind each project, and how curiosity, humor and a dash of persistence turned ordinary questions into prize-winning research.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:19 - Physics Prize: Cacio e Pepe Sauce30:40 - Pediatrics Prize: Garlic Breast Milk44:48 - Psychology Prize: How to Boost Narcissism#ignobel2025 #cacioepepe #pastasauce #thermodynamics  #psychology  #dairy #pecorino
• What Science can Learn from Startups | Adam Marblestone on Focused Research Organizations 07.10.2025 1t 41min

  Science has stalled. And Adam Marblestone thinks he knows why.Check out the Research Gap Map here: https://www.gap-map.org/?sort=rankIn this episode, we sit down with Adam Marblestone, neuroscientist, nanotechnologist, and founder of Convergent Research, to explore how new “Focused Research Organizations” (FROs) could reignite scientific progress. From DNA “ticker-tape” neural recording to optical connectomics and Neuralink, Marblestone explains how emerging neurotechnologies reveal both the brilliance and the bottlenecks of today’s research system.We discuss why traditional funding often fails to support ambitious, interdisciplinary projects, how FROs borrow the focus and speed of startups to build scientific infrastructure, and why projects like OpenAI, E11 Bio, and ultrasound-on-a-chip exemplify this new model. Marblestone breaks down his “Gap Map” of unsolved scientific challenges - from room-temperature superconductors to artificial ribosomes - and does the math on how tens of billions of dollars could close them.Whether you’re fascinated by neuroscience, scientific innovation, or the future of research itself, this conversation offers a rare insider’s look at how new institutions could rebuild the engine of discovery—and why the next wave of breakthroughs might depend more on organization than on ideas.Follow us for more technical interviews with the world’s greatest scientists:Twitter: https://x.com/632nmPodcastInstagram: https://www.instagram.com/632nmpodcast?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==LinkedIn: https://www.linkedin.com/company/632nm/about/Substack: https://632nmpodcast.substack.com/Follow our hosts!Michael Dubrovsky: https://x.com/MikeDubrovskyMisha Shalaginov: https://x.com/MYShalaginovXinghui Yin: https://x.com/XinghuiYinSubscribe:Apple Podcasts: https://podcasts.apple.com/us/podcast/632nm/id1751170269Spotify: https://open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6ORWebsite: https://www.632nm.comTimestamps:00:00 - Intro01:25 - Working with George Church13:03 - Neuralink22:23 - Gap Maps31:47 - Artificial Ribosome36:45 - What is Convergent Research?40:03 - What are FROs?44:16 - What Made OpenAI So Successful?48:19 - Has AI Actually Impacted Science?52:15 - Notable FROs1:05:43 - Why Haven't There Been More Scientific Breakthroughs?1:09:47 - Lithography and Chip Design1:13:41 - We Can't Beat Insects1:16:45 - What Separates Good FROs1:18:40 - East vs West Coast Innovation1:27:21 - Research into Longevity1:33:27 - Advice for Grad Students1:39:40 - How to Get Involved in FROs#neuroscience #molecularbiology #quantumphysics #researchfunding #startups