The Metabolic Link

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• Inflammation and Glycation: The Two Heads of Chronic Disease | Dr. Paul Reynolds, PhD | The Metabolic Link Ep. 96 02.06.2026 1год 14хв

  Dr. Paul Reynolds has spent his career studying what he calls “two heads of the same beast”: inflammation and glycation — two interlocking processes that may help explain why so many chronic diseases are connected, even when they are treated as separate conditions. Dr. Reynolds is a professor and research scientist at Brigham Young University whose NIH-funded research program studies inflammation, lung biology, glycation, and the AGE/RAGE receptor system that links metabolic and environmental...
• Metabolic Psychiatry in Clinical Practice: Brain Energy, Common Pitfalls, & Precision Nutrition | Dr. Bret Scher, MD | The Metabolic Link Ep. 95 19.05.2026 51хв

  In people with severe depression and cognitive decline, brain glucose metabolism has been shown in some studies to decline measurably. Ketone metabolism, by contrast, appears relatively preserved. That single observation is reshaping how researchers think about psychiatric illness. In this episode, Dominic D'Agostino sits down with Bret Scher, a cardiologist who pivoted to metabolic psychiatry and now leads clinical education and content for Metabolic Mind at the Baszucki Group. Dr. Scher bri...
• Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94 05.05.2026 1год 26хв

  A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants alive. Dr. Gideon Mailer and Nicola Hale join The Metabolic Link to present their hypothesis that the CPT1A L479 Arctic variant is not anti-ketogenic but pro-metabolic flexibility, conserving glucose by upregulating ketosis at the fed-state thresh...
• Understanding Female Metabolism: PCOS, Postpartum, and Menopause | Madison Kackley, PhD | The Metabolic Link 21.04.2026 1год 24хв

  In a 12-week clinical trial at The Ohio State University, every woman with PCOS who completed the intervention experienced a change in her menstrual status. One participant, who had never had a period in her life, began menstruating within a week. Another saw spotting after five years of amenorrhea while taking only a ketone supplement without adopting a ketogenic diet. These are among the earliest controlled findings linking ketogenic interventions directly to reproductive hormone restoratio...
• Vagal Nerve Stimulation, TBI, and Brain Health: Rethinking Neurological Care | Dr. Michael Hoffman, MD | The Metabolic Link Ep. 92 07.04.2026 1год 27хв

  A veteran walks into the clinic with a persistent migraine. Four minutes of vagal nerve stimulation later, the migraine is gone. This is not a one-off result. It is what Dr. Michael Hoffman has been observing for over seven years in the VA hospital system, using non-invasive devices he considers severely underutilized. Dr. Hoffman is a stroke and cognitive-behavioral neurologist who trained at Columbia University, spent 14 years in the VA system, and has evaluated an estimated 10,000 stroke ...
• What's in Your Tap Water? Contaminants, Filtration, and How to Test It | Johnny Pujol | The Metabolic Link Ep. 91 24.03.2026 1год 11хв

  You could have elevated levels of contaminants like uranium or arsenic in your drinking water—and not know it. Many of these compounds are colorless, odorless, and undetectable without testing. Johnny Pujol is a water chemist and the founder of Tap Score, a drinking water testing platform supported by a network of roughly 270 specialized laboratories. His path from electrochemistry research to consumer water testing was driven by a simple realization: the chemistry inside what looks like a cl...
• Rethinking Cognitive Decline: Stimulus, Exercise, and the Aging Brain | Dr. Tommy Wood, MD, PhD | The Metabolic Link Ep. 90 10.03.2026 1год 42хв

  Register for a live Q&A with Dr. Tommy Wood on Wednesday, March 25th. Decreased glucose uptake in the brain is often considered a hallmark of Alzheimer's disease. But Dr. Tommy Wood asks whether part of that metabolic signature may reflect how little cognitive demand we place on the brain. He sits down with Dr. Dominic D'Agostino for a nuanced conversation on metabolic health and cognitive function.. Dr. Wood is a neuroscientist, neonatal brain injury researcher, and author of The Stimula...
• Journal Club: Five Papers Pushing the Boundaries of Metabolic Therapy | The Metabolic Link Ep. 89 03.03.2026 1год 8хв

  Get free access to our new Ketogenic Metabolic Therapy ebook here. Could changing your metabolism reduce alcohol cravings, ease psychiatric symptoms, and even make cancer immunotherapy more effective? The science is pointing to yes, and the mechanisms are fascinating. In this Journal Club episode, co-hosts Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff break down five peer-reviewed papers from their newly released Ketogenic Metabolic Therapy ebook (Volume 4). From a French precli...
• Mitochondria, Muscle, & Aging: What Longevity Drugs Miss | Dr. Mark Tarnopolsky | The Metabolic Link Ep. 88 24.02.2026 1год 31хв

  Dr. Mark Tarnopolsky's VO2 max was once 87.6 ml/kg/min — an elite-level mark few humans have reached. He's competed at three world championships in three different sports. He's also had three cardiac ablation surgeries, bled from his bowels after races, and watched his vision tunnel to a speck crossing a finish line. His story is a master class in where the line falls between peak performance and self-destruction. Now 63, Tarnopolsky is a neurologist, neuromuscular disease specialist, and sup...
• Trauma, Inflammation, and Neurodegeneration: A New Framework for Alzheimer's | Dr. Caesar Hernandez, MS, PhD | The Metabolic Link Ep. 87 10.02.2026 1год 18хв

  Roughly 90% of Alzheimer's patients develop neuropsychiatric symptoms including anxiety, persistent fear, and an inability to recognize safety — but little research is being done to investigate why. New data connecting PTSD, trauma, and accelerated brain aging may hold the answer. Dr. Caesar Hernandez is a behavioral, molecular, and circuit neuroscientist and assistant professor in the Division of Gerontology, Geriatrics & Palliative Care at the University of Alabama at Birmingham. His re...
• The Metabolic Roots of Cardiovascular Disease: A Vascular Surgeon's Perspective | Dr. Lily Johnston | The Metabolic Link Ep. 86 27.01.2026 1год 18хв

  What if the sequence we've always assumed—plaque causes arterial stiffness—is actually backwards? Dr. Lily Johnston proposes that impaired nitric oxide signaling may stiffen arteries first, creating the endothelial injury that then promotes plaque formation. Dr. Lily Johnston is a board-certified vascular surgeon and newly certified obesity medicine physician who bridges the operating room and metabolic medicine. After years of scraping plaque from arterial walls, she began questioning why su...
• Ultra-Processed Food and Nutrition Policy: What We're Getting Wrong | Dr. David Ludwig | The Metabolic Link Ep. 85 13.01.2026 1год 21хв

  The term “ultra-processed food” appeared nearly 100 times in the White House’s Make America Healthy Again report. But questions remain about whether the concept is precise enough to guide effective policy. Dr. David Ludwig—Harvard endocrinologist, obesity researcher, and author of Always Hungry—joins Dr. Dominic D'Agostino to dismantle the ultra-processed food framework from the inside out. Ludwig reveals why the NOVA classification system lumps protein bars with soda, why the FDA admitted th...
• Metabolic Oncology: From Theory To Clinical Application | Dr. Tomás Duraj | The Metabolic Link Ep. 84 30.12.2025 55хв

  Glioblastoma has a long-term survival rate under 1% at ten years. After decades of research focusing primarily on mutation-targeted therapies, median survival has improved by only a few months. Dr. Tomás Duraj believes there's a better path forward. Dr. Duraj is a physician-scientist at Boston College working on the metabolic vulnerabilities of cancer. In this Metabolic Health Summit presentation, he outlines a clinical framework for studying ketogenic metabolic therapy — one built on biomark...
• Metabolic Health: The Missing Link in Cancer Therapy? | Dr. Christy Kesslering | The Metabolic Link Ep. 83 16.12.2025 1год 8хв

  After 20+ years treating cancer patients, Dr. Christy Kesslering started asking a question her colleagues weren't asking: why are so many of my breast cancer patients metabolically sick — even when they're not obese? That question changed everything. Dr. Kesslering is a classically-trained radiation oncologist, metabolic health practitioner, and terrain theorist. She spent two decades practicing oncology in the Chicagoland area before transitioning to focus full-time on what she believes is...
• Health Optimization Medicine: HBOT, Nervous System Regulation, and Mitochondrial Healing | The Metabolic Link Ep. 82 | Dr. Scott Sherr| 02.12.2025 1год 12хв

  A patient arrives at shock trauma with flesh-eating bacteria, limbs appearing unsalvageable. Hours later, after treatment in a massive submarine-like chamber, those same limbs show signs of recovery. This pivotal moment launched Dr. Scott Sherr's journey into the world of hyperbaric oxygen therapy and its untapped potential for metabolic healing. Victoria Field welcomes Dr. Scott Sherr, a board certified internal medicine physician who transformed his practice after witnessing HBOT's dramatic...
• Metabolic Neurology: Fasting, Ketosis, & the Future of Brain Health | Dr. Matthew Phillips | The Metabolic Link Ep. 81 18.11.2025 1год 19хв

  What if the key to treating neurodegenerative diseases lies not in attacking symptoms, but in healing mitochondria? Dr. Matthew Phillips, a neurologist who coined the term "metabolic neurologist," shares groundbreaking insights from his decade-long journey implementing ketogenic diets and fasting protocols for Parkinson's, Alzheimer's, and glioblastoma patients. In this episode, Dr. Phillips reveals his clinical framework combining metabolic therapies with standard of care, his current gliobl...
• Dr. Nina Teicholz | America's Metabolic Decline: The High-Cost of Low Fat | The Metabolic Link Ep 80 04.11.2025 1год 5хв

  For over fifty years, Americans have been told that cutting fat was the key to better health. Yet after decades of low-fat guidelines, rates of obesity, diabetes, and metabolic dysfunction have skyrocketed - now affecting more than 88% of the population. In this episode of The Metabolic Link, Victoria Field sits down with Dr. Nina Teicholz, science journalist and author of The Big Fat Surprise, whose decade-long investigation into nutrition science uncovered how flawed evidence and policy dec...
• Metabolic Therapy for Pets: The Future of Veterinary Medicine | Dr. Loren Nations | The Metabolic Link Ep. 79 21.10.2025 1год 9хв

  When veterinarian Dr. Loren Nations lost his wife to aggressive cancer despite the best conventional treatments, he didn't just grieve—he revolutionized his entire approach to medicine. In this deeply personal conversation, Dr. Nations reveals how tragedy led him to discover that our pets are experiencing metabolic disease at rates even higher than humans, with 61% of cats and 59% of dogs now obese. Dr. Loren Nations is a board-certified veterinarian with over 30 years of experience. He's the...
• Can a Ketogenic Diet Improve Sleep Apnea? | Dr. Jonathan Jun | The Metabolic Link Ep. 78. 08.10.2025 47хв

  What if the food you eat could change the way you breathe at night? In this episode, recorded live at The Metabolic Health Summit, Dr. Jonathan Jun reveals how metabolism and sleep-disordered breathing are deeply connected, and why shifting from carbs to fat might improve more than just your waistline. Dr. Jonathan Jun, a leading researcher on obesity hypoventilation syndrome (OHS) and obstructive sleep apnea (OSA), walks us through the groundbreaking KETOHS trial, where a ketogenic diet was ...
• The Metabolic Approach to Treating Food Addiction | Dr. Tro Kalayjian | The Metabolic Link Ep. 77 01.10.2025 1год 22хв

  Could treating food like a drug be the breakthrough we've needed in food addiction treatment? In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Tro Kalayjian - physician, researcher, and former obesity patient - to explore whether food addiction should be classified as a true addiction, and how his TOWARD model is helping patients overcome binge eating and food-related compulsions. Dr. Tro shares findings from his recent peer-reviewed paper, TOWARD: a Metabolic ...