Bloody Minded

Episodes

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  Episode 108 - Single MALT | Marginal Zone Lymphoma 14.10.2026 44m

  What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe. Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway. TIMESTAMPS 0:57 - Whisky sponsorship pls and thx 2:11 - W...
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  Episode 107 - Folliculi Follicula | Follicular Lymphoma 07.10.2026 44m

  Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands. Timestamps 00:52 - Bashar is banned from the Aquarium a second time 02:13 - Follicular Lymphoma Overview 06:07 - Pathophysiology of FL 09:50 - Follicular Lymphoma In Situ (Old Name) 11:54 - Clinical & Morphology 17:24 - Identifying FL in the Lab 20:0...
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  Episode 106 - Seal Team L | Chronic Lymphocytic Leukaemia (CLL) 30.09.2026 48m

  Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia! TIMESTAMPS 0:55 - No animals were harmed in the making of this bit 4:13 - Epidemiology of CLL 5:56 - Pathophysiology of CLL 11:42 - MBL 12:36 - SLL 15:54 - Clinical features of CLL 18:1...
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  Episode 105 - Lymphoverview – An Overview of the Lymphoid Disorders 23.09.2026 42m

  Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot. 0:52 - Lymphoid Planet 2:50 - Leukaemia vs Lymphoma 4:51 - Two Questions & A Recap 8:49 - Identifying a Cell 16:22 - Indolent vs Aggressive...
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  Episode 104 - Immunology 102 | Lymphocyte Maturation & The Lymph Node 16.09.2026 29m

  For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutat...
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  Episode 103 - On The Wards: Breaking Bad . . . Cells | Tumour Lysis Syndrome 02.09.2026 42m

  Have you been asked to review “TLS” bloods?? Are you concerned the nursing staff are pranking you with haematology bloods that don’t include a FBC or coags? Why could you possibly want to look at something that isn’t a cell count? What crazy person decided after hours bloods needed to be collected on ICE? And WHY ?!?! Join us for an On The Wards approach to dealing with those TDS TLS SOS calls. TIMESTAMPS: 0:56 - The team breaking stuff 3:40 - Episode overview 5:07 - Setting the scene 6:33 - ...
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  Episode 102 - Reign in Blood | Heavy Metals in Haematology 19.08.2026 31m

  It’s the heaviest matter of haematology as we look at the role of heavy metals in our favourite metalloenzymes. What - you don’t have a favourite metalloenzyme? But nothing else matters?! Anyway, this is no esoteric surgical content, join us as Nick, Cale and Bashar get comfy with the weirder parts of the periodic table and how they apply to less common deficiencies or toxicities in haematology. Look we’ll be honest with you - this is pretty low yield listening but it was fun, and reall...
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  Episode 101 - Let’s get K-rakin | All about Vitamin K 12.08.2026 42m

  Is it a giant Cthulu-esque sea monster? Is it an excellent Australian parody breakfast show? No - it’s everyone’s favourite (well everyone who counts) coagulation related Vitamin - Vitamin K! Where does it come from? Why is it so hard to find on the eMR when you want to prescribe it and what is it doing under phytomenadione? Can we test for it? After listening to Nick, Cale and Bashar wax lyrical about carboxylation for half an hour you’ll be ready to vitamin K-nock yourself out. TIMESTAMPS 0...
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  Episode 100 - 100 Not Out | A Bloody History of Haematology 05.08.2026 37m

  Four humours in balance, the ancients decreed - so open a vein, let the bad blood be freed. From Galen to Harvey, from humours to genes, From black bile and phlegm to the things on our screens. From PML::RARA to blood counts okay Let’s celebrate our specialty - we’ve come a damn long way Join us as we travel from the first man to see a red cell, to the first to give people arsenic on purpose who was actually well-intentioned! Pour one out for Galen who was confidently incorrect f...
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  Episode 99 - It’s the B’s Knees | In The Lab : B12 and B9 (Folate) Testing 29.07.2026 25m

  Two vitamins survived the great B-numbering cull to become the tests we order most and trust least. Meet the 80% of your B12 result your cells can't touch, and the antibody that sabotages the very test built to catch it. Join the Bloody Minded Crew as we come to the lab for a second time this season to learn how B12 and folate assays are performed. TIMESTAMPS 0:55 - The boys check out a new lab 2:25 - Episode overview 3:43 - Sample requirements 4:12 - B12 refresher &nb...
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  Episode 98 - Liver Storage World | Approach to Hyperferritinaemia 22.07.2026 27m

  ‘This bad boy can fit so much iron in it’ he said slapping the roof of a badly photoshopped molecule of apoferritin superimposed on a car. Is too much ferritin bad for you? Of course it is - too much is precisely the quantity that is in excess. But most of the time hyperferritinaemia has nothing to do with iron overload. Strap in to your 1992 Honda Civic as the Bloody Minded Crew learn all about ferritin, and why most of the time too much of it has nothing to do with your iron levels at all. ...
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  BONUS - BloodyMinded x THANZ go to ISTH2026 21.07.2026 28m

  It's a BONUS episode today as the Bloody Minded Crew are delighted to partner with the Thrombosis and Haemostasis Society of Australia and New Zealand (THANZ). After (correctly) exiling Nick to another country after he suggested yet more coagulation themed episodes, he's returned like Gandalf stronger and more powerful than ever. We cornered THANZ members at the International Society for Thrombosis and Haemostasis 2026 meeting to chat about what was keeping them interested. Special thanks to ...
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  Episode 97 - There's a Hole in My Bucket | Iron, B12 and Folate Deficiency in Clinic 15.07.2026 39m

  Nick wanted to talk about buckets all episode. I’ve convinced him to at least let us get angry at iron polymaltose, hypophosphatemia and nangs all over again. You don’t think you need this episode but you’d be amazed how many consults come through to Haem thinking we’re the gatekeepers of iron in the building. Ironic, really. TIMESTAMPS 0:56 - 1960s pop culture reference 3:20 - Episode overview 4:40 - Iron deficiency 6:28 - Pica chat 7:53 - Presentations of iron deficiency 8:36 - Causes of ir...
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  Episode 96 - On the Ning Nang Nongs | B12 and Folate Metabolism 08.07.2026 34m

  On the Ning Nang Nongs where the youths smoke bongs and the marrow all screams HELP! Join the Bloody Minded crew as they go through the round window, follow B12 and folate around the body in a Nang induced haze, presumably just like the writers on Play School once were. Mandatory viewing: https://www.youtube.com/watch?v=3SUU1f3Mgpc&list=RD3SUU1f3Mgpc&start_radio=1 TIMESTAMPS 0:53 - A Bloody Minded After School Special 1:50 - Megaloblastic Anaemias 2:59 - An Intro to B12 7:49 - B...
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  Episode 95 - Feeling Rusty? | In The Lab: Iron Studies 01.07.2026 26m

  Heal with steel? Absolutely not - There’s no alloys or for that matter surgeons allowed in the safe space of the laboratory. Join us on another wonderful lab adventure as Bashar, Cale and Nick head down to the biochemistry lab to work out exactly how our iron studies are performed in the lab before you throw the serum iron in the bin. TIMESTAMPS 0:53 - An early etymological diversion 2:53 - Serum iron 9:43 - UIBC 11:22 - TIBC 13:34 - Transferrin 15:45 - Transferrin saturation 17:25 - Ferritin...
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  Episode 94 - It should be a Fe-lony | Interpeting Iron Studies 24.06.2026 25m

  Taunted by transferrin? Befuddled by ferritin? Scratching your head at why we throw the serum iron results directly into the confidential waste bin, which is a more dignified burial than it deserves? Come along as the boys discuss the interpretation of iron studies in a definitely tight, definitely 20ish minute episode. Timestamps 00:54 - Just Iron Studies with No Nonsense 02:21 - Overview of Iron Stuides 03:42 - Serum Iron 05:35 - Transferrin 07:32 - TIBC 08:35 - UIBC 10:47 - Transferrin Sat...
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  Episode 93 - The Silmaril-IRON | Iron Metabolism 17.06.2026 44m

  One molecule to rule them all, one molecule to find them. One molecule to bring them all, and in the liver bind them. Hepcidin is the key to understanding iron metabolism and we examine how iron gets into, around and out of the body. We promise not to be too Celebrimbor-ing as you join Nick, Cale and Bashar for this discussion of the basic science of iron handling in preparation for our journey into the building blocks of blood. Welcome to Lord of the Haematinics. TIMESTAMPS 0:56...
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  Episode 92 - On The Wards: A Practical Guide To Anticoagulants | Part 3 (Fancy Anticoagulants) 03.06.2026 40m

  Has your ward team been hit with HITT? Is Jane the only Fonda you know? Is BAD an 80s hit and not a trio of anti-coagulation infusions (Bivalirudin, Argatroban and Danaparoid). Is Alison showing her age? Never fear; join Alison, Bashar, Nick and Cale as they aim to de-mystify less commonly used anticoagulation that may come up on the wards. TIMESTAMPS 0:56 - It's Fancypants Wednesday! 2:15 - Episode overview 4:37 - Fondaparinux 9:07 - When to use fonda 12:35 - Argatroban 17:25 - When to...
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  Episode 91 - Have you tried turning it off and on again? | Allogeneic transplant in AML with Prof John Moore 20.05.2026 57m

  Join us in our third straight week of incredibly nice and incredibly talented haematology gurus as Professor John Moore joins us as an expert guest to discuss stem cell transplant in the myeloid disease setting. TIMESTAMPS 1:00 – HYTTIOAOA 1:47 – Introducing Professor John Moore 8:06 – Advice to RMOs on the Allo Term 11:02 – The history of allogeneic transplantation 18:26 – Modern morbidity/mortality from alloSCT for AML 23:05 – Use of transplant scor...
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  Episode 90 - GENEsis | In the Lab: NGS in AML with Dr Michael Krigstein 13.05.2026 54m

  This week we continue the pattern of guests who are really really ridiculously good at haematology and also really really ridiculously nice people as well. We are very excited to be joined by Dr Michael Krigstein who many of you would know as the a molecular haematology guru who has gotten countless patients through their diagnoses and countless haematology trainees through their exams. Timestamps: 01:30 - Introducing Dr Michael Krigstein 04:23 - Getting into Lab Haem 08:30 - The Mechanics of...